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Balance Sheet
Assets
Flat$142,045,531
Flat from 2012
Net Assets
Flat$139,194,788
Flat from 2012
Liabilities
Flat$2,850,743
Flat from 2012
Revenue And Expenses
Revenue
-
No earlier filing loaded for comparison.
Expenses
Flat$40,164,028
Flat from 2012
Net Income
-
No earlier filing loaded for comparison.
Historical Trend
Jump To
Filing Snapshot
- Filing Period
- Jan 1, 2012 to Dec 31, 2012
- Signed
- Nov 13, 2013
- Return Version
- 2012v2.1
- Gross Receipts
- $61,386,918
Mission and Program Overview
Mission
The mission of path vaccine solutions (pvs) is to improve the health of children in low-income countries by accelerating the development of vaccines that will be effective and affordable for those who need them most. From initial discovery through clinical trials, pvs works with commercial partners, such as vaccine manufacturers and biotechnology firms, and nonprofit partners, such as universities and research institutions, to shorten the timeline for vaccine development.pvs works with partners to develop new vaccines by providing funding and expertise in preclinical development, manufacturing, and clinical development, with a focus on low-resource countries. In return, partners agree to terms that help ensure the resulting products are affordable and available in developing countries.
Filing and Contact Details
Filer
- EIN
- 83-0431851
Raw XML AppendixShowing 400 of 1,233 raw XML fields
This appendix keeps the raw XML leaves available for debugging and edge-case review. The human report above is the primary experience.
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| IRS990/Description | 0 | PVS WORKS TO PREVENT DEATHS FROM PNEUMONIA, INFLUENZA, RESPIRATORY SYNCYTIAL VIRUS, POLIO, AND DIARRHEA AMONG CHILDREN AROUND THE WORLD. WE ACCELERATE THE DEVELOPMENT OF SAFE, EFFICACIOUS, AND AFFORDABLE VACCINES IN PARTNERSHIP WITH PUBLIC AND PRIVATE GROUPS. IN 2012, PVS ADVANCED RESEARCH AND DEVELOPMENT OF A NUMBER OF PROMISING PNEUMOCOCCAL VACCINE CANDIDATES AND RELATED TECHNOLOGIES. THIS WORK RANGED FROM PRELIMINARY RESEARCH TO PRECLINICAL DEVELOPMENT TO CLINICAL TRIALS FOR SEVERAL CANDIDATES. FOR EXAMPLE, WE ADVANCED AN INACTIVATED WHOLE-CELL VACCINE CANDIDATE DEVELOPED IN PARTNERSHIP WITH BOSTON CHILDREN'S HOSPITAL INTO A FIRST-IN-HUMAN PHASE 1 CLINICAL TRIAL. THE VACCINE CANDIDATE DEMONSTRATED AN ACCEPTABLE SAFETY AND REACTOGENICITY PROFILE AS WELL AS POSITIVE IMMUNOGENICITY RESULTS THAT SUPPORT CONTINUING CLINICAL DEVELOPMENT. IN PARTNERSHIP WITH SERUM INSTITUTE OF INDIA, LTD., WE CONTINUED PREPARING TO BRING A 10-VALENT PNEUMOCOCCAL CONJUGATE VACCINE (PCV-10) CANDIDATE FROM PRECLINICAL RESEARCH INTO CLINICAL DEVELOPMENT. TAILORED TO CHILDREN'S NEEDS IN LOW-RESOURCE COUNTRIES, THE PCV-10 CANDIDATE IS DESIGNED TO BE AFFORDABLE AND FOCUSES ON VARIETIES OF THE PNEUMOCOCCUS BACTERIUM THAT ARE PREVALENT IN THE DEVELOPING WORLD. INFECTION WITH ROTAVIRUS IS A MAJOR CAUSE OF SEVERE DIARRHEA AND DEATH AMONG YOUNG CHILDREN IN LOW-INCOME COUNTRIES. PVS AIMS TO ACCELERATE INTRODUCTION OF SAFE, AFFORDABLE, AND EFFECTIVE ROTAVIRUS VACCINES BY PROVIDING TECHNICAL AND FINANCIAL SUPPORT TO EMERGING-COUNTRY MANUFACTURERS. HIGHLIGHTS DURING 2012 INCLUDED WORKING WITH BHARAT BIOTECH INTERNATIONAL, LTD. IN INDIA TO CONDUCT A PHASE 3 EFFICACY TRIAL OF ITS ROTAVIRUS VACCINE CANDIDATE, ACHIEVING SUFFICIENT STUDY ENDPOINTS TO ALLOW FOR DATABASE LOCK IN NOVEMBER 2012 AND PREPARATION FOR PRIMARY DATA ANALYSIS TO OCCUR IN EARLY 2013; PARTNERING WITH THE SERUM INSTITUTE OF INDIA, LTD., TO PREPARE FOR A PHASE 3 EFFICACY TRIAL OF ITS ROTAVIRUS VACCINE CANDIDATE, INCLUDING THE CONDUCT OF A PREPARATORY STUDY AT FOUR TRIAL SITES IN INDIA; AND LAUNCHING A FIRST-IN-HUMAN PHASE 1 TRIAL OF THE P2-VP8 NONREPLICATING ROTAVIRUS VACCINE CANDIDATE DEVELOPED BY THE US NATIONAL INSTITUTES OF HEALTH.PVS ALSO ADVANCES RESEARCH AND DEVELOPMENT OF VACCINES AGAINST THE TWO LEADING BACTERIAL CAUSES OF DIARRHEA, SHIGELLA AND ENTEROTOXIGENIC ESCHERICHIA COLI (ETEC). MUCH OF THIS WORK IS DONE THROUGH PARTNERSHIPS WITH PUBLIC- AND PRIVATE-SECTOR ORGANIZATIONS. KEY ACTIVITIES IN 2012 INCLUDED COMPLETING A FOLLOW-ON STUDY OF AN ETEC HUMAN CHALLENGE MODEL, CONDUCTING TWO PHASE 1 TRIALS OF ETEC VACCINE CANDIDATES (AN INACTIVATED TETRAVALENT AND A LIVE ATTENUATED TRIVALENT) ADMINISTERED WITH AND WITHOUT A NOVEL MUCOSAL ADJUVANT, AND COMPLETING TWO PHASE 1 TRIALS OF SHIGELLA CANDIDATES (AN INACTIVATED WHOLE-CELL VACCINE AND A LIVE ATTENUATED VACCINE). |
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| IRS990ScheduleF/AcctsActvsOutUSTable/NumberOfOffices | 2 | 0 |
| IRS990ScheduleF/AcctsActvsOutUSTable/NumberOfOffices | 3 | 0 |
| IRS990ScheduleF/AcctsActvsOutUSTable/NumberOfOffices | 4 | 0 |
| IRS990ScheduleF/AcctsActvsOutUSTable/NumberOfOffices | 5 | 0 |
| IRS990ScheduleF/AcctsActvsOutUSTable/NumberOfOffices | 6 | 0 |
| IRS990ScheduleF/AcctsActvsOutUSTable/NumberOfOffices | 7 | 0 |
| IRS990ScheduleF/AcctsActvsOutUSTable/NumberOfOffices | 8 | 0 |
| IRS990ScheduleF/AcctsActvsOutUSTable/NumberOfOffices | 9 | 0 |
| IRS990ScheduleF/AcctsActvsOutUSTable/NumberOfOffices | 10 | 0 |
| IRS990ScheduleF/AcctsActvsOutUSTable/NumberOfOffices | 11 | 0 |
| IRS990ScheduleF/AcctsActvsOutUSTable/NumberOfOffices | 12 | 0 |
| IRS990ScheduleF/AcctsActvsOutUSTable/NumberOfOffices | 13 | 0 |
| IRS990ScheduleF/AcctsActvsOutUSTable/NumberOfOffices | 14 | 0 |
| IRS990ScheduleF/AcctsActvsOutUSTable/NumberOfOffices | 15 | 0 |
| IRS990ScheduleF/AcctsActvsOutUSTable/NumberOfOffices | 16 | 0 |
| IRS990ScheduleF/AcctsActvsOutUSTable/Region | 0 | EAST ASIA AND THE PACIFIC |
| IRS990ScheduleF/AcctsActvsOutUSTable/Region | 1 | EAST ASIA AND THE PACIFIC |
| IRS990ScheduleF/AcctsActvsOutUSTable/Region | 2 | EUROPE |
| IRS990ScheduleF/AcctsActvsOutUSTable/Region | 3 | EUROPE |
| IRS990ScheduleF/AcctsActvsOutUSTable/Region | 4 | MIDDLE EAST AND NORTH AFRICA |
| IRS990ScheduleF/AcctsActvsOutUSTable/Region | 5 | NORTH AMERICA |
| IRS990ScheduleF/AcctsActvsOutUSTable/Region | 6 | NORTH AMERICA |
| IRS990ScheduleF/AcctsActvsOutUSTable/Region | 7 | RUSSIA AND THE NEWLY INDEPENDENT STATES |
| IRS990ScheduleF/AcctsActvsOutUSTable/Region | 8 | RUSSIA AND THE NEWLY INDEPENDENT STATES |
| IRS990ScheduleF/AcctsActvsOutUSTable/Region | 9 | SOUTH AMERICA |
| IRS990ScheduleF/AcctsActvsOutUSTable/Region | 10 | SOUTH AMERICA |
| IRS990ScheduleF/AcctsActvsOutUSTable/Region | 11 | SOUTH ASIA |
| IRS990ScheduleF/AcctsActvsOutUSTable/Region | 12 | SOUTH ASIA |
| IRS990ScheduleF/AcctsActvsOutUSTable/Region | 13 | SOUTH ASIA |
| IRS990ScheduleF/AcctsActvsOutUSTable/Region | 14 | SOUTH ASIA |
| IRS990ScheduleF/AcctsActvsOutUSTable/Region | 15 | SUB-SAHARAN AFRICA |
| IRS990ScheduleF/AcctsActvsOutUSTable/Region | 16 | SUB-SAHARAN AFRICA |
| IRS990ScheduleF/AcctsActvsOutUSTable/SpecificServicesProvided | 0 | VACCINES AND IMMUNIZATIONS |
| IRS990ScheduleF/AcctsActvsOutUSTable/SpecificServicesProvided | 1 | VACCINES AND IMMUNIZATIONS |
| IRS990ScheduleF/AcctsActvsOutUSTable/SpecificServicesProvided | 2 | VACCINES AND IMMUNIZATIONS |
| IRS990ScheduleF/AcctsActvsOutUSTable/SpecificServicesProvided | 3 | VACCINES AND IMMUNIZATIONS |
| IRS990ScheduleF/AcctsActvsOutUSTable/SpecificServicesProvided | 4 | VACCINES AND IMMUNIZATIONS |
| IRS990ScheduleF/AcctsActvsOutUSTable/SpecificServicesProvided | 5 | VACCINES AND IMMUNIZATIONS |
| IRS990ScheduleF/AcctsActvsOutUSTable/SpecificServicesProvided | 6 | MANAGEMENT & GENERAL |
| IRS990ScheduleF/AcctsActvsOutUSTable/SpecificServicesProvided | 7 | HEALTH TECHNOLOGIES |
| IRS990ScheduleF/AcctsActvsOutUSTable/SpecificServicesProvided | 8 | VACCINES AND IMMUNIZATIONS |
| IRS990ScheduleF/AcctsActvsOutUSTable/SpecificServicesProvided | 9 | VACCINES AND IMMUNIZATIONS |
| IRS990ScheduleF/AcctsActvsOutUSTable/TotalExpenditures | 0 | 430704 |
| IRS990ScheduleF/AcctsActvsOutUSTable/TotalExpenditures | 1 | 1039215 |
| IRS990ScheduleF/AcctsActvsOutUSTable/TotalExpenditures | 2 | 1211597 |
| IRS990ScheduleF/AcctsActvsOutUSTable/TotalExpenditures | 3 | 1428434 |
| IRS990ScheduleF/AcctsActvsOutUSTable/TotalExpenditures | 4 | 155 |
| IRS990ScheduleF/AcctsActvsOutUSTable/TotalExpenditures | 5 | 56626 |
| IRS990ScheduleF/AcctsActvsOutUSTable/TotalExpenditures | 6 | -59411 |
| IRS990ScheduleF/AcctsActvsOutUSTable/TotalExpenditures | 7 | 548200 |
| IRS990ScheduleF/AcctsActvsOutUSTable/TotalExpenditures | 8 | 375000 |
| IRS990ScheduleF/AcctsActvsOutUSTable/TotalExpenditures | 9 | 33470 |
| IRS990ScheduleF/AcctsActvsOutUSTable/TotalExpenditures | 10 | -267342 |
| IRS990ScheduleF/AcctsActvsOutUSTable/TotalExpenditures | 11 | 144 |
| IRS990ScheduleF/AcctsActvsOutUSTable/TotalExpenditures | 12 | 1108 |
| IRS990ScheduleF/AcctsActvsOutUSTable/TotalExpenditures | 13 | 575013 |
| IRS990ScheduleF/AcctsActvsOutUSTable/TotalExpenditures | 14 | 1374833 |
| IRS990ScheduleF/AcctsActvsOutUSTable/TotalExpenditures | 15 | 22584 |
| IRS990ScheduleF/AcctsActvsOutUSTable/TotalExpenditures | 16 | 533269 |
| IRS990ScheduleF/AcctsActvsOutUSTable/TypeOfActivitiesConducted | 0 | PROGRAM SERVICES |
| IRS990ScheduleF/AcctsActvsOutUSTable/TypeOfActivitiesConducted | 1 | GRANTMAKING |
| IRS990ScheduleF/AcctsActvsOutUSTable/TypeOfActivitiesConducted | 2 | PROGRAM SERVICES |
| IRS990ScheduleF/AcctsActvsOutUSTable/TypeOfActivitiesConducted | 3 | GRANTMAKING |
| IRS990ScheduleF/AcctsActvsOutUSTable/TypeOfActivitiesConducted | 4 | PROGRAM SERVICES |
| IRS990ScheduleF/AcctsActvsOutUSTable/TypeOfActivitiesConducted | 5 | PROGRAM SERVICES |
| IRS990ScheduleF/AcctsActvsOutUSTable/TypeOfActivitiesConducted | 6 | GRANTMAKING |
| IRS990ScheduleF/AcctsActvsOutUSTable/TypeOfActivitiesConducted | 7 | PROGRAM SERVICES |
| IRS990ScheduleF/AcctsActvsOutUSTable/TypeOfActivitiesConducted | 8 | GRANTMAKING |
| IRS990ScheduleF/AcctsActvsOutUSTable/TypeOfActivitiesConducted | 9 | PROGRAM SERVICES |
| IRS990ScheduleF/AcctsActvsOutUSTable/TypeOfActivitiesConducted | 10 | GRANTMAKING |
| IRS990ScheduleF/AcctsActvsOutUSTable/TypeOfActivitiesConducted | 11 | PROGRAM SERVICES |
| IRS990ScheduleF/AcctsActvsOutUSTable/TypeOfActivitiesConducted | 12 | PROGRAM SERVICES |
| IRS990ScheduleF/AcctsActvsOutUSTable/TypeOfActivitiesConducted | 13 | PROGRAM SERVICES |
| IRS990ScheduleF/AcctsActvsOutUSTable/TypeOfActivitiesConducted | 14 | GRANTMAKING |
| IRS990ScheduleF/AcctsActvsOutUSTable/TypeOfActivitiesConducted | 15 | PROGRAM SERVICES |
| IRS990ScheduleF/AcctsActvsOutUSTable/TypeOfActivitiesConducted | 16 | GRANTMAKING |
| IRS990ScheduleF/BoycottCountries | 0 | 0 |
| IRS990ScheduleF/ContAmountSpent | 0 | 2648079 |
| IRS990ScheduleF/ContNumberOfEmployees | 0 | 5 |
| IRS990ScheduleF/ContNumberOfOffices | 0 | 0 |
| IRS990ScheduleF/ForeignPartnership | 0 | 0 |
| IRS990ScheduleF/Form990ScheduleFPartV/Explanation | 0 | SCHEDULE F, PART I, LINE 2: SUBRECIPIENTS ARE REQUIRED TO SUBMIT PROGRESS REPORTS, WHICH ARE REVIEWED BY RESPONSIBLE PROGRAM MANAGERS AND PROGRAM ADMINISTRATORS TO ENSURE THAT PROGRAM GOALS ARE ATTAINED IN ACCORDANCE WITH AGREEMENT REQUIREMENTS. THE RESPONSIBLE PROGRAM MANAGERS AND PROGRAM ADMINISTRATORS CONTACT SUBRECIPIENTS WITH QUESTIONS AND FOLLOW UP ON ANY CONCERNS. IN SOME CASES, SUBAWARD TERMS MAY REQUIRE SPECIFIED DELIVERABLES IN ADDITION TO, OR IN LIEU OF, TECHNICAL REPORTS. IN ADDITION, DISCRETIONARY ON-SITE VISITS ARE CONDUCTED TO EVALUATE BOTH COMPLIANCE WITH THE SCIENTIFIC OBJECTIVES OF THE PROJECT AND THE APPROPRIATENESS OF THE SUBRECIPIENT'S ADMINISTRATIVE SYSTEMS AND PROCESSES. |
| IRS990ScheduleF/Form990ScheduleFPartV/Identifier | 0 | PROCEDURE FOR MONITORING GRANTS OUTSIDE THE U.S.: |
| IRS990ScheduleF/GrantRecordsMaintained | 0 | 1 |
| IRS990ScheduleF/GrantsToOrgsOutsideUS/AmountOfCashGrant | 0 | 395000 |
Document Assets
No mirrored PDF or thumbnail assets are attached yet.
Filings
Displayed year
2012 • Form 990Facts available. Structured filing facts are available, but richer extracted sections are limited.
- Assets
- $142,045,531
- Liabilities
- $2,850,743
- Net assets
- $139,194,788
- Revenue
- -
- Expenses
- $40,164,028
- Net income
- -