Civic Intelligence

Sage Bionetworks

990 • Fiscal year 2018 • EIN 26-4489946

Jan 01, 2018 to Dec 31, 2018 • Filed on Oct 15, 2019

Organization Profilewww.sagebionetworks.org

View Organization Page

2901 Third Ave Ste 330Seattle, WA 98121

(206) 928-8250

Siviq Scores

Precomputed percentiles for this filing year versus similar nonprofits in the same peer cohort.

Liabilities / Assets

50th percentile

0.21x

Higher debt load relative to assets than 50% of similar nonprofits.

2018 filings • 501(c)3 • $10M-$25M nonprofits • Source year 2018

Liabilities / Revenue

22nd percentile

0.07x

Higher debt load relative to revenue than 22% of similar nonprofits.

2018 filings • 501(c)3 • $10M-$25M nonprofits • Source year 2018

Net Margin

76th percentile

18%

Higher net margin than 76% of similar nonprofits.

2018 filings • 501(c)3 • $10M-$25M nonprofits • Source year 2018

Top Officer Pay

76th percentile

$282,140

Higher top officer pay than 76% of similar nonprofits.

Top officer pay equals 1.6% of source-year revenue.

2018 filings • 501(c)3 • $10M-$25M nonprofits • Source year 2018

Asset Growth

96th percentile

85%

Faster asset growth than 96% of similar nonprofits.

2018 filings • 501(c)3 • $10M-$25M nonprofits • Annualized from 2017 to 2018

Revenue Growth

92nd percentile

74%

Faster revenue growth than 92% of similar nonprofits.

2018 filings • 501(c)3 • $10M-$25M nonprofits • Annualized from 2017 to 2018

Balance Sheet
Liabilities / Assets50th percentile

Assets

Up

$5,921,898

Up $2,728,734 (+85%) from 2017

Net Assets

Up

$4,676,343

Up $3,236,499 (+225%) from 2017

Liabilities

Down

$1,245,555

Down $507,765 (-29%) from 2017

Revenue And Expenses
Liabilities / Revenue22nd percentileNet Margin76th percentile

Revenue

Up

$17,958,815

Up $7,620,033 (+74%) from 2017

Expenses

Up

$14,722,316

Up $3,717,569 (+34%) from 2017

Net Income

Up

$3,236,499

Up $3,902,464 (+586%) from 2017

Historical Trend

Balance Sheet Trend

Asset Growth96th percentile

The highlighted filing sits inside the broader history for assets, liabilities, and net assets.

$15M$10M$5.0M$0Assets 2010: $1,718,285Liabilities 2010: $1,013,527Net Assets 2010: $704,7582010Assets 2011: $916,996Liabilities 2011: $438,447Net Assets 2011: $478,5492011Assets 2012: $1,396,269Liabilities 2012: $952,109Net Assets 2012: $444,1602012Assets 2013: $4,036,587Liabilities 2013: $1,707,127Net Assets 2013: $2,329,4602013Assets 2014: $5,497,513Liabilities 2014: $1,005,378Net Assets 2014: $4,492,1352014Assets 2015: $4,810,343Liabilities 2015: $1,001,568Net Assets 2015: $3,808,7752015Assets 2016: $2,986,406Liabilities 2016: $880,597Net Assets 2016: $2,105,8092016Assets 2017: $3,193,164Liabilities 2017: $1,753,320Net Assets 2017: $1,439,8442017Assets 2018: $5,921,898Liabilities 2018: $1,245,555Net Assets 2018: $4,676,3432018Assets 2019: $4,610,169Liabilities 2019: $2,534,319Net Assets 2019: $2,075,8502019Assets 2020: $7,217,285Liabilities 2020: $4,430,328Net Assets 2020: $2,786,9572020Assets 2021: $7,319,840Liabilities 2021: $3,344,800Net Assets 2021: $3,975,0402021Assets 2022: $11,242,073Liabilities 2022: $7,577,144Net Assets 2022: $3,664,9292022Assets 2023: $10,800,289Liabilities 2023: $7,213,444Net Assets 2023: $3,586,8452023Assets 2024: $8,199,571Liabilities 2024: $4,769,009Net Assets 2024: $3,430,5622024

Highlighted filing

2018

Assets$5,921,898
Liabilities$1,245,555
Net Assets$4,676,343
Open 2018 Filing

Operations Trend

Revenue Growth92nd percentile

Revenue, expenses, and net income across loaded years, with this filing highlighted.

$30M$20M$10M$0-$10MExpenses 2010: $4,777,1512010Expenses 2011: $6,181,3842011Expenses 2012: $6,818,7392012Revenue 2013: $8,504,224Expenses 2013: $6,618,924Net Income 2013: $1,885,3002013Revenue 2014: $9,381,925Expenses 2014: $7,444,250Net Income 2014: $1,937,6752014Revenue 2015: $7,695,817Expenses 2015: $8,379,177Net Income 2015: -$683,3602015Revenue 2016: $7,415,116Expenses 2016: $9,118,082Net Income 2016: -$1,702,9662016Revenue 2017: $10,338,782Expenses 2017: $11,004,747Net Income 2017: -$665,9652017Revenue 2018: $17,958,815Expenses 2018: $14,722,316Net Income 2018: $3,236,4992018Revenue 2019: $15,519,146Expenses 2019: $16,840,351Net Income 2019: -$1,321,2052019Revenue 2020: $19,251,112Expenses 2020: $19,724,290Net Income 2020: -$473,1782020Revenue 2021: $26,396,727Expenses 2021: $25,208,644Net Income 2021: $1,188,0832021Revenue 2022: $23,911,041Expenses 2022: $24,221,152Net Income 2022: -$310,1112022Revenue 2023: $26,329,869Expenses 2023: $26,407,953Net Income 2023: -$78,0842023Revenue 2024: $24,549,384Expenses 2024: $24,705,667Net Income 2024: -$156,2832024

Highlighted filing

2018

Revenue$17,958,815
Expenses$14,722,316
Net Income$3,236,499
Open 2018 Filing
Jump To
Filing Snapshot
Filing Period
Jan 1, 2018 to Dec 31, 2018
Signed
Oct 15, 2019
Return Version
2018v3.0
Gross Receipts
$17,958,815
Mission and Program Overview

Mission

Sage Bionetworks is a strategic research organization with a mission to coordinate and link academic and commercial biomedical researchers, patients and citizens through a Commons that represents a new paradigm for genomics intellectual property, researcher cooperation and contributor evolved resources. This mission has several interdependent themes, including: conducting research on network models of disease; building the computational platform for the Commons; and activating public engagement.

Balance Sheet Detail
LineBeginningEndChange
Assets
Pledges and Grants Receivable$2,570,019$3,134,674▲ $564,655
Accounts Receivable$46,969$1,021,718▲ $974,749
Savings and Temporary Cash Investments$488,278$564,479▲ $76,201
Land, Buildings, and Equipment, Net$3,755$91,295▲ $87,540
Prepaid Expenses and Deferred Charges$84,143$88,014▲ $3,871
Cash and Non-Interest-Bearing Accounts$0$0→ $0
Other Notes and Loans Receivable, Net$0$0→ $0
Receivable From Disqualified Prsn$0$0→ $0
Receivables From Officers Etc$0$0→ $0
Investments Other Securities$0--
Investments Program Related$0--
Investments in Publicly Traded Securities$0--
Intangible Assets$0--
Inventories for Sale or Use$0$0→ $0
Loans From Officers Directors$0$0→ $0
Total Assets$3,193,164$5,921,898▲ $2,728,734
Other Assets Total$0$1,021,718▲ $1,021,718
Liabilities
Accounts Payable and Accrued Expenses$759,381$750,306▼ $9,075
Deferred Revenue$993,939$457,667▼ $536,272
Other Liabilities$0$37,582▲ $37,582
Grants Payable$0$0→ $0
Mortgage Notes Payable Secured by Investment Property$0$0→ $0
Unsecured Notes Loans Payable$0$0→ $0
Escrow Account Liability$0$0→ $0
Tax Exempt Bond Liabilities$0$0→ $0
Total Liabilities$1,753,320$1,245,555▼ $507,765
Net Assets / Fund Balance
Unrestricted Net Assets$1,280,854$2,352,896▲ $1,072,042
Temporarily Rstr Net Assets$158,990$2,323,447▲ $2,164,457
Permanently Rstr Net Assets$0$0→ $0
Total Net Assets Fund Balance$1,439,844$4,676,343▲ $3,236,499
Total Liabilities and Net Assets / Fund Balance$3,193,164$5,921,898▲ $2,728,734

Asset Categories

AssetBook ValueDepreciationBasis
Buildings$0$0$0
Other Land Buildings$0$0$0
Land$0-$0
Equipment$91,295$13,208$0
Leasehold Improvements$0$0$0
Other Assets Org$1,021,718--
Compensation and Service Providers
Top Officer Pay76th percentile

Employees

NameTitleFull / Part TimeBaseOtherTotal
Lara MangravitePresidentFT$245,496$36,644$282,140
John WilbanksChief Commons OfficerFT$231,848$21,981$253,829
Mike KellenChief Technology OfficerFT$210,759$23,947$234,706
Justin GuinneyVice President, Computational OncologyFT$195,821$36,057$231,878
Bruce HoffDirector, Synapse TeamFT$166,334$39,614$205,948
Diane GarySecretaryFT$166,446$30,837$197,283
Larsson OmbergVice President, Systems BiologyFT$166,446$30,832$197,278
Erin MountsPrinciple SW EngineerFT$161,735$30,504$192,239
Dwayne JengPrincipal SW EngineerFT$156,897$19,987$176,884
John WoodburnDirector, DesignFT$154,830$19,835$174,665
Alx DarkPrinciple Software EngineerFT$156,811$11,529$168,340

Board Members and Trustees

NameTitle
Stephen FriendChairman of the Board
Eric SchadtDirector/Chair of Scientific Advisory Board
Gustavo StolovitskyDirector
Tetsu MaruyamaDirector
Tony Ford-HutchinsonDirector

Highest Paid Contractors

ContractorServicesLocationCompensation
Stockard SimonIT Design44564 SE 144th St, North Bend, WA 98045$152,386
Yuangang GuanScientific challenges744 Eagle Ave, Ann Arbor, MI 48103$113,917
Revenue and Support

Revenue Composition

Contributions and Grants
$15,555,426
Program Service Revenue
$2,402,775
Investment Income
$614
Other Revenue
$0
All Other Contributions
$4,933,165
Change in Net Assets
$3,236,499

Noncash Contribution Practices

Property subject to holding requirements
No
Reviewed unusual noncash gifts
No
Third parties used for noncash contributions
No

Audited Revenue Reconciliation

Revenue per Audited Statements
$17,958,815
Revenue Not Reported on Financial Statements
$0
Revenue Not Reported on Form 990
$0
Other Revenue Adjustments
$0
Total Revenue per Audited Statements
$17,958,815
Total Revenue per Form 990
$17,958,815
Expenses and Functional Allocation

Major Expense Lines

Line ItemAmount
Salaries, Compensation, and Employee Benefits$8,601,831
Other Expenses$4,233,682
Grants and Similar Amounts Paid$1,886,803
Total Fundraising Expense$40,673
Professional Fundraising Fees$0

Functional Expense Allocation

Line ItemProgramManagementFundraisingTotal
Other Salaries and Wages$5,505,292$209,658$18,200$5,733,150
Fees for Services Other$2,355,780$15,505$1,014$2,372,299
Grants to Domestic Orgs$1,660,903--$1,660,903
Current Officers, Directors, Trustees, and Key Employees$1,218,969$235,992$10,719$1,465,680
Other Employee Benefits$893,899$23,077$2,532$919,508
Occupancy$568,352$35,200$2,302$605,854
Travel$341,123$22,008$1,439$364,570
All Other Expenses$338,797$17,558$1,148$357,503
Payroll Taxes$232,870$17,341$723$250,934
Pension Plan Contributions$217,633$14,278$648$232,559
Foreign Grants$225,900--$225,900
Information Technology$150,148$9,299$608$160,055
Fees for Services Legal$129,901$8,045$526$138,472
Fees for Services Management$58,815$3,643$238$62,696
Office Expenses$46,129$2,857$187$49,173
Fees for Services Accounting$36,339$2,251$147$38,737
Conferences and Meetings$37,287$1,024$67$38,378
Insurance$27,335$1,693$111$29,139
Depreciation Depletion$15,766$976$64$16,806
Total Functional Expenses$14,061,238$620,405$40,673$14,722,316

Audited Expense Reconciliation

Line ItemAmount
Expenses per Audited Statements$14,722,316
Total Expenses per Audited Statements$14,722,316
Total Expenses per Form 990$14,722,316
Expenses Not Reported on Financial Statements$0
Expenses Not Reported on Form 990$0
Other Expense Adjustments$0
International Activity

Grant and Assistance Recipients

RecipientLocationCategoryPurposeAmount
Institute for Systems BiologySeattle, WA-Assist in the development of an integrative platform: the Pan-cancer Immune Atlas (iAtlas) to host the data and results derived from the PanCancerAtlas Immune Response Working Group and to provide external investigators witht the ability to reproduce results of the IRWG. Provide expertise related to the analyses of the metabolic and transcriptional regulatory networksand will work collaboratively to develop, implement, test, and benchmark all methods related to the dynamic analyses of the transcriptional regulatory and metabolic networks aimed at drug target discovery for Alzheimer's Disease. The Institute for Systems Biology will provide expertise related to the (dynamic) analyses of the metabolic and transcriptional regulatory networks and will work collaboratively to develop, implement, test, and benchmark all methods related to the dynamic analyses of the transcriptional regulatory and metabolic networks aimed at drug target discovery for the AMP-AD CC project.$489,494
Icahn School of Medicine at Mount SinaiNew York, NY-Perform computational and integrative analysis of the AMP/AD data sets to develop a set of high probability therapeutic targets necessary for their assessment and integration into drug discovery efforts for the Agora project. Image-guided studies to determine the contribution of breast cancer cells to metastatic outgrowth Leukemias for the CSBC project.$325,616
University of California San DiegoLa Jolla, CA-To determine the test validity and test-retest reliability of smartphone-based measurement of CRF. To evaluate the feasibility and acceptability of using a smartphone application to measure CRF. This will be examined using a system usability scale and assessing compliance and overall satisfaction with the administered protocol. Provide expert consultation in the use of agile science methods for creating strategies for facilitating sustained engagement with the MPower 2.0 application. This includes providing expertise related to behavioral theory, human centered design, and measurement strategies. Develop an experimental design and broader strategy for gathering evidence to foster iterative improvement on mPower to foster improved sustained engagement with the tool.$206,908
Stanford UniversityStanford, CA-Oversee the genomic profiling, analysis, and computational modeling of metastatic colorectal cancer patient data. Prioritize candidate metastasisassociated genes and provide for modeling in organoids. Contribute to the analysis of cell fitness and clone size distributions in the metastatic colon organoid models. Interpret the data from the microenvironmental arrays. Create a baseline model for future comparison using existing framework for Digital Mammography Challenge.$175,960
Fred Hutchinson Cancer Research CenterSeattle, WA-Study the mechanisms that underlie metastatic castrate resistant prostate cancer(CRPC). We will combine approaches from pharmacology, as well as cell and computational biology to identify kinases that are functionally important for driving cell growth and proliferation in CRPC. We will employ Kinome regression approach to: (1) identify kinases in CRPC cell lines and patient-derived organoid models and test in silico predicted candidate kinase inhibitors in 3D bone-mimetic cultures; and (2) validate the effect of candidate kinase inhibitors in in vivo CRPC bone metastasis models, followed by molecular characterization.$56,144
University of PittsburghPittsburgh, PA-Combine approaches from pharmacology, as well as cell and computational biology to identify specific kinases that are functionally important for the growth of metastatic CRPC. We will also build a computational model to predict response to >300 naive kinase inhibitors in a physiological-relevant CRPC bone metastasis model. Further, we will probe the spatial nature of the kinase-driven signaling patterns in the tumors, which is critical to understanding the mechanisms of drug response. Overall, these studies have a strong potential to advance medical practices; a new therapeutic option for metastatic CRPC could give unprecedented hope to the providers and patients who currently face this disease with severely limited alternatives.$56,016
The University of Texas MD Anderson Cancer CenterHouston, TX-Validate in 3D the top kinase inhibitors selected in the 2D screening. These experiments will be performed on up to 3 prostate cancer cellular models, including cell lines and patient-derived xenografts, testing different concentration of the inhibitors.$55,976
Duke UniversityDurham, NC-Metastasis is the primary cause of cancer patient mortality and is virtually uncurable. In colorectal cancer (CRC), which represents the third leading cause of cancer-related mortality in the United States, 10-20% of patients with Stage II disease and 50% with Stage III develop recurrence, while another 20% of patients present with metastases at diagnosis. Current targeted therapies for metastatic colorectal cancer (mCRC) prolong survival by mere months with little benefit in the adjuvant setting. Improved treatment strategies are thus urgently needed, but require characterization of the molecular drivers and microenvironmental determinants of the metastatic phenotype. Critically, the advent of advanced genome-engineering and lineage tracing technologies, 3-D organotypic culture systems and platforms to probe the tumor microenvironment provides an unprecedented opportunity for rapid, functional and phenotypic screens towards delineation of the genotype-phenotype map in cancer.$52,160
Partners Healthcare System IncSomerville, MA-Combine mouse mammary cancer models with high-resolution imaging to quantify early vs late disseminated cancer cells, outgrown metastases, and their colocalization and dynamics. To quantify behavior of disseminated cancer cells using laser scanning confocal microscopy and other techniques available at the MGH Center for Systems Biology.$47,732
University of Massachusetts WorcesterWorcester, MA-There is an ongoing debate concerning whether early DCCs or late DCCs drive metastasis during the life of a patient when both population will likely co-exist. We hypothesize that in fact both early and late disseminated cancer cells (DCCs) cooperate to drive metastatic outgrowth. Here, we adopt an innovative interdisciplinary approach combining metastatic tumor modeling, tissue engineering, high-resolution in vivo microscopy, and integrative omics analysis to tackle the problem. We believe the success of this pilot proposal will provide novel strategies to combat the deadly metastatic diseases, as well as foster our future collaborations.$46,255
University of ArizonaTucson, AZ-The goal of the project is to develop small molecules (from in silico docking on the CD44 binding pocket and peptidomimetics of CD44 peptide) and peptides (from the peptide array) to disrupt the interaction between CD44 and FERM domain-containing proteins. These tools will help to define if the proteins are druggable, and whether targeting protein-protein interactions can have a more specific effects than global inhibition of the ectodomain of CD44 using antibodies or small molecules. This will pave the way to testing therapeutic hypotheses for AMP-AD targets relating to protein-protein interactions.$38,685
Rutgers the State University of New JerseyPiscataway, NJ-The research proposal outlines image-guided studies to determine the contribution of breast disseminated cancer cells to metastatic outgrowth.$36,570
Oregon Health & Science UniversityPortland, OR-CSBC Pilot testing and optimization of MCAT/Her2 crainbow cells on MEMA platform and MEMA optimization and screening.$21,269
San Ysidro HealthSan Diego, CA-San Ysidro Health (SYHealth) will participate in the "All of Us Research Program Sage Bionetworks - Federally Qualified Health Centers Consent Study" for participant recruitment and data collection. Findings from this study will be used immediately to improve, elaborate, and/or supplement AoURP informed consent materials for AoURP national launch. The project begins with formative work to determine study approach and contribute to study protocols and ends with data submission and analysis verification by the site PI.$19,929
Hudson River Healthcare FoundationPeekskill, NY-Research Assistants (RAs) will recruit potential participants using a variety of techniques including engagement tabling in Barham House, a senior apartment building, at the Peekskill Kiley Center with the Community Action Program, and at local community venues like the Salvation Army, the Peekskill Library, and a local homeless shelter, in addition to health-center based recruitment. The RAs and Pilot Coordinator will liaise with community stakeholders to coordinate such recruitment efforts. Interested individuals are screened by RAs using the REALM-SF tool and, if eligible, invited to participate in a 1:1 interview or a focus group. Each session lasts approximately 1 hour and is facilitated and recorded by a Research Assistant. An additional RA participates for notetaking purposes as appropriate. In addition to these implementation activities, our PIs and Project Coordinators liaise with the other FQHCs involved, with Sage, and with MITRE to provide ongoing feedback on the REALM$18,845
University of RochesterRochester, NY-Provide consultation on interpretation and guidance on mPower 1.0 analysis and design and scientific strategy for mPower 2.0 data collection.$7,667
New York UniversityNew York, NY-Data generation and analysis for the Proteogenomics Computational Challenge$5,677

International Summary

Offices
0
Employees
0
Spending
$225,900

International Compliance

Foreign grant records maintained
Yes
Activity in boycott countries
No
Foreign corporation ownership
No
Foreign partnership interest
No
Interest in foreign trust
No
Passive foreign investment company interest
No
Transfers to foreign corporations
No

International Activities

RegionActivityServicesOfficesEmployeesSpending
Europe (including Iceland and Greenland)GrantmakingData generation for our Coordinated biocomputational studies. To enable testing of the therapeutic hypothesis, and to further prioritize targets for more extensive drug development programs, we will develop a toolkit of experimental reagents and data - termed a Target Enabling Package (TEP) - for 10 AMP-AD targets. The TEP is meant to bridge the gap between identification of candidate targets, and the ability to launch a chemical biology or drug discovery program. A TEP will typically include purified protein, biochemical assays, crystal structures, and tool compounds. In some cases, the TEP will identify sequences for mutation in CRISPR/Cas9 loss-of function editing, but in most cases it will enable the initiation of a small molecule chemical probe or antibody discovery project by proving that the target is tractable and reducing the barrier to drug discovery.00$225,900
Fundraising, Events, and Gaming
Fundraising activities
No
Gaming activities
No
Professional fundraiser used
No

Fundraising and Gaming Totals

Line ItemAmount
Professional Fundraising Fees$0
Political and Lobbying Activity
Political campaign activity
No
Lobbying activity
No
Subject to proxy tax
No
Insider Transactions and Loans

Loans and Receivables

Line ItemBeginningEndChange
Loans from Officers, Directors, Trustees, and Key Employees$0$0→ $0
Receivables from Disqualified Persons$0$0→ $0
Receivables from Officers, Directors, Trustees, and Key Employees$0$0→ $0
Debt and Bond Financing

Other Reported Liabilities

LiabilityAmount
Deferred building rent$37,582
Governance and Compliance

Governance Checklist

Compiled or reviewed by an accountant
Yes
Annual disclosure for covered persons
Yes
Audit committee
Yes
Business relationship with family members
No
Business relationship with organization members
No
Material changes to governing documents
No
Compensation from other sources disclosed
No
CEO compensation reviewed
Yes
Other officer compensation reviewed
No
Conflict-of-interest policy
Yes
Audited financial statements prepared
No
Key decisions subject to board approval
No
Management duties delegated
No

Governance Explanations

Form 990, Part VI, Section B, Line 11B

“The 990 is reviewed by the company's Vice President of Operations and President prior to filing.”

Form 990, Part VI, Section B, Line 12C

“Sage Bionetworks has a Financial Conflict of Interest Policy (FCOI) that complies with the National Institutes of Health-specific requirements promoting objectivity in research, 42 CFR Part 50 subpart F. On an annual basis, Sage Bionetworks Officers, Directors, and members of committees of Board of Directors authorized to act on behalf of the board, and employees designated by the President of Sage Bionetworks, including any employees serving as an investigator on a federal/Public Health Services award, must review and update the Sage Bionetworks Annual Conflict of Interest Questionnaire. New employees serving as investigators are required to complete a FCOI form within 30 days of their start date. In addition, all investigators must submit an ad hoc disclosure of a Significant Financial Interest they acquire or discover during the course of the year within 30 days of discovering or acquiring the Significant Financial Interest. Forms are reviewed and any potential conflicts are referred to the President and outside counsel.”

Form 990, Part VI, Section B, Line 15

“Executive compensation was set by the Board of Directors Compensation Committee.”

Form 990, Part VI, Section C, Line 19

“The organization's financials are contained within its 990 returns. These returns are available to the public through organizations such as Guidestar, dedicated to publicizing information about nonprofit organizations. The organization's governing documents and conflict of interest policies are available upon request.”

Filing and Contact Details

Filer

Filer Name
Sage Bionetworks
EIN
26-4489946
Phone
2069288250
Address
2901 Third Ave Ste 330, Seattle, WA 98121

Signing Officer

Name
Lara Mangravite
Title
President
Phone
2069288250
Signed
2019-10-15

Organization Details

Principal Officer
Lara Mangravite
Formed
2009
Legal Domicile
Wa
Voting Board Members
6
Independent Board Members
5
Employees
71
Volunteers
5
Supplemental Narrative

Additional Explanations

Form 990, Part IX, Line 11G

“Scientific Reseach Expenses $1,109,936; Assembly Expenses $179,475; Platform/Scientific Computing Expenses $847,697; Professional Services Expenses $235,191.”

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IRS990/Desc0Research Communities and Challenges: Sage Bionetworks conducts research independently as well as with collaborators worldwide across a variety of disease areas. We work to redefine how complex biological data is gathered, shared and used through open systems, incentives, and norms. Our work includes the building of platforms and services and undertaking research developing predictors relating to health. Research: As biological research has become more data intensive, the breadth of data and expertise required to address research problems has expanded. It requires the integrated efforts of a distributed set of researchers (such as bench/data scientists, data engineers, project managers, administrators, governance experts, and clinical researchers) with shared interests and complementary resources. Effective collaboration depends on a collective ability to work together in trusted ways that lead to translatable biomedical insights. We call this scientific coordination. Sage's scientific coordination stack includes: 1) hypothesis and data generation, 2) data curation, 3) analysis, 4) interpretation, and 5) dissemination. We focus on building a federated network of individuals who bring diverse expertise and approaches to develop robust solutions. New research projects initiated in 2018 included: * Human Tumor Atlas Network (HTAN) - Funded by NCI, Sage is the data coordinating center for HTAN which aims to leverage the power of human genome sequencing and other state-of-the-art profiling technologies, to analyze changes in individual tumors. * VEOIBD Portal - Funded by the Helmsley Charitable Trust, the VEOIBD Portal aggregates Consortium-identified genotypic data with data from other data sources to find causes and treatments for Inflammatory Bowel Disease (IBD). Ongoing research communities included: * Agora - funded by the NIA, Agora is a platform that enables researchers to access information about how genes are associated with Alzheimer's disease. It aggregates lines of biological evidence from multiple sources, so researchers can better prioritize which genes they want to follow up on for development of new therapies. * All of Us - a program to engage over one million participants in a study to improve the ability to prevent and treat disease based on individual differences in lifestyle, environment and genetics. * CD2H (National Center for Data to Health) - with aims to foster collaboration across more than 50 premier medical research institutions within the prestigious Clinical and Translational Science Awards, or CTSA, network. * Cancer Systems Biology Consortium (CSBC) - Sage serves as the Coordinating Center for the CSBC and Physical Sciences in Oncology Network (PS-ON) program. This five-year award builds on the work of the NCI funded Sage Bionetworks' Center for Cancer Systems Biology from 2010 through 2015. * iAtlas -together with the Institute for Systems Biology, Sage was funded by the Cancer Research Institute to build iAtlas, an online database and web resource designed to help basic and clinical researchers navigate immunological data across multiple tumor types. * KiAAP - funded by Bill and Melinda Gates Foundation, Sage was engaged to support the distributed efforts of BMGF funded data scientists across a number of ongoing research projects in neurocognitive development. * MODEL-AD Consortium - Sage runs the Knowledge Portal, the distribution site for data, analysis results, analytical methodology and research tools generated by the AMP-AD and M2OVE-AD Consortia. * Synodos Consortium - a first-of-its-kind Neurofibromatosis research collaboration dedicated to defeating the rare genetic disorder neurofibromatosis type 2. * The Cancer Genome Atlas (TCGA) - with data from 12 cancers, TCGA is an ongoing effort to simultaneously analyze molecular platforms for patterns across cancer types. * Tumor Neoantigen Selection Alliance (TESLA) - a global research alliance with 30 public and private groups to advance the deve
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IRS990/Form990PartVIISectionAGrp/TitleTxt7Chief Commons Officer
IRS990/Form990PartVIISectionAGrp/TitleTxt8Chief Technology Officer
IRS990/Form990PartVIISectionAGrp/TitleTxt9Vice President, Computational Oncology
IRS990/Form990PartVIISectionAGrp/TitleTxt10Vice President, Systems Biology
IRS990/Form990PartVIISectionAGrp/TitleTxt11Director, Synapse Team
IRS990/Form990PartVIISectionAGrp/TitleTxt12Principle SW Engineer
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IRS990/MissionDesc0Sage Bionetworks is a strategic research organization with a mission to coordinate and link academic and commercial biomedical researchers, patients and citizens through a Commons that represents a new paradigm for genomics intellectual property, researcher cooperation and contributor evolved resources. This mission has several interdependent themes, including: conducting research on network models of disease; building the computational platform for the Commons; and activating public engagement. Sage Bionetworks is a non-profit research organization that seeks to develop predictors of disease and accelerate health research through the creation of open systems, incentives, and standards. We create strategies and platforms that empower researchers to share and interpret data on a colossal scale, crowdsource tests for new hypotheses, and contribute to knowledge through community challenges.
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Document Assets

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Filings

Displayed year

2018 • Form 990Detailed filing. Detailed filing data is available for this year.

Open filing
Assets
$5,921,898
Liabilities
$1,245,555
Net assets
$4,676,343
Revenue
$17,958,815
Expenses
$14,722,316
Net income
$3,236,499
Balance SheetOperations
YearAssetsLiabilitiesNet AssetsRevenueExpensesNet Income
2024Facts available. Structured filing facts are available, but richer extracted sections are limited.$8.20$4.77$3.43$24.5$24.7$0.16
2023XML pending. An XML filing is linked for this year, but detailed extraction is still pending.$10.8$7.21$3.59$26.3$26.4$0.08
2022Facts available. Structured filing facts are available, but richer extracted sections are limited.$11.2$7.58$3.66$23.9$24.2$0.31
2021XML pending. An XML filing is linked for this year, but detailed extraction is still pending.$7.32$3.34$3.98$26.4$25.2$1.19
2020XML pending. An XML filing is linked for this year, but detailed extraction is still pending.$7.22$4.43$2.79$19.3$19.7$0.47
2019XML pending. An XML filing is linked for this year, but detailed extraction is still pending.$4.61$2.53$2.08$15.5$16.8$1.32
2018Detailed filing. Detailed filing data is available for this year.$5.92$1.25$4.68$18.0$14.7$3.24
2017XML pending. An XML filing is linked for this year, but detailed extraction is still pending.$3.19$1.75$1.44$10.3$11.0$0.67
2016XML pending. An XML filing is linked for this year, but detailed extraction is still pending.$2.99$0.88$2.11$7.42$9.12$1.70
2015Detailed filing. Detailed filing data is available for this year.$4.81$1.00$3.81$7.70$8.38$0.68
2014Detailed filing. Detailed filing data is available for this year.$5.50$1.01$4.49$9.38$7.44$1.94
2013Detailed filing. Detailed filing data is available for this year.$4.04$1.71$2.33$8.50$6.62$1.89
2012Facts available. Structured filing facts are available, but richer extracted sections are limited.$1.40$0.95$0.44$6.82
2011Facts available. Structured filing facts are available, but richer extracted sections are limited.$0.92$0.44$0.48$6.18
2010Facts available. Structured filing facts are available, but richer extracted sections are limited.$1.72$1.01$0.70$4.78