Food Allergy Science Initiative Inc

“The organization's form 990 is prepared by a reputable cpa firm specializing in not for profit tax. The form 990 is provided to the ceo for review and comment and any changes are incorporated. The organization provides a draft copy of form 990 for the board to review prior to filing. Upon approval the organization files its 990.”

“Each FASI Director, Advisor and staff member SIGNS A CONFLICT OF INTEREST FORM AND receives an annual reminder of Conflict of Interest Policy in January of each year. While reaffirmation of the Policy is not required, existing FASI Directors, Advisors and staff must notify the Executive Director and/or his/her delegate immediately of any change in status related to potential Conflict of Interest issues. In addition, FASI will conduct periodic reviews of arrangements and policies to ensure that FASI operates in a manner consistent with charitable purposes and does not engage in activities that could jeopardize its tax-exempt status.”

“Compensation process for top official: the organization uses the department of labor statistics and salary guide to obtain comparable data on positions. Furthermore, the organization periodically review the compensation arrangements and benefits to ensure that they are reasonable, based on competent survey information and the result of arm's length bargaining.”

“Governing documents, disclosure explanation, the financial statements, and other documents, such as the conflict of interest policy and governing documents are available upon request.”

“The food allergy science initiative ("fasi") was founded in 2016 by a group of parents united through a shared experience that no parent should have to go through: witnessing their child experience a life-threatening allergic reaction. Frustrated by the lack of options to treat food allergies, they identified a fundamental issue: despite many decades of research into the immune system and advances in clinical medicine, shockingly little is known about the fundamental biology behind the cause and pathological drivers of food allergies. Importantly, what happens when an individual first becomes sensitized to an allergen? Why are certain foods more likely to be allergenic? Why do some people react more vigorously to allergens, or naturally outgrow some food allergies, or respond differently to treaments, while others do not? What changes might be happening in our environments and our exposures that are contributing to the prolific rise in food allergies? By recognizing that a comprehensive understanding of the multiple and complex mechanisms underlying food allergy pathology cannot be achieved by myopic research, the founders of fasi were driven to organize a landmark symposium in 2015 that brought together world-class experts from multiple disciplines of science to discuss how their research sheds light on this enormously complex problem and how their research could synergize to make inroads in developing a much needed cure. Thus, in 2016 fasi was launched with the broad institute of mit and harvard (the "broad"). With just six labs at inception, fasi has grown and evolved into an independent 501(c)(3) multi-faceted non-profit research organization, and as of june 2024, operates with more than 20 world-class labs and over 100+ scientists across the united states. The fasi network brings together clinical experts in food allergies, type 2 inflammatory disorders, chronic inflammatory diseases, as well as research experts with deep expertise in studying the immune system, the digestive system, the nervous system, and the gut microbiome, all of which intersect and contribute to the underlying causes of food allergies. Though a collaborative operating model, fasi's team of researchers are laser focused on understanding the root causes of food allergies, translating these findings from labs to clinics, and beginning to intervene through the generation of novel therapeutic candidates to one day deliver a cure to those affected by food allergies. Some of our achievements: -fasi's scientific founder, ruslan medzhitov, has been visionary in developing a conceptual framework of food allergy by proposing that the allergic response is a hyperactive reaction of the body's food quality control system - a paradigm shift that has guided fasi's inter-disciplinary collaborative research approach. -fasi is creating a detailed unbiased cellular atlas comparing guts from food allergic and non-allergic patients. By examining differences that underlie disease-relevant human tissues, this atlas will help us - and the wider scientific community as a whole - identify and characterize which cells-types are expanded and dysregulated in food allergy pathology, and to identify pathways of therapeutic intervention to reverse pathological differences. -fasi scientists were among the first to identify crucial links between the gut immune and nervous systems by identifying specific cell-types and molecular mediators involved in the process of allergic sensitization and augmentation of allergic immune responses. These critical interactions serve as decision checkpoints for how the body decides to either trigger an allergic reaction or maintain normal physiological functioning. -fasi is uncovering pathways of bi-directional communications between the gut and the brain. The brain performs the critical function of sensing internal changes with the body and orchestrating systemic physiological responses, including mobilizing energy reserves to meet metabolic demands,”

“Grants refunded $ 356,671”