Epigenetic Clock Development Corporation

“Financials are prepared by a bookkeeper with input from a certified public accountant. Tax accountants prepare the filing. Executive director reviews and receives input from legal counsel prior to filing.”

“Officers, directors, employees and volunteers of epigenetic clock development foundation are encouraged to bring any alleged unlawful activity, policy or practice to the attenion of epigenetic clock development foundation. A protest, concern or complaint shall be made in writing to the president of epigenetic clock development foundation.”

“Board members and donor organizations are made aware of and able to review executive and key employee compensation through independent reports and through approval of annual budgets.”

“Board members and donor organizations are made aware of and able to review executive and key employee compensation through independent reports and through approval of annual budgets.”

“The documents are made available upon request.”

“The clock foundation was formed for the specific and primary purpose of conducting medical research on aging and age-related diseases. Developing the epigenetic aging clock into a useful technology will require medical research on aging and age-related diseases. Consequently, the activity will advance clock foundation's specific purpose of conducting medical research on aging and age-related diseases. If the medical research of the clock foundation is successful and the fda approves the clock foundation's testing method, many new drugs or treatments that are able to reverse epigenetic aging could then be formally approved by the fda for the treatment of aging and for use in preventative medicine.”

“Internal research program: hiring of additional clock foundation team members we hired an additional phd biostatistician, along with additional part-time operational, administration, and finance staff. We continued to work closely with our scientific advisory board, especially on the development of rigorous approaches for epigenetic clock testing. Exclusive ucla ip license completed an exclusive license to the horvath ip portfolio was obtained in june 2021. No additional sublicenses or outlicensing agreements have been entered into, although we entered into several research collaboration agreements with groups this year.”

“External research collaborations: many interventional studies completed one of the most significant promises of epigenetic clocks is to act as a reliable biomarker to evaluate putative longevity treatments. We conducted many new interventional studies, for clinical trials and also preclinical studies, some with exciting effects and others with mediocre or negative results. This includes studies on plasmapharesis, young plasma treatment, stem cell exosomes, umbilical cord plasma, and a senolytic gene therapy. Mechanisms of aging studies ongoing another key application of epigenetic clocks is to help enable mechanistic studies, including the link of epigenetic aging to other aging hallmarks. Exciting mechanistic studies this past year included ones on ercc1 progeria models, bone marrow transplants, and progeria cell lines.”

“OTHER PROGRAM SERVICES”

“Intl property 142,706 0 0 advisory fee 93,604 0 0 advisory fee - vugene llc 94,167 0 0 total 330,477 0 0”