Civic Intelligence

Hunters Cmt4B3 Research Foundation Inc

EIN 85-3259676 • 501(c)3 • New York, NY

Profile

To fund scientific research leading to the discovery, development, and clinical applications for therepeutic treatments and cures for charcot-marie-tooth disease type 4b3 (cmt 4b3), and to improve the quality of life for people with cmt4b3.

180 East 79th Street 3DNew York, NY 10075

www.cmt4b3research.org

Siviq Scores

Precomputed percentiles relative to similar nonprofits. These scores are descriptive rather than judgmental.

Liabilities / Assets

31st percentile

0.01x

Higher debt load relative to assets than 31% of similar nonprofits.

501(c)3 • $1M-$5M nonprofits • Source year 2025

Liabilities / Revenue

34th percentile

0.02x

Higher debt load relative to revenue than 34% of similar nonprofits.

501(c)3 • $1M-$5M nonprofits • Source year 2025

Net Margin

91st percentile

57%

Higher net margin than 91% of similar nonprofits.

501(c)3 • $1M-$5M nonprofits • Source year 2025

Top Officer Pay

40th percentile

$0

Higher top officer pay than 40% of similar nonprofits.

Top officer pay equals 0.0% of source-year revenue.

501(c)3 • $1M-$5M nonprofits • Source year 2025

Asset Growth

86th percentile

34%

Faster asset growth than 86% of similar nonprofits.

501(c)3 • $1M-$5M nonprofits • Annualized from 2024 to 2025

Revenue Growth

68th percentile

22%

Faster revenue growth than 68% of similar nonprofits.

501(c)3 • $1M-$5M nonprofits • Annualized from 2024 to 2025

Balance Sheet
Liabilities / Assets31st percentile

Assets

Up

$1,476,047

Up $376,166 (+34%) from 2024

Liabilities

Down

$11,921

Down $234 (-1.9%) from 2024

Net Assets

Up

$1,464,126

Up $376,400 (+35%) from 2024

Operations
Liabilities / Revenue34th percentileNet Margin91st percentile

Revenue

Up

$608,710

Up $107,875 (+22%) from 2024

Expenses

Up

$259,832

Up $11,636 (+4.7%) from 2024

Net Income

Up

$348,878

Up $96,239 (+38%) from 2024

Trend Graphs

Balance Sheet Trend

Asset Growth86th percentile

Grouped bars show assets, liabilities, and net assets across loaded filings.

$1.5M$1.0M$500K$0Assets 2020: $110,824Liabilities 2020: $02020Assets 2021: $650,515Liabilities 2021: $8,881Net Assets 2021: $641,6342021Assets 2022: $692,726Liabilities 2022: $19,202Net Assets 2022: $673,5242022Assets 2023: $824,518Liabilities 2023: $8,834Net Assets 2023: $815,6842023Assets 2024: $1,099,881Liabilities 2024: $12,155Net Assets 2024: $1,087,7262024Assets 2025: $1,476,047Liabilities 2025: $11,921Net Assets 2025: $1,464,1262025

Highlighted filing

2025

Assets$1,476,047
Liabilities$11,921
Net Assets$1,464,126
Open 2025 Filing

Operations Trend

Revenue Growth68th percentile

Revenue, expenses, and net income by year, with the latest filing highlighted.

$800K$600K$400K$200K$0Revenue 2020: $111,190Expenses 2020: $366Net Income 2020: $110,8242020Revenue 2021: $620,438Expenses 2021: $100,579Net Income 2021: $519,8592021Revenue 2022: $352,665Expenses 2022: $306,267Net Income 2022: $46,3982022Revenue 2023: $407,129Expenses 2023: $287,397Net Income 2023: $119,7322023Revenue 2024: $500,835Expenses 2024: $248,196Net Income 2024: $252,6392024Revenue 2025: $608,710Expenses 2025: $259,832Net Income 2025: $348,8782025

Highlighted filing

2025

Revenue$608,710
Expenses$259,832
Net Income$348,878
Open 2025 Filing

Filings

Most recent year

2025 • Form 990Detailed filing. Detailed filing data is available for this year.

Open filing
Assets
$1,476,047
Liabilities
$11,921
Net assets
$1,464,126
Revenue
$608,710
Expenses
$259,832
Net income
$348,878
Balance SheetOperations
YearAssetsLiabilitiesNet AssetsRevenueExpensesNet Income
2025Detailed filing. Detailed filing data is available for this year.$1.48$0.01$1.46$0.61$0.26$0.35
2024Detailed filing. Detailed filing data is available for this year.$1.10$0.01$1.09$0.50$0.25$0.25
2023Detailed filing. Detailed filing data is available for this year.$0.82$0.01$0.82$0.41$0.29$0.12
2022Detailed filing. Detailed filing data is available for this year.$0.69$0.02$0.67$0.35$0.31$0.05
2021Detailed filing. Detailed filing data is available for this year.$0.65$0.01$0.64$0.62$0.10$0.52
2020Summary only. Only limited summary data is available for this year.$0.11$0.00$0.11$0.00$0.11
Latest Filing Detail
Jump To
Filing Snapshot
Filing Period
Jan 1, 2025 to Dec 31, 2025
Signed
Feb 12, 2026
Return Version
2025v4.0
Gross Receipts
$701,889
Mission and Program Overview

Mission

To fund scientific research leading to the discovery, development, and clinical applications for therepeutic treatments and cures for charcot-marie-tooth disease type 4b3 (cmt 4b3), and to improve the quality of life for people with cmt4b3.

To fund scientific research leading to the discovery and development of cures for cmt4b3.

Balance Sheet Detail
LineBeginningEndChange
Assets
Investments in Publicly Traded Securities$1,009,534$1,402,322▲ $392,788
Cash and Non-Interest-Bearing Accounts$85,347$73,725▼ $11,622
Prepaid Expenses and Deferred Charges$5,000$0▼ $5,000
Total Assets$1,099,881$1,476,047▲ $376,166
Liabilities
Accounts Payable and Accrued Expenses$12,155$11,921▼ $234
Total Liabilities$12,155$11,921▼ $234
Net Assets / Fund Balance
Net Assets Without Donor Restrictions$1,087,726$1,464,126▲ $376,400
Total Net Assets Fund Balance$1,087,726$1,464,126▲ $376,400
Total Liabilities and Net Assets / Fund Balance$1,099,881$1,476,047▲ $376,166
Compensation and Service Providers
Top Officer Pay40th percentile

Board Members and Trustees

NameTitle
Iris SchultzPresident
Brett SchultzVice President
Amy Cayne SchwartzDirector
Harry FeinbergDirector
Lianne Chan CappoDirector
Mandeep Kaur ChohanDirector
Lindsay ZakenSecretary
Robin SchultzTreasurer
Revenue and Support

Revenue Composition

Contributions and Grants
$558,628
Program Service Revenue
$0
Investment Income
$50,082
Other Revenue
$0
All Other Contributions
$219,981
Change in Net Assets
$348,878
Expenses and Functional Allocation

Major Expense Lines

Line ItemAmount
Grants and Similar Amounts Paid$208,468
Other Expenses$51,364
Total Fundraising Expense$15,765
Professional Fundraising Fees$0
Salaries, Compensation, and Employee Benefits$0

Functional Expense Allocation

Line ItemProgramManagementFundraisingTotal
Grants to Domestic Orgs$189,659--$189,659
Foreign Grants$18,809--$18,809
Advertising$543$780$10,686$12,009
Conferences and Meetings$10,132$1,198-$11,330
Fees for Services Legal-$7,250-$7,250
Office Expenses-$1,101$5,055$6,156
Insurance-$863-$863
Fees for Service Investment Mgmnt Fees-$95-$95
Other Expenses$652$34$24$58
Total Functional Expenses$219,795$24,272$15,765$259,832
International Activity

Grant and Assistance Recipients

RecipientLocationCategoryPurposeAmount
University of MiamiMiami, FL-Developing Human Platforms for Therapy Developments$87,992
Johns HopkinsBaltimore, MD-Discovering Cell Type Specific Biology of Mtmr5$80,000
Johns HopkinsBaltimore, MD-Mount Eye Characterization and Treatment Development$21,667

International Summary

Offices
0
Employees
0
Spending
$18,809

International Compliance

Foreign grant records maintained
Yes
Activity in boycott countries
No
Foreign corporation ownership
No
Foreign partnership interest
No
Interest in foreign trust
No
Passive foreign investment company interest
No
Transfers to foreign corporations
No

International Activities

RegionActivityServicesOfficesEmployeesSpending
North America - Canada and Mexico, But Not the United StatesGrant MakingResearch Grants--$18,809
Fundraising, Events, and Gaming
Fundraising activities
Yes
Gaming activities
No
Professional fundraiser used
No

Fundraising and Gaming Totals

Line ItemAmount
Fundraising Direct Expenses$93,179
Fundraising Gross Income$93,179
Professional Fundraising Fees$0

Fundraising Events

EventGross ReceiptsGross RevenueDirect ExpensesNet Income
Golf Outing$431,826$93,179$30,511$62,668
Total Events$431,826$93,179$93,179$0
Political and Lobbying Activity
Political campaign activity
No
Lobbying activity
No
Subject to proxy tax
No
Governance and Compliance

Governance Checklist

Compiled or reviewed by an accountant
Yes
Annual disclosure for covered persons
Yes
Audit committee
Yes
Business relationship with 35% controlled entity
No
Business relationship with family members
No
Business relationship with organization members
No
Material changes to governing documents
No
Compensation from other sources disclosed
No
CEO compensation reviewed
No
Other officer compensation reviewed
No
Conflict-of-interest policy
Yes
Audited financial statements prepared
No
Key decisions subject to board approval
No
Management duties delegated
No

Governance Explanations

Form 990, Part VI, Section A, Line 2

“Iris and brett schultz are married robin schultz is brett's mother lindsay zaken is the niece of robin schultz”

Form 990, Part VI, Section B, Line 11B

“Hunters cmt4b3 research foundation provides and electronic copy of the draft form 990 to all board members prior to filing, as well as the final copy filed with the irs to be kept in their board notebook.”

Form 990, Part VI, Section B, Line 12C

“All board members and officers fill out and sign a document annually asserting they have read and understood the conflict of interest policy and disclose their compliance. The conflict of interest policy is reviewed and updated annually. The organization has an annual workshop for all board members. The board chairman and ceo review and monitor the conflict of interest disclosures. If a conflict of interest is identified, the responsible person shall refrain from any action that may affect cmt4b3's participation in such contract of transaction.”

Form 990, Part VI, Section C, Line 18

“The 990 is available through guidestar and on the irs website”

Form 990, Part VI, Section C, Line 19

“Copies are sent upon written request.”

Filing and Contact Details

Filer

Filer Name
Hunters Cmt4b3 Research Foundation Inc
EIN
85-3259676
Phone
9174532319
Address
180 EAST 79TH STREET 3D, NEW YORK, NY 10075

Signing Officer

Name
Iris Schultz
Title
President
Phone
9145898047
Signed
2026-02-12
Discuss with paid preparer
Yes

Organization Details

Principal Officer
Iris Schultz
Formed
2020
Legal Domicile
De
Voting Board Members
8
Independent Board Members
8
Employees
0
Volunteers
0

Preparer

Firm
TOBIN & COMPANY CPA'S
Address
2500 WESTCHESTER AVENUE, PURCHASE, NY 10577
Preparer
Brian Wiener CPA
Phone
9148332200
Supplemental Narrative

Additional Explanations

Form 990, Part XII, Line 2C

“The organization has not changed its oversight process during the year.”

Raw XML AppendixShowing 400 of 463 raw XML fields

This appendix keeps the raw XML leaves available for debugging and edge-case review. The human report above is the primary experience.

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IRS990/Desc0CMT4B3 AWARDS RESEARCH FELLOWSHIP AND GRANTS FOR RESEARCH ON CHARCOT-MARIE-TOOTH DISEASE TYPE 4B3. IT ALSO HOSTS ANNUAL MEETINGS OF ALL RESEARCHERS RECEIVING ITS FUNDING AND ITS SCIENTIFIC ADVISORY BOARD TO PROMOTE KNOWLEDGE EXCHANGE AND SYNERGY. IT USES THE SERVICES OF ITS SCIENTIFIC ADVISORY BOARD TO CAREFULLY OVERSEE AND REVIEW THE SELECTION OF THE RECIPIENTS OF THE RESEARCH FUNDING. THE SAB EVALUATES EACH PROPOSAL BASED ON THE EXCELLENCE OF THE INVESTIGATOR, THE WORK PLAN AND THE PROPOSALS' ABILITY TO BE TRANSLATED INTO TREATMENTS FOR PEOPLE WITH CMT4B3. APPLICATIONS ARE REVIEWED ON A ROLLING BASIS. THE LAW FIRM OF KATTEN MUCHIN ROSENMAN, LLP WRITES THE GRANT AGREEMENT CONTRACTS WITH THESE RESEARCHERS, UNIVERSITIES, OR ACADEMIC INSTITUTIONS.THE BOARD MEMBERS, IRIS SCHULTZ AND ROBIN SCHULTZ, ATTEND THE YEARLY MEETING OF THE PERIPHERAL NERVE SOCIETY AND THE CMTRF ANNUAL CONFERENCE. CMT4B3 IS LISTED AS A PATIENT RESOURCE OF THE PNS. ATTENDANCE AT THE PNS GIVES BOARD MEMBERS THE ABILITY TO MEET WITH AND EXCHANGE IDEAS WITH INTERNATIONAL RESEARCHERS OF CMT AND CMT4B3.CMT4B3 MAINTAINS A WEBSITE FOR PATIENTS, THEIR FAMILIES AND MEDICAL PRACTITIONERS TO ASSIST IN UNDERSTANDING AND TREATING CHARCOT-MARIE-TOOTH DISEASE TYPE 4B3. THE WEBSITE CONTAINS LINKS TO OUR RESEARCH PROJECTS, A NEW PATIENT PORTAL TO JOIN OUR NEUROGENETICS REGISTRY AND THE ABILITY TO JOIN OUR NATURAL HISTORY STUDIES. CMT4B3 PRODUCES EDUCATIONAL MATERIALS DISSEMINATED AT CONFERENCES AND AT PUBLIC EVENTS TO RAISE AWARENESS. CMT4B3 MAINTAINS CLIENT MANAGEMENT SOFTWARE. IT RETAINS ACCOUNTING SERVICES. CMT4B3 FOUNDATION IS COMPOSED OF VOLUNTEERS WHO WORK FROM HOME AND DO NOT TAKE ANY SALARIES.THE FOUNDATION MAINTAINS A BIOREPOSITORY OF CMT4B3 CELLULAR MODELS AND RENEWABLE BIOLOGICAL RESOURCES AT SAMPLED, LOCATED IN PISCATAWAY, NEW JERSEY. THE FOUNDATION COLLECTS AND STORES MOLECULAR BIOLOGY SAMPLES FROM CMT4B3 PATIENTS AND THEIR IMMEDIATE FAMILY MEMBERS AT NO COST TO THE PATIENTS. SAMPLES ARE PROVIDED TO LABORATORIES AND RESEARCHERS WORLDWIDE AT NO COST, UPON REQUEST. THE SCIENTIFIC ADVISORY BOARD MEMBERS ARE REQUIRED TO SIGN CONFIDENTIALITY AGREEMENTS.
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IRS990/PrepaidExpensesDefrdChargesGrp/BOYAmt05000
IRS990/PrepaidExpensesDefrdChargesGrp/EOYAmt00
IRS990/PrincipalOfficerNm0IRIS SCHULTZ
IRS990/ProfessionalFundraisingInd00
IRS990/ProhibitedTaxShelterTransInd00
IRS990/PYBenefitsPaidToMembersAmt00
IRS990/PYContributionsGrantsAmt0467417
IRS990/PYExcessBenefitTransInd00
IRS990/PYGrantsAndSimilarPaidAmt0189118
IRS990/PYInvestmentIncomeAmt033418
IRS990/PYOtherExpensesAmt059078
IRS990/PYOtherRevenueAmt00
IRS990/PYProgramServiceRevenueAmt00
IRS990/PYRevenuesLessExpensesAmt0252639
IRS990/PYSalariesCompEmpBnftPaidAmt00
IRS990/PYTotalExpensesAmt0248196
IRS990/PYTotalProfFndrsngExpnsAmt00
IRS990/PYTotalRevenueAmt0500835
IRS990/QuidProQuoContributionsInd00
IRS990/ReconcilationRevenueExpnssAmt0348878
IRS990/RegularMonitoringEnfrcInd01
IRS990/RelatedEntityInd00
IRS990/RelatedOrganizationCtrlEntInd00
IRS990/ReportInvestmentsOtherSecInd00
IRS990/ReportLandBuildingEquipmentInd00
IRS990/ReportOtherAssetsInd00
IRS990/ReportOtherLiabilitiesInd00
IRS990/ReportProgramRelatedInvstInd00
IRS990ScheduleA/AmountsRcvdDsqlfyPersonGrp/TotalAmt00
IRS990ScheduleA/GiftsGrantsContrisRcvd509Grp/CurrentTaxYearAmt0219981
IRS990ScheduleA/GiftsGrantsContrisRcvd509Grp/CurrentTaxYearMinus1YearAmt0204882
IRS990ScheduleA/GiftsGrantsContrisRcvd509Grp/CurrentTaxYearMinus2YearsAmt0184066
IRS990ScheduleA/GiftsGrantsContrisRcvd509Grp/CurrentTaxYearMinus3YearsAmt0347900
IRS990ScheduleA/GiftsGrantsContrisRcvd509Grp/CurrentTaxYearMinus4YearsAmt0620436
IRS990ScheduleA/GiftsGrantsContrisRcvd509Grp/TotalAmt01577265
IRS990ScheduleA/GrossInvestmentIncome509Grp/CurrentTaxYearAmt077510
IRS990ScheduleA/GrossInvestmentIncome509Grp/CurrentTaxYearMinus1YearAmt052823
IRS990ScheduleA/GrossInvestmentIncome509Grp/CurrentTaxYearMinus2YearsAmt018182
IRS990ScheduleA/GrossInvestmentIncome509Grp/CurrentTaxYearMinus3YearsAmt04265
IRS990ScheduleA/GrossInvestmentIncome509Grp/CurrentTaxYearMinus4YearsAmt02
IRS990ScheduleA/GrossInvestmentIncome509Grp/TotalAmt0152782
IRS990ScheduleA/GrossReceiptsAdmissionsGrp/CurrentTaxYearAmt0431826
IRS990ScheduleA/GrossReceiptsAdmissionsGrp/CurrentTaxYearMinus1YearAmt0355093
IRS990ScheduleA/GrossReceiptsAdmissionsGrp/CurrentTaxYearMinus2YearsAmt0276963
IRS990ScheduleA/GrossReceiptsAdmissionsGrp/TotalAmt01063882
IRS990ScheduleA/InvestmentIncomeAndUBTIGrp/CurrentTaxYearAmt077510
IRS990ScheduleA/InvestmentIncomeAndUBTIGrp/CurrentTaxYearMinus1YearAmt052823
IRS990ScheduleA/InvestmentIncomeAndUBTIGrp/CurrentTaxYearMinus2YearsAmt018182
IRS990ScheduleA/InvestmentIncomeAndUBTIGrp/CurrentTaxYearMinus3YearsAmt04265
IRS990ScheduleA/InvestmentIncomeAndUBTIGrp/CurrentTaxYearMinus4YearsAmt02
IRS990ScheduleA/InvestmentIncomeAndUBTIGrp/TotalAmt0152782
IRS990ScheduleA/InvestmentIncomeCYPct00.05470
IRS990ScheduleA/InvestmentIncomePYPct00.03390
IRS990ScheduleA/PubliclySupportedOrg509a2Ind0X
IRS990ScheduleA/PublicSupportCY509Pct00.94530
IRS990ScheduleA/PublicSupportPY509Pct00.96610
IRS990ScheduleA/PublicSupportTotal509Amt02641147
IRS990ScheduleA/SubstAndDsqlfyPrsnsTotGrp/TotalAmt00
IRS990ScheduleA/SubstantialContributorsAmtGrp/TotalAmt00
IRS990ScheduleA/ThirtyThrPctSuprtTestsCY509Ind0X
IRS990ScheduleA/Total509Grp/CurrentTaxYearAmt0651807
IRS990ScheduleA/Total509Grp/CurrentTaxYearMinus1YearAmt0559975
IRS990ScheduleA/Total509Grp/CurrentTaxYearMinus2YearsAmt0461029
IRS990ScheduleA/Total509Grp/CurrentTaxYearMinus3YearsAmt0347900
IRS990ScheduleA/Total509Grp/CurrentTaxYearMinus4YearsAmt0620436
IRS990ScheduleA/Total509Grp/TotalAmt02641147
IRS990ScheduleA/TotalSupportCalendarYearGrp/CurrentTaxYearAmt0729317
IRS990ScheduleA/TotalSupportCalendarYearGrp/CurrentTaxYearMinus1YearAmt0612798
IRS990ScheduleA/TotalSupportCalendarYearGrp/CurrentTaxYearMinus2YearsAmt0479211
IRS990ScheduleA/TotalSupportCalendarYearGrp/CurrentTaxYearMinus3YearsAmt0352165
IRS990ScheduleA/TotalSupportCalendarYearGrp/CurrentTaxYearMinus4YearsAmt0620438
IRS990ScheduleA/TotalSupportCalendarYearGrp/TotalAmt02793929
IRS990ScheduleB/ContributorInformationGrp/ContributorBusinessName/BusinessNameLine10RESTRICTED
IRS990ScheduleB/ContributorInformationGrp/ContributorNum0RESTRICTED
IRS990ScheduleB/ContributorInformationGrp/ContributorUSAddress/AddressLine10RESTRICTED
IRS990ScheduleB/ContributorInformationGrp/ContributorUSAddress/AddressLine20RESTRICTED
IRS990ScheduleB/ContributorInformationGrp/ContributorUSAddress/City0RESTRICTED
IRS990ScheduleB/ContributorInformationGrp/ContributorUSAddress/State0RESTRICTED
IRS990ScheduleB/ContributorInformationGrp/ContributorUSAddress/ZIPCode0RESTRICTED
IRS990ScheduleB/ContributorInformationGrp/TotalContributionsAmt0RESTRICTED
IRS990/ScheduleBRequiredInd01
IRS990ScheduleF/AccountActivitiesOutsideUSGrp/RegionTotalExpendituresAmt018809
IRS990ScheduleF/AccountActivitiesOutsideUSGrp/RegionTxt0NORTH AMERICA - CANADA AND MEXICO, BUT NOT THE UNITED STATES
IRS990ScheduleF/AccountActivitiesOutsideUSGrp/SpecificServicesProvidedTxt0RESEARCH GRANTS
IRS990ScheduleF/AccountActivitiesOutsideUSGrp/TypeOfActivitiesConductedTxt0GRANT MAKING
IRS990ScheduleF/BoycottCountriesInd00
IRS990ScheduleF/ContinuationSpentAmt00
IRS990ScheduleF/ContinuationTotalEmployeeCnt00
IRS990ScheduleF/ContinuationTotalOfficeCnt00
IRS990ScheduleF/ForeignCorpOwnershipInd00
IRS990ScheduleF/ForeignPartnershipInd00
IRS990ScheduleF/GrantRecordsMaintainedInd01
IRS990ScheduleF/GrantsToOrgOutsideUSGrp/CashGrantAmt018809
IRS990ScheduleF/GrantsToOrgOutsideUSGrp/MannerOfCashDisbursementTxt0WIRE
IRS990ScheduleF/GrantsToOrgOutsideUSGrp/NonCashAssistanceAmt00
IRS990ScheduleF/GrantsToOrgOutsideUSGrp/PurposeOfGrantTxt0INVESTIGATING CMT4B3
IRS990ScheduleF/GrantsToOrgOutsideUSGrp/RegionTxt0NORTH AMERICA - CANADA AND MEXICO, BUT NOT THE UNITED STATES
IRS990ScheduleF/GrantsToOrgOutsideUSGrp/ValuationMethodUsedDesc0FMV
IRS990ScheduleF/InterestInForeignTrustInd00
IRS990ScheduleF/PassiveForeignInvestmestCoInd00
IRS990ScheduleF/SubtotalEmployeesCnt00
IRS990ScheduleF/SubtotalOfficesCnt00
IRS990ScheduleF/SubtotalSpentAmt018809
IRS990ScheduleF/SupplementalInformationDetail/ExplanationTxt0CMT4B3 REQUIRES (BY CONTRACT) PERIOD PROGRESS REPORTS ON THE FUNDED RESEARCH. THE PROGRESS REPORTS ARE REVIEWED BY THE SCIENTIFIC ADVISORY BOARD AND THE BOARD OF DIRECTORS. ITS GRANT AGREEMENT CONTRACTS ALSO INCLUDE A FULL RESEARCH PLAN WITH BUDGETS AND DELIVERABLES. CMT4B3 USES THE SERVICES OF ITS SCIENTIFIC ADVISORY BOARD WHEN REVIEWING INTERNATIONAL GRANTEES, TO CAREFULLY OVERSEE AND REVIEW THE SELECTION OF THE RECIPIENTS OF THE RESEARCH FUNDING. THE SAB EVALUATES EACH PROPOSAL BASED ON THE EXCELLENCE OF THE INTERNATIONAL INVESTIGATOR, THE WORK PLAN, AND THE PROPOSALS' ABILITY TO BE TRANSLATED INTO TREATMENTS FOR PEOPLE. WITH CMT4B3. APPLICATIONS ARE REVIEWED ON A ROLLING BASIS.
IRS990ScheduleF/SupplementalInformationDetail/ExplanationTxt1PROFESSOR JIM DOWLING - SICK KIDS HOSPITAL - DRUG DISCOVERY FOR CMT4B3 USING ZEBRAFISH MODEL PATIENTS WITH CMT4B3 HAVE BIALLELIC, LOSS OF EXPRESSION/FUNCTION MUTATIONS IN MTMR5. USING CRISPR/CAS9 GENE EDITING, WE WILL ACCURATELY MODEL THE DISEASE BY CREATING BIALLELIC NULL MUTATIONS IN MTMR5. WE WILL CHARACTERIZE THE RESULTING PHENOTYPE OF THESE MTMR5 "KNOCKOUT" FISH, WITH AN EMPHASIS ON IDENTIFYING PHENOTYPES SUITABLE FOR DRUG SCREENING.
IRS990ScheduleF/SupplementalInformationDetail/FormAndLineReferenceDesc0PART I, LINE 2:
IRS990ScheduleF/SupplementalInformationDetail/FormAndLineReferenceDesc1SUPPLEMENTAL INFORMATION (PART V, OTHER)
IRS990ScheduleF/TotalEmployeeCnt00
IRS990ScheduleF/TotalOfficeCnt00
IRS990ScheduleF/TotalSpentAmt018809
IRS990ScheduleF/TransferToForeignCorpInd00
IRS990ScheduleG/FundraisingEventInformationGrp/CharitableContributionsTotAmt0338647
IRS990ScheduleG/FundraisingEventInformationGrp/CharitableContriEvent1Amt0338647
IRS990ScheduleG/FundraisingEventInformationGrp/DirectExpenseSummaryEventsAmt093179
IRS990ScheduleG/FundraisingEventInformationGrp/EntertainmentEvent1Amt01750
IRS990ScheduleG/FundraisingEventInformationGrp/EntertainmentTotalEventsAmt01750
IRS990ScheduleG/FundraisingEventInformationGrp/Event1Nm0GOLF OUTING
IRS990ScheduleG/FundraisingEventInformationGrp/GrossReceiptsEvent1Amt0431826
IRS990ScheduleG/FundraisingEventInformationGrp/GrossReceiptsTotalAmt0431826
IRS990ScheduleG/FundraisingEventInformationGrp/GrossRevenueEvent1Amt093179
IRS990ScheduleG/FundraisingEventInformationGrp/GrossRevenueTotalEventsAmt093179
IRS990ScheduleG/FundraisingEventInformationGrp/NetIncomeSummaryAmt00
IRS990ScheduleG/FundraisingEventInformationGrp/OthDirectExpnssTotalEventsAmt030511
IRS990ScheduleG/FundraisingEventInformationGrp/OtherDirectExpensesEvent1Amt030511
IRS990ScheduleG/FundraisingEventInformationGrp/RentFacilityCostsEvent1Amt060918
IRS990ScheduleG/FundraisingEventInformationGrp/RentFcltyCostsTotalEventsAmt060918
IRS990ScheduleI/GrantRecordsMaintainedInd01
IRS990ScheduleI/RecipientTable/CashGrantAmt080000
IRS990ScheduleI/RecipientTable/CashGrantAmt187992
IRS990ScheduleI/RecipientTable/CashGrantAmt221667
IRS990ScheduleI/RecipientTable/NonCashAssistanceAmt00
IRS990ScheduleI/RecipientTable/NonCashAssistanceAmt10
IRS990ScheduleI/RecipientTable/NonCashAssistanceAmt20
IRS990ScheduleI/RecipientTable/PurposeOfGrantTxt0DISCOVERING CELL TYPE SPECIFIC BIOLOGY OF MTMR5
IRS990ScheduleI/RecipientTable/PurposeOfGrantTxt1DEVELOPING HUMAN PLATFORMS FOR THERAPY DEVELOPMENTS
IRS990ScheduleI/RecipientTable/PurposeOfGrantTxt2MOUNT EYE CHARACTERIZATION AND TREATMENT DEVELOPMENT
IRS990ScheduleI/RecipientTable/RecipientBusinessName/BusinessNameLine1Txt0JOHNS HOPKINS
IRS990ScheduleI/RecipientTable/RecipientBusinessName/BusinessNameLine1Txt1UNIVERSITY OF MIAMI
IRS990ScheduleI/RecipientTable/RecipientBusinessName/BusinessNameLine1Txt2JOHNS HOPKINS
IRS990ScheduleI/RecipientTable/USAddress/AddressLine1Txt03400 N CHARLES ST
IRS990ScheduleI/RecipientTable/USAddress/AddressLine1Txt11320 S DIXIE HIGHWAY
IRS990ScheduleI/RecipientTable/USAddress/AddressLine1Txt2733 N BROADWAY SUITE 117
IRS990ScheduleI/RecipientTable/USAddress/CityNm0BALTIMORE
IRS990ScheduleI/RecipientTable/USAddress/CityNm1MIAMI
IRS990ScheduleI/RecipientTable/USAddress/CityNm2BALTIMORE
IRS990ScheduleI/RecipientTable/USAddress/StateAbbreviationCd0MD
IRS990ScheduleI/RecipientTable/USAddress/StateAbbreviationCd1FL
IRS990ScheduleI/RecipientTable/USAddress/StateAbbreviationCd2MD
IRS990ScheduleI/RecipientTable/USAddress/ZIPCd021218
IRS990ScheduleI/RecipientTable/USAddress/ZIPCd133146
IRS990ScheduleI/RecipientTable/USAddress/ZIPCd221205
IRS990ScheduleI/SupplementalInformationDetail/ExplanationTxt0THE FOUNDATION REQUIRES BY CONTRACT PERIOD PROGRESS REPORTS ON THE FUNDED RESEARCH. THE PROGRESS REPORTS ARE REVIEWED BY THE SCIENTIFIC ADVISORY BOARD AND THE BOARD OF DIRECTORS. ITS GRANT AGREEMENT CONTRACTS ALSO INCLUDE A FULL RESEARCH PLAN WITH BUDGETS AND DELIVERABLES. THE FOUNDATION USES THE SERVICES OF ITS SCIENTIFIC ADVISORY BOARD WHEN REVIEWING DOMESTIC GRANTEES, TO CAREFULLY OVERSEE AND REVIEW THE SELECTION OF THE RECIPIENTS OF THE RESEARCH FUNDING. THE SAB EVALUATES EACH PROPOSAL BASED ON THE EXCELLENCE OF THE DOMESTIC INVESTIGATOR, THE WORK PLAN AND THE PROPOSALS ABILITY TO BE TRANSLATED INTO TREATMENTS FOR PEOPLE WITH CMT4B3. APPLICATIONS ARE REVIEWED ON A ROLLING BASIS.
IRS990ScheduleI/SupplementalInformationDetail/ExplanationTxt1JASON CHUA - JOHN HOPKINS PURPOSE: DISCOVERING THE CELL-TYPE SPECIFIC BIOLOGY OF MTMR5 USING A NOVEL IPSC-DERIVED MODEL SYSTEM OF CMT4B3 AIM 1: ESTABLISH A PSN MODEL SYSTEM OF CMT4B3 AIM 2: DISCOVER THE NEUTRAL INTERACTOME OF MTMR5 DR. STEPHAN ZUCHNER, UNIVERSITY OF MIAMI PURPOSE: MTMR5 MINIGENE CONSTRUCTION AND VALIDATION TO CURE CMT4B3. AIM 1: CONSTRUCT UP TO 20 CANDIDATE MTMR5 MINIGENE IN SILICO MODELS, BASED ON STRUCTURAL, CONSERVATION, AND OTHER CONSIDERATIONS AIM 2: TEST THESE MODELS IN DIFFERENT PROTEIN MODELING PROGRAMS AND ITERATIVELY IMPROVE UPON THEIR DESIGN. SELECT THE 5 BEST MODELS. AIM 3: SYNTHESIZE THE 5 BEST MTMR5 MODELS, CREATE VECTORS FOR IN VITRO CELL TRANSFECTION OF HEK293 OR SIMILAR CELL FOR EVALUATING TOXICITY. DR. JEFFERSON DOYLE PURPOSE: OCULAR PHENOTYPING OF MOUSE MODEL FOR CMT4B3 AIM 1: OCULAR IMAGING OF SBF1 MICE TO EVALUATE FOR AXIAL MYOPIA AND OTHER OCULAR PATHOLOGY. AIM 2: EVALUATE THE EFFECT OF ATROPINE EYE DROPS ON EYE GROWTH IN SBF1 MICE AIM 3: EX-VIVO EVALUATION OF EYES AND OTHER TISSUES IN PLACEBO AND ATROPINE TREATED SBF1 MICE
IRS990ScheduleI/SupplementalInformationDetail/FormAndLineReferenceDesc0PART I, LINE 2:
IRS990ScheduleI/SupplementalInformationDetail/FormAndLineReferenceDesc1ADDITIONAL INFORMATION FOR SCHEDULE I
IRS990/ScheduleJRequiredInd00
IRS990/ScheduleORequiredInd01
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt0IRIS AND BRETT SCHULTZ ARE MARRIED ROBIN SCHULTZ IS BRETT'S MOTHER LINDSAY ZAKEN IS THE NIECE OF ROBIN SCHULTZ
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt1HUNTERS CMT4B3 RESEARCH FOUNDATION PROVIDES AND ELECTRONIC COPY OF THE DRAFT FORM 990 TO ALL BOARD MEMBERS PRIOR TO FILING, AS WELL AS THE FINAL COPY FILED WITH THE IRS TO BE KEPT IN THEIR BOARD NOTEBOOK.
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt2ALL BOARD MEMBERS AND OFFICERS FILL OUT AND SIGN A DOCUMENT ANNUALLY ASSERTING THEY HAVE READ AND UNDERSTOOD THE CONFLICT OF INTEREST POLICY AND DISCLOSE THEIR COMPLIANCE. THE CONFLICT OF INTEREST POLICY IS REVIEWED AND UPDATED ANNUALLY. THE ORGANIZATION HAS AN ANNUAL WORKSHOP FOR ALL BOARD MEMBERS. THE BOARD CHAIRMAN AND CEO REVIEW AND MONITOR THE CONFLICT OF INTEREST DISCLOSURES. IF A CONFLICT OF INTEREST IS IDENTIFIED, THE RESPONSIBLE PERSON SHALL REFRAIN FROM ANY ACTION THAT MAY AFFECT CMT4B3'S PARTICIPATION IN SUCH CONTRACT OF TRANSACTION.
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt3THE 990 IS AVAILABLE THROUGH GUIDESTAR AND ON THE IRS WEBSITE
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt4COPIES ARE SENT UPON WRITTEN REQUEST.
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt5THE ORGANIZATION HAS NOT CHANGED ITS OVERSIGHT PROCESS DURING THE YEAR.
IRS990ScheduleO/SupplementalInformationDetail/FormAndLineReferenceDesc0FORM 990, PART VI, SECTION A, LINE 2
IRS990ScheduleO/SupplementalInformationDetail/FormAndLineReferenceDesc1FORM 990, PART VI, SECTION B, LINE 11B
IRS990ScheduleO/SupplementalInformationDetail/FormAndLineReferenceDesc2FORM 990, PART VI, SECTION B, LINE 12C
IRS990ScheduleO/SupplementalInformationDetail/FormAndLineReferenceDesc3FORM 990, PART VI, SECTION C, LINE 18
IRS990ScheduleO/SupplementalInformationDetail/FormAndLineReferenceDesc4FORM 990, PART VI, SECTION C, LINE 19
IRS990ScheduleO/SupplementalInformationDetail/FormAndLineReferenceDesc5FORM 990, PART XII, LINE 2C
IRS990/SchoolOperatingInd00
IRS990/SignificantChangeInd00
IRS990/SignificantNewProgramSrvcInd00
IRS990/StatesWhereCopyOfReturnIsFldCd0NY
IRS990/SubjectToExcsTaxNetInvstIncInd00
IRS990/SubjectToProxyTaxInd00
IRS990/SubjToTaxRmnrtnExPrchtPymtInd00
IRS990/TaxablePartyNotificationInd00
IRS990/TaxExemptBondsInd00
IRS990/TerminateOperationsInd00
IRS990/TotalAssetsBOYAmt01099881
IRS990/TotalAssetsEOYAmt01476047
IRS990/TotalAssetsGrp/BOYAmt01099881
IRS990/TotalAssetsGrp/EOYAmt01476047
IRS990/TotalCompGreaterThan150KInd00

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