Liabilities / Assets
60th percentile
Tied with the lowest-debt nonprofits in its peer group.
EIN 85-4079051 • 501(c)3 • Mendenhall, PA
Profile
Support those impacted by foxp1 syndrome and raise funds for further research into foxp1 syndrome and possible treatments.
Precomputed percentiles relative to similar nonprofits. These scores are descriptive rather than judgmental.
Liabilities / Assets
60th percentile
Tied with the lowest-debt nonprofits in its peer group.
Liabilities / Revenue
62nd percentile
Tied with the lowest-debt nonprofits in its peer group.
Net Margin
83rd percentile
Higher net margin than 83% of similar nonprofits.
Top Officer Pay
81st percentile
Higher top officer pay than 81% of similar nonprofits.
Top officer pay equals 0.0% of source-year revenue.
Asset Growth
89th percentile
Faster asset growth than 89% of similar nonprofits.
Revenue Growth
93rd percentile
Faster revenue growth than 93% of similar nonprofits.
Assets
Up$291,034
Up $119,624 (+70%) from 2023
Liabilities
Flat$0
Flat from 2023
Net Assets
Up$291,034
Up $119,624 (+70%) from 2023
Revenue
Up$339,333
Up $193,949 (+133%) from 2023
Expenses
Up$229,022
Up $179,170 (+359%) from 2023
Net Income
Up$110,311
Up $14,779 (+15%) from 2023
Most recent year
2024 • Form 990Detailed filing. Detailed filing data is available for this year.
Support those impacted by foxp1 syndrome and raise funds for further research into foxp1 syndrome and possible treatments.
| Line | Beginning | End | Change |
|---|---|---|---|
| Assets | |||
| Cash and Non-Interest-Bearing Accounts | $171,410 | $291,034 | ▲ $119,624 |
| Rtn Earn Endowment Incm Other Fnds | $171,410 | $291,034 | ▲ $119,624 |
| Pd in Cap Srpls Land Bldg Eqp Fund | $0 | $0 | → $0 |
| Cap Stk Tr Prin Current Funds | $0 | $0 | → $0 |
| Total Assets | $171,410 | $291,034 | ▲ $119,624 |
| Liabilities | |||
| Total Liabilities | $0 | $0 | → $0 |
| Net Assets / Fund Balance | |||
| Total Net Assets Fund Balance | $171,410 | $291,034 | ▲ $119,624 |
| Total Liabilities and Net Assets / Fund Balance | $171,410 | $291,034 | ▲ $119,624 |
| Name | Title |
|---|---|
| Adam Geller | Co-founder & Co-president |
| Karl Whitney | Co-founder & Co-president |
| Katharine Mowery | Vice President |
| Caroline Dury | Member at Large |
| Cheryl Richt | Member at Large |
| Gail Clark | Member at Large |
| Samit Dasgupta | Member at Large |
| Chris Sullivan | Secretary |
| Adam Mowery | Treasurer |
| Line Item | Amount |
|---|---|
| Grants and Similar Amounts Paid | $185,674 |
| Other Expenses | $43,348 |
| Total Fundraising Expense | $5,636 |
| Professional Fundraising Fees | $0 |
| Salaries, Compensation, and Employee Benefits | $0 |
| Line Item | Program | Management | Fundraising | Total |
|---|---|---|---|---|
| Grants to Domestic Orgs | $123,274 | - | - | $123,274 |
| Foreign Grants | $62,400 | - | - | $62,400 |
| Travel | - | $19,488 | - | $19,488 |
| Fees for Services Other | - | $6,783 | - | $6,783 |
| Advertising | - | $3,737 | - | $3,737 |
| Fees for Services Accounting | - | $1,740 | - | $1,740 |
| Insurance | - | $1,253 | - | $1,253 |
| Conferences and Meetings | - | $507 | - | $507 |
| Office Expenses | - | $381 | - | $381 |
| Other Expenses | - | $74 | $5,636 | $74 |
| Total Functional Expenses | $185,674 | $37,712 | $5,636 | $229,022 |
| Recipient | Location | Category | Purpose | Amount |
|---|---|---|---|---|
| Genevieve Konopka and Jay Gibson Ut Southwestern Med Center | Dallas, TX | 501(c)(3) | Research on Functional Restoration of Foxp1 Haploinsufficiency Using Aav-mediated Gene Rescue in the Brain | $73,274 |
| Joseph Buxbaum Seaver Autism Institute Mt Sinai Hospital | New York, NY | 501(c)(3) | Research on Three-dimensional Organoid Model of Foxp1 Syndrome | $50,000 |
| Region | Activity | Services | Offices | Employees | Spending |
|---|---|---|---|---|---|
| Europe (including Iceland & Greenland) | Grant to Recipients Located in the Region | - | 0 | 0 | $62,400 |
| Line Item | Amount |
|---|---|
| Professional Fundraising Fees | $0 |
“Adam mowery and katharine mowery are spouses.”
“Form 990 draft was sent to the board for review and comments.”
“AVAILABLE UPON REQUEST.”
This appendix keeps the raw XML leaves available for debugging and edge-case review. The human report above is the primary experience.
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| IRS990/Desc | 0 | THREE-DIMENSIONAL ORGANOID MODEL OF FOXP1 SYNDROME-THE ULTIMATE GOAL OF THIS PROJECT IS TO DEVELOP AN IN VITRO MEDIUM-TO-HIGH THROUGHPUT ASSAY FOR SCREENING OF COMPOUND LIBRARIES. THE "HITS" FROM SUCH A SCREEN WILL BE DEFINED AS COMPOUNDS THAT "NORMALIZE" THE FOXP1 ORGANOID PHENOTYPE IN A DOSE-DEPENDENT MANNER. WHILE THERE IS NO OBVIOUS MECHANISTIC OR FUNCTIONAL LINK BETWEEN THE ORGANOID PHENOTYPE AND THE CLINICAL PRESENTATIONS, IT IS REASONABLE TO ASSUME THAT CHANGES IN ORGANOID DEVELOPMENT REFLECT CHANGES IN BRAIN DEVELOPMENT AND THAT UTILIZING ORGANOID PHENOTYPES VALIDATED IN PATIENT-DERIVED CELL LINES CARRYING CLINICALLY-RELEVANT MUTATIONS WILL ENSURE IDENTIFICATION OF POTENTIAL DRUG CANDIDATES. THIS APPROACH IS IN LINE WITH THE CURRENT INDUSTRY STANDARDS FOR DEVELOPMENT OF THE HIGH-THROUGHPUT SCREENING ASSAYS. THESE DRUG CANDIDATES (HITS) WILL BE FURTHER VALIDATED IN A NUMBER OF IN VITRO AND IN VIVO ASSAYS TO VALIDATE PRECLINICAL EFFICACY AND PROVIDE MORE MECHANISTIC INSIGHT. |
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| IRS990/MissionDesc | 0 | SUPPORT THOSE IMPACTED BY FOXP1 SYNDROME AND RAISE FUNDS FOR FURTHER RESEARCH INTO FOXP1 SYNDROME AND POSSIBLE TREATMENTS. |
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| IRS990/ProgSrvcAccomActy2Grp/Desc | 0 | FUNCTIONAL RESTORATION OF FOXP1 HAPLOINSUFFICIENCY USING AAV-MEDIATED GENE RESCUE IN THE BRAIN-UNDERSTANDING FOXP1 FUNCTION IN THE MOUSE BRAIN IS CRUCIAL TO DEVELOP EFFECTIVE THERAPEUTICS FOR FOXP1 SYNDROME IN HUMANS. IN THIS PROJECT, WE WILL USE A MOUSE MODEL THAT MIMICS THE GENETIC BASIS OF MANY FORMS OF FOXP1 SYNDROME, WHERE ONLY ONE OUT OF THE TWO FUNCTIONAL COPIES OF FOXP1 GENE IS PRESENT. WE WILL PERFORM INTRACEREBROVENTRICULAR (ICV) INJECTIONS OF A UNIQUE ADENO ASSOCIATED VIRUS (AAV) CALLED AAV9 AND/OR ITS MODIFIED AND IMPROVISED VERSION (AAV-PHP.EB) AT AN EARLY DEVELOPMENTAL STAGE TO RESTORE FOXP1 EXPRESSION IN THE BRAINS OF THESE MICE. IN THIS STRATEGY, FOXP1 WILL BE RE-EXPRESSED UNDER THE CONTROL OF THE HUMAN SYNAPSIN 1 PROMOTER, ENSURING NEURON SPECIFIC EXPRESSION. WE WILL THEN EXAMINE WHETHER FOXP1 GENE REPLACEMENT CAN CORRECT BEHAVIORAL DEFICITS IN THE MICE. IF SUCCESSFUL, WE WILL EXTEND THE GENE RESTORATION TO LATER DEVELOPMENTAL TIME POINTS TO DETERMINE A POTENTIAL CRITICAL WINDOW OF GENE REPLACEMENT THERAPY IN THIS MOUSE MODEL. RESULTS FROM THIS PROJECT SHOULD PROVIDE FUNDAMENTAL KNOWLEDGE ABOUT THE FEASIBILITY OF FOXP1 GENE THERAPY IN HUMANS AND FORM THE BASIS FOR FUTURE CLINICAL TRIALS. |
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| IRS990/ProgSrvcAccomActy3Grp/Desc | 0 | TESTING A POTENTIAL TREATMENT FOR FOXP1 SYNDROME IN STRIATAL ORGANOIDS DERIVED FROM INDIVIDUALS WITH PATHOGENIC FOXP1 VARIANTS -DR. FRHLICH AND PROF. RAPPOLD AT THE INSTITUTE OF HUMAN GENETICS IN HEIDELBERG, GERMANY HAVE DISCOVERED THAT MURINE FOXP1 HAPLOINSUFFICIENCY LEADS TO MITOCHONDRIAL DYSFUNCTION IN THE STRIATUM AND ALTERED EXPRESSION OF STRIATUM-SPECIFIC PHOSPHODIESTERASE 10A (PDE10A), AN ENZYME THAT PLAYS A CRUCIAL ROLE IN THE REGULATION OF BASAL GANGLIA CIRCUITS. SPECIFIC INHIBITION OF PDE10A WITH MP-10 SIGNIFICANTLY IMPROVED THE EXISTING BEHAVIORAL DEFICITS IN THESE ANIMALS. WORKING WITH ORGANOIDS HAS SIGNIFICANT IMPLICATIONS FOR A SAFE AND HUMANE TESTING OF NEW DRUGS, PARTICULARLY WHEN ORGANOIDS ARE GROWN FROM A PATIENT'S OWN CELLS. IN THE PLANNED PROJECT, IPSC LINES DERIVED FROM FOXP1 PATIENT AND CONTROL CELLS WILL BE USED AND DIFFERENTIATED INTO STRIATAL ORGANOIDS TO INVESTIGATE WHETHER MITOCHONDRIAL DYSFUNCTION AND PDE10A DYSREGULATION CAN ALSO BE FOUND IN HUMAN CELLS. IN ADDITION, IT WILL BE ANALYZED HOW THE ADMINISTRATION OF MP-10 AFFECTS GENE EXPRESSION AND SIGNALING PATHWAYS IN STRIATAL MEDIUM SPINY NEURONS AND WHETHER THE DRUG IMPROVES MITOCHONDRIAL FUNCTION. |
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| IRS990ScheduleA/GiftsGrantsContrisRcvd509Grp/CurrentTaxYearMinus1YearAmt | 0 | 145384 |
| IRS990ScheduleA/GiftsGrantsContrisRcvd509Grp/CurrentTaxYearMinus2YearsAmt | 0 | 71764 |
| IRS990ScheduleA/GiftsGrantsContrisRcvd509Grp/CurrentTaxYearMinus3YearsAmt | 0 | 6760 |
| IRS990ScheduleA/GiftsGrantsContrisRcvd509Grp/TotalAmt | 0 | 573125 |
| IRS990ScheduleA/GrossInvestmentIncome509Grp/CurrentTaxYearAmt | 0 | 125 |
| IRS990ScheduleA/GrossInvestmentIncome509Grp/TotalAmt | 0 | 125 |
| IRS990ScheduleA/InvestmentIncomeAndUBTIGrp/CurrentTaxYearAmt | 0 | 125 |
| IRS990ScheduleA/InvestmentIncomeAndUBTIGrp/TotalAmt | 0 | 125 |
| IRS990ScheduleA/InvestmentIncomeCYPct | 0 | 0.00020 |
| IRS990ScheduleA/PubliclySupportedOrg509a2Ind | 0 | X |
| IRS990ScheduleA/PublicSupportCY509Pct | 0 | 0.99980 |
| IRS990ScheduleA/PublicSupportPY509Pct | 0 | 1.00000 |
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| IRS990ScheduleA/Total509Grp/CurrentTaxYearMinus2YearsAmt | 0 | 71764 |
| IRS990ScheduleA/Total509Grp/CurrentTaxYearMinus3YearsAmt | 0 | 6760 |
| IRS990ScheduleA/Total509Grp/TotalAmt | 0 | 573125 |
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| IRS990ScheduleA/TotalSupportCalendarYearGrp/CurrentTaxYearMinus1YearAmt | 0 | 145384 |
| IRS990ScheduleA/TotalSupportCalendarYearGrp/CurrentTaxYearMinus2YearsAmt | 0 | 71764 |
| IRS990ScheduleA/TotalSupportCalendarYearGrp/CurrentTaxYearMinus3YearsAmt | 0 | 6760 |
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| IRS990ScheduleF/AccountActivitiesOutsideUSGrp/RegionTxt | 0 | EUROPE (INCLUDING ICELAND & GREENLAND) |
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| IRS990ScheduleF/ForeignPartnershipInd | 0 | 0 |
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| IRS990ScheduleF/GrantsToOrgOutsideUSGrp/MannerOfCashDisbursementTxt | 0 | ELECTRONIC FUNDS TRANSFER |
| IRS990ScheduleF/GrantsToOrgOutsideUSGrp/NonCashAssistanceAmt | 0 | 0 |
| IRS990ScheduleF/GrantsToOrgOutsideUSGrp/PurposeOfGrantTxt | 0 | TESTING A POTENTIAL TREATMENT FOR FOXP1 SYNDROME IN STRIATAL ORGANOIDS DERIVED FROM INDIVIDUALS WITH PATHOGENIC FOXP1 VARIANTS |
| IRS990ScheduleF/GrantsToOrgOutsideUSGrp/RegionTxt | 0 | EUROPE |
| IRS990ScheduleF/InterestInForeignTrustInd | 0 | 0 |
| IRS990ScheduleF/PassiveForeignInvestmestCoInd | 0 | 0 |
| IRS990ScheduleF/SubtotalEmployeesCnt | 0 | 0 |
| IRS990ScheduleF/SubtotalOfficesCnt | 0 | 0 |
| IRS990ScheduleF/SubtotalSpentAmt | 0 | 62400 |
| IRS990ScheduleF/Total501c3OrgCnt | 0 | 1 |
| IRS990ScheduleF/TotalEmployeeCnt | 0 | 0 |
| IRS990ScheduleF/TotalOfficeCnt | 0 | 0 |
| IRS990ScheduleF/TotalSpentAmt | 0 | 62400 |
| IRS990ScheduleF/TransferToForeignCorpInd | 0 | 0 |
| IRS990ScheduleI/GrantRecordsMaintainedInd | 0 | 1 |
| IRS990ScheduleI/RecipientTable/CashGrantAmt | 0 | 50000 |
| IRS990ScheduleI/RecipientTable/CashGrantAmt | 1 | 73274 |
| IRS990ScheduleI/RecipientTable/IRCSectionDesc | 0 | 501(C)(3) |
| IRS990ScheduleI/RecipientTable/IRCSectionDesc | 1 | 501(C)(3) |
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| IRS990ScheduleI/RecipientTable/NonCashAssistanceAmt | 1 | 0 |
| IRS990ScheduleI/RecipientTable/PurposeOfGrantTxt | 0 | RESEARCH ON THREE-DIMENSIONAL ORGANOID MODEL OF FOXP1 SYNDROME |
| IRS990ScheduleI/RecipientTable/PurposeOfGrantTxt | 1 | RESEARCH ON FUNCTIONAL RESTORATION OF FOXP1 HAPLOINSUFFICIENCY USING AAV-MEDIATED GENE RESCUE IN THE BRAIN |
| IRS990ScheduleI/RecipientTable/RecipientBusinessName/BusinessNameLine1Txt | 0 | JOSEPH BUXBAUM SEAVER AUTISM INSTITUTE MT SINAI HOSPITAL |
| IRS990ScheduleI/RecipientTable/RecipientBusinessName/BusinessNameLine1Txt | 1 | GENEVIEVE KONOPKA AND JAY GIBSON UT SOUTHWESTERN MED CENTER |
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| IRS990ScheduleI/RecipientTable/RecipientEIN | 1 | 756002868 |
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| IRS990ScheduleI/RecipientTable/USAddress/AddressLine1Txt | 1 | 5323 HARRY HINES BLVD |
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| IRS990ScheduleI/RecipientTable/USAddress/ZIPCd | 1 | 75390 |
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| IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt | 0 | ADAM MOWERY AND KATHARINE MOWERY ARE SPOUSES. |
| IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt | 1 | FORM 990 DRAFT WAS SENT TO THE BOARD FOR REVIEW AND COMMENTS. |
| IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt | 2 | AVAILABLE UPON REQUEST. |
| IRS990ScheduleO/SupplementalInformationDetail/FormAndLineReferenceDesc | 0 | FORM 990, PART VI, SECTION A, LINE 2 |
| IRS990ScheduleO/SupplementalInformationDetail/FormAndLineReferenceDesc | 1 | FORM 990, PART VI, SECTION B, LINE 11B |
| IRS990ScheduleO/SupplementalInformationDetail/FormAndLineReferenceDesc | 2 | FORM 990, PART VI, SECTION C, LINE 19 |
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| IRS990/SignificantChangeInd | 0 | 0 |
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| IRS990/TotalFunctionalExpensesGrp/ProgramServicesAmt | 0 | 185674 |
| IRS990/TotalFunctionalExpensesGrp/TotalAmt | 0 | 229022 |
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| IRS990/TotalLiabilitiesBOYAmt | 0 | 0 |
| IRS990/TotalLiabilitiesEOYAmt | 0 | 0 |
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| IRS990/TotalLiabilitiesGrp/EOYAmt | 0 | 0 |
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| IRS990/TotalNetAssetsFundBalanceGrp/EOYAmt | 0 | 291034 |
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| IRS990/TotalRevenueGrp/TotalRevenueColumnAmt | 0 | 339333 |
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| IRS990/TotReportableCompRltdOrgAmt | 0 | 0 |
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| IRS990/TravelGrp/TotalAmt | 0 | 19488 |
| IRS990/TrnsfrExmptNonChrtblRltdOrgInd | 0 | 0 |
| IRS990/TypeOfOrganizationCorpInd | 0 | X |
| IRS990/UnrelatedBusIncmOverLimitInd | 0 | 0 |
| IRS990/UponRequestInd | 0 | X |
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| IRS990/USAddress/CityNm | 0 | MENDENHALL |
| IRS990/USAddress/StateAbbreviationCd | 0 | PA |
| IRS990/USAddress/ZIPCd | 0 | 19357 |
| IRS990/VotingMembersGoverningBodyCnt | 0 | 9 |
| IRS990/VotingMembersIndependentCnt | 0 | 9 |
| IRS990/WebsiteAddressTxt | 0 | WWW.FOXP1.ORG |
| IRS990/WhistleblowerPolicyInd | 0 | 0 |
| ReturnHeader/BuildTS | 0 | 2025-03-06 01:10:19Z |
| ReturnHeader/BusinessOfficerGrp/DiscussWithPaidPreparerInd | 0 | 1 |
| ReturnHeader/BusinessOfficerGrp/PersonNm | 0 | ADAM MOWERY |
| ReturnHeader/BusinessOfficerGrp/PersonTitleTxt | 0 | TREASURER |
| ReturnHeader/BusinessOfficerGrp/PhoneNum | 0 | 7176486109 |
| ReturnHeader/BusinessOfficerGrp/SignatureDt | 0 | 2025-05-13 |
| ReturnHeader/Filer/BusinessName/BusinessNameLine1Txt | 0 | INTERNATIONAL FOXP1 FOUNDATION |
| ReturnHeader/Filer/BusinessNameControlTxt | 0 | INTE |
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