Stowers Institute for Medical Research

“Jonathan thomas, richard w. Brown, david a. Welte, brent kreider, charles german, alberzine freeman, and alejandro snchez alvarado, all directors of simr, have a business relationship. Jonathan thomas, richard w. Brown, charles german, brent kreider, and alberzine freeman, directors of simr, and penny spence, officer of simr, have a business relationship. Richard w. Brown, charles german, george l. Satterlee and brent kreider, directors of simr, and penny spence, officer of simr, have a business relationship.”

“The data and information necessary to prepare simr's form 990 was compiled by simr's accounting department and then reviewed by the institute's tax attorney at bryan cave leighton paisner, llp. Forvis, llp, the institute's external tax preparers, used this information to prepare the form 990. The completed form 990, including required schedules, is reviewed by the officers of simr before it is filed with the irs. After the preparation and review process described above, the form 990, including required schedules, is provided to each voting member of the organization's board before it is filed with the irs.”

“Simr has adopted a "conflicts of interest and director independence policy". Each director, officer, and all other persons in a position to exercise substantial influence over decisions of simr are required to annually complete and sign a disclosure statement that is part of the policy. A covered person must also disclose the existence of a potential conflict and all material facts to the governing board as soon as the person has knowledge that a potential conflict might exist. Per the policy, the board then reviews the disclosure to determine whether a conflict exists. After the covered person makes the relevant disclosure, they are recused and may not participate in the deliberations and decisions regarding the transaction. Simr conducts periodic and adhoc reviews of transactions and agreements to ensure that it engages only in activities that are consistent with its tax-exempt purpose.”

“The compensation for alejandro snchez alvarado, chief scientific officer, was established pursuant to the procedures of treas. Reg. Section 53.4958-6, including (1) review and approval by simr's compensation committee comprised of independent persons, (2) relying on comparability data, including data prepared by a nationally known compensation consultant regarding comparable salary and benefits for similarly qualified persons in functionally comparable positions at similarly situated organizations, and (3) contemporaneous documentation and record keeping of the deliberation and decisions regarding the compensation arrangement. This process was last undertaken in 2021.”

“The compensation for kausik si, scientific director, was established pursuant to the procedures of treas. Reg. Section 53.4958-6, including (1) review and approval by simr's compensation committee comprised of independent persons, (2) relying on comparability data, including data prepared by a nationally known compensation consultant regarding comparable salary and benefits for similarly qualified persons in functionally comparable positions at similarly situated organizations, and (3) contemporaneous documentation and record keeping of the deliberation and decisions regarding the compensation arrangement. This process was last undertaken in 2021.”

“Simr's governing documents, conflict of interest policy, and financial statements are available upon request.”

“Simr receives investment management services from american century investments ("aci"). Aci is a wholly owned subsidiary of american century companies, inc. ("acci"). In selecting aci to manage its liquid investments, simr not only chose a high-quality mutual fund company with an outstanding track record, but also placed its liquid investments in a company in which it owns stock and receives dividends. Simr pays aci the same administrative fees for these services as any arms-length investor. Those investment fees for a shared investment pool are paid by its supporting organization, stowers resource management.”

“The stowers institute for medical research ("simr") performs medical research in the public interest with the goal of expanding the understanding of fundamental processes in living cells and improving life's quality through innovative approaches to the causes, treatment, and prevention of disease.”

“2022 Program Service Accomplishments The Stowers Institute for Medical Research ("Stowers Institute"Institute") is a private, nonprofit medical research organization. The Institute was founded in 1994 by Jim and Virginia Stowers, who each survived a bout with cancer and subsequently dedicated their fortune to supporting fundamental research in molecular and cell biology, development, regeneration, genetics, and neuroscience that will provide long-term solutions to human diseases. The Stowers Institute conducts basic biomedical research in the public interest that will ultimately provide a greater understanding of the genes, proteins, and biological processes that control how cells in our bodies multiply, form tissues, and die. Studying the fundamental biology of cells and organisms enables scientists to discover how genes and molecular processes cause many diseases, including cancer, birth defects, and dementia. History has shown that foundational medical research is often a key first step in the development of new treatments, cures, and preventions for many human diseases. 2022 Notable Research Results In 2022, Stowers research teams made discoveries meriting publication in leading peer-reviewed scientific journals - 58 original research papers in all. Stowers research teams also produced 24 other publications including reviews, commentaries, book chapters, and books. Some of the highlights among these papers and other advances involving Stowers research include the following: The Gerton Lab participated in a multi-institutional, international collaboration to fill in approximately 100 gaps in the DNA sequence of Human Genome Project, thus generating the first complete human reference genome. The missing genetic sequences were particularly difficult to assemble due to their length, similarity, and repetition. Stowers researchers contributed to the development of imaging techniques, DNA amplification methods, and bioinformatics approaches to determine the exact number and location of these repetitive regions, which happen to be important components of human genetic makeup and diversity. This research effort resulted in three articles published on April 1, 2022, in Science. The Gibson Lab developed a precise operational model for the stinging organelle of the starlet sea anemone, providing crucial insights into the extraordinarily complex architecture and firing mechanism of stinging organelles. This work revealed that the energy required for piercing and poisoning a target with the stinger is stored within multiple organelle substructures. The researchers characterized the explosive discharge and biomechanical transformation of the stinger during firing. Insights from the work could lead to beneficial applications in medicine, including the development of microscopic therapeutic delivery devices for humans. This report was published on June 17, 2022, in Nature Communications. The Halfmann Lab uncovered mechanistic details about a switch-like property of the immune system. In response to a very small stimulus such as an invading molecule, a large protein complex called a signalosome is assembled which activates the immune system in an all-or-nothing fashion. They found that a large energy barrier prevents signalosome assembly from easily occurring but that this same barrier enables an adapter protein that encodes the switch to naturally be supersaturated within a cell. This in turn increases the certainty and rapidity of assembly at some point in the cell's future. The findings have broad implications for uncovering the causes and progression of inflammatory illness and other age-related diseases like Alzheimer's. This research was published on June 21, 2022, in eLife. The Piotrowski Lab discovered that in zebrafish, the regeneration of sensory hair cells occurs in three sequential phases. These cells, which help the fish detect water movement, are very similar to hair cells of the human inner ear that allow us to hear, except”

“Comprehensive Lists of 2022 Original Research Papers, Reviews, Commentaries, Chapters, and Books Original Research Papers 1. Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development. Chang YC, Manent J, Schroeder J, Wong SFL, Hauswirth GM, Shylo NA, Moore EL, Achilleos A, Garside V, Polo JM, Trainor P, McGlinn E. Nat Commun. 2022;13:7766 doi: 10.1038/s41467-022-35303-4. 2. S. pombe wtf use dual transcriptional regulation and selective protein exclusion from spores to cause meiotic drive. Nuckolls NL, Nidamangala Srinivasa A, Mok AC, Helston RM, Bravo Nunez MA, Lange JJ, Gallagher TJ, Seidel CW, Zanders SE. PLos Genet. 2022:e1009847 doi: 10.1371/journal.pgen.1009847. 3. Deciphering the role of retinoic acid in hepatic patterning and induction in the mouse. Guertin TM, Palaria A, Mager J, Sandell LL, Trainor PA, Tremblay KD. Dev Biol. 2022;491:31-42. 4. Genome-wide quantification of contributions to sexual fitness identifies genes required for spore viability and health in fission yeast. Billmyre RB, Eickbush MT, Craig CJ, Lange JJ, Wood C, Helston RM, Zanders SE. PLoS Genet. 2022;18:e1010462 doi: 10.1371/journal.pgen.1010462. 5. Rap1 prevents fusions between long telomeres in fission yeast. Pan L, Tormey D, Bobon N, Baumann P. EMBO J. 2022:e110458. 6. Paramutation-like epigenetic conversion by piRNA at the telomere of Drosophila virilis. Dorador AP, Dalikova M, Cerbin S, Stillman CM, Zych MG, Hawley RS, Miller DE, Ray DA, Funikov SY, Evgen'ev MB, Blumenstiel JP. Biology (Basel). 2022;11 doi: 10.3390/biology11101480. 7. Semi-automated assembly of high-quality diploid human reference genomes. Jarvis ED, Formenti G, Rhie A, Guarracino A, Yang C, Wood J, Tracey A, Thibaud-Nissen F, Vollger MR, Porubsky D, Cheng H, Asri M, Logsdon GA, Carnevali P, Chaisson MJP, Chin CS, Cody S, Collins J, Ebert P, Escalona M, Fedrigo O, Fulton RS, Fulton LL, Garg S, Gerton JL, Ghurye J, Granat A, Green RE, Harvey W, Hasenfeld P, Hastie A, Haukness M, Jaeger EB, Jain M, Kirsche M, Kolmogorov M, Korbel JO, Koren S, Korlach J, Lee J, Li D, Lindsay T, Lucas J, Luo F, Marschall T, Mitchell MW, McDaniel J, Nie F, Olsen HE, Olson ND, Pesout T, Potapova T, Puiu D, Regier A, Ruan J, Salzberg SL, Sanders AD, Schatz MC, Schmitt A, Schneider VA, Selvaraj S, Shafin K, Shumate A, Stitziel NO, Stober C, Torrance J, Wagner J, Wang J, Wenger A, Xiao C, Zimin AV, Zhang G, Wang T, Li H, Garrison E, Haussler D, Hall I, Zook JM, Eichler EE, Phillippy AM, Paten B, Howe K, Miga KH, Human Pangenome Reference C. Nature. 2022;611:519-531. 8. The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years. De Carvalho M, Jia GS, Nidamangala Srinivasa A, Billmyre RB, Xu YH, Lange JJ, Sabbarini IM, Du LL, Zanders SE. eLife. 2022;11. doi: 10.7554/eLife.81149. 9. Ontology Development Kit: a toolkit for building, maintaining and standardizing biomedical ontologies. Matentzoglu N, Goutte-Gattat D, Tan SZK, Balhoff JP, Carbon S, Caron AR, Duncan WD, Flack JE, Haendel M, Harris NL, Hogan WR, Hoyt CT, Jackson RC, Kim H, Kir H, Larralde M, McMurry JA, Overton JA, Peters B, Pilgrim C, Stefancsik R, Robb SM, Toro S, Vasilevsky NA, Walls R, Mungall CJ, Osumi-Sutherland D. Database (Oxford). 2022;2022. 10. Lamb-type solution and properties of unsteady Stokes equation. Fouxon I, Leshansky A, Rubinstein B, Or Y. Phys Rev Fluids. 2022;7:094103 doi: 10.1103/PhysRevFluids.7.094103. 11. An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish. Denans N, Tran NTT, Swall ME, Diaz DC, Blanck J, Piotrowski T. Nat Commun. 2022;13:5356 doi: 10.1038/s41467-022-33015-3. 12. Protocol to detect RNAs from tissue sections in mice using Y-branched probe in-situ hybridization. Wu Y, Yu CR. STAR Protoc. 2022;3:101686 doi: 10.1016/j.xpro.2022.101686. 13. A freeze-substitution approach with solvent-based glyoxal fixative to prevent distortion of ocular structures. Pang J, Zhao X, Deng F,”

“32. The 3' Pol II pausing at replication-dependenthistone genes is regulated by Mediator throughCajal bodies' association with histone locus bodies. Suzuki H, Abe R, Shimada M, Hirose T, Hirose H, Noguchi K, Ike Y, Yasui N, Furugori K, Yamaguchi Y, Toyoda A, Suzuki Y, Yamamoto T, Saitoh N, Sato S, Tomomori-Sato C, Conaway RC, Conaway JW, Takahashi H. Nat Commun. 2022;13:2905. doi: 2910.1038/s41467-41022-30632-w. 33. Hmx gene conservation identifies the origin of vertebrate cranial ganglia. Papadogiannis V, Pennati A, Parker HJ, Rothbacher U, Patthey C, Bronner ME, Shimeld SM. [published ahead of print May 19 2022]. Nature. 2022. 34. Genome-wide analysis of cis-regulatory changes in the metabolic adaptation of cavefish. Krishnan J, Seidel CW, Zhang N, Singh NP, VanCampen J, Peuss R, Xiong S, Kenzior A, Li H, Conaway JW, Rohner N. Nat Genet. 2022;54:684-693. 35. UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1. Herlihy AE, Boeing S, Weems JC, Walker J, Dirac-Svejstrup AB, Lehner MH, Conaway RC, Conaway JW, Svejstrup JQ. DNA Repair (Amst). 2022;115:103343. doi: 103310.101016/j.dnarep.102022.103343. 36. In-depth Satellitome Analyses of 37 Drosophila species illuminate repetitive DNA evolution in the Drosophila genus. de Lima LG, Ruiz-Ruano FJ. Genome Biol Evol. [published ahead of print May 6 2022]. 2022. 37. Robust and sensitive in situ RNA detection method using Yn-situ. Wu Y, Xu W, Yu Z, Wang Y, Yu CR. Cell Rep Methods. 2022;2:100201. doi: 100210.101016/j.crmeth.102022.100201. 38. Lack of VMP1 Impairs Hepatic Lipoprotein Secretion and Promotes Nonalcoholic Steatohepatitis. Jiang X, Fulte S, Deng F, Chen S, Xie Y, Chao X, He XC, Zhang Y, Li T, Li F, McCoin C, Morris EM, Thyfault J, Liu W, Li L, Davidson NO, Ding WX, Ni HM. Lack of VMP1 Impairs Hepatic Lipoprotein Secretion and Promotes Nonalcoholic Steatohepatitis. [Published ahead of print April 23 2022]. J Hepatol. 2022. 39. Maximal Dependence Capturing as a Principle of Sensory Processing. Raj R, Dahlen D, Duyck K, Yu CR. Front Comput Neurosci. 2022;16:857653. 40. Enhanced lipogenesis through Ppary helps cavefish adapt to food scarcity. Xiong S, Wang W, Kenzior A, Olsen L, Krishnan J, Persons J, Medley K, Peuss R, Wang Y, Chen S, Zhang N, Thomas N, Miles JM, SNCHEZ Alvarado A, Rohner N. [published ahead of print April 8 2022]. Curr Biol. 2022. 41. Complete genomic and epigenetic maps of human centromeres. Altemose N, Logsdon GA, Bzikadze AV, Sidhwani P, Langley SA, Caldas GV, Hoyt SJ, Uralsky L, Ryabov FD, Shew CJ, Sauria MEG, Borchers M, Gershman A, Mikheenko A, Shepelev VA, Dvorkina T, Kunyavskaya O, Vollger MR, Rhie A, McCartney AM, Asri M, Lorig-Roach R, Shafin K, Lucas JK, Aganezov S, Olson D, de Lima LG, Potapova T, Hartley GA, Haukness M, Kerpedjiev P, Gusev F, Tigyi K, Brooks S, Young A, Nurk S, Koren S, Salama SR, Paten B, Rogaev EI, Streets A, Karpen GH, Dernburg AF, Sullivan BA, Straight AF, Wheeler TJ, Gerton JL, Eichler EE, Phillippy AM, Timp W, Dennis MY, O'Neill RJ, Zook JM, Schatz MC, Pevzner PA, Diekhans M, Langley CH, Alexandrov IA, Miga KH. [published ahead of print April 1 2022]. Science. 2022;376:eabl4178. 42. From telomere to telomere: The transcriptional and epigenetic state of human repeat elements. Hoyt SJ, Storer JM, Hartley GA, Grady PGS, Gershman A, de Lima LG, Limouse C, Halabian R, Wojenski L, Rodriguez M, Altemose N, Rhie A, Core LJ, Gerton JL, Makalowski W, Olson D, Rosen J, Smit AFA, Straight AF, Vollger MR, Wheeler TJ, Schatz MC, Eichler EE, Phillippy AM, Timp W, Miga KH, O'Neill RJ. [published ahead of print April 1 2022]. Science. 2022;376:eabk3112. 43. Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe. Varberg JM, Unruh JR, Bestul AJ, Khan AA, Jaspersen SL. [published ahead of print April 1 2022]. Life Sci Alliance. 2022;5:e202201423. doi: 10.26508/lsa.XXX-XX-XXXX 44. The complete sequence of a human genome. Nurk S, Koren S, Rhie A, Rautia”

“58. Optimized CRISPR-RfxCas13d system for RNA targeting in zebrafish embryos. Hernandez-Huertas L, Kushawah G, Diaz-Moscoso A, Tomas-Gallardo L, Moreno-SNCHEZ I, da Silva Prescador G, Bazzini AA, Moreno-Mateos MA. STAR-Protocol. 2022;3:101058. doi: 10.1016/j.xpro.2021.101058. Reviews, Commentaries, Chapters, Books 1. Casting CRISPR-Cas13d to fish for microprotein functions in animal development. Treichel AJ, Bazzini AA. iScience. 2022;25:105547 doi: 10.1016/j.isci.2022.105547. 2. Nucleolar Organizer Regions as transcription-based scaffolds of nucleolar structure and function. Cockrell AJ, Gerton JL. In: M Kloc, and JZ Kubiak, eds. Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine. Results and Problems in Cell Differentiation. 2022/11/09 ed; 2022;70:551-580. 3. Guide for collecting and reporting metadata on protocol variables and parameters from slide-based histotechnology assays to enhance reproducibility. Chiriboga L, Callis GM, Wang Y, Chlipala E. J Histotechnol. 2022:132-147. 4. RNA-Responsive gRNAs for Controlling CRISPR Activity: Current Advances, Future Directions, and Potential Applications. Pelea O, Fulga TA, Sauka-Spengler T. CRISPR J. 2022;5:642-659. 5. Drug Resistance and Evolvability in an Emerging Human Fungal Pathogen. Billmyre RB. mBio. 2022:e0187622 doi: 10.1128/mbio.01876-22. 6. Poor eyesight reveals a new vision gene. Biswas T, Krishnan J, Rohner N. eLife. 2022;11 doi: 10.7554/eLife.81520. 7. p57Kip2 indirectly regulates AGM HSCs. Mao X, Li L. Blood. 2022;140:411-412. 8. What can we learn from selfish loci that break Mendel's law? Zanders SE. PLoS Biol. 2022;20:e3001700. doi: 10.1371/journal.pbio.3001700. 9. Standardized annotation of translated open reading frames. Mudge JM, Ruiz-Orera J, Prensner JR, Brunet MA, Calvet F, Jungreis I, Gonzalez JM, Magrane M, Martinez TF, Schulz JF, Yang YT, Alba MM, Aspden JL, Baranov PV, Bazzini AA, Bruford E, Martin MJ, Calviello L, Carvunis AR, Chen J, Couso JP, Deutsch EW, Flicek P, Frankish A, Gerstein M, Hubner N, Ingolia NT, Kellis M, Menschaert G, Moritz RL, Ohler U, Roucou X, Saghatelian A, Weissman JS, van Heesch S. Nat Biotechnol. 2022;40:994-999. 10. Beyond Moco Biosynthesis-Moonlighting Roles of MoaE and MOCS2. Suganuma T. Molecules. 2022;27:3733. doi: 3710.3390/molecules27123733. 11. Diversification and Functional Evolution of HOX Proteins. Singh NP, Krumlauf R. Front Cell Dev Biol. 2022;10:798812. doi: 798810.793389/fcell.792022.798812. 12. Developmental biology is poised to discover altogether new principles in biology in the 21st century. SNCHEZ Alvarado A. Dev Biol. 2022;488:47-53. 13. RNA Polymerases I and III in development and disease. Watt KE, Macintosh J, Bernard G, Trainor PA. [published ahead of print April 16 2022]. Semin Cell Dev Biol. 2022. 14. Split-GFP Complementation to Study the Nuclear Membrane Proteome Using Microscopy. Shelton SN, Smith SE, Jaspersen SL. In: MW Goldberg, ed. Methods Mol Biol 2022/04/13 ed. New York, NY: Humana; 2022;2502 205-213. 15. Heat Therapy Can Improve Hepatic Mitochondrial Function and Glucose Control. Johnson CN, Jensen RS, Von Schulze AT, Geiger PC. [published ahead of print April 9 2022]. Exerc Sport Sci Rev. 2022. 16. Schmidtea happens: Re-establishing the planarian as a model for studying the mechanisms of regeneration. Newmark PA, SNCHEZ Alvarado A. Curr Top Dev Biol. 2022;147:307-344. 17. Cornelia de Lange syndrome and the Cohesin complex: Abstracts from the 9th Biennial Scientific and Educational Virtual Symposium 2020. Oliver C, Groves L, Hansen BD, Salehi M, Kheradmand S, Carrico CS, Caudill P, Mattingly M, Dorsett D, Chea S, Singh VP, Krantz ID, Huisman S, Deardorff MA, Kline AD. Am J Med Genet A. 2022;188A:1005-1014. 18. Standardized Statement for the Ethical Use of Human Cadaveric Tissues in Anatomy Research Papers: Recommendations from Anatomical Journal Editors-in-Chief. Iwanaga J, Singh V, Takeda S, Ogeng'o J, Kim HJ, Morys J, Ravi KS, Ribatti D, Trainor PA, Sanudo JR, Apaydin N, S”

“- Ariel Bazzini, Ph.D., Associate Investigator, joined the Stowers Institute in 2016 from the lab of Antonio J. Giraldez, Ph.D., in the Department of Genetics at Yale University, where he completed a postdoctoral fellowship. Bazzini received his Ph.D. in molecular biology at the University of Buenos Aires, Argentina. For his doctoral dissertation, he studied plant genetics at the Institute of Biotechnology in Argentina's National Institute of Agricultural Technology (INTA). Research focus: the regulation of gene expression in vertebrates. - Jennifer Gerton, Ph.D., Investigator, joined the Stowers Institute in 2002 from a postdoctoral fellowship in the laboratory of Joseph DeRisi, Ph.D., in the Department of Biochemistry and Biophysics at the University of California-San Francisco. Gerton received a Ph.D. in microbiology and immunology from Stanford University. Research focus: genomic and genetic analysis of chromosome segregation and chromosome dynamics. - Matthew Gibson, Ph.D., Investigator and Dean of the Graduate School, joined the Stowers Institute in 2006 from a Jane Coffin Childs Memorial Fund postdoctoral fellowship with Norbert Perrimon, Ph.D., at Harvard Medical School. Gibson received a Ph.D. in zoology from the University of Washington. Research focus: genetic analysis of mechanisms controlling signal transduction, cell proliferation, and epithelial morphogenesis during fruit fly, sea anemone, and coral development. - Randal Halfmann, Ph.D., Associate Investigator, joined the Stowers Institute in 2015 from The University of Texas (UT) Southwestern Medical Center. He received a Ph.D. in biology from the Massachusetts Institute of Technology, where he was a National Science Foundation Predoctoral Fellow. After completing his graduate studies, Halfmann obtained an independent position at UT Southwestern Medical Center where he was a Sara and Frank McKnight Fellow and received a Director's Early Independence Award from the National Institutes of Health. Research focus: Cellular and evolutionary implications of protein self-assembly using genetic, biochemical, and cell-biological approaches. - R. Scott Hawley, Ph.D., Investigator and Dean Emeritus of the Graduate School, joined the Stowers Institute in 2001 from the University of California-Davis where he was a professor of genetics in the Molecular and Cellular Biology section. Hawley earned a Ph.D. in genetics from the University of Washington and completed postdoctoral training as a Helen Hay Whitney Fellow at the Institute for Cancer Research in Philadelphia. Research focus: investigation of mechanisms that influence how chromosomes pair and segregate during meiosis using Drosophila as an experimental system. - Robert Krumlauf, Ph.D., Scientific Director Emeritus and Investigator, joined the Stowers Institute in 2000 from England's National Institute for Medical Research, The Ridgeway, Mill Hill, London, where he was head of the Division of Developmental Neurobiology. Krumlauf received a Ph.D. in developmental biology from Ohio State University. Research focus: analysis of molecular pathways that regulate how the mammalian head, brain and nervous system are built, using a variety of vertebrate research organisms. - Linheng Li, Ph.D., Investigator, joined the Stowers Institute in 2000 from the University of Washington Medical Center where he held a faculty appointment after completing postdoctoral training in the laboratory directed by Leroy Hood, M.D., Ph.D. Li earned his Ph.D. in molecular and cellular biology from New York University Medical School under the mentoring of Edward Ziff, Ph.D. Research focus: Investigation of molecular and genetic pathways controlling adult stem cell development in the hematopoietic and intestinal systems using transgenic and gene targeting animal model approaches. - Tatjana Piotrowski, Ph.D., Investigator, joined the Stowers Institute in 2011 from the University of Utah's School of Medicine, where she was an associate professor in the”

“Other changes in net assets include the following: uncollectible grants ($ 88,967) grants receivables and other receivables consist primarily of amounts due from federal and other grant funding agencies on a cost-reimbursable basis and from other nonprofit organizations that reimburse the institute primarily for collaboration expenses or provide contribution to the institute. Based on historical experience, these receivables are paid in full on a timely basis. However, based on review of outstanding receivables and existing conditions, an allowance for uncollectible accounts and bad debt & collection fees accounts were established in 2022 for $88,967.”