Liabilities / Assets
34th percentile
Higher debt load relative to assets than 34% of similar nonprofits.
EIN 13-4128413 • 501(c)3 • New York, NY
Profile
Tb alliance is a not-for-profit organization dedicated to the discovery, development and delivery of better, faster-acting and affordable tuberculosis drugs that are available to those who need them.
Precomputed percentiles relative to similar nonprofits. These scores are descriptive rather than judgmental.
Liabilities / Assets
34th percentile
Higher debt load relative to assets than 34% of similar nonprofits.
Liabilities / Revenue
52nd percentile
Higher debt load relative to revenue than 52% of similar nonprofits.
Net Margin
46th percentile
Higher net margin than 46% of similar nonprofits.
Top Officer Pay
81st percentile
Higher top officer pay than 81% of similar nonprofits.
Top officer pay equals 1.7% of source-year revenue.
Asset Growth
40th percentile
Faster asset growth than 40% of similar nonprofits.
Revenue Growth
43rd percentile
Faster revenue growth than 43% of similar nonprofits.
Assets
Up$204,316,428
Up $6,996,887 (+3.5%) from 2023
Liabilities
Up$28,006,599
Up $2,386,608 (+9.3%) from 2023
Net Assets
Up$176,309,829
Up $4,610,279 (+2.7%) from 2023
Revenue
Up$63,732,557
Up $3,492,071 (+5.8%) from 2023
Expenses
Up$61,508,783
Up $6,130,204 (+11%) from 2023
Net Income
Down$2,223,774
Down $2,638,133 (-54%) from 2023
Most recent year
2024 • Form 990XML pending. An XML filing is linked for this year, but detailed extraction is still pending.
The latest 2024 filing currently has linked XML that has not been fully parsed yet. Showing the latest detailed filing from 2022 below.
Tb alliance is a not-for-profit organization dedicated to the discovery, development and delivery of better, faster-acting and affordable tuberculosis drugs that are available to those who need them.
To accelerate the discovery & development of new drugs to facilitate the control of tuberculosis throughout the world and the accessibility of these drugs to the global community.
| Line | Beginning | End | Change |
|---|---|---|---|
| Assets | |||
| Savings and Temporary Cash Investments | $181,065,855 | $159,750,193 | ▼ $21,315,662 |
| Investments in Publicly Traded Securities | $0 | $9,761,242 | ▲ $9,761,242 |
| Pledges and Grants Receivable | $4,258,015 | $4,239,015 | ▼ $19,000 |
| Accounts Receivable | $755,218 | $1,094,599 | ▲ $339,381 |
| Prepaid Expenses and Deferred Charges | $964,669 | $1,057,756 | ▲ $93,087 |
| Land, Buildings, and Equipment, Net | $457,341 | $724,376 | ▲ $267,035 |
| Cash and Non-Interest-Bearing Accounts | $0 | $0 | → $0 |
| Other Notes and Loans Receivable, Net | $0 | $0 | → $0 |
| Receivable From Disqualified Prsn | $0 | $0 | → $0 |
| Receivables From Officers Etc | $0 | $0 | → $0 |
| Investments Other Securities | $0 | $0 | → $0 |
| Investments Program Related | $0 | $0 | → $0 |
| Intangible Assets | $0 | $0 | → $0 |
| Inventories for Sale or Use | $0 | $0 | → $0 |
| Loans From Officers Directors | $0 | $0 | → $0 |
| Total Assets | $187,560,796 | $176,686,879 | ▼ $10,873,917 |
| Other Assets Total | $59,698 | $59,698 | → $0 |
| Liabilities | |||
| Accounts Payable and Accrued Expenses | $9,644,841 | $11,073,526 | ▲ $1,428,685 |
| Deferred Revenue | $12,159,240 | $419,100 | ▼ $11,740,140 |
| Other Liabilities | $116,142 | $13,734 | ▼ $102,408 |
| Grants Payable | $0 | $0 | → $0 |
| Mortgage Notes Payable Secured by Investment Property | $0 | $0 | → $0 |
| Unsecured Notes Loans Payable | $0 | $0 | → $0 |
| Escrow Account Liability | $0 | $0 | → $0 |
| Tax Exempt Bond Liabilities | $0 | $0 | → $0 |
| Total Liabilities | $21,920,223 | $11,506,360 | ▼ $10,413,863 |
| Net Assets / Fund Balance | |||
| Net Assets Without Donor Restrictions | $165,640,573 | $165,180,519 | ▼ $460,054 |
| Net Assets With Donor Restrictions | $0 | $0 | → $0 |
| Total Net Assets Fund Balance | $165,640,573 | $165,180,519 | ▼ $460,054 |
| Total Liabilities and Net Assets / Fund Balance | $187,560,796 | $176,686,879 | ▼ $10,873,917 |
| Asset | Book Value | Depreciation | Basis |
|---|---|---|---|
| Leasehold Improvements | $44,709 | $3,644,605 | $3,689,314 |
| Other Land Buildings | $671,509 | $458,251 | $1,129,760 |
| Equipment | $8,158 | $664,931 | $673,089 |
| Name | Title | Full / Part Time | Base | Other | Total |
|---|---|---|---|---|---|
| Dr Melvin Spigelman | President/CEO | FT | $614,073 | $395,784 | $1,009,857 |
| Dr Nader Fotouhi | Chief Scientific Officer | FT | $408,888 | $233,130 | $642,018 |
| Dr Eugene Sun | SR. VP, RESEARCH & DEV'T | FT | $421,778 | $213,688 | $635,466 |
| Colleen Pero | Secretary/CAO | FT | $344,302 | $168,272 | $512,574 |
| Robert Lorette | Sr. VP, Business Development | FT | $329,048 | $178,701 | $507,749 |
| Angela Vanderploeg | Treasurer/CFO | FT | $308,367 | $190,824 | $499,191 |
| Kathleen Schostack | Sr. VP, Prog. & Alliance Mgmt | FT | $318,246 | $178,264 | $496,510 |
| Sandeep Juneja | Sr. VP, Market Access | FT | $304,384 | $189,000 | $493,384 |
| Dr Paul Bruinenberg | Sr. Medical Officer | FT | $336,592 | $136,183 | $472,775 |
| Salah Foraida | Sr. Director, Medical Affairs | FT | $344,959 | $112,513 | $457,472 |
| Maria Beumont | VP, Chief Medical Officer | FT | $380,489 | $73,336 | $453,825 |
| Pietro Turilli | Sr.VP, Ext Aff(as of 06/01/22) | FT | $161,060 | $48,242 | $209,302 |
| Name | Title |
|---|---|
| Dr Bruce Carter | Chairman |
| Dr Mario Raviglione | Vice Chair |
| Ariel Pablos-mendez | Director |
| David Norton | Director |
| Eric Goosby | Director |
| Jane Griffiths | Director |
| Mitchell Warren | Director |
| Shalini Sharp | Director |
| Sundar Kodiyalam | Director |
| Kim Schwartz | Director (as of 09/01/22) |
| Rasha Hibri | Director (as of 09/01/22) |
| Sangita Reddy | Director (thru 05/15/22) |
| Contractor | Services | Location | Compensation |
|---|---|---|---|
| Wuxi Apptec Hongkong Limited | Integrated R&d Svcs | 28395 NETWORK PLACE, Chicago, IL 60673, Ch | $4,408,831 |
| University Of Illinois | Research Collab. | 1 PROMENADE BLVD SUITE 1101, Fair Lawn, NJ 07410, Uk | $2,580,920 |
| Ppd Global Limited | Global Cro | 28760 TRES CANTOS, Madrid, 0, Sp | $2,459,365 |
| Tkl Research INC | Research & Devt. | - | $1,867,665 |
| Glaxosmithkline Investigacion | Ext. Mini Portfolios | - | $1,600,000 |
| Line Item | Amount |
|---|---|
| Other Expenses | $39,262,643 |
| Salaries, Compensation, and Employee Benefits | $16,259,751 |
| Total Fundraising Expense | $754,480 |
| Grants and Similar Amounts Paid | $263,496 |
| Professional Fundraising Fees | $0 |
| Line Item | Program | Management | Fundraising | Total |
|---|---|---|---|---|
| Fees for Services Other | $8,958,244 | $505,159 | $12,000 | $9,475,403 |
| Other Salaries and Wages | $7,381,992 | $1,551,113 | $348,195 | $9,281,300 |
| Current Officers, Directors, Trustees, and Key Employees | $2,665,394 | $1,140,409 | $156,430 | $3,962,233 |
| Other Employee Benefits | $1,158,078 | $261,692 | $52,676 | $1,472,446 |
| Information Technology | $599,562 | $557,660 | $25,403 | $1,182,625 |
| Occupancy | $841,629 | $234,708 | $50,131 | $1,126,468 |
| Pension Plan Contributions | $697,269 | $141,413 | $34,002 | $872,684 |
| Fees for Services Legal | $739,134 | $55,680 | - | $794,814 |
| Payroll Taxes | $512,410 | $133,223 | $25,455 | $671,088 |
| Travel | $421,117 | $165,914 | $9,876 | $596,907 |
| Depreciation Depletion | $300,060 | $85,979 | $18,435 | $404,474 |
| Foreign Grants | $263,496 | - | - | $263,496 |
| Other Expenses | $96,779 | $108,226 | $19,617 | $224,622 |
| Office Expenses | $64,091 | $132,306 | $1,643 | $198,040 |
| Insurance | $57,221 | $131,366 | - | $188,587 |
| Fees for Services Accounting | $30,000 | $123,496 | - | $153,496 |
| Conferences and Meetings | $30,112 | $20,134 | $617 | $50,863 |
| Fees for Service Investment Mgmnt Fees | - | $11,470 | - | $11,470 |
| Total Functional Expenses | $49,671,462 | $5,359,948 | $754,480 | $55,785,890 |
| Line Item | Amount |
|---|---|
| Total Expenses per Form 990 | $55,785,890 |
| Expenses per Audited Statements | $55,774,420 |
| Total Expenses per Audited Statements | $55,774,420 |
| Expenses Not Reported on Financial Statements | $11,470 |
| Region | Activity | Services | Offices | Employees | Spending |
|---|---|---|---|---|---|
| East Asia and the Pacific | Program Services | R&d Research | 0 | 11 | $5,592,649 |
| Europe (Including Iceland and Greenland) | Program Services | Admin Expenses | 0 | 0 | $3,803,063 |
| Europe (Including Iceland and Greenland) | Program Services | Admin Expenses | 0 | 24 | $2,509,860 |
| East Asia and the Pacific | Program Services | Admin Expenses | 0 | 0 | $1,802,531 |
| Sub-Saharan Africa | Program Services | - | 1 | 6 | $1,530,951 |
| South Asia | Program Services | Salary & Fringe Benefi | 0 | 0 | $920,326 |
| South Asia | Program Services | R&d Research | 0 | 9 | $813,033 |
| Europe (Including Iceland and Greenland) | Program Services | R&d Research | 0 | 0 | $463,661 |
| Sub-Saharan Africa | Program Services | - | 0 | 14 | $413,777 |
| Sub-Saharan Africa | Program Services | - | 0 | 0 | $185,460 |
| Russia and the Newly Independent States | Program Services | R&d Research | 0 | 0 | $139,233 |
| Sub-Saharan Africa | Program Services | - | 0 | 0 | $128,171 |
| Sub-Saharan Africa | Grantmaking | - | 0 | 0 | $124,138 |
| Russia and the Newly Independent States | Grantmaking | R&d Research | 0 | 0 | $60,322 |
| North America | Program Services | Admin Expenses | 0 | 3 | $52,014 |
| Russia and the Newly Independent States | Program Services | Consulting Services | 0 | 4 | $46,890 |
| South America | Grantmaking | Admin Expenses | 0 | 0 | $44,036 |
| South America | Program Services | Consulting Services | 0 | 3 | $40,280 |
| Europe (Including Iceland and Greenland) | Grantmaking | Consulting Services | 0 | 0 | $25,000 |
| Middle East and North Africa | Program Services | Consulting Services | 0 | 0 | $24,864 |
| East Asia and the Pacific | Grantmaking | Admin Expenses | 0 | 0 | $10,000 |
| North America | Program Services | R&d Research | 0 | 0 | $2,615 |
| North America | Program Services | Consulting Services | 0 | 0 | $1,650 |
| Russia and the Newly Independent States | Program Services | Consulting Services | 0 | 0 | $1,393 |
| East Asia and the Pacific | Program Services | Consulting Services | 0 | 0 | $580 |
| Line Item | Amount |
|---|---|
| Fundraising Direct Expenses | $0 |
| Fundraising Gross Income | $0 |
| Gaming Direct Expenses | $0 |
| Gaming Gross Income | $0 |
| Professional Fundraising Fees | $0 |
| Line Item | Beginning | End | Change |
|---|---|---|---|
| Loans from Officers, Directors, Trustees, and Key Employees | $0 | $0 | → $0 |
| Receivables from Disqualified Persons | $0 | $0 | → $0 |
| Receivables from Officers, Directors, Trustees, and Key Employees | $0 | $0 | → $0 |
| Liability | Amount |
|---|---|
| Deferred Rent | $13,734 |
“Form 990 was prepared by a nationally recognized accounting firm in conjunction with the organization's finance department. The draft of form 990 was reviewed by the organization's finance department and senior management, and then provided to all members of the board of directors in draft via electronic mail, with an opportunity for them to comment or make inquiry before it was filed with the internal revenue service.”
“The organization's conflict of interest policy is distributed to officers and directors annually along with a questionnaire that is completed by all officers and directors in which they are asked to disclose information regarding actual or potential conflicts of interest. These questionnaires are collected and reviewed annually to ensure compliance with the conflict of interest policy. The policy itself also requires any director or officer to promptly disclose any conflict of interest. Interested directors and officers are required to recuse themselves from any decision on matters in which they have an interest, and such recusal is noted in the minutes.”
“The compensation committee, which consists of three independent board members, annually reviews the ceo and officers compensation in conjunction with an evaluation of organizational performance. The committee recommends adjustments in compensation to the full board for review and approval, within the context of an agreed upon competitive position. The competitiveness of compensation is periodically benchmarked using independent salary survey data from the not-for-profit and for-profit industry. The compensation committee documentation includes the performance assessment, comparable data and the source of this data, and the recommended adjustments. The minutes of the full board include documentation of the approved decisions. The minutes of the board and committee are prepared before the later of the next meeting or 60 days after the final decision of the board and the committee.”
“The organization makes its governing documents, conflict of interest policy, and financial statements available to the public upon request.”
“Professional services and agreements include individual consultants who are contributing their specific expertise related to our clinical trials and other early stage and preclinical discovery work. Expertise in such areas as pharmacovigilance, non-glp bioanalysis, analytical evaluation of drug stability and program management are some of the services required in order to complete our scientific research and development. These consultants are managed by our staff, who coordinate the work necessary to be completed among all outside parties.”
“Foreign translation loss....$ (79,155)”
“Description:prof. Svcs & agreements total fees:9475403”
“Tb alliance is subject to the provisions of the financial accounting standards board's (fasb) accounting standards codification (asc) topic 740, income taxes, as it relates to accounting and reporting for uncertainty in income taxes. Tb alliance does not believe it has taken any material uncertain tax positions and due to its general not-for-profit status, management believes asc topic 740 has not had, and is not anticipated to have, a material impact on tb alliance's financial statements.”
This appendix keeps the raw XML leaves available for debugging and edge-case review. The human report above is the primary experience.
| Path | # | Value |
|---|---|---|
| IRS990/AccountantCompileOrReviewInd | 0 | false |
| IRS990/AccountsPayableAccrExpnssGrp/BOYAmt | 0 | 9644841 |
| IRS990/AccountsPayableAccrExpnssGrp/EOYAmt | 0 | 11073526 |
| IRS990/AccountsReceivableGrp/BOYAmt | 0 | 755218 |
| IRS990/AccountsReceivableGrp/EOYAmt | 0 | 1094599 |
| IRS990/ActivitiesConductedPrtshpInd | 0 | false |
| IRS990/ActivityOrMissionDesc | 0 | TO ACCELERATE THE DISCOVERY & DEVELOPMENT OF NEW DRUGS TO FACILITATE THE CONTROL OF TUBERCULOSIS THROUGHOUT THE WORLD AND THE ACCESSIBILITY OF THESE DRUGS TO THE GLOBAL COMMUNITY. |
| IRS990/AddressChangeInd | 0 | X |
| IRS990/AdvertisingGrp/TotalAmt | 0 | 0 |
| IRS990/AllOtherContributionsAmt | 0 | 22874535 |
| IRS990/AnnualDisclosureCoveredPrsnInd | 0 | true |
| IRS990/AuditCommitteeInd | 0 | true |
| IRS990/BackupWthldComplianceInd | 0 | true |
| IRS990/BenefitsToMembersGrp/TotalAmt | 0 | 0 |
| IRS990/BooksInCareOfDetail/PersonNm | 0 | ANGELA VANDERPLOEG |
| IRS990/BooksInCareOfDetail/PhoneNum | 0 | 2122277540 |
| IRS990/BooksInCareOfDetail/USAddress/AddressLine1Txt | 0 | 80 PINE STREET 20TH FLOOR |
| IRS990/BooksInCareOfDetail/USAddress/CityNm | 0 | NEW YORK |
| IRS990/BooksInCareOfDetail/USAddress/StateAbbreviationCd | 0 | NY |
| IRS990/BooksInCareOfDetail/USAddress/ZIPCd | 0 | 10005 |
| IRS990/BusinessRlnWith35CtrlEntInd | 0 | false |
| IRS990/BusinessRlnWithFamMemInd | 0 | false |
| IRS990/BusinessRlnWithOrgMemInd | 0 | false |
| IRS990/CashNonInterestBearingGrp/BOYAmt | 0 | 0 |
| IRS990/CashNonInterestBearingGrp/EOYAmt | 0 | 0 |
| IRS990/ChangeToOrgDocumentsInd | 0 | false |
| IRS990/CntrctRcvdGreaterThan100KCnt | 0 | 66 |
| IRS990/CollectionsOfArtInd | 0 | false |
| IRS990/CompCurrentOfcrDirectorsGrp/FundraisingAmt | 0 | 156430 |
| IRS990/CompCurrentOfcrDirectorsGrp/ManagementAndGeneralAmt | 0 | 1140409 |
| IRS990/CompCurrentOfcrDirectorsGrp/ProgramServicesAmt | 0 | 2665394 |
| IRS990/CompCurrentOfcrDirectorsGrp/TotalAmt | 0 | 3962233 |
| IRS990/CompDisqualPersonsGrp/TotalAmt | 0 | 0 |
| IRS990/CompensationFromOtherSrcsInd | 0 | false |
| IRS990/CompensationProcessCEOInd | 0 | true |
| IRS990/CompensationProcessOtherInd | 0 | true |
| IRS990/ConferencesMeetingsGrp/FundraisingAmt | 0 | 617 |
| IRS990/ConferencesMeetingsGrp/ManagementAndGeneralAmt | 0 | 20134 |
| IRS990/ConferencesMeetingsGrp/ProgramServicesAmt | 0 | 30112 |
| IRS990/ConferencesMeetingsGrp/TotalAmt | 0 | 50863 |
| IRS990/ConflictOfInterestPolicyInd | 0 | true |
| IRS990/ConservationEasementsInd | 0 | false |
| IRS990/ConsolidatedAuditFinclStmtInd | 0 | false |
| IRS990/ContractorCompensationGrp/CompensationAmt | 0 | 4408831 |
| IRS990/ContractorCompensationGrp/CompensationAmt | 1 | 2580920 |
| IRS990/ContractorCompensationGrp/CompensationAmt | 2 | 2459365 |
| IRS990/ContractorCompensationGrp/CompensationAmt | 3 | 1867665 |
| IRS990/ContractorCompensationGrp/CompensationAmt | 4 | 1600000 |
| IRS990/ContractorCompensationGrp/ContractorAddress/ForeignAddress/AddressLine1Txt | 0 | UNIT C 20/F NO 998 CANTON RD |
| IRS990/ContractorCompensationGrp/ContractorAddress/ForeignAddress/AddressLine1Txt | 1 | GRANTA PARK GREAT ABINGTON |
| IRS990/ContractorCompensationGrp/ContractorAddress/ForeignAddress/AddressLine1Txt | 2 | 28760 TRES CANTOS |
| IRS990/ContractorCompensationGrp/ContractorAddress/ForeignAddress/CityNm | 0 | KOWLOON |
| IRS990/ContractorCompensationGrp/ContractorAddress/ForeignAddress/CityNm | 1 | CAMBRIDGE |
| IRS990/ContractorCompensationGrp/ContractorAddress/ForeignAddress/CityNm | 2 | MADRID |
| IRS990/ContractorCompensationGrp/ContractorAddress/ForeignAddress/CountryCd | 0 | CH |
| IRS990/ContractorCompensationGrp/ContractorAddress/ForeignAddress/CountryCd | 1 | UK |
| IRS990/ContractorCompensationGrp/ContractorAddress/ForeignAddress/CountryCd | 2 | SP |
| IRS990/ContractorCompensationGrp/ContractorAddress/ForeignAddress/ForeignPostalCd | 0 | CB21 6GQ |
| IRS990/ContractorCompensationGrp/ContractorAddress/ForeignAddress/ProvinceOrStateNm | 0 | 0 |
| IRS990/ContractorCompensationGrp/ContractorAddress/ForeignAddress/ProvinceOrStateNm | 1 | 0 |
| IRS990/ContractorCompensationGrp/ContractorAddress/ForeignAddress/ProvinceOrStateNm | 2 | 0 |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/AddressLine1Txt | 0 | 28395 NETWORK PLACE |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/AddressLine1Txt | 1 | 1 PROMENADE BLVD SUITE 1101 |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/CityNm | 0 | CHICAGO |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/CityNm | 1 | FAIR LAWN |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/StateAbbreviationCd | 0 | IL |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/StateAbbreviationCd | 1 | NJ |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/ZIPCd | 0 | 60673 |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/ZIPCd | 1 | 07410 |
| IRS990/ContractorCompensationGrp/ContractorName/PersonNm | 0 | WUXI APPTEC HONGKONG LIMITED |
| IRS990/ContractorCompensationGrp/ContractorName/PersonNm | 1 | UNIVERSITY OF ILLINOIS |
| IRS990/ContractorCompensationGrp/ContractorName/PersonNm | 2 | PPD GLOBAL LIMITED |
| IRS990/ContractorCompensationGrp/ContractorName/PersonNm | 3 | TKL RESEARCH INC |
| IRS990/ContractorCompensationGrp/ContractorName/PersonNm | 4 | GLAXOSMITHKLINE INVESTIGACION |
| IRS990/ContractorCompensationGrp/ServicesDesc | 0 | INTEGRATED R&D SVCS |
| IRS990/ContractorCompensationGrp/ServicesDesc | 1 | RESEARCH COLLAB. |
| IRS990/ContractorCompensationGrp/ServicesDesc | 2 | GLOBAL CRO |
| IRS990/ContractorCompensationGrp/ServicesDesc | 3 | RESEARCH & DEVT. |
| IRS990/ContractorCompensationGrp/ServicesDesc | 4 | EXT. MINI PORTFOLIOS |
| IRS990/CostOfGoodsSoldAmt | 0 | 0 |
| IRS990/CreditCounselingInd | 0 | false |
| IRS990/CYBenefitsPaidToMembersAmt | 0 | 0 |
| IRS990/CYContributionsGrantsAmt | 0 | 52646326 |
| IRS990/CYGrantsAndSimilarPaidAmt | 0 | 263496 |
| IRS990/CYInvestmentIncomeAmt | 0 | 2631898 |
| IRS990/CYOtherExpensesAmt | 0 | 39262643 |
| IRS990/CYOtherRevenueAmt | 0 | 934739 |
| IRS990/CYProgramServiceRevenueAmt | 0 | 0 |
| IRS990/CYRevenuesLessExpensesAmt | 0 | 427073 |
| IRS990/CYSalariesCompEmpBnftPaidAmt | 0 | 16259751 |
| IRS990/CYTotalExpensesAmt | 0 | 55785890 |
| IRS990/CYTotalFundraisingExpenseAmt | 0 | 754480 |
| IRS990/CYTotalProfFndrsngExpnsAmt | 0 | 0 |
| IRS990/CYTotalRevenueAmt | 0 | 56212963 |
| IRS990/DecisionsSubjectToApprovaInd | 0 | false |
| IRS990/DeductibleArtContributionInd | 0 | false |
| IRS990/DeductibleNonCashContriInd | 0 | false |
| IRS990/DeferredRevenueGrp/BOYAmt | 0 | 12159240 |
| IRS990/DeferredRevenueGrp/EOYAmt | 0 | 419100 |
| IRS990/DelegationOfMgmtDutiesInd | 0 | false |
| IRS990/DepreciationDepletionGrp/FundraisingAmt | 0 | 18435 |
| IRS990/DepreciationDepletionGrp/ManagementAndGeneralAmt | 0 | 85979 |
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| IRS990/Desc | 0 | RESEARCH AND DEVELOPMENT - TB ALLIANCE IS A NOT-FOR-PROFIT PRODUCT DEVELOPMENT PARTNERSHIP (PDP), UNIQUELY POSITIONED TO LEVERAGE A GLOBAL NETWORK OF PUBLIC AND PRIVATE PARTNERS TO MOST EFFICIENTLY ADVANCE TB DRUG DEVELOPMENT. A PDP BUILDS PARTNERSHIPS BETWEEN THE PUBLIC, PRIVATE, ACADEMIC, AND PHILANTHROPIC SECTORS TO DRIVE THE DEVELOPMENT OF NEW PRODUCTS FOR UNDERSERVED MARKETS. PDPS RETAIN DIRECT MANAGEMENT OVERSIGHT OF THEIR PROJECTS, THOUGH MUCH OF THE LABORATORY AND CLINICAL WORK IS DONE THROUGH EXTERNAL RESEARCH FACILITIES AND CONTRACTORS. WE COMBINE THE RESEARCH AND DEVELOPMENT EXPERTISE OF OUR STAFF WITH THE SKILLS AND RESOURCES OF OUR PARTNERS TO HARNESS THE MOST PROMISING SCIENCE WHEREVER IT MAY EXIST AROUND THE WORLD. THIS MODEL MINIMIZES COSTS, INCLUDING OVERHEAD AND INVESTMENTS IN INFRASTRUCTURE, WHILE OPTIMIZING SCIENTIFIC CAPABILITY TO SPEED NEW TB DRUG DEVELOPMENT. OUR BUSINESS MODEL AND DIVERSE PARTNERSHIPS ALLOW TB ALLIANCE TO LEVERAGE ADDITIONAL PARTNER SERVICES FOR EVERY DOLLAR INVESTED IN ITS PROGRAMS. SIMPLICITB - SIMPLICITB IS EVALUATING THE EFFICACY, SAFETY, AND TOLERABILITY OF A NOVEL AND POTENTIALLY SHORTER DRUG REGIMEN (BPAMZ) FOR PATIENTS WITH DRUG-SENSITIVE (DS) AND DRUG-RESISTANT (MDR) PULMONARY TUBERCULOSIS (SPECIFICALLY MULTIDRUG-RESISTANT TB AND MONO-RESISTANCE TO ISONIAZID OR RIFAMPICIN). THE BPAMZ REGIMEN IS COMPRISED OF FOUR DIFFERENT ANTIMICROBIALS: BEDAQUILINE (B), PRETOMANID (PA), MOXIFLOXACIN (M) AND PYRAZINAMIDE (Z). THE DRUG REGIMEN IS ADMINISTERED FOR FOUR MONTHS TO PATIENTS WITH DS-TB, AND FOR SIX MONTHS TO PATIENTS WITH MDR-TB OR MONO-RESISTANCE TO RIFAMPICIN OR ISONIAZID. RESULTS IN THE DS-TB ARM WILL BE COMPARED TO A CONTROL GROUP OF THE STANDARD SIX-MONTH DRUG REGIMEN FOR DS-TB (HRZE). ZENIX - THE PHASE 3 ZENIX CLINICAL TRIAL EVALUATED THE BPAL REGIMEN TO TREAT EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS (XDR-TB) AND THOSE WITH PRE-XDR-TB AND MULTIDRUG-RESIDENT TB (MDR-TB) WHOSE PRIOR TREATMENT HAS FAILED OR WHO HAVE NOT TOLERATED THEIR TREATMENT. IT SOUGHT TO OPTIMIZE LINEZOLID DOSING AS PART OF THE BPAL REGIMEN, EVALUATING BOTH THE LINEZOLID DOSE AND THE LINEZOLID DURATION. THE TOP-LINE RESULTS OF ZENIX WERE PRESENTED AT IAS 2021, SHOWING THAT THE EFFECTIVENESS OF THE BPAL REGIMEN COULD BE MAINTAINED WITH REDUCED DOSING OF LINEZOLID. THESE RESULTS WERE ACCEPTED AND PUBLISHED IN THE NEW ENGLAND JOURNAL OF MEDICINE IN THE SEPTEMBER 2022 ISSUE. THE RESULTS OF THE ZENIX TRIAL WERE INCORPORATED INTO A RAPID COMMUNICATION ON FORTHCOMING WORLD HEALTH ORGANIZATION GUIDELINES FOR THE TREATMENT OF DRUG-RESISTANT TB, ISSUED IN MAY 2022. THESE GUIDELINES WILL ENABLE A SIGNIFICANTLY BROADER PATIENT POPULATION TO BE TREATED WITH BPAL-BASED REGIMENS. BUILDING ON EVIDENCE FIRST DEVELOPED FROM TB ALLIANCE FROM THE NIX-TB AND ZENIX CLINICAL TRIALS, AS WELL AS THE TB-PRACTECAL TRIAL RUN BY MSF, ALMOST ALL PATIENTS WITH DR-TB CAN NOW BE TREATED IN SIX MONTHS WITH AN ALL-ORAL REGIMEN. NEW WORLD HEALTH ORGANIZATION GUIDELINES ALLOW FOR PROGRAMMATIC IMPLEMENTATION OF TREATING ALMOST ALL FORMS OF DRUG-RESISTANT TUBERCULOSIS WITH EITHER BPALM (A COMBINATION OF BEDAQUILINE, PRETOMANID, LINEZOLID, AND MOXIFLOXACIN) OR BPAL (BEDAQUILINE, PRETOMANID, AND LINEZOLID). LIFT-TB (LEVERAGING INNOVATION FOR FASTER TREATMENT OF TB) - THIS ACCESS PROGRAM, LAUNCHED IN 2020, SEEKS TO INCREASE TREATMENT COMPLETION RATES FOR DRUG-RESISTANT TB THROUGH ADOPTION AND SCALE UP OF NEW REGIMENS, BEGINNING WITH BPAL. IT FOCUSES ON SEVEN HIGH-BURDEN SOUTHEAST AND CENTRAL ASIAN COUNTRIES THAT SHOULDER APPROXIMATELY 1 IN 5 OF THE GLOBAL TB CASES. AS OF 2022, 50 COUNTRIES HAVE PROCURED THE SIX-MONTH, ALL-ORAL BPAL REGIMEN TO TREAT MORE THAN 7,000 PEOPLE WITH DRUG-RESISTANT TB. SUTEZOLID - SUTEZOLID IS A PROMISING CLINICAL-STAGE TB DRUG CANDIDATE FROM THE OXAZOLIDINONE CLASS. TB ALLIANCE HAS IMPLEMENTED AN OPEN DEVELOPMENT APPROACH TO ADVANCE THE PHASE 2 TB DRUG CANDIDATE, SUTEZOLID, WHICH COULD BE A COMPONENT OF A NEXT-GENERATION TB |
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| IRS990/GovernmentGrantsAmt | 0 | 29771791 |
| IRS990/GrantAmt | 0 | 0 |
| IRS990/GrantsPayableGrp/BOYAmt | 0 | 0 |
| IRS990/GrantsPayableGrp/EOYAmt | 0 | 0 |
| IRS990/GrantsToDomesticIndividualsGrp/TotalAmt | 0 | 0 |
| IRS990/GrantsToDomesticOrgsGrp/ProgramServicesAmt | 0 | 0 |
| IRS990/GrantsToDomesticOrgsGrp/TotalAmt | 0 | 0 |
| IRS990/GrantsToIndividualsInd | 0 | false |
| IRS990/GrantsToOrganizationsInd | 0 | false |
| IRS990/GrantToRelatedPersonInd | 0 | false |
| IRS990/GrossAmountSalesAssetsGrp/SecuritiesAmt | 0 | 496224 |
| IRS990/GrossReceiptsAmt | 0 | 56730633 |
| IRS990/GrossSalesOfInventoryAmt | 0 | 0 |
| IRS990/GroupReturnForAffiliatesInd | 0 | false |
| IRS990/IncludeFIN48FootnoteInd | 0 | true |
| IRS990/IncmFromInvestBondProceedsGrp/TotalRevenueColumnAmt | 0 | 0 |
| IRS990/IndependentAuditFinclStmtInd | 0 | true |
| IRS990/IndependentVotingMemberCnt | 0 | 11 |
| IRS990/IndivRcvdGreaterThan100KCnt | 0 | 42 |
| IRS990/IndoorTanningServicesInd | 0 | false |
| IRS990/InfoInScheduleOPartIIIInd | 0 | X |
| IRS990/InfoInScheduleOPartIXInd | 0 | X |
| IRS990/InfoInScheduleOPartVIIInd | 0 | X |
| IRS990/InfoInScheduleOPartVIInd | 0 | X |
| IRS990/InfoInScheduleOPartXIInd | 0 | X |
| IRS990/InformationTechnologyGrp/FundraisingAmt | 0 | 25403 |
| IRS990/InformationTechnologyGrp/ManagementAndGeneralAmt | 0 | 557660 |
| IRS990/InformationTechnologyGrp/ProgramServicesAmt | 0 | 599562 |
| IRS990/InformationTechnologyGrp/TotalAmt | 0 | 1182625 |
| IRS990/InsuranceGrp/ManagementAndGeneralAmt | 0 | 131366 |
| IRS990/InsuranceGrp/ProgramServicesAmt | 0 | 57221 |
| IRS990/InsuranceGrp/TotalAmt | 0 | 188587 |
| IRS990/IntangibleAssetsGrp/BOYAmt | 0 | 0 |
| IRS990/IntangibleAssetsGrp/EOYAmt | 0 | 0 |
| IRS990/InterestGrp/TotalAmt | 0 | 0 |
| IRS990/InventoriesForSaleOrUseGrp/BOYAmt | 0 | 0 |
| IRS990/InventoriesForSaleOrUseGrp/EOYAmt | 0 | 0 |
| IRS990/InvestmentIncomeGrp/ExclusionAmt | 0 | 2653344 |
| IRS990/InvestmentIncomeGrp/TotalRevenueColumnAmt | 0 | 2653344 |
| IRS990/InvestmentIncomeGrp/UnrelatedBusinessRevenueAmt | 0 | 0 |
| IRS990/InvestmentInJointVentureInd | 0 | false |
| IRS990/InvestmentsOtherSecuritiesGrp/BOYAmt | 0 | 0 |
| IRS990/InvestmentsOtherSecuritiesGrp/EOYAmt | 0 | 0 |
| IRS990/InvestmentsProgramRelatedGrp/BOYAmt | 0 | 0 |
| IRS990/InvestmentsProgramRelatedGrp/EOYAmt | 0 | 0 |
| IRS990/InvestmentsPubTradedSecGrp/BOYAmt | 0 | 0 |
| IRS990/InvestmentsPubTradedSecGrp/EOYAmt | 0 | 9761242 |
| IRS990/IRPDocumentCnt | 0 | 72 |
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