Civic Intelligence

Arc Research Institute

EIN 87-1920284 • 501(c)3 • Palo Alto, CA

Profile

Our mission is to accelerate scientific progress, understand the root causes of disease, and narrow the gap between discoveries and impact on patients.

3181 Porter DrPalo Alto, CA 94304-1249

arcinstitute.org

Siviq Scores

Precomputed percentiles relative to similar nonprofits. These scores are descriptive rather than judgmental.

Liabilities / Assets

66th percentile

0.45x

Higher debt load relative to assets than 66% of similar nonprofits.

501(c)3 • $100M-$250M nonprofits • Source year 2024

Liabilities / Revenue

64th percentile

0.68x

Higher debt load relative to revenue than 64% of similar nonprofits.

501(c)3 • $100M-$250M nonprofits • Source year 2024

Net Margin

84th percentile

32%

Higher net margin than 84% of similar nonprofits.

501(c)3 • $100M-$250M nonprofits • Source year 2024

Top Officer Pay

21st percentile

$284,523

Higher top officer pay than 21% of similar nonprofits.

Top officer pay equals 0.3% of source-year revenue.

501(c)3 • $100M-$250M nonprofits • Source year 2022

Asset Growth

68th percentile

11%

Faster asset growth than 68% of similar nonprofits.

501(c)3 • $100M-$250M nonprofits • Annualized from 2022 to 2024

Revenue Growth

65th percentile

13%

Faster revenue growth than 65% of similar nonprofits.

501(c)3 • $100M-$250M nonprofits • Annualized from 2022 to 2024

Assets

Up

$184,388,461

Up $28,690,265 (+18%) from 2023

Liabilities

Down

$83,668,141

Down $10,146,039 (-11%) from 2023

Net Assets

Up

$100,720,320

Up $38,836,304 (+63%) from 2023

Revenue

Up

$122,280,682

Up $68,669,238 (+128%) from 2023

Expenses

Up

$82,781,856

Up $18,578,158 (+29%) from 2023

Net Income

Up

$39,498,826

Up $50,091,080 (+473%) from 2023

Trend Graphs

Balance Sheet Trend

Grouped bars show assets, liabilities, and net assets across loaded filings.

$200M$150M$100M$50M$0Assets 2021: $86,734,431Liabilities 2021: $78,039,067Net Assets 2021: $8,695,3642021Assets 2022: $150,115,619Liabilities 2022: $77,639,349Net Assets 2022: $72,476,2702022Assets 2023: $155,698,196Liabilities 2023: $93,814,180Net Assets 2023: $61,884,0162023Assets 2024: $184,388,461Liabilities 2024: $83,668,141Net Assets 2024: $100,720,3202024

Highlighted filing

2024

Assets$184,388,461
Liabilities$83,668,141
Net Assets$100,720,320

Operations Trend

Revenue, expenses, and net income by year, with the latest filing highlighted.

$150M$100M$50M$0-$50MRevenue 2021: $15,446,292Expenses 2021: $6,520,686Net Income 2021: $8,925,6062021Revenue 2022: $96,576,028Expenses 2022: $32,795,122Net Income 2022: $63,780,9062022Revenue 2023: $53,611,444Expenses 2023: $64,203,698Net Income 2023: -$10,592,2542023Revenue 2024: $122,280,682Expenses 2024: $82,781,856Net Income 2024: $39,498,8262024

Highlighted filing

2024

Revenue$122,280,682
Expenses$82,781,856
Net Income$39,498,826

Filings

Latest Filing Detail
Jump To
Filing Snapshot
Filing Period
Jan 1, 2024 to Dec 31, 2024
Signed
Nov 12, 2025
Return Version
2024v5.1
Gross Receipts
$122,280,682
Mission and Program Overview

Mission

Our mission is to accelerate scientific progress, understand the root causes of disease, and narrow the gap between discoveries and impact on patients.

Our mission is to accelerate scientific progress and understand the root causes of complex diseases. This challenge requires researchers across many disciplines to study fundamental biological mechanisms, develop new technologies, and innovate on therapeutic concepts. By doing this, we aim to improve human health by narrowing the gap between discoveries and impact on patients.

Balance Sheet Detail
LineBeginningEndChange
Assets
Land, Buildings, and Equipment, Net$90,883,127$86,376,957▼ $4,506,170
Savings and Temporary Cash Investments$618,831$35,705,534▲ $35,086,703
Cash and Non-Interest-Bearing Accounts$4,091,658$7,617,326▲ $3,525,668
Prepaid Expenses and Deferred Charges$1,232,853$2,931,957▲ $1,699,104
Investments Other Securities$1,000,000$1,000,000→ $0
Accounts Receivable$6,564$238,439▲ $231,875
Receivable From Disqualified Prsn$0$0→ $0
Receivables From Officers Etc$0$0→ $0
Investments Program Related$0--
Loans From Officers Directors$0$0→ $0
Total Assets$155,698,196$184,388,461▲ $28,690,265
Other Assets Total$57,865,163$50,518,248▼ $7,346,915
Liabilities
Other Liabilities$66,238,464$58,640,256▼ $7,598,208
Unsecured Notes Loans Payable$16,080,816$14,444,510▼ $1,636,306
Accounts Payable and Accrued Expenses$11,494,900$10,583,375▼ $911,525
Total Liabilities$93,814,180$83,668,141▼ $10,146,039
Net Assets / Fund Balance
Net Assets Without Donor Restrictions$61,884,016$100,720,320▲ $38,836,304
Total Net Assets Fund Balance$61,884,016$100,720,320▲ $38,836,304
Total Liabilities and Net Assets / Fund Balance$155,698,196$184,388,461▲ $28,690,265

Asset Categories

AssetBook ValueDepreciationBasis
Leasehold Improvements$66,532,220$11,978,396$78,510,616
Equipment$19,844,737$6,742,659$26,587,396
Other Assets Org$50,518,248--
Compensation and Service Providers

Employees

NameTitleFull / Part TimeBaseOtherTotal
Alden J WoodrowChief Operating OfficerFT$380,749$836,167$1,216,916
Julia M KazaksGeneral Counsel/ SecretaryFT$334,663$215,204$549,867
Patrick D Hsu PhDCore Investigator/ Co-FounderFT$464,075$64,561$528,636
Yusuf H Roohani PHDGroup lead, machine learningFT$111,440$333,331$444,771
Lynn M HendricksonUniversity Relations & Academic Affairs/ Compliance OfficerFT$267,311$151,504$418,815
Nianzhen Li PHDSenior Director, Multi-omics technology developmentFT$291,705$108,337$400,042
Therese A CostelloHead of PeopleFT$291,449$68,615$360,064
Lingyin Li PHDCore InvestigatorFT$255,752$102,054$357,806
Nicolle D SeussSenior Operations Program ManagerFT$236,962$105,478$342,440
Hani Goodarzi PHDCore InvestigatorFT$225,107$95,457$320,564
Luke A Gilbert PHDCore InvestigatorFT$245,502$49,035$294,537
Silvana M Konermann PhDExecutive Director/ PresidentFT$211,402$53,144$264,546
Susan T CullSenior Finance ManagerFT$163,520$35,606$199,126
Michael K TengHead of Finance/ Treasurer (as of 7/01/2024)FT$150,482$37,635$188,117
Rose E HarrisFinance (until 7/15/24)FT$127,201$262$127,463
Dave BurkeChief Technology Officer (as of 10/31/2024)FT$65,712$10,401$76,113
Daniel P Dever PhDHead of Scientific Operations (until 1/26/24)FT$62,998$5,760$68,758
Nathaniel FriedmanDirector-$36,000-$36,000
Reid HoffmanDirector-$36,000-$36,000
Susan LiDirector-$36,000-$36,000

Highest Paid Contractors

ContractorServicesLocationCompensation
Pulse OneConsulting290 Maple Court, Suite 168, Ventura, CA 93003$1,314,517
WilmerHaleLegal Services3040 Newmark Drive, Suite 750, Miamisburg, OH 45342$371,768
Milltown Partners LPMarketing550 Montgomery Street, San Francisco, CA 94111$329,890
Arnold & Porter Kaye Scholer LLPLegal ServicesPO Box 759451, Philadelphia, PA 19171-9451$267,843
Innovive LLCConsulting10019 Waples Court, San Diego, CA 92121$218,577
Revenue and Support

Revenue Composition

Contributions and Grants
$120,446,690
Program Service Revenue
$166,647
Investment Income
$1,667,345
Other Revenue
$0
All Other Contributions
$120,446,690
Change in Net Assets
$39,498,826

Audited Revenue Reconciliation

Revenue per Audited Statements
$122,280,682
Revenue Not Reported on Financial Statements
$0
Revenue Not Reported on Form 990
$0
Other Revenue Adjustments
$0
Total Revenue per Audited Statements
$122,280,682
Total Revenue per Form 990
$122,280,682
Expenses and Functional Allocation

Major Expense Lines

Line ItemAmount
Other Expenses$47,289,556
Salaries, Compensation, and Employee Benefits$24,229,467
Grants and Similar Amounts Paid$11,262,833
Professional Fundraising Fees$0
Total Fundraising Expense$0

Functional Expense Allocation

Line ItemProgramManagementFundraisingTotal
Other Salaries and Wages$10,445,724$5,551,676-$15,997,400
Occupancy$13,849,690$1,524,008-$15,373,698
Grants to Domestic Orgs$11,262,833--$11,262,833
Depreciation Depletion$7,126,564$2,978,114-$10,104,678
Current Officers, Directors, Trustees, and Key Employees$2,904,945$1,543,916-$4,448,861
Fees for Services Other$372,626$2,381,425$0$2,754,051
Other Employee Benefits$1,424,858$480,809-$1,905,667
All Other Expenses$756,158$840,607$0$1,596,765
Payroll Taxes$895,434$358,493-$1,253,927
Fees for Services Legal$209,966$889,173-$1,099,139
Office Expenses$403,476$512,243-$915,719
Pension Plan Contributions$407,196$216,416-$623,612
Travel$379,155$201,527-$580,682
Conferences and Meetings$43,811$233,105-$276,916
Fees for Services Management$151,719$16,858-$168,577
Other Expenses$164,638$672,408-$164,638
Insurance-$87,263-$87,263
Fees for Services Accounting-$73,383-$73,383
Advertising$3,910$35,028-$38,938
Total Functional Expenses$64,083,480$18,698,376$0$82,781,856

Audited Expense Reconciliation

Line ItemAmount
Total Expenses per Audited Statements$83,444,377
Expenses per Audited Statements$82,781,856
Total Expenses per Form 990$82,781,856
Expenses Not Reported on Form 990$662,521
Expenses Not Reported on Financial Statements$0
Other Expense Adjustments$0
International Activity

Grant and Assistance Recipients

RecipientLocationCategoryPurposeAmount
University of California San FranciscoSan Francisco, CA501(c)(3)Goldberg-Benioff Endowed Professorship in Prostate Cancer Translational Biology$4,000,000
Stanford UniversityStanford, CA501(c)(3)University Fellowships$3,794,924
Stanford UniversityStanford, CA501(c)(3)Innovation Investigator$1,330,409
University of California San FranciscoSan Francisco, CA501(c)(3)Innovation Investigator$1,265,000
University of California BerkeleyBerkeley, CA501(c)(3)Innovation Investigator$605,000
University of California BerkeleyBerkeley, CA501(c)(3)Funds to cover the cost of a UCB instructor not teaching classes$157,500
University of California San FranciscoSan Francisco, CA501(c)(3)Ignite awards$110,000

International Summary

Offices
0
Employees
1
Spending
$150,762

International Compliance

Activity in boycott countries
No
Foreign corporation ownership
No
Foreign partnership interest
No
Interest in foreign trust
No
Passive foreign investment company interest
No
Transfers to foreign corporations
No

International Activities

RegionActivityServicesOfficesEmployeesSpending
North America (Canada & Mexico only)Salaries and wages-01$150,762
Fundraising, Events, and Gaming
Fundraising activities
No
Gaming activities
No
Professional fundraiser used
No

Fundraising and Gaming Totals

Line ItemAmount
Professional Fundraising Fees$0
Political and Lobbying Activity
Political campaign activity
No
Lobbying activity
No
Subject to proxy tax
No
Insider Transactions and Loans

Loans and Receivables

Line ItemBeginningEndChange
Loans from Officers, Directors, Trustees, and Key Employees$0$0→ $0
Receivables from Disqualified Persons$0$0→ $0
Receivables from Officers, Directors, Trustees, and Key Employees$0$0→ $0
Debt and Bond Financing

Other Reported Liabilities

LiabilityAmount
Federal Income Taxes$58,640,256
Lease liability-
Governance and Compliance

Governance Checklist

Compiled or reviewed by an accountant
No
Annual disclosure for covered persons
Yes
Audit committee
Yes
Backup withholding compliance
Yes
Business relationship with 35% controlled entity
No
Business relationship with family members
No
Business relationship with organization members
No
Material changes to governing documents
No
Compensation from other sources disclosed
No
CEO compensation reviewed
No
Other officer compensation reviewed
No
Conflict-of-interest policy
Yes
Audited financial statements prepared
No
Key decisions subject to board approval
Yes
Management duties delegated
No

Governance Explanations

Form 990, Part VI, Line 15B Process to establish compensation

Compensation is reviewed and approved by the Executive Director, COO, and Head of People. Radford survey data was used to determine compensation ranges, as well as publicly available data and compensation policies from Stanford and the University of California system. All deliberations and decisions are documented.

Form 990, Part VI, Line 15A Process to establish compensation for top management official

Compensation, including benefits, is reviewed and approved by the board for the executive director to ensure that it is just and reasonable. This occurs upon hiring, term renewal/extension (when applicable), and whenever the officer's compensation is modified, unless there is a universal modification of compensation that extends to substantially all employees. Arc engaged a compensation consultant in 2021 who completed a compensation survey to give an opinion to determine the appropriate compensation of the executive director, which was approved by the board. Comparability data was used from the survey to determine compensation ranges, as well as publicly available data and compensation policies from Stanford and the University of California system. All compensation increases must be approved by the board and are documented accordingly.

Form 990, Part VI, Line 6 Classes of members or stockholders

The Institute has, and will only have, one member at a time. The Member shall serve until the Member's death, incapacity or resignation. The Member and each successive Member shall name his/her successor. If at any time there is no Member serving and no successor has been designated, the Board of Directors shall designate the Member.

Form 990, Part VI, Line 7A Members or stockholders electing members of governing body

The Board of Directors shall be elected or appointed by the Member. The Member may remove and replace any member of the Board of Directors at any time for any or no reason.

Form 990, Part VI, Line 7B Decisions requiring approval by members or stockholders

The member has the following governing powers: -The annual meeting of the Member for the election of directors and for the transaction of such other business as may properly come before the meeting shall be held at such date, time and place, if any, as shall be determined by the Board of Directors and stated in the notice of the meeting. -Special meetings of the Member for any purpose or purposes shall be called pursuant to a resolution approved by the Board of Directors and may be called by the Member. The only business which may be conducted at a special meeting shall be the matter or matters set forth in the notice of such meeting. -Any meeting of the Member, annual or special, may be adjourned from time to time to reconvene at the same or some other place, if any, and notice need not be given of any such adjourned meeting if the time, place, if any, thereof, and the means of remote communication, if any, are announced at the meeting at which the adjournment is taken. At the adjourned meeting, the Corporation may transact any business which might have been transacted at the original meeting. If after the adjournment a new record date is fixed for the Member at the adjourned meeting, the Board of Directors shall fix a new record date for notice of the adjourned meeting and shall give notice of the adjourned meeting to the Member. -Notice of the place, if any, date, hour, and means of remote communication, if any, of every meeting of the Member shall be given by the Corporation not less than 10 days nor more than 60 days before the meeting (unless a different time is specified by law) to the Member. Notices of special meetings shall also specify the purpose or purposes for which the meeting has been called. Notices of meetings to the Member may be given by mailing the same, addressed to the Member, at the Member's mailing address as it appears on the records of the corporation and such notice shall be deemed to be given when deposited in the U.S. mail, postage prepaid. Without limiting the manner by which notices of meetings otherwise may be given effectively to the Member, any such notice may be given by electronic transmission in accordance with applicable law. For purposes of these bylaws, "electronic transmission" means any form of communication, not directly involving the physical transmission of paper, that creates a record that may be retained, retrieved, and reviewed by a recipient thereof, and that may be directly reproduced in paper form by such a recipient through an automated process. -The Board of Directors may adopt by resolution with the approval of the Member such rules and regulations for the conduct of the meeting of the Member as it shall deem appropriate. At every meeting of the Member, the Member, or in his/her absence or inability to act, such other officer or person appointed by the Member, shall act as chair of, and preside at, the meeting. The secretary or, in his/her absence or inability to act, the person whom the chair of the meeting shall appoint secretary of the meeting, shall act as secretary of the meeting and keep the minutes thereof. Except to the extent inconsistent with such rules and regulations as adopted by the Board of Directors, the chair of any meeting shall have the right and authority to prescribe such rules, regulations, and procedures and to do all such acts as, in the judgment of such chair, are appropriate for the proper conduct of the meeting. Such rules, regulations, or procedures, whether adopted by the Board of Directors with approval of the Member or prescribed by the chair of the meeting, may include, without limitation, the following: (a) the establishment of an agenda or order of business for the meeting; and (b) rules and procedures for maintaining order at the meeting and the safety of those present. Meetings of the Member may be held by means of telephone conference or other communications equipment by means of which all persons participating in the meeting can hear e

Form 990, Part VI, Line 8B Documentation of meetings held by committees of governing body

There is no committee with authority to act on behalf of the governing body, so this question has been intentionally answered "no."

Form 990, Part VI, Line 11B Review of form 990 by governing body

THE FORM 990 AND SUPPLEMENTAL SCHEDULES ARE PREPARED AND REVIEWED BY AN EXTERNAL ACCOUNTING FIRM. IT IS THEN REVIEWED INTERNALLY BY MANAGEMENT and the audit committee. A COMPLETE COPY OF THE FORM IS PROVIDED TO ALL MEMBERS OF THE BOARD OF DIRECTORS AND AUDIT COMMITTEE AND THEY ARE REQUESTED TO REVIEW AND SUBMIT ANY QUESTIONS prior to filing.

Form 990, Part VI, Line 12C Conflict of interest policy

The Institute has a conflict of interest policy that requires directors, officers, key employees and other designated individuals to disclose if they have a personal interest or relationship in a transaction involving the Institute, whether directly or indirectly through a family member, controlled entity or business or investment relationship. Any individual with a personal interest or relationship in a transaction involving the Institute must be recused from the discussions and approval for that transaction. The transaction must be reviewed by disinterested persons who do not have a personal interest in the transaction under review, and such disinterested persons may approve the transaction after determining that the terms are fair and reasonable to the Institute.

Form 990, Part VI, Line 19 Required documents available to the public

The organization's governing documents, conflict of interest policy and financial statements are available upon request.

Filing and Contact Details

Filer

Filer Name
Arc Research Institute
EIN
87-1920284
Phone
6508994880
Address
3181 Porter Dr, Palo Alto, CA 94304-1249

Signing Officer

Name
Silvana M Konermann
Title
Executive Director
Phone
6508994880
Signed
2025-11-12
Discuss with paid preparer
Yes

Organization Details

Formed
2021
Legal Domicile
De
Voting Board Members
3
Independent Board Members
3
Employees
155
Volunteers
12

Preparer

Firm
Crowe Llp
Address
575 Market Street Suite 3300, San Francisco, CA 94105-5829
Preparer
Diane Kirmaci
Phone
4155761100
Supplemental Narrative

Additional Explanations

Form 990, Part XI, Line 9 Other changes in net assets or fund balances

REVERSAL OF GRANT FUNDS - -662521; Total - -662521;

Financial Statement Notes

Schedule D, Part X, Line 2 FIN 48 (ASC 740) footnote

The Institute qualifies as a tax-exempt organization under Section 501(c)(3) of the Internal Revenue Code and has been classified as a Medical Research Organization under Section 170(b)(1)(A)(iii). The Institute has adopted accounting guidance related to accounting for uncertainty in income taxes. This guidance requires the Institute to recognize a tax benefit only if it is more likely than not the tax position would be sustained in a tax examination, with a tax examination being presumed to occur. The amount recognized is the largest amount of tax benefit that is greater than 50 percent likely of being realized on examination. For tax positions not meeting the more-likely-than-not test, no tax benefit is recorded. The Institute has examined this issue and has determined there are no material contingent liabilities or questionable tax positions. The Institute does not expect the total amount of unrecognized tax benefits to significantly change in the next 12 months. The Institute recognizes interest and/or penalties to income tax matters in income tax expense. The Institute did not have any amounts accrued for interest and penalties as of December 31, 2024.

Schedule D, Part XII, Line 2(D) Other expenses in audited financial statements not in form 990

Reversal of grant funds - 662521

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IRS990/Desc0- Core Investigators (which include the following labs) are provided with no-strings-attached, multi-year funding as well as cutting-edge scientific and infrastructure support to enable high-risk, high-reward science. They are innovative pioneers enabled to pursue their very best ideas. The Gilbert lab has an expertise in synthetic biology, functional genomics and cancer biology. We build CRISPR epigenetic editing tools to turn genes on and off and to perturb gene regulatory elements. We are developing CRISPR functional genomics approaches to map individual genes or sets of genes that regulate phenotypes of interest in vitro and in vivo. We are focused on utilizing our expertise to tackle big problems in deadly human cancers such as metastasis and drug resistance. The Hsu Lab works at the intersection of synthetic biology and genomics to invent new biotechnologies for improving human health. The Konermann lab develops and applies next-generation functional genomics to understand the cellular and molecular pathways underlying the neuronal system and neurodegenerative disease, with the long-term goal of developing rationally targeted therapeutics for neurodegenerative disorders. The Li Lab combines chemistry, biochemistry, immunology, and physiology to uncover basic mechanisms in innate immunity and, in parallel, develop therapeutic hypotheses and lead molecules. Innate immune pathways as the first line of defense against pathogens present many exciting opportunities for scientists from many disciplines. These pathways are a rich source of novel chemistry: they involve diverse molecular patterns in pathogens, little-explored second messengers, and drugs with poorly understood mechanism. Activation of innate immunity is a proven therapeutic strategy for vaccination, viral infection, and cancer, while inhibition is a strategy for treating autoimmune diseases and neurodegeneration. To date, however, most modulators of innate immunity are broad, non-specific, and poorly characterized, such as killed bacteria, alum crystals, and steroids. The Li lab seeks to improve understanding of these pathways and facilitate the development of more precise drugs for preventing or treating specific diseases. The Horns Lab creates and uses new technologies to understand and manipulate cells. We aim to discover the fundamental principles governing how cells and tissues operate, and to harness these insights to improve human health. Our work unites molecular engineering, synthetic biology, and genomics to answer questions and solve problems in immunology, neuroscience, cancer, and aging. The Goodarzi Lab combines modern experimental and computational technologies to understand complex human diseases at a molecular level. We are predominantly focused on metastatic progression in multiple cancers and neurodegenerative diseases as the biggest challenges to human health in the 21st century. - Technology Development Centers As biomedical research has become more advanced, it has become more dependent on complicated tooling that is difficult or impossible for any single lab to pursue today. Arc Technology Centers are focused on advancing and distributing key biomedical technologies within the institute that require high capital scale, targeted expertise, and systematic innovation. Our Technology Centers provide long-term career options for Arc scientists beyond their training period. By enabling competitive compensation relative to the biotech and tech industries (such as for research scientists and computer programmers), our goal is to expand the ecosystem of available career paths in research and maintain continuity in critical technical know-how. We have 5 staffed Technology Centers focused on 1. Cellular Models 2. Genome Engineering 3. Mammalian Models 4. Multi-omics 5. Computational biology - Translational Programs Making an impact on complex diseases requires new fundamental biological insights into disease mechanisms and new technologies that can ta
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