Civic Intelligence

Cohen Veterans Bioscience Inc.

990 • Fiscal year 2019 • EIN 47-1981973

Jul 01, 2018 to Jun 30, 2019 • Filed on May 07, 2020

Organization ProfileWWW.COHENVETERANSBIOSCIENCE.ORG

View Organization Page

1 Broadway 14th FloorCambridge, MA 02142

(646) 970-4325

Siviq Scores

Precomputed percentiles for this filing year versus similar nonprofits in the same peer cohort.

Liabilities / Assets

75th percentile

0.54x

Higher debt load relative to assets than 75% of similar nonprofits.

2019 filings • 501(c)3 • $10M-$25M nonprofits • Source year 2019

Liabilities / Revenue

72nd percentile

0.62x

Higher debt load relative to revenue than 72% of similar nonprofits.

2019 filings • 501(c)3 • $10M-$25M nonprofits • Source year 2019

Net Margin

54th percentile

4.1%

Higher net margin than 54% of similar nonprofits.

2019 filings • 501(c)3 • $10M-$25M nonprofits • Source year 2019

Top Officer Pay

93rd percentile

$633,866

Higher top officer pay than 93% of similar nonprofits.

Top officer pay equals 3.0% of source-year revenue.

2019 filings • 501(c)3 • $10M-$25M nonprofits • Source year 2019

Asset Growth

93rd percentile

48%

Faster asset growth than 93% of similar nonprofits.

2019 filings • 501(c)3 • $10M-$25M nonprofits • Annualized from 2018 to 2019

Revenue Growth

82nd percentile

25%

Faster revenue growth than 82% of similar nonprofits.

2019 filings • 501(c)3 • $10M-$25M nonprofits • Annualized from 2018 to 2019

Balance Sheet
Liabilities / Assets75th percentile

Assets

Up

$24,190,269

Up $7,836,905 (+48%) from 2018

Net Assets

Up

$11,201,348

Up $868,511 (+8.4%) from 2018

Liabilities

Up

$12,988,921

Up $6,968,394 (+116%) from 2018

Revenue And Expenses
Liabilities / Revenue72nd percentileNet Margin54th percentile

Revenue

Up

$21,039,448

Up $4,193,907 (+25%) from 2018

Expenses

Up

$20,170,937

Up $5,374,277 (+36%) from 2018

Net Income

Down

$868,511

Down $1,180,370 (-58%) from 2018

Historical Trend

Balance Sheet Trend

Asset Growth93rd percentile

The highlighted filing sits inside the broader history for assets, liabilities, and net assets.

$30M$20M$10M$0-$10MAssets 2015: $450,595Liabilities 2015: $326,443Net Assets 2015: $124,1522015Assets 2016: $25,419,016Liabilities 2016: $10,161,873Net Assets 2016: $15,257,1432016Assets 2017: $14,863,415Liabilities 2017: $6,579,459Net Assets 2017: $8,283,9562017Assets 2018: $16,353,364Liabilities 2018: $6,020,527Net Assets 2018: $10,332,8372018Assets 2019: $24,190,269Liabilities 2019: $12,988,921Net Assets 2019: $11,201,3482019Assets 2020: $18,865,456Liabilities 2020: $8,431,760Net Assets 2020: $10,433,6962020Assets 2021: $17,952,584Liabilities 2021: $6,826,523Net Assets 2021: $11,126,0612021Assets 2022: $15,587,351Liabilities 2022: $3,699,826Net Assets 2022: $11,887,5252022Assets 2023: $11,743,398Liabilities 2023: $3,853,705Net Assets 2023: $7,889,6932023Assets 2024: $3,075,275Liabilities 2024: $3,105,844Net Assets 2024: -$30,5692024Assets 2025: $1,835,419Liabilities 2025: $98,368Net Assets 2025: $1,737,0512025

Highlighted filing

2019

Assets$24,190,269
Liabilities$12,988,921
Net Assets$11,201,348
Open 2019 Filing

Operations Trend

Revenue Growth82nd percentile

Revenue, expenses, and net income across loaded years, with this filing highlighted.

$40M$30M$20M$10M$0-$10MRevenue 2015: $70,035Expenses 2015: $651,553Net Income 2015: -$581,5182015Revenue 2016: $31,399,759Expenses 2016: $16,266,768Net Income 2016: $15,132,9912016Revenue 2017: $4,366,629Expenses 2017: $11,339,816Net Income 2017: -$6,973,1872017Revenue 2018: $16,845,541Expenses 2018: $14,796,660Net Income 2018: $2,048,8812018Revenue 2019: $21,039,448Expenses 2019: $20,170,937Net Income 2019: $868,5112019Revenue 2020: $16,470,665Expenses 2020: $18,162,920Net Income 2020: -$1,692,2552020Revenue 2021: $16,252,270Expenses 2021: $18,110,420Net Income 2021: -$1,858,1502021Revenue 2022: $18,082,398Expenses 2022: $17,523,784Net Income 2022: $558,6142022Revenue 2023: $11,343,534Expenses 2023: $15,341,366Net Income 2023: -$3,997,8322023Revenue 2024: $8,377,751Expenses 2024: $14,079,910Net Income 2024: -$5,702,1592024Revenue 2025: $3,369,809Expenses 2025: $1,377,761Net Income 2025: $1,992,0482025

Highlighted filing

2019

Revenue$21,039,448
Expenses$20,170,937
Net Income$868,511
Open 2019 Filing
Jump To
Filing Snapshot
Filing Period
Jul 1, 2018 to Jun 30, 2019
Signed
May 7, 2020
Return Version
2018v3.1
Gross Receipts
$21,039,448
Mission and Program Overview

Mission

Cohen veterans bioscience is the only 501(c)3 non-profit research organization with a singular focus on ptsd and tbi research. We are dedicated to fast-tracking the development of diagnostic tests and personalized medicines for the millions of veterans and civilians who suffer the devastating effects of trauma on the brain.

Cohen veterans bioscience, inc. Is a national 501(c)(3) research biotech dedicated to fast-tracking the development of diagnostic tests and personalized therapeutics for the millions of veterans and civilians who suffer the devastating effects of trauma-related and other brain disorders.

Balance Sheet Detail
LineBeginningEndChange
Assets
Savings and Temporary Cash Investments$7,142,648$16,036,550▲ $8,893,902
Pledges and Grants Receivable$8,208,158$7,527,477▼ $680,681
Cash and Non-Interest-Bearing Accounts$607,164$465,961▼ $141,203
Prepaid Expenses and Deferred Charges$258,542$61,526▼ $197,016
Land, Buildings, and Equipment, Net$0$50,226▲ $50,226
Total Assets$16,353,364$24,190,269▲ $7,836,905
Other Assets Total$136,852$48,529▼ $88,323
Liabilities
Grants Payable$4,605,358$10,118,262▲ $5,512,904
Accounts Payable and Accrued Expenses$1,415,169$2,672,945▲ $1,257,776
Deferred Revenue$0$197,714▲ $197,714
Total Liabilities$6,020,527$12,988,921▲ $6,968,394
Net Assets / Fund Balance
Temporarily Rstr Net Assets$9,949,957$10,360,356▲ $410,399
Unrestricted Net Assets$382,880$840,992▲ $458,112
Total Net Assets Fund Balance$10,332,837$11,201,348▲ $868,511
Total Liabilities and Net Assets / Fund Balance$16,353,364$24,190,269▲ $7,836,905

Asset Categories

AssetBook ValueDepreciationBasis
Equipment$35,218$4,755$39,973
Other Land Buildings$15,008$4,759$19,767
Compensation and Service Providers
Top Officer Pay93rd percentile

Employees

NameTitleFull / Part TimeBaseOtherTotal
Magali Haas Md PhdCEO & PresidentFT$441,005$192,861$633,866
Allyson Gage PhdChief Medical OfficerFT$348,208$182,753$530,961
Andreas Jeromin PhdChief Scientific OfficerFT$309,015$144,553$453,568
Daniela Brunner PhdExecutive Director of Digital HealthFT$111,883$62,776$174,659
Patricia KabitzkeSr. Scientific Program ManagerFT$118,439$32,075$150,514
Sean MccreeryFormer Chief Operations OfficerFT$127,928$21,827$149,755
Heather Lasseter PhdAssoc. Director, Scientific ProgramsFT$124,437$15,075$139,512
Keith RobinsonDirector of OperationsFT$116,473$6,700$123,173

Board Members and Trustees

NameTitle
Douglas HaynesBoard Member
Theresa FrangiosaSecretary
Michael SullivanTreasurer

Highest Paid Contractors

ContractorServicesLocationCompensation
Iconic Event StudiosEvent Management1861 SUNSET PLAZA DRIVE, Los Angeles, CA 90069, Uk$956,925
Morgan Lewis And Bockius LLPLegal Services1701 MARKET STREET, Philadelphia, PA 19103$855,766
Deep Net Ai LtdData Science Consultant4550 MONTGOMERY AVENUE SUITE 800, North Bethesda, MD 20814$281,204
Grf Cpa's & AdvisorsAccounting And Bookkeeping1500 SPRING GARDEN STREET 4TH FLOOR, Philadelphia, PA 19130$214,742
Clarivate Analytics (us) LLCAnalytic Services-$169,735
Revenue and Support

Revenue Composition

Contributions and Grants
$20,795,052
Program Service Revenue
$0
Investment Income
$98,872
Other Revenue
$145,524
All Other Contributions
$20,094,263
Change in Net Assets
$868,511

Audited Revenue Reconciliation

Revenue per Audited Statements
$21,039,448
Revenue Not Reported on Financial Statements
$0
Revenue Not Reported on Form 990
$0
Total Revenue per Audited Statements
$21,039,448
Total Revenue per Form 990
$21,039,448
Expenses and Functional Allocation

Major Expense Lines

Line ItemAmount
Other Expenses$12,390,028
Salaries, Compensation, and Employee Benefits$4,994,068
Grants and Similar Amounts Paid$2,786,841
Total Fundraising Expense$53,373
Professional Fundraising Fees$0

Functional Expense Allocation

Line ItemProgramManagementFundraisingTotal
Fees for Services Other$7,963,926$106,685$2,291$8,072,902
Other Salaries and Wages$2,439,868$283,546$10,084$2,733,498
Grants to Domestic Orgs$2,724,238--$2,724,238
Current Officers, Directors, Trustees, and Key Employees$1,495,480$129,311$32,328$1,657,119
Conferences and Meetings$1,654,673$1,174-$1,655,847
Fees for Services Legal$732,749$36,691-$769,440
Travel$441,527$65,561$2,263$509,351
Occupancy$430,178$31,286-$461,464
Fees for Services Accounting$6,542$314,164-$320,706
Payroll Taxes$260,580$27,488$2,793$290,861
Office Expenses$58,691$180,200$541$239,432
Other Employee Benefits$146,186$17,937$1,823$165,946
Pension Plan Contributions$132,030$13,688$926$146,644
Fees for Services Lobbying$87,500--$87,500
Foreign Grants$62,603--$62,603
Information Technology$55,369$1,697$126$57,192
Insurance$15,053$19,664$162$34,879
Depreciation Depletion$9,120$358$36$9,514
Other Expenses$164,801$7,000-$7,000
Total Functional Expenses$18,881,114$1,236,450$53,373$20,170,937

Audited Expense Reconciliation

Line ItemAmount
Expenses per Audited Statements$20,170,937
Total Expenses per Audited Statements$20,170,937
Total Expenses per Form 990$20,170,937
Expenses Not Reported on Financial Statements$0
Expenses Not Reported on Form 990$0
International Activity

Grant and Assistance Recipients

RecipientLocationCategoryPurposeAmount
University of ChicagoChicago, IL501(c)3Provide Services and Support for Brain Commons (data-repository)$883,650
The Broad Institute of Mit and HarvardCambridge, MA501(c)3Ptsd Research Programs$528,915
CHILDREN'S HOSPITAL OF PHILADELPHIAPhiladephia, PA501(c)3Validating Constructs Relevant to Ptsd in a Model of Individual Differences in Response to Social Defeat in Rats$300,757
American College of Radiology (acr)Philadelphia, PA501(c)3Conduct Study to Establish a National Normative Neuroimaging Library$262,528
Harvard UniversityCambridge, MA501(c)3Advancing the Study of Deployment Trauma in the Tracts Cohort$148,805
Early Signal Foundation IncNew York, NY501(c)3Biosensors and Mobile Health Platform for Brain Diseases$128,000
Louisiana State UniversityNew Orleans, LAGovernmentPtsd-aud Comorbidity Model Development$125,884
Boston Va Research InstituteBoston, MA501(c)3Advancing the Study of Deployment Trauma in the Tracts Cohort$79,103
Regents of the University of MichiganAnn Arbor, MI501(c)3High-density Recording in the Sps Model of Ptsd$76,330
University of California Santa BarbaraSanta Barbara, CAGovernmentStudy of Tau Biology and Pathology for Ad, Tbi and Other Disorders$53,000
Columbia UniversityNew York, NY501(c)3Ptsd Research Programs$46,000
University of CincinnatiCleveland, OHGovernmentThe Role of Stress Hormones and Dopamine in a Novel Genetic Rat Model of Ptsd$32,669
NATIONAL ASSOCIATION OF VETERANS' RESEARCH AND EDUCATION FOUNDATIONWashington, DCC CorpNavred Annual Conference Sponsorship$30,000
University of VirginiaCharlottesville, VA501(c)3Normative Neuroimaging Library$28,598

International Summary

Offices
0
Employees
1
Spending
$312,683

International Compliance

Foreign grant records maintained
Yes
Activity in boycott countries
No
Foreign corporation ownership
No
Foreign partnership interest
No
Interest in foreign trust
No
Passive foreign investment company interest
No
Transfers to foreign corporations
No

International Activities

RegionActivityServicesOfficesEmployeesSpending
Europe (including Iceland & Greenland) - Albania, Andorra, Austria, BelgiumProgram ActivitiesPayment for Contracted Services01$250,080
Europe (including Iceland & Greenland) - Albania, Andorra, Austria, BelgiumGrants to Recipients Located in RegionN/a00$60,114
North America - Canada and Mexico, But Not the United StatesGrants to Recipients Located in RegionN/a00$2,489
Fundraising, Events, and Gaming
Fundraising activities
No
Gaming activities
No
Professional fundraiser used
No

Fundraising and Gaming Totals

Line ItemAmount
Professional Fundraising Fees$0
Political and Lobbying Activity
Political campaign activity
No
Lobbying activity
Yes
Subject to proxy tax
No
Insider Transactions and Loans

Interested-Person Transactions

Interested PartyRelationshipDescriptionShared RevenueAmount
-Owner Is an Officer of the OrganizationProvided Discounted Strategic Consulting Services to Organization.No$101,475
Governance and Compliance

Governance Checklist

Compiled or reviewed by an accountant
No
Annual disclosure for covered persons
Yes
Audit committee
Yes
Business relationship with family members
No
Business relationship with organization members
No
Material changes to governing documents
No
Compensation from other sources disclosed
No
CEO compensation reviewed
Yes
Other officer compensation reviewed
Yes
Conflict-of-interest policy
Yes
Audited financial statements prepared
No
Key decisions subject to board approval
No
Management duties delegated
No

Governance Explanations

Form 990, Part VI, Section B, Line 11B

“The board of directors reviewed and approved the form 990 prior to its filing. The form 990 was then authorized and signed by the organization's ceo & president.”

Form 990, Part VI, Section B, Line 12C

“The board of directors requires an annual declaration from all board members and senior management as to the existence and disclosure of any potential conflicts of interest. The board members sign a disclosure statement. Any potential conflicts are discussed by the dis-interested board members, while the party in potential conflict is required to leave the room. Board meeting minutes will document the discussion and decision making process. In the event of a potential conflict, procedures to obtain competitive bids and diligence on fair market value will be established.”

Form 990, Part VI, Section B, Line 15

“Cvb's executive compensation program is administered by the board of directors. The board is responsible for establishing and maintaining a competitive compensation program for the key executives of the organization. The board meets as needed to review the compensation program and make recommendations for any changes, as appropriate. A performance evaluation is conducted and reviewed each year and is intended to ensure that the compensation program falls within a reasonable range of competitive practices for comparable positions among similarly situated organizations. Following this review, the board reviews and approves, for selected key executives, base salaries and annual incentive opportunity adjustments, and objectives and goals upcoming year's annual incentive plan. The board reviews and recommends to the board salary approval and incentive awards for the ceo/president and selected key senior staff.”

Form 990, Part VI, Section C, Line 19

“Upon request and forms available through charity navigator website as well.”

Filing and Contact Details

Filer

Filer Name
Cohen Veterans Bioscience Inc
EIN
47-1981973
Phone
6469704325
Address
1 BROADWAY 14TH FLOOR, CAMBRIDGE, MA 02142

Signing Officer

Name
Magali Haas Md Phd
Title
CEO & President
Phone
6469704325
Signed
2020-05-07
Discuss with paid preparer
Yes

Organization Details

Principal Officer
Magali Haas Md Phd
Formed
2014
Legal Domicile
Ma
Voting Board Members
4
Independent Board Members
2
Employees
25
Volunteers
0

Preparer

Firm
Smith Sullivan & Brown Pc
Address
80 FLANDERS ROAD - SUITE 200, WESTBOROUGH, MA 01581
Preparer
Sandra M Brown CPA
Phone
5088717178
Supplemental Narrative

Additional Explanations

Form 990, Part IX, Line 11G

“Professional fees: program service expenses 3,451. Management and general expenses 84,137. Fundraising expenses 0. Total expenses 87,588. Research collaboration expenses: program service expenses 6,016,814. Management and general expenses 0. Fundraising expenses 0. Total expenses 6,016,814. Contracted services: program service expenses 1,943,661. Management and general expenses 22,548. Fundraising expenses 2,291. Total expenses 1,968,500.”

Financial Statement Notes

PART X, LINE 2:

“Tax position: the organization currently evaluates all tax positions, and makes a determination regarding the likelihood of those positions being upheld under review. The primary tax position made by the organization is the existence of unrelated business income tax and the organization's status as a tax-exempt organization under section 501(c)(3) of the internal revenue code. For the year presented, the organization has not recognized any tax benefits or loss contingencies for uncertain tax positions based on this evaluation.”

Raw XML AppendixShowing 400 of 840 raw XML fields

This appendix keeps the raw XML leaves available for debugging and edge-case review. The human report above is the primary experience.

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IRS990/MissionDesc0WCOHEN VETERANS BIOSCIENCE, INC. IS A NATIONAL 501(C)(3) RESEARCH BIOTECH DEDICATED TO FAST-TRACKING THE DEVELOPMENT OF DIAGNOSTIC TESTS AND PERSONALIZED THERAPEUTICS FOR THE MILLIONS OF VETERANS AND CIVILIANS WHO SUFFER THE DEVASTATING EFFECTS OF TRAUMA-RELATED AND OTHER BRAIN DISORDERS.
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IRS990/ProgSrvcAccomActy2Grp/Desc0BRAIN TRAUMA PROGRAMS: POST TRAUMATIC STRESS DISORDER ("PTSD") AND TRAUMATIC BRAIN INJURY ("TBI"):IN JULY 2015, THIS CVB PROGRAM WAS FOUNDED TO ESTABLISH A NATIONAL RESEARCH ROADMAP FOR PTSD, TBI AND RELATED CONDITIONS (E.G. SUICIDALITY). BRAIN TRAUMA BLUEPRINT - STATE OF THE SCIENCE SUMMITS:THE BRAIN TRAUMA BLUEPRINT IS A SERIES OF STATE OF THE SCIENCE SUMMITS("SOSS") AIMED TO BUILD CONSENSUS AROUND KNOWLEDGE GAPS AND DEVELOP STRATEGIES TO MOVE THE FIELD FORWARD FOR TRAUMA-RELATED CONDITIONS BY LEVERAGING THE COMBINED INTELLECTUAL RESOURCES OF THE FULL RESEARCH COMMUNITY.THE STATE OF THE SCIENCE SUMMITS ARE DESIGNED AS 2-DAY RETREATS FOR 100 TO 200 STAKEHOLDERS TO COME TOGETHER TO REALIZE TRUE IMPACT. THE STAKEHOLDERS WILL ENCOMPASS A BROAD SWATH OF THE COMMUNITY FROM ACADEMIC INSTITUTIONS TO GOVERNMENT AGENCIES, FOUNDATIONS SUPPORTING TRANSLATIONAL RESEARCH, AND INDUSTRY.EACH SUMMIT SERVES AS A LAUNCHPAD FOR ONGOING WORKING GROUPS TO DEVELOP EVIDENCE-BASED STRATEGIES AND RECOMMENDATIONS ON HOW TO FILL THOSE GAPS, IDENTIFY NEW GAPS AS OTHERS ARE FILLED, AND DISSEMINATE THESE FINDINGS BACK TO THE COMMUNITY AT LARGE THROUGH WHITE PAPERS AND PROCEEDINGS.THE INAUGURAL STATE OF THE SCIENCE SUMMIT, HELD IN SEPTEMBER 2018, FOCUSED ON DIAGNOSIS OF TRAUMA-RELATED BRAIN DISORDERS WITH A MAJOR FOCUS ON POST-TRAUMATIC STRESS DISORDER. THE TRAUMA-RELATED BRAIN DISORDERS RESEARCH COMMUNITY HAS IDENTIFIED A NEED TO ESTABLISH A MECHANISM-BASED TAXONOMY FOR THESE CONDITIONS TO ADVANCE BIOMARKER DISCOVERY AS WELL AS DIAGNOSIS AND THERAPEUTIC DEVELOPMENT. A SHIFT FROM A SYNDROMIC CLASSIFICATION SYSTEM TO A MECHANISTIC ONE NECESSITATES A REVIEW OF THE CURRENT SCIENTIFIC KNOWLEDGE, ADOPTION OF NEW SCIENTIFIC MODELS, AND IDENTIFICATION OF RESEARCH AND KNOWLEDGE GAPS. THE SOSS BROUGHT TOGETHER MULTIDISCIPLINARY STAKEHOLDERS WITH DEEP SCIENTIFIC AND CLINICAL EXPERTISE TO ADDRESS THIS PRESSING NEED.THE THEME OF THE SECOND STATE OF THE SCIENCE SUMMIT, HELD IN MAY 2019 WAS PATHS TO TREATMENT FOR TRAUMATIC BRAIN INJURY(S) WITH A FOCUS ON THE TAXONOMY AND NOSOLOGY OF THE CHRONIC SEQUELAE, CHALLENGES AND OPPORTUNITIES IN CLINICAL PRACTICE AND DEVELOPMENT, AND ETIOLOGY AND MECHANISM OF PERSISTENT SYMPTOMS. AS MEASUREMENT TOOLS ADVANCE, RESEARCH HAS BEEN ABLE TO FOCUS ON DIFFERENT TYPES OF INJURY, BEYOND THE MILD, MODERATE, AND SEVERE CLASSIFICATIONS OF TBI. TO AUGMENT AND SUPPORT THE MANY EFFORTS ACROSS FIELDS AND ORGANIZATIONS OVER THE PAST DECADE, WE AIM TO MAP A CONSENSUS BLUEPRINT TO DRIVE TRANSLATIONAL SCIENCE FOR TBI.ADAPTIVE PLATFORM TRIALS:CVB IS SPEARHEADING THE DESIGN AND APPLICATION OF "SMART- OR "ADAPTIVE-" CLINICAL TRIALS FOR NEUROPSYCHIATRIC AND NEURODEGENERATIVE CONDITIONS. THESE STUDIES INCLUDE A PROSPECTIVELY PLANNED OPPORTUNITY FOR MODIFICATION OF ONE OR MORE SPECIFIED ASPECTS OF THE STUDY DESIGN BASED ON DATA (USUALLY INTERIM DATA) COLLECTED FROM SUBJECTS IN THE STUDY. TO EXECUTE SUCH A PROGRAM, OUR CENTRALLY-MANAGED PLATFORM CLINICAL TRIAL INFRASTRUCTURE (BRAIN-NET) WILL BE LEVERAGED TO CONDUCT STUDIES ACROSS BRAIN CONDITIONS AND POPULATIONS INCLUDING ACADEMIC, PRIVATE, VA, AND POTENTIALLY MILITARY RESEARCH CENTERS.CURRENTLY, ONLY TWO DRUGS ARE APPROVED BY THE U.S. FOOD AND DRUG ADMINISTRATION FOR THE TREATMENT OF PTSD, ALTHOUGH BOTH ARE ONLY MODESTLY EFFECTIVE IN TREATING MILITARY-RELATED PTSD. OVER THE PAST 17 YEARS, INDIVIDUAL ACADEMIC INVESTIGATORS AND COMPANIES HAVE NOT DELIVERED ALTERNATIVE FDA-APPROVED DRUGS. IN RESPONSE TO THIS UNMET NEED, OUR PROGRAM WILL TEST MULTIPLE DRUGS TO ADVANCE THEM THROUGH REGULATORY APPROVAL. IN THE FUTURE, WE WILL EXPAND OUR EFFORTS TO OTHER THERAPEUTIC SOLUTIONS (E.G. DEVICES, ALTERNATIVE THERAPIES), THROUGH OUR EVIDENCE-DRIVEN CLINICAL TRIAL NETWORK INFRASTRUCTURE.IN SEPTEMBER 2018, THE U.S. ARMY MEDICAL MATERIEL DEVELOPMENT ACTIVITY, A SUBORDINATE COMMAND OF THEU.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND, ANNOUNCED AN AWARD OF DEFENSE HEALTH AGENCY UNDER AN OTHER TRANSACTION AGREEMENT, TO CVB
IRS990/ProgSrvcAccomActy3Grp/Desc0BEST BIOMARKER PTSD STUDY:DESPITE THE EFFICACY OF PSYCHOTHERAPY AS FIRST-LINE TREATMENT FOR PTSD, LARGE INTER-INDIVIDUAL DIFFERENCES IN OUTCOMES EXIST, WITH ROUGHLY 50% OF PATIENTS RESPONDING TO TREATMENT AND FEWER THAN THAT FULLY REMITTING. THIS GRANT SUPPORTED THE DEVELOPMENT OF A RESPONSE DIAGNOSTIC TEST BASED ON PRELIMINARY FINDINGS FOR A COMBINATION COGNITIVE/IMAGING MARKER RESULTING FROM CVB'S INVESTMENT IN THE COHEN VETERANS CENTER STUDY AT NYU/STANFORD. THE PROGRAM, CONCLUDING IN LATE 2019, INCLUDES A CLINICAL STUDY AT TWO CENTERS OF OVER 200 SUBJECTS TO REPLICATE THE INITIAL FINDING, AND IS SEEKING QUALIFICATION VIA THE FOOD AND DRUG ADMINISTRATION ("FDA") GUIDANCE TO SUPPORT THE COMMERCIALIZATION AND/OR AVAILABILITY OF THE TEST FOR CLINICAL PRACTICE AND RESEARCH AND DEVELOPMENT. PTSD GENETICS PROGRAM:THE PSYCHIATRIC GENETICS CONSORTIUM-PTSD WORKING GROUP - BROAD INSTITUTE COLLABORATION IS SUPPORTING THE LARGEST GLOBAL GENOME WIDE ASSOCIATION STUDY ("GWAS") OF PTSD TO DATE WITH DATA FROM OVER 200,000 INDIVIDUALS ANALYZED. THE MAIN GOAL IS TO UNCOVER THE GENETIC UNDERPINNINGS OF PTSD RISK AND PUBLISH ALL RESULTS. SUBSEQUENT TO YEAR END, SEMINAL FINDINGS OF THE FIRST PTSD GENETIC RISK LOCI FROM THIS PROGRAM WERE PUBLISHED IN NATURE COMMUNICATIONS IN OCTOBER 2019.THE PROGRAM WITH THE BROAD INSTITUTE WAS EXTENDED IN FY 2018 TO INCLUDE FUNCTIONAL GENOMICS STUDIES OF IDENTIFIED GENETIC MARKERS AS WELL AS GENETIC EXPRESSION ANALYSIS OF AMYGDALA CELLULAR CIRCUITS IN ORDER TO INITIATE THE IDENTIFICATION OF POTENTIAL TARGETS FOR THERAPEUTIC INTERVENTION IN PTSD.RTMS BIOMARKER PTSD STUDY:THIS PROJECT SEEKS TO DEVELOP TREATMENT PREDICTION INDICES AND EXPLORE TREATMENT TRACKING AND MEDIATING INDICES USING A COMBINATION OF A VERBAL MEMORY TEST AND RESTING AND TMS-EVOKED EEG DATA RECORDED BEFORE AND AFTER RTMS TREATMENT FOR PTSD. SPECIFICALLY, THIS IS AN ADD-ON STUDY, AT SELECTED SITES, INTEGRATED INTO A PIVOTAL STUDY SEEKING FDA APPROVAL OF H7 DEEP TMS COIL AS A TREATMENT FOR PTSD.NATIONAL NEUROIMAGING NORMATIVE LIBRARY PROGRAM:CVB HAS CREATED AN IMAGING REFERENCE LIBRARY ESSENTIAL TO THE DEVELOPMENT OF EFFECTIVE CLINICAL IMAGING TOOLS FOR DIAGNOSING AND MANAGING PATIENTS WITH BRAIN DISORDERS. ADVANCED NEUROIMAGING CAN NOW DETECT MICROSCOPIC CHANGES IN BRAIN STRUCTURE CAUSED BY TRAUMA OR DISEASE. THESE ADVANCED IMAGING APPROACHES INCLUDE DIFFUSION TENSOR IMAGING (DTI), FUNCTIONAL CONNECTIVITY, PERFUSION WEIGHTED IMAGING, AND VOLUMETRIC IMAGING. DESPITE THEIR PROMISE, THESE ADVANCED APPROACHES ARE CURRENTLY PRIMARILY CONFINED TO RESEARCH USE. THE NUMERICAL NATURE OF THE INFORMATION THESE ADVANCED IMAGING APPROACHES YIELD IS DIFFICULT TO TRANSLATE FROM THE STUDY OF GROUPS OF INDIVIDUALS TO A SINGLE PATIENT WITHOUT A REFERENCE. THE IMAGING DATABASE IS BASED ON THE RESULTS OF A NATIONAL STUDY OF NORMATIVE INDIVIDUALS, SPONSORED BY CVB AT UNIVERSITY OF VIRGINIA, BAYLOR UNIVERSITY AND UNIVERSITY OF UTAH. STANDARDIZED ADVANCED NEUROIMAGING SCANS ON 3,000 ADULT VOLUNTEERS WHO HAVE NOT BEEN AFFECTED BY BRAIN TRAUMA OR DISEASE WERE PERFORMED. THE RESULTING IMAGING DATA, ALONG WITH DEMOGRAPHIC INFORMATION AND THE RESULTS OF NEUROCOGNITIVE ASSESSMENTS, IS FORMING A LIBRARY DOCUMENTING POPULATION VARIATION IN BRAIN STRUCTURE AND FUNCTION AS MEASURED BY THESE ADVANCED IMAGING METHODS.THROUGH THIS IMAGING DATABASE, IT IS OUR GOAL TO ADVANCE NEUROIMAGING TO DRAMATICALLY IMPROVE THE IDENTIFICATION OF AFFECTED INDIVIDUALS AND ALLOW PHYSICIANS TO OBJECTIVELY AND EFFICIENTLY DIAGNOSE CONDITIONS SUCH AS TBI, DEMENTIA AND OTHER BRAIN DISORDERS WHERE BRAIN STRUCTURE IS DETECTED VIA MRI.PTSD TIA-1 PROGRAM:CVB HAS FUNDED COLUMBIA UNIVERSITY TO SUPPORT A MULTI-PRONGED SCIENTIFIC PROGRAM THAT WILL STUDY THE INTERPLAY BETWEEN THE TIA GENE AND PROTEIN PRODUCTS, STRESS GRANULES, STRESS CIRCUITS AND PTSD AND TBI. FURTHER RESEARCH WILL LOOK AT WAYS TO MAINTAIN THE GENE'S PROTECTIVE FEATURES, WHICH COULD ULTIMATELY LEAD TO THE DEVELOPMENT OF DRUGS TO PREVENT AND T
IRS990/ProgSrvcAccomActyOtherGrp/Desc0COMPUTATIONAL MODELING & DATA SCIENCES:CVB HAS ESTABLISHED AN INTRAMURAL DATA SCIENCES PROGRAM TO BUILD MACHINE-LEARNING AND ARTIFICIAL INTELLIGENCE BASED PREDICTIVE MODELS OF DISEASE. THIS PROGRAM BUILDS ON OUR ORIGINAL ORION MS BIO-MODELLING PROGRAM AND FOCUSES ON MODELS OF PTSD, TBI, PARKINSONS AND DEMENTIA AND OTHER CONDITIONS.MULTIPLE SCLEROSIS (MS) 1.0:THE ORION BIONETWORKS FLAGSHIP PROGRAM SUCCESSFULLY PILOTED THE ESTABLISHMENT OF A MULTIPLE SCLEROSIS ("MS") BIONETWORK COMPRISED OF ACADEMIC (NEUROSCIENCE INSTITUTE OF THE BRIGHAM AND WOMEN'S HOSPITAL), ADVOCACY (ACCELERATED CURE PROJECT FOR MS), COMPUTATIONAL (GNS HEALTHCARE, METACELL, THOMSON REUTERS), INFORMATICS (CONVERGE BY DELOITTE, RANCHO BIOSCIENCES, EXAPTIVE), AND ONLINE PATIENT COMMUNITY PARTNERS (PATIENTSLIKEME [PLM]). DE-IDENTIFIED HIPPA-COMPLIANT DATA FROM THREE DATABASES WERE CURATED AND LOADED INTO A CLOUD-BASED DATA KNOWLEDGE MANAGEMENT SYSTEM. THE INTEGRATED REPOSITORY INCLUDES 9,000 SUBJECTS WITH MS AND RELATED CONDITIONS. THE ALLIANCE DEVELOPED A ROADMAP FOR JOINT EXECUTION WITH SPECIFIC SCIENTIFIC AIMS. TO DATE, THE ALLIANCE HAS GENERATED THREE MODELS BASED ON THE DATA REPOSITORY USING DIFFERENT ALGORITHMIC APPROACHES: PHENOTYPIC PROGNOSTIC MODEL AND TWO MOLECULAR PROGNOSTIC MODELS.PARKINSON'S PROGRESSION MARKERS INITIATIVE (PPMI) DATA SCIENCE MODELING GROUP:EXISTING DIAGNOSES FOR COMPLEX BRAIN DISORDERS SUCH AS PARKINSON'S DISEASE (PD) FOCUS ON UNDERSTANDING CLUSTERS OF MAJOR SYMPTOMS. IN ORDER TO DRIVE PROGRESS IN THE DEVELOPMENT OF NEW TREATMENTS IT IS IMPORTANT TO UNDERSTAND THE ROLE OF SPECIFIC BIOLOGICAL PROCESSES IN DETERMINING PATIENT OUTCOMES. IN THIS PROGRAM WE MODEL THE MICHAEL J. FOX FOUNDATION (MJFF) SPONSORED PARKINSON'S PROGRESSION MODEL INITIATIVE (PPMI) STUDY. THE STUDY HAS EVALUATED PARTICIPANTS' CLINICAL STATUS WHILE COLLECTING IMAGING, BEHAVIORAL, 'OMICS AND OTHER ASSESSMENTS LONGITUDINALLY SINCE 2010. IN OUR ALIGNED MISSIONS TO ADVANCE BRAIN HEALTH, MJFF SELECTED COHEN VETERAN'S BIOSCIENCE DATA SCIENCE TEAM TO LEVERAGE THIS COHORT TOGETHER WITH A MULTI-DISCIPLINARY APPROACH TO QUANTITATIVELY EXPLORE, EVALUATE, AND PREDICT DISEASE TRAJECTORY, RISK FACTORS, AND SUBTYPES. GIVEN THE BREADTH AND DEPTH OF THE PPMI DATA AND RICH OPPORTUNITIES TO DEVELOP IMPACTFUL DISEASE MODELS, THE TEAM USE THEIR SUBJECT MATTER EXPERTISE ACROSS TRANSLATIONAL SCIENCE TO GENERATE INSIGHTS FROM 'OMICS, IMAGING, GENETIC AND CLINICAL DATA BY INTEGRATING TECHNIQUES ACROSS ADVANCED STATISTICS, MACHINE LEARNING, AND COMPUTATIONAL MODELING TO FACILITATE PD BIOMARKER DISCOVERY AND DEEPEN OUR UNDERSTANDING OF DISEASE PROGRESSION.PTSD AND TBI KNOWLEDGEMAP:THE BRAINTRAUMA KNOWLEDGEMAP PROJECT WITH FRAUNHOFER SCAI AND EXAPTIVE IS USING INFORMATION TECHNOLOGY AND VISUALIZATION TO BUILD AN INNOVATIVE NEW INTERACTIVE TOOL TO EXTRACT INFORMATION FROM PUBLISHED PAPERS FOR THE RESEARCH COMMUNITY. THE WORK WAS EXTENDED TO INCLUDE EXTRACTION OF PTSD BIOMARKER AND TBI LITERATURE IN FY 2018.GLOBAL PRECLINICAL DATA FORUM:THE GLOBAL PRECLINICAL DATA FORUM IS A JOINTLY SPONSORED U.S. AND EUROPEAN INITIATIVE THAT ENCOURAGES GLOBAL COLLABORATION TO ADDRESS THE CHALLENGE OF ENSURING THAT PRECLINICAL RESEARCH IS REPRODUCIBLE, ROBUST AND TRANSLATABLE TO SUPPORT DISEASE RESEARCH UTILITY FOR CLINICAL RESEARCH AND DEVELOPMENT (R&D). IT SUPPORTS BEST RESEARCH PRACTICES, THE DEVELOPMENT AND IMPLEMENTATION OF DATA QUALITY STANDARDS, PRECLINICAL DATA AND TECHNOLOGICAL PLATFORMS, AND TRAINING PROGRAMS FOR THE NEUROSCIENCE COMMUNITY WITH THE GOAL OF ENHANCING THE DATA UTILITY DERIVED FROM PRECLINICAL MODELS. IN 2018, WE SUPPORTED THE WORLD'S FIRST NEGATIVE DATA PRIZE AS AN INCENTIVE FOR PRECLINICAL RESEARCHERS TO PUBLISH "NEGATIVE DATA" RESULTS TO ENSURE ALL NEUROSCIENCE STUDIES PROPERLY ADVANCE KNOWLEDGE.THIS FIRST NEGATIVE DATA PRIZE WAS AWARDED TO LAURA LUYTEN AND TOM BECKERS (KU LEUVEN, BELGIUM) FOR THE FOLLOWING PAPER:LUYTEN L, BECKERS T (2017) A PREREGISTERED, DIRECT REPLICATION ATTEMPT O
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Filings

Displayed year

2019 • Form 990Detailed filing. Detailed filing data is available for this year.

Open filing
Assets
$24,190,269
Liabilities
$12,988,921
Net assets
$11,201,348
Revenue
$21,039,448
Expenses
$20,170,937
Net income
$868,511
Balance SheetOperations
YearAssetsLiabilitiesNet AssetsRevenueExpensesNet Income
2025XML pending. An XML filing is linked for this year, but detailed extraction is still pending.$1.84$0.10$1.74$3.37$1.38$1.99
2024Facts available. Structured filing facts are available, but richer extracted sections are limited.$3.08$3.11$0.03$8.38$14.1$5.70
2023Facts available. Structured filing facts are available, but richer extracted sections are limited.$11.7$3.85$7.89$11.3$15.3$4.00
2022Facts available. Structured filing facts are available, but richer extracted sections are limited.$15.6$3.70$11.9$18.1$17.5$0.56
2021Facts available. Structured filing facts are available, but richer extracted sections are limited.$18.0$6.83$11.1$16.3$18.1$1.86
2020XML pending. An XML filing is linked for this year, but detailed extraction is still pending.$18.9$8.43$10.4$16.5$18.2$1.69
2019Detailed filing. Detailed filing data is available for this year.$24.2$13.0$11.2$21.0$20.2$0.87
2018Facts available. Structured filing facts are available, but richer extracted sections are limited.$16.4$6.02$10.3$16.8$14.8$2.05
2017XML pending. An XML filing is linked for this year, but detailed extraction is still pending.$14.9$6.58$8.28$4.37$11.3$6.97
2016XML pending. An XML filing is linked for this year, but detailed extraction is still pending.$25.4$10.2$15.3$31.4$16.3$15.1
2015Detailed filing. Detailed filing data is available for this year.$0.45$0.33$0.12$0.07$0.65$0.58