Civic Intelligence

Institute of Quantitative Systems Pharmacology Iqsp

EIN 81-2862096 • 501(c)3 • Carlsbad, CA

Profile

IQSP's mission is to advance drug development through instruction in and application of quantitative systems pharmacology

1815 Aston Ave STE STE 107Carlsbad, CA 92008-7340

i-qsp.org

Siviq Scores

Precomputed percentiles relative to similar nonprofits. These scores are descriptive rather than judgmental.

Liabilities / Assets

10th percentile

0.00x

Higher debt load relative to assets than 10% of similar nonprofits.

501(c)3 • $5M-$10M nonprofits • Source year 2024

Liabilities / Revenue

12th percentile

0.00x

Higher debt load relative to revenue than 12% of similar nonprofits.

501(c)3 • $5M-$10M nonprofits • Source year 2024

Net Margin

92nd percentile

61%

Higher net margin than 92% of similar nonprofits.

501(c)3 • $5M-$10M nonprofits • Source year 2024

Top Officer Pay

23rd percentile

$0

Higher top officer pay than 23% of similar nonprofits.

Top officer pay equals 0.0% of source-year revenue.

501(c)3 • $5M-$10M nonprofits • Source year 2024

Asset Growth

75th percentile

15%

Faster asset growth than 75% of similar nonprofits.

501(c)3 • $5M-$10M nonprofits • Annualized from 2023 to 2024

Revenue Growth

43rd percentile

3.9%

Faster revenue growth than 43% of similar nonprofits.

501(c)3 • $5M-$10M nonprofits • Annualized from 2023 to 2024

Assets

Up

$6,611,143

Up $1,742,087 (+36%) from 2022

Liabilities

Down

$1,965

Down $1,777 (-47%) from 2022

Net Assets

Up

$6,609,178

Up $1,743,864 (+36%) from 2022

Revenue

Down

$1,152,158

Down $77,020 (-6.3%) from 2022

Expenses

Down

$447,576

Down $66,243 (-13%) from 2022

Net Income

Down

$704,582

Down $10,777 (-1.5%) from 2022

Trend Graphs

Balance Sheet Trend

Grouped bars show assets, liabilities, and net assets across loaded filings.

$8.0M$6.0M$4.0M$2.0M$0Assets 2017: $2,274,403Liabilities 2017: $19,856Net Assets 2017: $2,254,5472017Assets 2020: $3,909,662Liabilities 2020: $14,110Net Assets 2020: $3,895,5522020Assets 2021: $4,669,293Liabilities 2021: $8,832Net Assets 2021: $4,660,4612021Assets 2022: $4,869,056Liabilities 2022: $3,742Net Assets 2022: $4,865,3142022Assets 2024: $6,611,143Liabilities 2024: $1,965Net Assets 2024: $6,609,1782024

Highlighted filing

2024

Assets$6,611,143
Liabilities$1,965
Net Assets$6,609,178

Operations Trend

Revenue, expenses, and net income by year, with the latest filing highlighted.

$3.0M$2.0M$1.0M$0Revenue 2017: $2,163,582Expenses 2017: $87,360Net Income 2017: $2,076,2222017Revenue 2020: $1,233,187Expenses 2020: $547,758Net Income 2020: $685,4292020Revenue 2021: $1,275,093Expenses 2021: $378,753Net Income 2021: $896,3402021Revenue 2022: $1,229,178Expenses 2022: $513,819Net Income 2022: $715,3592022Revenue 2024: $1,152,158Expenses 2024: $447,576Net Income 2024: $704,5822024

Highlighted filing

2024

Revenue$1,152,158
Expenses$447,576
Net Income$704,582

Filings

Latest Filing Detail
Jump To
Filing Snapshot
Filing Period
Jan 1, 2024 to Dec 31, 2024
Signed
Oct 29, 2025
Return Version
2024v5.2
Gross Receipts
$1,152,158
Mission and Program Overview

Mission

IQSP's mission is to advance drug development through instruction in and application of quantitative systems pharmacology

IQSPs mission is to advance drug development through instruction in and application of quantitative systems pharmacology

Balance Sheet Detail
LineBeginningEndChange
Assets
Investments in Publicly Traded Securities$5,032,517$5,784,382▲ $751,865
Accounts Receivable$500,000$505,000▲ $5,000
Savings and Temporary Cash Investments$71,513$233,386▲ $161,873
Cash and Non-Interest-Bearing Accounts$131,435$88,375▼ $43,060
Total Assets$5,735,465$6,611,143▲ $875,678
Liabilities
Accounts Payable and Accrued Expenses$-3,248$1,965▲ $5,213
Total Liabilities$-3,248$1,965▲ $5,213
Net Assets / Fund Balance
Net Assets With Donor Restrictions$5,299,990$6,058,424▲ $758,434
Net Assets Without Donor Restrictions$438,723$550,754▲ $112,031
Total Net Assets Fund Balance$5,738,713$6,609,178▲ $870,465
Total Liabilities and Net Assets / Fund Balance$5,735,465$6,611,143▲ $875,678
Compensation and Service Providers

Board Members and Trustees

NameTitle
Jessie L Au Pharmd PhdChair
Dan Lu PhdDirector
Vincent H Lee Phd DscDirector
M Guillaume WientjesSecretary Treasurer
Revenue and Support

Revenue Composition

Contributions and Grants
$865,554
Program Service Revenue
$0
Investment Income
$286,604
Other Revenue
$0
All Other Contributions
$689,930
Change in Net Assets
$704,582
Expenses and Functional Allocation

Major Expense Lines

Line ItemAmount
Salaries, Compensation, and Employee Benefits$295,151
Other Expenses$152,425
Grants and Similar Amounts Paid$0
Professional Fundraising Fees$0
Total Fundraising Expense$0

Functional Expense Allocation

Line ItemProgramManagementFundraisingTotal
Other Salaries and Wages$165,580--$165,580
Office Expenses-$123,017-$123,017
Current Officers, Directors, Trustees, and Key Employees$66,972$30,566-$97,538
Other Employee Benefits$19,323--$19,323
Payroll Taxes$12,710--$12,710
Insurance-$6,230-$6,230
Other Expenses$5,438$3,180-$5,438
Fees for Services Accounting-$1,730-$1,730
Advertising-$720-$720
Fees for Services Other-$400-$400
Total Functional Expenses$279,735$167,841$0$447,576
Fundraising, Events, and Gaming
Fundraising activities
No
Gaming activities
No
Professional fundraiser used
No

Fundraising and Gaming Totals

Line ItemAmount
Professional Fundraising Fees$0
Political and Lobbying Activity
Political campaign activity
No
Lobbying activity
No
Governance and Compliance

Governance Checklist

Compiled or reviewed by an accountant
No
Annual disclosure for covered persons
Yes
Backup withholding compliance
Yes
Business relationship with 35% controlled entity
No
Business relationship with family members
No
Business relationship with organization members
No
Material changes to governing documents
No
Compensation from other sources disclosed
No
CEO compensation reviewed
Yes
Other officer compensation reviewed
Yes
Conflict-of-interest policy
Yes
Audited financial statements prepared
No
Key decisions subject to board approval
No
Management duties delegated
No

Governance Explanations

Part VI Line 2

Jessie Au (Chair) and M Guill Wientjes (Secretary, Treasurer) are married

Part VI Line 11B

No review was or will be conducted.

Part VI Line 12C

Potential conflicts of interest for all officers and key personnel are

Part VI Line 12C

reviewed annually

Part VI Line 15A or B

Compensation for performance of officer duties in IQSP is $0

Part VI Line 19

IQSP documents are available at: https://rct.doj.ca.gov/ (Reg Ver Search T)

Part VI Line 19

Additional documents are available to the public upon request.

Filing and Contact Details

Filer

Filer Name
Institute of Quantitative Systems Pharmacology
EIN
81-2862096
In Care Of
% M Guillaume Wientjes
Phone
6145708878
Address
1815 Aston Ave STE STE 107, Carlsbad, CA 92008-7340
Doing Business As
Iqsp

Signing Officer

Name
M Guillaume Wientjes
Title
Secretary
Phone
6145708878
Signed
2025-10-29

Organization Details

Principal Officer
M Guillaume Wientjes
Formed
2016
Legal Domicile
CA
Voting Board Members
3
Independent Board Members
3
Employees
1
Supplemental Narrative

Additional Explanations

Part XI Line 9

Rounding

Part III, line 4A

PROGRAM ACCOMPLISHMENTS

Part III, line 4A

High failure rate in drug development is a factor driving up the

Part III, line 4A

health care costs in the US and around the world. The Food and

Part III, line 4A

Drug Administration (FDA) and National Institutes of Health

Part III, line 4A

(NIH) recognize that increased application of computational

Part III, line 4A

modeling, often referred to as Model-Informed Drug Development

Part III, line 4A

or Quantitative Systems Pharmacology, will be an important factor

Part III, line 4A

leading to smarter drug development processes and better decision

Part III, line 4A

making. The NIH even issued a White Paper in 2011 naming

Part III, line 4A

establishment of research and teaching programs in quantitative

Part III, line 4A

systems pharmacology as a national high priority. The FDA, under

Part III, line 4A

the 2017 FDA Reauthorization Act, has committed to adopting

Part III, line 4A

Model-Informed Drug Development (MIDD) in regulatory consideration

Part III, line 4A

of applications for new drugs and generic drugs.

Part III, line 4A

Quantitative Systems Pharmacology (QSP) uses

Part III, line 4A

computational modeling to gain or enhance understanding of

Part III, line 4A

biological systems. MIDD is a sub-area of QSP and refers to using

Part III, line 4A

quantitative models to facilitate the decision-making process and

Part III, line 4A

address drug development and regulatory questions in four

Part III, line 4A

categories: dose optimization, supportive evidence for efficacy,

Part III, line 4A

clinical trial design, and informing policy. MIDD is multidisciplinary

Part III, line 4A

and requires knowledge in diverse fields including biology, physics,

Part III, line 4A

chemistry, pharmacology, pharmaceutical sciences, computational

Part III, line 4A

modeling, clinical sciences, and regulatory sciences. IQSP pursues

Part III, line 4A

research and training in various areas of QSP and MIDD.

Part III, line 4A

Research in support of FDA contract award 75F40119C10139 was

Part III, line 4A

performed.

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IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt0Jessie Au (Chair) and M Guill Wientjes (Secretary, Treasurer) are married
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IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt3reviewed annually
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt4Compensation for performance of officer duties in IQSP is $0
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IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt6Additional documents are available to the public upon request.
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt7Rounding
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt8PROGRAM ACCOMPLISHMENTS
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt9High failure rate in drug development is a factor driving up the
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IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt11Drug Administration (FDA) and National Institutes of Health
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt12(NIH) recognize that increased application of computational
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt13modeling, often referred to as Model-Informed Drug Development
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt14or Quantitative Systems Pharmacology, will be an important factor
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt15leading to smarter drug development processes and better decision
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt16making. The NIH even issued a White Paper in 2011 naming
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt17establishment of research and teaching programs in quantitative
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt18systems pharmacology as a national high priority. The FDA, under
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt19the 2017 FDA Reauthorization Act, has committed to adopting
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt20Model-Informed Drug Development (MIDD) in regulatory consideration
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt21of applications for new drugs and generic drugs.
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt22Quantitative Systems Pharmacology (QSP) uses
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt23computational modeling to gain or enhance understanding of
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt24biological systems. MIDD is a sub-area of QSP and refers to using
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt25quantitative models to facilitate the decision-making process and
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt26address drug development and regulatory questions in four
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt27categories: dose optimization, supportive evidence for efficacy,
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt28clinical trial design, and informing policy. MIDD is multidisciplinary
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt29and requires knowledge in diverse fields including biology, physics,
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt30chemistry, pharmacology, pharmaceutical sciences, computational
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt31modeling, clinical sciences, and regulatory sciences. IQSP pursues
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt32research and training in various areas of QSP and MIDD.
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt33Research in support of FDA contract award 75F40119C10139 was
IRS990ScheduleO/SupplementalInformationDetail/ExplanationTxt34performed.
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