Civic Intelligence

Global Alliance for Tb Drug Development Inc

EIN 13-4128413 • 501(c)3 • New York, NY

Profile

Tb alliance is a not-for-profit organization dedicated to the discovery, development and delivery of better, faster-acting and affordable tuberculosis drugs that are available to those who need them.

80 Pine Street 20th FloorNew York, NY 10005

www.tballiance.org

Siviq Scores

Precomputed percentiles relative to similar nonprofits. These scores are descriptive rather than judgmental.

Liabilities / Assets

34th percentile

0.14x

Higher debt load relative to assets than 34% of similar nonprofits.

501(c)3 • $100M-$250M nonprofits • Source year 2024

Liabilities / Revenue

52nd percentile

0.44x

Higher debt load relative to revenue than 52% of similar nonprofits.

501(c)3 • $100M-$250M nonprofits • Source year 2024

Net Margin

46th percentile

3.5%

Higher net margin than 46% of similar nonprofits.

501(c)3 • $100M-$250M nonprofits • Source year 2024

Top Officer Pay

81st percentile

$1,052,936

Higher top officer pay than 81% of similar nonprofits.

Top officer pay equals 1.7% of source-year revenue.

501(c)3 • $100M-$250M nonprofits • Source year 2024

Asset Growth

40th percentile

3.5%

Faster asset growth than 40% of similar nonprofits.

501(c)3 • $100M-$250M nonprofits • Annualized from 2023 to 2024

Revenue Growth

43rd percentile

5.8%

Faster revenue growth than 43% of similar nonprofits.

501(c)3 • $100M-$250M nonprofits • Annualized from 2023 to 2024

Assets

Up

$204,316,428

Up $6,996,887 (+3.5%) from 2023

Liabilities

Up

$28,006,599

Up $2,386,608 (+9.3%) from 2023

Net Assets

Up

$176,309,829

Up $4,610,279 (+2.7%) from 2023

Revenue

Up

$63,732,557

Up $3,492,071 (+5.8%) from 2023

Expenses

Up

$61,508,783

Up $6,130,204 (+11%) from 2023

Net Income

Down

$2,223,774

Down $2,638,133 (-54%) from 2023

Trend Graphs

Balance Sheet Trend

Grouped bars show assets, liabilities, and net assets across loaded filings.

$300M$200M$100M$0Assets 2011: $51,559,287Liabilities 2011: $10,964,473Net Assets 2011: $40,594,8142011Assets 2012: $58,144,210Liabilities 2012: $13,900,275Net Assets 2012: $44,243,9352012Assets 2013: $71,932,038Liabilities 2013: $22,007,511Net Assets 2013: $49,924,5272013Assets 2014: $87,024,911Liabilities 2014: $34,708,677Net Assets 2014: $52,316,2342014Assets 2015: $104,991,923Liabilities 2015: $49,390,211Net Assets 2015: $55,601,7122015Assets 2016: $83,056,988Liabilities 2016: $28,520,027Net Assets 2016: $54,536,9612016Assets 2017: $72,985,406Liabilities 2017: $16,431,067Net Assets 2017: $56,554,3392017Assets 2018: $75,171,538Liabilities 2018: $15,761,770Net Assets 2018: $59,409,7682018Assets 2019: $189,418,881Liabilities 2019: $24,731,091Net Assets 2019: $164,687,7902019Assets 2020: $191,155,661Liabilities 2020: $26,697,735Net Assets 2020: $164,457,9262020Assets 2021: $187,560,796Liabilities 2021: $21,920,223Net Assets 2021: $165,640,5732021Assets 2022: $176,686,879Liabilities 2022: $11,506,360Net Assets 2022: $165,180,5192022Assets 2023: $197,319,541Liabilities 2023: $25,619,991Net Assets 2023: $171,699,5502023Assets 2024: $204,316,428Liabilities 2024: $28,006,599Net Assets 2024: $176,309,8292024

Highlighted filing

2024

Assets$204,316,428
Liabilities$28,006,599
Net Assets$176,309,829

Operations Trend

Revenue, expenses, and net income by year, with the latest filing highlighted.

$200M$150M$100M$50M$0-$50MRevenue 2011: $46,946,367Expenses 2011: $36,738,555Net Income 2011: $10,207,8122011Revenue 2012: $46,256,409Expenses 2012: $42,645,054Net Income 2012: $3,611,3552012Revenue 2013: $46,117,957Expenses 2013: $40,579,516Net Income 2013: $5,538,4412013Revenue 2014: $45,896,921Expenses 2014: $43,236,701Net Income 2014: $2,660,2202014Revenue 2015: $61,262,524Expenses 2015: $57,842,666Net Income 2015: $3,419,8582015Revenue 2016: $53,033,369Expenses 2016: $54,033,661Net Income 2016: -$1,000,2922016Revenue 2017: $58,006,498Expenses 2017: $56,120,604Net Income 2017: $1,885,8942017Revenue 2018: $63,283,490Expenses 2018: $60,315,645Net Income 2018: $2,967,8452018Revenue 2019: $174,873,899Expenses 2019: $69,535,079Net Income 2019: $105,338,8202019Revenue 2020: $61,267,452Expenses 2020: $61,720,389Net Income 2020: -$452,9372020Revenue 2021: $58,653,379Expenses 2021: $57,430,605Net Income 2021: $1,222,7742021Revenue 2022: $56,212,963Expenses 2022: $55,785,890Net Income 2022: $427,0732022Revenue 2023: $60,240,486Expenses 2023: $55,378,579Net Income 2023: $4,861,9072023Revenue 2024: $63,732,557Expenses 2024: $61,508,783Net Income 2024: $2,223,7742024

Highlighted filing

2024

Revenue$63,732,557
Expenses$61,508,783
Net Income$2,223,774

Filings

Balance SheetOperations
YearAssetsLiabilitiesNet AssetsRevenueExpensesNet Income
2024XML pending. An XML filing is linked for this year, but detailed extraction is still pending.$204$28.0$176$63.7$61.5$2.22
2023Summary only. Only limited summary data is available for this year.$197$25.6$172$60.2$55.4$4.86
2022Facts available. Structured filing facts are available, but richer extracted sections are limited.$177$11.5$165$56.2$55.8$0.43
2021XML pending. An XML filing is linked for this year, but detailed extraction is still pending.$188$21.9$166$58.7$57.4$1.22
2020Facts available. Structured filing facts are available, but richer extracted sections are limited.$191$26.7$164$61.3$61.7$0.45
2019XML pending. An XML filing is linked for this year, but detailed extraction is still pending.$189$24.7$165$175$69.5$105
2018XML pending. An XML filing is linked for this year, but detailed extraction is still pending.$75.2$15.8$59.4$63.3$60.3$2.97
2017Facts available. Structured filing facts are available, but richer extracted sections are limited.$73.0$16.4$56.6$58.0$56.1$1.89
2016Summary only. Only limited summary data is available for this year.$83.1$28.5$54.5$53.0$54.0$1.00
2015Summary only. Only limited summary data is available for this year.$105$49.4$55.6$61.3$57.8$3.42
2014Summary only. Only limited summary data is available for this year.$87.0$34.7$52.3$45.9$43.2$2.66
2013Summary only. Only limited summary data is available for this year.$71.9$22.0$49.9$46.1$40.6$5.54
2012Summary only. Only limited summary data is available for this year.$58.1$13.9$44.2$46.3$42.6$3.61
2011Summary only. Only limited summary data is available for this year.$51.6$11.0$40.6$46.9$36.7$10.2
Latest Detailed Filing

The latest 2024 filing currently has linked XML that has not been fully parsed yet. Showing the latest detailed filing from 2022 below.

Jump To
Filing Snapshot
Filing Period
Jan 1, 2022 to Dec 31, 2022
Signed
Oct 31, 2023
Return Version
2022v5.0
Gross Receipts
$56,730,633
Mission and Program Overview

Mission

Tb alliance is a not-for-profit organization dedicated to the discovery, development and delivery of better, faster-acting and affordable tuberculosis drugs that are available to those who need them.

To accelerate the discovery & development of new drugs to facilitate the control of tuberculosis throughout the world and the accessibility of these drugs to the global community.

Balance Sheet Detail
LineBeginningEndChange
Assets
Savings and Temporary Cash Investments$181,065,855$159,750,193▼ $21,315,662
Investments in Publicly Traded Securities$0$9,761,242▲ $9,761,242
Pledges and Grants Receivable$4,258,015$4,239,015▼ $19,000
Accounts Receivable$755,218$1,094,599▲ $339,381
Prepaid Expenses and Deferred Charges$964,669$1,057,756▲ $93,087
Land, Buildings, and Equipment, Net$457,341$724,376▲ $267,035
Cash and Non-Interest-Bearing Accounts$0$0→ $0
Other Notes and Loans Receivable, Net$0$0→ $0
Receivable From Disqualified Prsn$0$0→ $0
Receivables From Officers Etc$0$0→ $0
Investments Other Securities$0$0→ $0
Investments Program Related$0$0→ $0
Intangible Assets$0$0→ $0
Inventories for Sale or Use$0$0→ $0
Loans From Officers Directors$0$0→ $0
Total Assets$187,560,796$176,686,879▼ $10,873,917
Other Assets Total$59,698$59,698→ $0
Liabilities
Accounts Payable and Accrued Expenses$9,644,841$11,073,526▲ $1,428,685
Deferred Revenue$12,159,240$419,100▼ $11,740,140
Other Liabilities$116,142$13,734▼ $102,408
Grants Payable$0$0→ $0
Mortgage Notes Payable Secured by Investment Property$0$0→ $0
Unsecured Notes Loans Payable$0$0→ $0
Escrow Account Liability$0$0→ $0
Tax Exempt Bond Liabilities$0$0→ $0
Total Liabilities$21,920,223$11,506,360▼ $10,413,863
Net Assets / Fund Balance
Net Assets Without Donor Restrictions$165,640,573$165,180,519▼ $460,054
Net Assets With Donor Restrictions$0$0→ $0
Total Net Assets Fund Balance$165,640,573$165,180,519▼ $460,054
Total Liabilities and Net Assets / Fund Balance$187,560,796$176,686,879▼ $10,873,917

Asset Categories

AssetBook ValueDepreciationBasis
Leasehold Improvements$44,709$3,644,605$3,689,314
Other Land Buildings$671,509$458,251$1,129,760
Equipment$8,158$664,931$673,089
Compensation and Service Providers

Employees

NameTitleFull / Part TimeBaseOtherTotal
Dr Melvin SpigelmanPresident/CEOFT$614,073$395,784$1,009,857
Dr Nader FotouhiChief Scientific OfficerFT$408,888$233,130$642,018
Dr Eugene SunSR. VP, RESEARCH & DEV'TFT$421,778$213,688$635,466
Colleen PeroSecretary/CAOFT$344,302$168,272$512,574
Robert LoretteSr. VP, Business DevelopmentFT$329,048$178,701$507,749
Angela VanderploegTreasurer/CFOFT$308,367$190,824$499,191
Kathleen SchostackSr. VP, Prog. & Alliance MgmtFT$318,246$178,264$496,510
Sandeep JunejaSr. VP, Market AccessFT$304,384$189,000$493,384
Dr Paul BruinenbergSr. Medical OfficerFT$336,592$136,183$472,775
Salah ForaidaSr. Director, Medical AffairsFT$344,959$112,513$457,472
Maria BeumontVP, Chief Medical OfficerFT$380,489$73,336$453,825
Pietro TurilliSr.VP, Ext Aff(as of 06/01/22)FT$161,060$48,242$209,302

Board Members and Trustees

NameTitle
Dr Bruce CarterChairman
Dr Mario RaviglioneVice Chair
Ariel Pablos-mendezDirector
David NortonDirector
Eric GoosbyDirector
Jane GriffithsDirector
Mitchell WarrenDirector
Shalini SharpDirector
Sundar KodiyalamDirector
Kim SchwartzDirector (as of 09/01/22)
Rasha HibriDirector (as of 09/01/22)
Sangita ReddyDirector (thru 05/15/22)

Highest Paid Contractors

ContractorServicesLocationCompensation
Wuxi Apptec Hongkong LimitedIntegrated R&d Svcs28395 NETWORK PLACE, Chicago, IL 60673, Ch$4,408,831
University Of IllinoisResearch Collab.1 PROMENADE BLVD SUITE 1101, Fair Lawn, NJ 07410, Uk$2,580,920
Ppd Global LimitedGlobal Cro28760 TRES CANTOS, Madrid, 0, Sp$2,459,365
Tkl Research INCResearch & Devt.-$1,867,665
Glaxosmithkline InvestigacionExt. Mini Portfolios-$1,600,000
Revenue and Support

Revenue Composition

Contributions and Grants
$52,646,326
Program Service Revenue
$0
Investment Income
$2,631,898
Other Revenue
$934,739
All Other Contributions
$22,874,535
Change in Net Assets
$427,073

Audited Revenue Reconciliation

Revenue per Audited Statements
$56,201,493
Revenue Not Reported on Financial Statements
$11,470
Revenue Not Reported on Form 990
$-807,972
Total Revenue per Audited Statements
$55,393,521
Total Revenue per Form 990
$56,212,963
Expenses and Functional Allocation

Major Expense Lines

Line ItemAmount
Other Expenses$39,262,643
Salaries, Compensation, and Employee Benefits$16,259,751
Total Fundraising Expense$754,480
Grants and Similar Amounts Paid$263,496
Professional Fundraising Fees$0

Functional Expense Allocation

Line ItemProgramManagementFundraisingTotal
Fees for Services Other$8,958,244$505,159$12,000$9,475,403
Other Salaries and Wages$7,381,992$1,551,113$348,195$9,281,300
Current Officers, Directors, Trustees, and Key Employees$2,665,394$1,140,409$156,430$3,962,233
Other Employee Benefits$1,158,078$261,692$52,676$1,472,446
Information Technology$599,562$557,660$25,403$1,182,625
Occupancy$841,629$234,708$50,131$1,126,468
Pension Plan Contributions$697,269$141,413$34,002$872,684
Fees for Services Legal$739,134$55,680-$794,814
Payroll Taxes$512,410$133,223$25,455$671,088
Travel$421,117$165,914$9,876$596,907
Depreciation Depletion$300,060$85,979$18,435$404,474
Foreign Grants$263,496--$263,496
Other Expenses$96,779$108,226$19,617$224,622
Office Expenses$64,091$132,306$1,643$198,040
Insurance$57,221$131,366-$188,587
Fees for Services Accounting$30,000$123,496-$153,496
Conferences and Meetings$30,112$20,134$617$50,863
Fees for Service Investment Mgmnt Fees-$11,470-$11,470
Total Functional Expenses$49,671,462$5,359,948$754,480$55,785,890

Audited Expense Reconciliation

Line ItemAmount
Total Expenses per Form 990$55,785,890
Expenses per Audited Statements$55,774,420
Total Expenses per Audited Statements$55,774,420
Expenses Not Reported on Financial Statements$11,470
International Activity

International Summary

Offices
1
Employees
74
Spending
$18,736,497

International Compliance

Foreign grant records maintained
Yes
Activity in boycott countries
No
Foreign corporation ownership
No
Foreign partnership interest
No
Interest in foreign trust
No
Passive foreign investment company interest
No
Transfers to foreign corporations
No

International Activities

RegionActivityServicesOfficesEmployeesSpending
East Asia and the PacificProgram ServicesR&d Research011$5,592,649
Europe (Including Iceland and Greenland)Program ServicesAdmin Expenses00$3,803,063
Europe (Including Iceland and Greenland)Program ServicesAdmin Expenses024$2,509,860
East Asia and the PacificProgram ServicesAdmin Expenses00$1,802,531
Sub-Saharan AfricaProgram Services-16$1,530,951
South AsiaProgram ServicesSalary & Fringe Benefi00$920,326
South AsiaProgram ServicesR&d Research09$813,033
Europe (Including Iceland and Greenland)Program ServicesR&d Research00$463,661
Sub-Saharan AfricaProgram Services-014$413,777
Sub-Saharan AfricaProgram Services-00$185,460
Russia and the Newly Independent StatesProgram ServicesR&d Research00$139,233
Sub-Saharan AfricaProgram Services-00$128,171
Sub-Saharan AfricaGrantmaking-00$124,138
Russia and the Newly Independent StatesGrantmakingR&d Research00$60,322
North AmericaProgram ServicesAdmin Expenses03$52,014
Russia and the Newly Independent StatesProgram ServicesConsulting Services04$46,890
South AmericaGrantmakingAdmin Expenses00$44,036
South AmericaProgram ServicesConsulting Services03$40,280
Europe (Including Iceland and Greenland)GrantmakingConsulting Services00$25,000
Middle East and North AfricaProgram ServicesConsulting Services00$24,864
East Asia and the PacificGrantmakingAdmin Expenses00$10,000
North AmericaProgram ServicesR&d Research00$2,615
North AmericaProgram ServicesConsulting Services00$1,650
Russia and the Newly Independent StatesProgram ServicesConsulting Services00$1,393
East Asia and the PacificProgram ServicesConsulting Services00$580
Fundraising, Events, and Gaming
Fundraising activities
No
Gaming activities
No
Professional fundraiser used
No

Fundraising and Gaming Totals

Line ItemAmount
Fundraising Direct Expenses$0
Fundraising Gross Income$0
Gaming Direct Expenses$0
Gaming Gross Income$0
Professional Fundraising Fees$0
Political and Lobbying Activity
Political campaign activity
No
Lobbying activity
No
Subject to proxy tax
No
Insider Transactions and Loans

Loans and Receivables

Line ItemBeginningEndChange
Loans from Officers, Directors, Trustees, and Key Employees$0$0→ $0
Receivables from Disqualified Persons$0$0→ $0
Receivables from Officers, Directors, Trustees, and Key Employees$0$0→ $0
Debt and Bond Financing

Other Reported Liabilities

LiabilityAmount
Deferred Rent$13,734
Governance and Compliance

Governance Checklist

Compiled or reviewed by an accountant
No
Annual disclosure for covered persons
Yes
Audit committee
Yes
Backup withholding compliance
Yes
Business relationship with 35% controlled entity
No
Business relationship with family members
No
Business relationship with organization members
No
Material changes to governing documents
No
Compensation from other sources disclosed
No
CEO compensation reviewed
Yes
Other officer compensation reviewed
Yes
Conflict-of-interest policy
Yes
Audited financial statements prepared
No
Key decisions subject to board approval
No
Management duties delegated
No

Governance Explanations

FORM 990, PART VI, SECTION B, LINE 11B:

Form 990 was prepared by a nationally recognized accounting firm in conjunction with the organization's finance department. The draft of form 990 was reviewed by the organization's finance department and senior management, and then provided to all members of the board of directors in draft via electronic mail, with an opportunity for them to comment or make inquiry before it was filed with the internal revenue service.

FORM 990, PART VI, SECTION B, LINE 12C:

The organization's conflict of interest policy is distributed to officers and directors annually along with a questionnaire that is completed by all officers and directors in which they are asked to disclose information regarding actual or potential conflicts of interest. These questionnaires are collected and reviewed annually to ensure compliance with the conflict of interest policy. The policy itself also requires any director or officer to promptly disclose any conflict of interest. Interested directors and officers are required to recuse themselves from any decision on matters in which they have an interest, and such recusal is noted in the minutes.

FORM 990, PART VI, SECTION B, LINES 15A AND 15B:

The compensation committee, which consists of three independent board members, annually reviews the ceo and officers compensation in conjunction with an evaluation of organizational performance. The committee recommends adjustments in compensation to the full board for review and approval, within the context of an agreed upon competitive position. The competitiveness of compensation is periodically benchmarked using independent salary survey data from the not-for-profit and for-profit industry. The compensation committee documentation includes the performance assessment, comparable data and the source of this data, and the recommended adjustments. The minutes of the full board include documentation of the approved decisions. The minutes of the board and committee are prepared before the later of the next meeting or 60 days after the final decision of the board and the committee.

FORM 990, PART VI, SECTION C, LINE 19:

The organization makes its governing documents, conflict of interest policy, and financial statements available to the public upon request.

Filing and Contact Details

Filer

Filer Name
Global Alliance for Tb Drug Development Inc
EIN
13-4128413
In Care Of
% ANGELA VANDERPLOEG
Phone
2122277540
Address
80 PINE STREET 20TH FLOOR, NEW YORK, NY 10005
Doing Business As
Tb Alliance

Signing Officer

Name
Melvin Spigelman
Title
President/CEO
Phone
2122277540
Signed
2023-10-31
Discuss with paid preparer
Yes

Organization Details

Principal Officer
Angela Vanderploeg
Formed
2000
Legal Domicile
De
Voting Board Members
12
Independent Board Members
11
Employees
54
Volunteers
13

Preparer

Firm
Bdo USA
Address
100 PARK AVENUE, NEW YORK, NY 10017-5001
Preparer
Paul Hammerschmidt
Phone
2128858000
Supplemental Narrative

Additional Explanations

FORM 990, PART IX, LINE 11G:

Professional services and agreements include individual consultants who are contributing their specific expertise related to our clinical trials and other early stage and preclinical discovery work. Expertise in such areas as pharmacovigilance, non-glp bioanalysis, analytical evaluation of drug stability and program management are some of the services required in order to complete our scientific research and development. These consultants are managed by our staff, who coordinate the work necessary to be completed among all outside parties.

FORM 990, PART XI, LINE 9:

Foreign translation loss....$ (79,155)

Form 990 Part IX Line 11G

Description:prof. Svcs & agreements total fees:9475403

Financial Statement Notes

PART X, LINE 2:

Tb alliance is subject to the provisions of the financial accounting standards board's (fasb) accounting standards codification (asc) topic 740, income taxes, as it relates to accounting and reporting for uncertainty in income taxes. Tb alliance does not believe it has taken any material uncertain tax positions and due to its general not-for-profit status, management believes asc topic 740 has not had, and is not anticipated to have, a material impact on tb alliance's financial statements.

Raw XML AppendixShowing 400 of 1,126 raw XML fields

This appendix keeps the raw XML leaves available for debugging and edge-case review. The human report above is the primary experience.

Path#Value
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IRS990/AccountsPayableAccrExpnssGrp/BOYAmt09644841
IRS990/AccountsPayableAccrExpnssGrp/EOYAmt011073526
IRS990/AccountsReceivableGrp/BOYAmt0755218
IRS990/AccountsReceivableGrp/EOYAmt01094599
IRS990/ActivitiesConductedPrtshpInd0false
IRS990/ActivityOrMissionDesc0TO ACCELERATE THE DISCOVERY & DEVELOPMENT OF NEW DRUGS TO FACILITATE THE CONTROL OF TUBERCULOSIS THROUGHOUT THE WORLD AND THE ACCESSIBILITY OF THESE DRUGS TO THE GLOBAL COMMUNITY.
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IRS990/Desc0RESEARCH AND DEVELOPMENT - TB ALLIANCE IS A NOT-FOR-PROFIT PRODUCT DEVELOPMENT PARTNERSHIP (PDP), UNIQUELY POSITIONED TO LEVERAGE A GLOBAL NETWORK OF PUBLIC AND PRIVATE PARTNERS TO MOST EFFICIENTLY ADVANCE TB DRUG DEVELOPMENT. A PDP BUILDS PARTNERSHIPS BETWEEN THE PUBLIC, PRIVATE, ACADEMIC, AND PHILANTHROPIC SECTORS TO DRIVE THE DEVELOPMENT OF NEW PRODUCTS FOR UNDERSERVED MARKETS. PDPS RETAIN DIRECT MANAGEMENT OVERSIGHT OF THEIR PROJECTS, THOUGH MUCH OF THE LABORATORY AND CLINICAL WORK IS DONE THROUGH EXTERNAL RESEARCH FACILITIES AND CONTRACTORS. WE COMBINE THE RESEARCH AND DEVELOPMENT EXPERTISE OF OUR STAFF WITH THE SKILLS AND RESOURCES OF OUR PARTNERS TO HARNESS THE MOST PROMISING SCIENCE WHEREVER IT MAY EXIST AROUND THE WORLD. THIS MODEL MINIMIZES COSTS, INCLUDING OVERHEAD AND INVESTMENTS IN INFRASTRUCTURE, WHILE OPTIMIZING SCIENTIFIC CAPABILITY TO SPEED NEW TB DRUG DEVELOPMENT. OUR BUSINESS MODEL AND DIVERSE PARTNERSHIPS ALLOW TB ALLIANCE TO LEVERAGE ADDITIONAL PARTNER SERVICES FOR EVERY DOLLAR INVESTED IN ITS PROGRAMS. SIMPLICITB - SIMPLICITB IS EVALUATING THE EFFICACY, SAFETY, AND TOLERABILITY OF A NOVEL AND POTENTIALLY SHORTER DRUG REGIMEN (BPAMZ) FOR PATIENTS WITH DRUG-SENSITIVE (DS) AND DRUG-RESISTANT (MDR) PULMONARY TUBERCULOSIS (SPECIFICALLY MULTIDRUG-RESISTANT TB AND MONO-RESISTANCE TO ISONIAZID OR RIFAMPICIN). THE BPAMZ REGIMEN IS COMPRISED OF FOUR DIFFERENT ANTIMICROBIALS: BEDAQUILINE (B), PRETOMANID (PA), MOXIFLOXACIN (M) AND PYRAZINAMIDE (Z). THE DRUG REGIMEN IS ADMINISTERED FOR FOUR MONTHS TO PATIENTS WITH DS-TB, AND FOR SIX MONTHS TO PATIENTS WITH MDR-TB OR MONO-RESISTANCE TO RIFAMPICIN OR ISONIAZID. RESULTS IN THE DS-TB ARM WILL BE COMPARED TO A CONTROL GROUP OF THE STANDARD SIX-MONTH DRUG REGIMEN FOR DS-TB (HRZE). ZENIX - THE PHASE 3 ZENIX CLINICAL TRIAL EVALUATED THE BPAL REGIMEN TO TREAT EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS (XDR-TB) AND THOSE WITH PRE-XDR-TB AND MULTIDRUG-RESIDENT TB (MDR-TB) WHOSE PRIOR TREATMENT HAS FAILED OR WHO HAVE NOT TOLERATED THEIR TREATMENT. IT SOUGHT TO OPTIMIZE LINEZOLID DOSING AS PART OF THE BPAL REGIMEN, EVALUATING BOTH THE LINEZOLID DOSE AND THE LINEZOLID DURATION. THE TOP-LINE RESULTS OF ZENIX WERE PRESENTED AT IAS 2021, SHOWING THAT THE EFFECTIVENESS OF THE BPAL REGIMEN COULD BE MAINTAINED WITH REDUCED DOSING OF LINEZOLID. THESE RESULTS WERE ACCEPTED AND PUBLISHED IN THE NEW ENGLAND JOURNAL OF MEDICINE IN THE SEPTEMBER 2022 ISSUE. THE RESULTS OF THE ZENIX TRIAL WERE INCORPORATED INTO A RAPID COMMUNICATION ON FORTHCOMING WORLD HEALTH ORGANIZATION GUIDELINES FOR THE TREATMENT OF DRUG-RESISTANT TB, ISSUED IN MAY 2022. THESE GUIDELINES WILL ENABLE A SIGNIFICANTLY BROADER PATIENT POPULATION TO BE TREATED WITH BPAL-BASED REGIMENS. BUILDING ON EVIDENCE FIRST DEVELOPED FROM TB ALLIANCE FROM THE NIX-TB AND ZENIX CLINICAL TRIALS, AS WELL AS THE TB-PRACTECAL TRIAL RUN BY MSF, ALMOST ALL PATIENTS WITH DR-TB CAN NOW BE TREATED IN SIX MONTHS WITH AN ALL-ORAL REGIMEN. NEW WORLD HEALTH ORGANIZATION GUIDELINES ALLOW FOR PROGRAMMATIC IMPLEMENTATION OF TREATING ALMOST ALL FORMS OF DRUG-RESISTANT TUBERCULOSIS WITH EITHER BPALM (A COMBINATION OF BEDAQUILINE, PRETOMANID, LINEZOLID, AND MOXIFLOXACIN) OR BPAL (BEDAQUILINE, PRETOMANID, AND LINEZOLID). LIFT-TB (LEVERAGING INNOVATION FOR FASTER TREATMENT OF TB) - THIS ACCESS PROGRAM, LAUNCHED IN 2020, SEEKS TO INCREASE TREATMENT COMPLETION RATES FOR DRUG-RESISTANT TB THROUGH ADOPTION AND SCALE UP OF NEW REGIMENS, BEGINNING WITH BPAL. IT FOCUSES ON SEVEN HIGH-BURDEN SOUTHEAST AND CENTRAL ASIAN COUNTRIES THAT SHOULDER APPROXIMATELY 1 IN 5 OF THE GLOBAL TB CASES. AS OF 2022, 50 COUNTRIES HAVE PROCURED THE SIX-MONTH, ALL-ORAL BPAL REGIMEN TO TREAT MORE THAN 7,000 PEOPLE WITH DRUG-RESISTANT TB. SUTEZOLID - SUTEZOLID IS A PROMISING CLINICAL-STAGE TB DRUG CANDIDATE FROM THE OXAZOLIDINONE CLASS. TB ALLIANCE HAS IMPLEMENTED AN OPEN DEVELOPMENT APPROACH TO ADVANCE THE PHASE 2 TB DRUG CANDIDATE, SUTEZOLID, WHICH COULD BE A COMPONENT OF A NEXT-GENERATION TB
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IRS990/InformationTechnologyGrp/TotalAmt01182625
IRS990/InsuranceGrp/ManagementAndGeneralAmt0131366
IRS990/InsuranceGrp/ProgramServicesAmt057221
IRS990/InsuranceGrp/TotalAmt0188587
IRS990/IntangibleAssetsGrp/BOYAmt00
IRS990/IntangibleAssetsGrp/EOYAmt00
IRS990/InterestGrp/TotalAmt00
IRS990/InventoriesForSaleOrUseGrp/BOYAmt00
IRS990/InventoriesForSaleOrUseGrp/EOYAmt00
IRS990/InvestmentIncomeGrp/ExclusionAmt02653344
IRS990/InvestmentIncomeGrp/TotalRevenueColumnAmt02653344
IRS990/InvestmentIncomeGrp/UnrelatedBusinessRevenueAmt00
IRS990/InvestmentInJointVentureInd0false
IRS990/InvestmentsOtherSecuritiesGrp/BOYAmt00
IRS990/InvestmentsOtherSecuritiesGrp/EOYAmt00
IRS990/InvestmentsProgramRelatedGrp/BOYAmt00
IRS990/InvestmentsProgramRelatedGrp/EOYAmt00
IRS990/InvestmentsPubTradedSecGrp/BOYAmt00
IRS990/InvestmentsPubTradedSecGrp/EOYAmt09761242
IRS990/IRPDocumentCnt072

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