Sophie'S Neighborhood

“Lauren rosenberg hosea rosenberg ceo vice pres. Family relationship”

“The board of directors reviews tax returns before filing”

“Governing documents are made availble upon written request”

“During the fiscal year ending april 2025, sophie's neighborhood funded major research initiatives to advance understanding and treatment of multicentric carpo-tarsal osteolysis (mcto) an ultra rare genetic bone and kidney disorder. 1.advancing mcto disease mechanisms through innovative mouse models sophie's neighborhood supported research at harvard school of dental medicine investigating bone remodeling activity and cellular changes mafb mouse models of mcto. This work includes transcriptomic analyses of cells and tissues within the skeletal microenvironment to uncover molecular mechanisms driving disease progression. 2.expanding stem cell-based and developmental models of mcto in collaboration with boston children's hospital, sophie's neighborhood continued to fund studies on mafb and developmental chondrogenesis. These efforts advance stem cell-based models of mcto and identify key transcriptional networks involved in bone and cartilage development. 3.establishing critical research infrastructure for rare disease discovery sophie's neighborhood supported the creation and ongoing maintenance of mcto mouse lines with specific mafb mutations at the jackson laboratory. These specialized models enable researchers to test hypotheses related to mafb protein accumulation and disease pathology, strengthening the foundation for future therapeutic research. 4.initiate antisense oligonucleotide (aso) development and screening to evaluate therapeutic efficacy in cellular and mouse models, with the goal of reversing bone and kidney phenotypes associated with mcto.”