Civic Intelligence

Prion Alliance Inc

EIN 46-0732060 • 501(c)3 • Cambridge, MA

Profile

Prion Alliance, Inc aims to catalyze the development of a treatment or cure for human prion diseases by funding, organizing and promoting scientific research. Our organization supports research directed at understanding prion disease biology, discovering and testing therapeutics, and developing novel lab and computational methodologies needed for furthering this research. Our operational model is to raise funds and disburse these to the most worthy scientific projects, with a view to the projects' relevance to our ultimate goal of a treatment or cure, as well as to the projects' ability to leverage Prion Alliance, Inc seed funding in order to pursue outside funding sources for continued research. We also strive to bring together top scientific minds to share data, methodology, and findings in a spirit of openness and collaboration.

PO Box 391953Cambridge, MA 02139

prionalliance.org

Siviq Scores

Precomputed percentiles relative to similar nonprofits. These scores are descriptive rather than judgmental.

Liabilities / Assets

61st percentile

0.00x

Higher debt load relative to assets than 61% of similar nonprofits.

501(c)3 • <$500k nonprofits • Source year 2024

Liabilities / Revenue

63rd percentile

0.00x

Higher debt load relative to revenue than 63% of similar nonprofits.

501(c)3 • <$500k nonprofits • Source year 2024

Net Margin

12th percentile

-64%

Higher net margin than 12% of similar nonprofits.

501(c)3 • <$500k nonprofits • Source year 2024

Top Officer Pay

81st percentile

$0

Higher top officer pay than 81% of similar nonprofits.

Top officer pay equals 0.0% of source-year revenue.

501(c)3 • <$500k nonprofits • Source year 2024

Asset Growth

23rd percentile

-40%

Faster asset growth than 23% of similar nonprofits.

501(c)3 • <$500k nonprofits • Annualized from 2023 to 2024

Revenue Growth

25th percentile

-35%

Faster revenue growth than 25% of similar nonprofits.

501(c)3 • <$500k nonprofits • Annualized from 2023 to 2024

Balance Sheet
Liabilities / Assets61st percentile

Assets

Down

$417,060

Down $276,046 (-40%) from 2023

Liabilities

Down

$400

Down $9,029 (-96%) from 2023

Net Assets

Down

$416,660

Down $267,017 (-39%) from 2023

Operations
Liabilities / Revenue63rd percentileNet Margin12th percentile

Revenue

Down

$419,737

Down $225,522 (-35%) from 2023

Expenses

Up

$686,754

Up $215,798 (+46%) from 2023

Net Income

Down

-$267,017

Down $441,320 (-253%) from 2023

Trend Graphs

Balance Sheet Trend

Asset Growth23rd percentile

Grouped bars show assets, liabilities, and net assets across loaded filings.

$800K$600K$400K$200K$0Assets 2017: $74,613Liabilities 2017: $0Net Assets 2017: $74,6132017Assets 2018: $177,751Liabilities 2018: $0Net Assets 2018: $177,7512018Assets 2019: $180,792Liabilities 2019: $0Net Assets 2019: $180,7922019Assets 2020: $249,694Liabilities 2020: $0Net Assets 2020: $249,6942020Assets 2021: $591,141Liabilities 2021: $0Net Assets 2021: $591,1412021Assets 2022: $412,041Liabilities 2022: $0Net Assets 2022: $412,0412022Assets 2023: $693,106Liabilities 2023: $9,429Net Assets 2023: $683,6772023Assets 2024: $417,060Liabilities 2024: $400Net Assets 2024: $416,6602024

Highlighted filing

2024

Assets$417,060
Liabilities$400
Net Assets$416,660
Open 2024 Filing

Operations Trend

Revenue Growth25th percentile

Revenue, expenses, and net income by year, with the latest filing highlighted.

$1.0M$500K$0-$500KRevenue 2017: $101,500Expenses 2017: $128,546Net Income 2017: -$27,0462017Revenue 2018: $247,110Expenses 2018: $143,972Net Income 2018: $103,1382018Revenue 2019: $280,158Expenses 2019: $277,118Net Income 2019: $3,0402019Revenue 2020: $190,882Expenses 2020: $121,980Net Income 2020: $68,9022020Revenue 2021: $535,617Expenses 2021: $194,170Net Income 2021: $341,4472021Revenue 2022: $245,129Expenses 2022: $424,229Net Income 2022: -$179,1002022Revenue 2023: $645,259Expenses 2023: $470,956Net Income 2023: $174,3032023Revenue 2024: $419,737Expenses 2024: $686,754Net Income 2024: -$267,0172024

Highlighted filing

2024

Revenue$419,737
Expenses$686,754
Net Income-$267,017
Open 2024 Filing

Filings

Most recent year

2024 • Form 990Detailed filing. Detailed filing data is available for this year.

Open filing
Assets
$417,060
Liabilities
$400
Net assets
$416,660
Revenue
$419,737
Expenses
$686,754
Net income
-$267,017
Balance SheetOperations
YearAssetsLiabilitiesNet AssetsRevenueExpensesNet Income
2024Detailed filing. Detailed filing data is available for this year.$4.17$0.00$4.17$4.20$6.87$2.67
2023Detailed filing. Detailed filing data is available for this year.$6.93$0.09$6.84$6.45$4.71$1.74
2022Detailed filing. Detailed filing data is available for this year.$4.12$0.00$4.12$2.45$4.24$1.79
2021Detailed filing. Detailed filing data is available for this year.$5.91$0.00$5.91$5.36$1.94$3.41
2020Detailed filing. Detailed filing data is available for this year.$2.50$0.00$2.50$1.91$1.22$0.69
2019Detailed filing. Detailed filing data is available for this year.$1.81$0.00$1.81$2.80$2.77$0.03
2018Detailed filing. Detailed filing data is available for this year.$1.78$0.00$1.78$2.47$1.44$1.03
2017Detailed filing. Detailed filing data is available for this year.$0.75$0.00$0.75$1.02$1.29$0.27
Latest Filing Detail
Jump To
Filing Snapshot
Filing Period
Jan 1, 2024 to Dec 31, 2024
Signed
May 1, 2025
Return Version
2024v5.1
Gross Receipts
$419,737
Mission and Program Overview

Mission

Prion Alliance, Inc aims to catalyze the development of a treatment or cure for human prion diseases by funding, organizing and promoting scientific research. Our organization supports research directed at understanding prion disease biology, discovering and testing therapeutics, and developing novel lab and computational methodologies needed for furthering this research. Our operational model is to raise funds and disburse these to the most worthy scientific projects, with a view to the projects' relevance to our ultimate goal of a treatment or cure, as well as to the projects' ability to leverage Prion Alliance, Inc seed funding in order to pursue outside funding sources for continued research. We also strive to bring together top scientific minds to share data, methodology, and findings in a spirit of openness and collaboration.

SEE SCHEDULE O

Balance Sheet Detail
LineBeginningEndChange
Assets
Cash and Non-Interest-Bearing Accounts$575,031$402,560▼ $172,471
Pledges and Grants Receivable$118,075--
Accounts Receivable-$14,500-
Total Assets$693,106$417,060▼ $276,046
Liabilities
Accounts Payable and Accrued Expenses$9,429$400▼ $9,029
Total Liabilities$9,429$400▼ $9,029
Net Assets / Fund Balance
Net Assets Without Donor Restrictions$683,677$416,660▼ $267,017
Total Net Assets Fund Balance$683,677$416,660▼ $267,017
Total Liabilities and Net Assets / Fund Balance$693,106$417,060▼ $276,046
Compensation and Service Providers
Top Officer Pay81st percentile

Board Members and Trustees

NameTitle
Sonia VallabhPresident
Greta BeekhuisCo-director
Eric MinikelTreasurer
Revenue and Support

Revenue Composition

Contributions and Grants
$419,737
Program Service Revenue
$0
Investment Income
$0
Other Revenue
$0
All Other Contributions
$419,737
Change in Net Assets
$-267,017
Expenses and Functional Allocation

Major Expense Lines

Line ItemAmount
Other Expenses$436,754
Grants and Similar Amounts Paid$250,000
Professional Fundraising Fees$0
Salaries, Compensation, and Employee Benefits$0
Total Fundraising Expense$0

Functional Expense Allocation

Line ItemProgramManagementFundraisingTotal
Fees for Services Other$357,974--$357,974
Grants to Domestic Orgs$250,000--$250,000
Fees for Services Accounting-$72,485-$72,485
Office Expenses-$1,851-$1,851
Insurance-$1,048-$1,048
Other Expenses-$80-$80
Total Functional Expenses$607,974$78,780$0$686,754
International Activity

Grant and Assistance Recipients

RecipientLocationCategoryPurposeAmount
The Broad InstituteCambridge, MA501c3DONATION FOR RESEARCH INITIATIVES THAT ARE IN-LINE WITH PRION'S MISSION$250,000
Fundraising, Events, and Gaming
Fundraising activities
No
Gaming activities
No
Professional fundraiser used
No

Fundraising and Gaming Totals

Line ItemAmount
Professional Fundraising Fees$0
Political and Lobbying Activity
Political campaign activity
No
Lobbying activity
No
Subject to proxy tax
No
Governance and Compliance

Governance Checklist

Compiled or reviewed by an accountant
No
Annual disclosure for covered persons
Yes
Backup withholding compliance
Yes
Business relationship with 35% controlled entity
No
Business relationship with family members
No
Business relationship with organization members
No
Material changes to governing documents
No
Compensation from other sources disclosed
No
CEO compensation reviewed
No
Other officer compensation reviewed
No
Conflict-of-interest policy
Yes
Audited financial statements prepared
No
Key decisions subject to board approval
No
Management duties delegated
No

Governance Explanations

Form 990, Part VI, Section A, Line 2

“Sonia vallabh and eric minikel are married.”

Form 990, Part VI, Section B, Line 11B

“Draft 990 is circulated to directors via email for review and approval prior to filing.”

Form 990, Part VI, Section B, Line 12

“Directors are required to disclose coi in writing. Annually, directors are asked to confirm their coi disclosure list.”

Form 990, Part VI, Section C, Line 19

“Organizational documents are available on our website prionalliance.org”

Filing and Contact Details

Filer

Filer Name
Prion Alliance Inc
EIN
46-0732060
Phone
6177147000
Address
PO BOX 391953, CAMBRIDGE, MA 02139

Signing Officer

Name
Eric Minikel
Title
Treasurer
Phone
6177147000
Signed
2025-05-01
Discuss with paid preparer
Yes

Organization Details

Principal Officer
Eric Minikel
Formed
2012
Legal Domicile
Ma
Voting Board Members
3
Independent Board Members
3
Employees
0
Volunteers
3

Preparer

Firm
Aafcpas Inc
Address
50 WASHINGTON STREET, WESTBOROUGH, MA 01581
Preparer
Joyce Ripianzi CPA
Phone
5083669100
Supplemental Narrative

Additional Explanations

Form 990, Part I, Line 1

“Prion alliance, inc. Aims to catalyze the development of a treatment or cure for human prion diseases by funding, organizing and promoting scientific research. Our organization supports research directed at understanding prion disease biology, discovering and testing therapeutics, and developing novel lab and computational methodologies needed for furthering this research. Our operational model is to raise funds and disburse these to the most worthy scientific projects, with a view to the projects' relevance to our ultimate goal of a treatment or cure, as well as to the projects' ability to leverage prion alliance, inc seed funding in order to pursue outside funding sources for continued research. We also strive to bring together top scientific minds to share data, methodology, and findings in a spirit of openness and collaboration.”

Form 990, Part IX, Line 11G

“Research: program service expenses 357,974. Management and general expenses 0. Fundraising expenses 0. Total expenses 357,974.”

FORM 990, PART XII, LINE 2C:

“This process has not changed from the prior year.”

Raw XML Appendix322 raw XML fields

This appendix keeps the raw XML leaves available for debugging and edge-case review. The human report above is the primary experience.

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IRS990ScheduleI/RecipientTable/RecipientBusinessName/BusinessNameLine1Txt0THE BROAD INSTITUTE
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IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt0PRION ALLIANCE, INC. AIMS TO CATALYZE THE DEVELOPMENT OF A TREATMENT OR CURE FOR HUMAN PRION DISEASES BY FUNDING, ORGANIZING AND PROMOTING SCIENTIFIC RESEARCH. OUR ORGANIZATION SUPPORTS RESEARCH DIRECTED AT UNDERSTANDING PRION DISEASE BIOLOGY, DISCOVERING AND TESTING THERAPEUTICS, AND DEVELOPING NOVEL LAB AND COMPUTATIONAL METHODOLOGIES NEEDED FOR FURTHERING THIS RESEARCH. OUR OPERATIONAL MODEL IS TO RAISE FUNDS AND DISBURSE THESE TO THE MOST WORTHY SCIENTIFIC PROJECTS, WITH A VIEW TO THE PROJECTS' RELEVANCE TO OUR ULTIMATE GOAL OF A TREATMENT OR CURE, AS WELL AS TO THE PROJECTS' ABILITY TO LEVERAGE PRION ALLIANCE, INC SEED FUNDING IN ORDER TO PURSUE OUTSIDE FUNDING SOURCES FOR CONTINUED RESEARCH. WE ALSO STRIVE TO BRING TOGETHER TOP SCIENTIFIC MINDS TO SHARE DATA, METHODOLOGY, AND FINDINGS IN A SPIRIT OF OPENNESS AND COLLABORATION.
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt1SONIA VALLABH AND ERIC MINIKEL ARE MARRIED.
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt2DRAFT 990 IS CIRCULATED TO DIRECTORS VIA EMAIL FOR REVIEW AND APPROVAL PRIOR TO FILING.
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt3DIRECTORS ARE REQUIRED TO DISCLOSE COI IN WRITING. ANNUALLY, DIRECTORS ARE ASKED TO CONFIRM THEIR COI DISCLOSURE LIST.
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt4ORGANIZATIONAL DOCUMENTS ARE AVAILABLE ON OUR WEBSITE PRIONALLIANCE.ORG
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt5RESEARCH: PROGRAM SERVICE EXPENSES 357,974. MANAGEMENT AND GENERAL EXPENSES 0. FUNDRAISING EXPENSES 0. TOTAL EXPENSES 357,974.
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt6THIS PROCESS HAS NOT CHANGED FROM THE PRIOR YEAR.
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IRS990ScheduleO/SupplementalInformationDetail/FormAndLineReferenceDesc1FORM 990, PART VI, SECTION A, LINE 2
IRS990ScheduleO/SupplementalInformationDetail/FormAndLineReferenceDesc2FORM 990, PART VI, SECTION B, LINE 11B
IRS990ScheduleO/SupplementalInformationDetail/FormAndLineReferenceDesc3FORM 990, PART VI, SECTION B, LINE 12
IRS990ScheduleO/SupplementalInformationDetail/FormAndLineReferenceDesc4FORM 990, PART VI, SECTION C, LINE 19
IRS990ScheduleO/SupplementalInformationDetail/FormAndLineReferenceDesc5FORM 990, PART IX, LINE 11G
IRS990ScheduleO/SupplementalInformationDetail/FormAndLineReferenceDesc6FORM 990, PART XII, LINE 2C:
IRS990/SchoolOperatingInd00
IRS990/SignificantChangeInd00
IRS990/SignificantNewProgramSrvcInd00
IRS990/StatesWhereCopyOfReturnIsFldCd0MA
IRS990/SubjectToExcsTaxNetInvstIncInd00
IRS990/SubjectToProxyTaxInd00
IRS990/SubjToTaxRmnrtnExPrchtPymtInd00
IRS990/TaxablePartyNotificationInd00
IRS990/TaxExemptBondsInd00
IRS990/TerminateOperationsInd00
IRS990/TotalAssetsBOYAmt0693106
IRS990/TotalAssetsEOYAmt0417060
IRS990/TotalAssetsGrp/BOYAmt0693106
IRS990/TotalAssetsGrp/EOYAmt0417060
IRS990/TotalCompGreaterThan150KInd00
IRS990/TotalContributionsAmt0419737
IRS990/TotalEmployeeCnt00
IRS990/TotalFunctionalExpensesGrp/FundraisingAmt00
IRS990/TotalFunctionalExpensesGrp/ManagementAndGeneralAmt078780
IRS990/TotalFunctionalExpensesGrp/ProgramServicesAmt0607974
IRS990/TotalFunctionalExpensesGrp/TotalAmt0686754
IRS990/TotalGrossUBIAmt00
IRS990/TotalLiabilitiesBOYAmt09429
IRS990/TotalLiabilitiesEOYAmt0400
IRS990/TotalLiabilitiesGrp/BOYAmt09429
IRS990/TotalLiabilitiesGrp/EOYAmt0400
IRS990/TotalNetAssetsFundBalanceGrp/BOYAmt0683677
IRS990/TotalNetAssetsFundBalanceGrp/EOYAmt0416660
IRS990/TotalOtherCompensationAmt00
IRS990/TotalProgramServiceExpensesAmt0607974
IRS990/TotalReportableCompFromOrgAmt00
IRS990/TotalRevenueGrp/ExclusionAmt00
IRS990/TotalRevenueGrp/RelatedOrExemptFuncIncomeAmt00
IRS990/TotalRevenueGrp/TotalRevenueColumnAmt0419737
IRS990/TotalRevenueGrp/UnrelatedBusinessRevenueAmt00
IRS990/TotalVolunteersCnt03
IRS990/TotLiabNetAssetsFundBalanceGrp/BOYAmt0693106
IRS990/TotLiabNetAssetsFundBalanceGrp/EOYAmt0417060
IRS990/TotReportableCompRltdOrgAmt00
IRS990/TrnsfrExmptNonChrtblRltdOrgInd00
IRS990/TypeOfOrganizationCorpInd0X
IRS990/UnrelatedBusIncmOverLimitInd00
IRS990/USAddress/AddressLine1Txt0PO BOX 391953
IRS990/USAddress/CityNm0CAMBRIDGE
IRS990/USAddress/StateAbbreviationCd0MA
IRS990/USAddress/ZIPCd002139
IRS990/VotingMembersGoverningBodyCnt03
IRS990/VotingMembersIndependentCnt03
IRS990/WebsiteAddressTxt0PRIONALLIANCE.ORG
IRS990/WhistleblowerPolicyInd01
ReturnHeader/BuildTS02025-03-06 01:10:19Z
ReturnHeader/BusinessOfficerGrp/DiscussWithPaidPreparerInd01
ReturnHeader/BusinessOfficerGrp/PersonNm0ERIC MINIKEL
ReturnHeader/BusinessOfficerGrp/PersonTitleTxt0TREASURER
ReturnHeader/BusinessOfficerGrp/PhoneNum06177147000
ReturnHeader/BusinessOfficerGrp/SignatureDt02025-05-01
ReturnHeader/Filer/BusinessName/BusinessNameLine1Txt0PRION ALLIANCE INC
ReturnHeader/Filer/BusinessNameControlTxt0PRIO
ReturnHeader/Filer/EIN0460732060
ReturnHeader/Filer/PhoneNum06177147000
ReturnHeader/Filer/USAddress/AddressLine1Txt0PO BOX 391953
ReturnHeader/Filer/USAddress/CityNm0CAMBRIDGE
ReturnHeader/Filer/USAddress/StateAbbreviationCd0MA
ReturnHeader/Filer/USAddress/ZIPCd002139
ReturnHeader/IRSResponsiblePrtyInfoCurrInd01
ReturnHeader/PreparerFirmGrp/PreparerFirmEIN0042571780
ReturnHeader/PreparerFirmGrp/PreparerFirmName/BusinessNameLine1Txt0AAFCPAS INC
ReturnHeader/PreparerFirmGrp/PreparerUSAddress/AddressLine1Txt050 WASHINGTON STREET
ReturnHeader/PreparerFirmGrp/PreparerUSAddress/CityNm0WESTBOROUGH
ReturnHeader/PreparerFirmGrp/PreparerUSAddress/StateAbbreviationCd0MA
ReturnHeader/PreparerFirmGrp/PreparerUSAddress/ZIPCd001581
ReturnHeader/PreparerPersonGrp/PhoneNum05083669100
ReturnHeader/PreparerPersonGrp/PreparationDt02025-05-01
ReturnHeader/PreparerPersonGrp/PreparerPersonNm0JOYCE RIPIANZI CPA
ReturnHeader/ReturnTs02025-05-06T06:48:42-05:00
ReturnHeader/ReturnTypeCd0990
ReturnHeader/TaxPeriodBeginDt02024-01-01
ReturnHeader/TaxPeriodEndDt02024-12-31
ReturnHeader/TaxYr02024

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