Liabilities / Assets
17th percentile
Higher debt load relative to assets than 17% of similar nonprofits.
EIN 81-1669175 • 501(c)3 • San Francisco, CA
Profile
Accelerating science through its mission to cure, prevent or manage all diseases by the end of the 21st century.
Precomputed percentiles relative to similar nonprofits. These scores are descriptive rather than judgmental.
Liabilities / Assets
17th percentile
Higher debt load relative to assets than 17% of similar nonprofits.
Liabilities / Revenue
66th percentile
Higher debt load relative to revenue than 66% of similar nonprofits.
Net Margin
2nd percentile
Higher net margin than 2% of similar nonprofits.
Top Officer Pay
25th percentile
Higher top officer pay than 25% of similar nonprofits.
Top officer pay equals 1.0% of source-year revenue.
Asset Growth
12th percentile
Faster asset growth than 12% of similar nonprofits.
Revenue Growth
1st percentile
Faster revenue growth than 1% of similar nonprofits.
Assets
Down$1,477,092,189
Down $2,493,017 (-0.2%) from 2023
Liabilities
Up$84,372,192
Up $40,364,983 (+92%) from 2023
Net Assets
Down$1,392,719,997
Down $42,858,000 (-3.0%) from 2023
Revenue
Down$99,552,025
Down $1,191,058,498 (-92%) from 2023
Expenses
Up$142,410,025
Up $34,383,537 (+32%) from 2023
Net Income
Down-$42,858,000
Down $1,225,442,035 (-104%) from 2023
Most recent year
2024 • Form 990Facts available. Structured filing facts are available, but richer extracted sections are limited.
Alleviating human suffering through its mission to cure, manage, and prevent all diseases by the end of the 21st century.
Conduct cutting edge medical research
| Line | Beginning | End | Change |
|---|---|---|---|
| Assets | |||
| Pledges and Grants Receivable | $1,275,341,448 | $1,201,347,646 | ▼ $73,993,802 |
| Savings and Temporary Cash Investments | $136,662,084 | $135,469,613 | ▼ $1,192,471 |
| Land, Buildings, and Equipment, Net | $29,361,389 | $55,580,514 | ▲ $26,219,125 |
| Cash and Non-Interest-Bearing Accounts | $9,095,362 | $12,081,948 | ▲ $2,986,586 |
| Prepaid Expenses and Deferred Charges | $5,427,457 | $3,750,045 | ▼ $1,677,412 |
| Investments Program Related | $564,098 | $831,423 | ▲ $267,325 |
| Accounts Receivable | $1,354,066 | $805,950 | ▼ $548,116 |
| Total Assets | $1,479,585,206 | $1,477,092,189 | ▼ $2,493,017 |
| Other Assets Total | $21,779,302 | $67,225,050 | ▲ $45,445,748 |
| Liabilities | |||
| Other Liabilities | $23,327,818 | $66,606,769 | ▲ $43,278,951 |
| Grants Payable | $8,551,517 | $11,082,022 | ▲ $2,530,505 |
| Accounts Payable and Accrued Expenses | $12,127,874 | $6,683,401 | ▼ $5,444,473 |
| Total Liabilities | $44,007,209 | $84,372,192 | ▲ $40,364,983 |
| Net Assets / Fund Balance | |||
| Net Assets With Donor Restrictions | $1,278,659,541 | $1,204,291,035 | ▼ $74,368,506 |
| Net Assets Without Donor Restrictions | $156,918,456 | $188,428,962 | ▲ $31,510,506 |
| Total Net Assets Fund Balance | $1,435,577,997 | $1,392,719,997 | ▼ $42,858,000 |
| Total Liabilities and Net Assets / Fund Balance | $1,479,585,206 | $1,477,092,189 | ▼ $2,493,017 |
| Asset | Book Value | Depreciation | Basis |
|---|---|---|---|
| Equipment | $34,256,410 | $28,843,011 | $63,099,421 |
| Other Land Buildings | $13,612,351 | - | $13,612,351 |
| Leasehold Improvements | $7,711,753 | $1,458,945 | $9,170,698 |
| Name | Title | Full / Part Time | Base | Other | Total |
|---|---|---|---|---|---|
| Joseph Derisi | Director, President CZB Sf (key Emp) | FT | $640,453 | $325,542 | $965,995 |
| Matthias Haury | COO/acting Executive Director, Czii | FT | $485,915 | $405,237 | $891,152 |
| Andrea Califano | President, CZB Ny | FT | $605,894 | $285,201 | $891,095 |
| Shana Kelley | President, CZB Chicago | FT | $582,363 | $279,891 | $862,254 |
| Clinton Potter | Founding Technical Director, Czii | FT | $547,636 | $287,734 | $835,370 |
| David Andrew Agard | Founding Technical Director, Czii | FT | $542,736 | $289,978 | $832,714 |
| Bridget Carragher | Founding Technical Director, Czii | FT | $550,013 | $276,427 | $826,440 |
| Sandra L Schmid | Chief Scientific Officer, CZB Sf | FT | $527,863 | $275,762 | $803,625 |
| Melinda Griffith | Sec (thru 1/29), COO & Couns, CZB Sf | FT | $510,912 | $271,298 | $782,210 |
| Victor Colunga | CFO & Treasurer (thru 6/30) | FT | $221,770 | $138,860 | $360,630 |
| Stephen Quake | President & Director | PT | $200,000 | $103,006 | $303,006 |
| Name | Title |
|---|---|
| Cori Bargmann | Director |
| Mark Zuckerberg | Director |
| Mike Schroepfer | Director |
| Paul Alivisatos | Director |
| Priscilla Chan | Director |
| Reid Hoffman | Director |
| Sam Altman | Director |
| Sam Hagwood | Director |
| Ben Roh | CFO |
| Marc Malandro | COO (from 1/29) |
| Sandy Yao | Secretary & CLO (from 1/29) |
| Contractor | Services | Location | Compensation |
|---|---|---|---|
| Zoe Life 400 Aberdeen LLC Dba Fulton Lab | Construction | 2100 MCKINNEY AVE STE 800, Dallas, TX 75201 | $3,553,298 |
| Dome Construction Corporation | Construction | 393 EAST GRAND AVE, South San Francisco, CA 94080 | $1,344,815 |
| Gary D Nelson Associates INC Dba Nelson | Professional Staffing | 19080 LOMITA AVE, Sonoma, CA 95476 | $1,200,887 |
| Arnold & Porter Kaye Scholer LLP | Legal | 601 MASSACHUSETTS AVE NW, Washington, DC 20001-3743 | $1,167,808 |
| Kilpatrick Townsend | Legal | 1100 PEACHTREE ST NE STE 2800, Atlanta, GA 30309 | $812,186 |
| Line Item | Amount |
|---|---|
| Salaries, Compensation, and Employee Benefits | $52,472,266 |
| Other Expenses | $49,554,468 |
| Grants and Similar Amounts Paid | $40,383,291 |
| Professional Fundraising Fees | $0 |
| Total Fundraising Expense | $0 |
| Line Item | Program | Management | Fundraising | Total |
|---|---|---|---|---|
| Grants to Domestic Orgs | $40,383,291 | - | - | $40,383,291 |
| Other Salaries and Wages | $29,004,359 | $8,291,901 | - | $37,296,260 |
| Occupancy | $17,559,414 | $2,063,507 | - | $19,622,921 |
| Depreciation Depletion | $7,816,051 | $389,914 | - | $8,205,965 |
| Information Technology | $3,857,193 | $1,098,352 | - | $4,955,545 |
| Pension Plan Contributions | $3,605,825 | $753,402 | - | $4,359,227 |
| Current Officers, Directors, Trustees, and Key Employees | $3,748,669 | $416,521 | - | $4,165,190 |
| Other Employee Benefits | $3,424,034 | $710,025 | - | $4,134,059 |
| Fees for Services Other | $1,165,508 | $2,712,922 | - | $3,878,430 |
| Payroll Taxes | $2,088,624 | $428,906 | - | $2,517,530 |
| Fees for Services Legal | $1,304,432 | $1,208,049 | - | $2,512,481 |
| Travel | $1,357,581 | $448,113 | - | $1,805,694 |
| Conferences and Meetings | $356,217 | $434,634 | - | $790,851 |
| Office Expenses | $166,499 | $592,700 | - | $759,199 |
| Fees for Services Accounting | - | $752,181 | - | $752,181 |
| Insurance | - | $366,732 | - | $366,732 |
| Other Expenses | $110,777 | $176,547 | - | $287,324 |
| Total Functional Expenses | $121,540,906 | $20,869,119 | $0 | $142,410,025 |
| Line Item | Amount |
|---|---|
| Total Expenses per Audited Statements | $154,422,510 |
| Expenses per Audited Statements | $142,410,025 |
| Total Expenses per Form 990 | $142,410,025 |
| Expenses Not Reported on Form 990 | $12,012,485 |
| Expenses Not Reported on Financial Statements | $0 |
| Recipient | Location | Category | Purpose | Amount |
|---|---|---|---|---|
| Regents of the University of California San Francisco | San Francisco, CA | State of California | Scientific and Medical Research | $12,257,389 |
| The Board of Trustees of the Leland Stanford Junior University | Redwood City, CA | 501(c)(3) | Scientific and Medical Research | $11,626,018 |
| Regents of the University of California at Berkeley | Berkeley, CA | State of California | Scientific and Medical Research | $5,535,784 |
| University of Illinois Foundation | Champaign, IL | 501(c)(3) | Scientific and Medical Research | $2,973,388 |
| University of Chicago | Chicago, IL | 501(c)(3) | Scientific and Medical Research | $2,868,865 |
| Northwestern University | Evanston, IL | 501(c)(3) | Scientific and Medical Research | $2,826,739 |
| The Trustees of Columbia University in the City of New York | New York, NY | 501(c)(3) | Scientific and Medical Research | $1,442,193 |
| Yale University | New Haven, CT | 501(c)(3) | Scientific and Medical Research | $434,943 |
| The Rockefeller University | New York, NY | 501(c)(3) | Scientific and Medical Research | $217,471 |
| University of California Berkeley Foundation | Berkeley, CA | 501(c)(3) | Scientific and Medical Research | $200,000 |
| Region | Activity | Services | Offices | Employees | Spending |
|---|---|---|---|---|---|
| Europe (including Iceland & Greenland) | Program Services | Speaking/attending Conferences | 0 | 0 | $116,904 |
| Europe (including Iceland & Greenland) | Program Services | Consulting Service | 0 | 0 | $100,202 |
| East Asia and the Pacific | Program Services | Speaking/attending Conferences | 0 | 0 | $84,630 |
| Sub-saharan Africa | Program Services | Speaking/attending Conferences | 0 | 0 | $72,332 |
| South America | Program Services | Speaking/attending Conferences | 0 | 0 | $32,998 |
| Russia and Neighboring States | Program Services | Speaking/attending Conferences | 0 | 0 | $14,930 |
| North America | Program Services | Speaking/attending Conferences | 0 | 0 | $1,698 |
| East Asia and the Pacific | Program Services | Consulting Service | 0 | 0 | $1,500 |
| Line Item | Amount |
|---|---|
| Professional Fundraising Fees | $0 |
| Interested Party | Relationship | Description | Shared Revenue | Amount |
|---|---|---|---|---|
| - | Czi LLC Is an Entity Managed by Directors Mark Zuckerberg & Priscilla Chan | Rent and Common Area Maintenance Fees Were Paid by Czi LLC to Biohub. All Fees Were Established at Fair Market Value. | No | $456,631 |
| Liability | Amount |
|---|---|
| Operating Lease Liabilities | $66,606,769 |
“Directors priscilla chan and mark zuckerberg have a family relationship.”
“Chan zuckerberg initiative llc designates all directors of the board.”
“Form 990 is prepared by the organization's accounting firm. A copy is provided to each director and counsel for review before being filed.”
“The conflict of interest policy applies to biohub and all disregarded entities. Each covered person must disclose in writing to the chief conflicts officer each of his or her conflicts of interest, including financial interests, when they join the company. To ensure that potential conflicts of interest and conflicts of commitment are disclosed, each covered person is required to update their disclosure each year and periodically throughout the year at any time when his or her previously disclosed financial interests change or a new potential conflict of commitment or conflict of interest arises. In addition, certain employees at the level of group or platform leader or above are required to file updated disclosure statements each year. The board of directors ("the board") approved the conflict of commitment and conflict of interest policy for the company, which outlines the mechanisms for implementing the policy. The board, or a conflicts committee designated by the board, and a chief conflicts officer appointed by the board is responsible for interpreting both conflicts of commitment and conflicts of interest under the policy. The primary responsibility of the chief conflicts officer or the conflicts committee is determining whether a conflict of commitment or conflict of interest exists and, if so, whether the proposed activity or the transaction or arrangement giving rise to the conflict is in the best interests of biohub and can proceed in a manner that protects biohub's financial, scientific and reputational interests. When a covered person discloses an actual or potential conflict of commitment or conflict of interest under this policy, the chief conflicts officer, the board, or the conflicts committee, as required under the policy, will follow the review procedures outlined in the policy. A covered person may not engage in any activity that gives rise to a conflict of commitment or a conflict of interest without receiving the approval(s) required in this policy. With respect to any conflict of interest, the covered person will be recused from all decisions involving the activity giving rise to the conflict, and the chief conflicts officer, the board, or a committee designed by the board will determine whether to proceed with the activity notwithstanding the conflict. If the covered person involved in the potential or actual conflict under review is an officer or director of biohub, the conflict review procedures will be performed by the disinterested members of the conflicts committee, assisted by the chief conflicts officer, and if reviewed by the conflicts committee, it may refer the conflict to the disinterested members of the board for final review. If requested by the board or committee, it may be referred to outside counsel.”
“The board of directors and executive committee of the board review and approve the compensation of biohub's co-presidents and officers. The process includes a review of the compensation against comparability data survey provided periodically by an independent compensation service. The approval process is documented contemporaneously. The most recent comparability data study was completed in 2022.”
“The organization's governing documents, conflict of interest policy and financial statements are made available to the public upon request when required by federal or state law.”
“The whistleblower policy and written retention and destruction policy apply to biohub and all disregarded entities.”
“Where 40 hours is listed as hours of service in respect of an individual, this is based on an estimated full-time work week. Actual hours devoted by the individual may vary significantly, and may exceed the 40 hour estimate.”
“No directors of biohub are compensated in their capacity as directors. In 2024 joseph derisi was compensated in his capacity as president of cz biohub sf llc, a disregarded entity of biohub, and should be classified as a key employee of biohub based on form 990 instructions. As form 990 instructions dictate that an individual can not be reported as both director and key employee, joseph derisi is reported as an officer solely to reflect his officer position at the disregarded entity.”
“Compensation has been paid to officers listed on part vii by an entity that is not listed as a "related organization" on schedule r. All services of the officers were donated free of charge to biohub, and no deduction was sought for such donation.”
“Form 990 part viii line 1 reports negative contribution revenue on line 1f as a result of applying the accounting rules with respect to (i) prior year pledges made by one donor and (ii) current year fulfilment of pledges by a second donor-as provided for under the pledge agreement. In order to accurately report all donor contributions, the total contributions reported on schedule b are greater than total contribution revenue on line 1h, resulting in the presentation of negative contribution revenue.”
“The internal revenue service (irs) has determined that biohub is described in section 501(c)(3) of the internal revenue code (the code) as a medical research organization operated in conjunction with a hospital and section 23701d of the california revenue and taxation code and accordingly, is generally exempt from federal income taxes under the provision of section 501(a) of the code. Biohub has no unrecognized tax benefits or liabilities as of december 31, 2024 or 2023.”
This appendix keeps the raw XML leaves available for debugging and edge-case review. The human report above is the primary experience.
| Path | # | Value |
|---|---|---|
| IRS990/AccountantCompileOrReviewInd | 0 | 0 |
| IRS990/AccountsPayableAccrExpnssGrp/BOYAmt | 0 | 12127874 |
| IRS990/AccountsPayableAccrExpnssGrp/EOYAmt | 0 | 6683401 |
| IRS990/AccountsReceivableGrp/BOYAmt | 0 | 1354066 |
| IRS990/AccountsReceivableGrp/EOYAmt | 0 | 805950 |
| IRS990/ActivitiesConductedPrtshpInd | 0 | 0 |
| IRS990/ActivityOrMissionDesc | 0 | CONDUCT CUTTING EDGE MEDICAL RESEARCH |
| IRS990/AllOtherContributionsAmt | 0 | -52607937 |
| IRS990/AnnualDisclosureCoveredPrsnInd | 0 | 1 |
| IRS990/AuditCommitteeInd | 0 | 1 |
| IRS990/BackupWthldComplianceInd | 0 | 1 |
| IRS990/BooksInCareOfDetail/BusinessName/BusinessNameLine1Txt | 0 | THE ORGANIZATION |
| IRS990/BooksInCareOfDetail/PhoneNum | 0 | 4155493300 |
| IRS990/BooksInCareOfDetail/USAddress/AddressLine1Txt | 0 | 499 ILLINOIS ST |
| IRS990/BooksInCareOfDetail/USAddress/CityNm | 0 | SAN FRANCISCO |
| IRS990/BooksInCareOfDetail/USAddress/StateAbbreviationCd | 0 | CA |
| IRS990/BooksInCareOfDetail/USAddress/ZIPCd | 0 | 94158 |
| IRS990/BusinessRlnWith35CtrlEntInd | 0 | 1 |
| IRS990/BusinessRlnWithFamMemInd | 0 | 0 |
| IRS990/BusinessRlnWithOrgMemInd | 0 | 0 |
| IRS990/CashNonInterestBearingGrp/BOYAmt | 0 | 9095362 |
| IRS990/CashNonInterestBearingGrp/EOYAmt | 0 | 12081948 |
| IRS990/ChangeToOrgDocumentsInd | 0 | 0 |
| IRS990/CntrctRcvdGreaterThan100KCnt | 0 | 26 |
| IRS990/CollectionsOfArtInd | 0 | 0 |
| IRS990/CompCurrentOfcrDirectorsGrp/ManagementAndGeneralAmt | 0 | 416521 |
| IRS990/CompCurrentOfcrDirectorsGrp/ProgramServicesAmt | 0 | 3748669 |
| IRS990/CompCurrentOfcrDirectorsGrp/TotalAmt | 0 | 4165190 |
| IRS990/CompensationFromOtherSrcsInd | 0 | 0 |
| IRS990/CompensationProcessCEOInd | 0 | 1 |
| IRS990/CompensationProcessOtherInd | 0 | 1 |
| IRS990/ConferencesMeetingsGrp/ManagementAndGeneralAmt | 0 | 434634 |
| IRS990/ConferencesMeetingsGrp/ProgramServicesAmt | 0 | 356217 |
| IRS990/ConferencesMeetingsGrp/TotalAmt | 0 | 790851 |
| IRS990/ConflictOfInterestPolicyInd | 0 | 1 |
| IRS990/ConservationEasementsInd | 0 | 0 |
| IRS990/ConsolidatedAuditFinclStmtInd | 0 | 1 |
| IRS990/ContractorCompensationGrp/CompensationAmt | 0 | 3553298 |
| IRS990/ContractorCompensationGrp/CompensationAmt | 1 | 1344815 |
| IRS990/ContractorCompensationGrp/CompensationAmt | 2 | 1200887 |
| IRS990/ContractorCompensationGrp/CompensationAmt | 3 | 1167808 |
| IRS990/ContractorCompensationGrp/CompensationAmt | 4 | 812186 |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/AddressLine1Txt | 0 | 2100 MCKINNEY AVE STE 800 |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/AddressLine1Txt | 1 | 393 EAST GRAND AVE |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/AddressLine1Txt | 2 | 19080 LOMITA AVE |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/AddressLine1Txt | 3 | 601 MASSACHUSETTS AVE NW |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/AddressLine1Txt | 4 | 1100 PEACHTREE ST NE STE 2800 |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/CityNm | 0 | DALLAS |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/CityNm | 1 | SOUTH SAN FRANCISCO |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/CityNm | 2 | SONOMA |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/CityNm | 3 | WASHINGTON |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/CityNm | 4 | ATLANTA |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/StateAbbreviationCd | 0 | TX |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/StateAbbreviationCd | 1 | CA |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/StateAbbreviationCd | 2 | CA |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/StateAbbreviationCd | 3 | DC |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/StateAbbreviationCd | 4 | GA |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/ZIPCd | 0 | 75201 |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/ZIPCd | 1 | 94080 |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/ZIPCd | 2 | 95476 |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/ZIPCd | 3 | 200013743 |
| IRS990/ContractorCompensationGrp/ContractorAddress/USAddress/ZIPCd | 4 | 30309 |
| IRS990/ContractorCompensationGrp/ContractorName/BusinessName/BusinessNameLine1Txt | 0 | ZOE LIFE 400 ABERDEEN LLC DBA FULTON LAB |
| IRS990/ContractorCompensationGrp/ContractorName/BusinessName/BusinessNameLine1Txt | 1 | DOME CONSTRUCTION CORPORATION |
| IRS990/ContractorCompensationGrp/ContractorName/BusinessName/BusinessNameLine1Txt | 2 | GARY D NELSON ASSOCIATES INC DBA NELSON |
| IRS990/ContractorCompensationGrp/ContractorName/BusinessName/BusinessNameLine1Txt | 3 | ARNOLD & PORTER KAYE SCHOLER LLP |
| IRS990/ContractorCompensationGrp/ContractorName/BusinessName/BusinessNameLine1Txt | 4 | KILPATRICK TOWNSEND |
| IRS990/ContractorCompensationGrp/ServicesDesc | 0 | CONSTRUCTION |
| IRS990/ContractorCompensationGrp/ServicesDesc | 1 | CONSTRUCTION |
| IRS990/ContractorCompensationGrp/ServicesDesc | 2 | PROFESSIONAL STAFFING |
| IRS990/ContractorCompensationGrp/ServicesDesc | 3 | LEGAL |
| IRS990/ContractorCompensationGrp/ServicesDesc | 4 | LEGAL |
| IRS990/CreditCounselingInd | 0 | 0 |
| IRS990/CYBenefitsPaidToMembersAmt | 0 | 0 |
| IRS990/CYContributionsGrantsAmt | 0 | 92527253 |
| IRS990/CYGrantsAndSimilarPaidAmt | 0 | 40383291 |
| IRS990/CYInvestmentIncomeAmt | 0 | 6102390 |
| IRS990/CYOtherExpensesAmt | 0 | 49554468 |
| IRS990/CYOtherRevenueAmt | 0 | 599993 |
| IRS990/CYProgramServiceRevenueAmt | 0 | 322389 |
| IRS990/CYRevenuesLessExpensesAmt | 0 | -42858000 |
| IRS990/CYSalariesCompEmpBnftPaidAmt | 0 | 52472266 |
| IRS990/CYTotalExpensesAmt | 0 | 142410025 |
| IRS990/CYTotalFundraisingExpenseAmt | 0 | 0 |
| IRS990/CYTotalProfFndrsngExpnsAmt | 0 | 0 |
| IRS990/CYTotalRevenueAmt | 0 | 99552025 |
| IRS990/DecisionsSubjectToApprovaInd | 0 | 0 |
| IRS990/DeductibleArtContributionInd | 0 | 0 |
| IRS990/DeductibleNonCashContriInd | 0 | 0 |
| IRS990/DelegationOfMgmtDutiesInd | 0 | 0 |
| IRS990/DepreciationDepletionGrp/ManagementAndGeneralAmt | 0 | 389914 |
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| IRS990/Desc | 0 | IN 2024, THE FOUR RESEARCH INSTITUTES OF CHAN ZUCKERBERG BIOHUB INC ("BIOHUB") MADE SIGNIFICANT ADVANCES IN THE ORGANIZATION'S OVERALL MISSION TO CURE, PREVENT OR MANAGE DISEASE.IN JUNE, RESEARCHERS AT THE CHAN ZUCKERBERG INSTITUTE FOR ADVANCED BIOLOGICAL IMAGING ANNOUNCED THAT THEY HAD SOLVED A MAJOR BOTTLENECK IN THE USE OF THE IMAGING TECHNIQUE KNOWN AS CRYOGENIC ELECTRON TOMOGRAPHY, OR CRYOET. THIS METHOD IS CAPABLE OF CAPTURING DETAILED STRUCTURAL IMAGES OF CELLS AND PROTEINS, BUT THE RESULTING 3D DATASETS, KNOWN AS TOMOGRAMS, MUST BE MANUALLY ANNOTATED, A PAINSTAKING PROCESS THAT CAN TAKE MONTHS, SLOWING THE PACE OF SCIENTIFIC DISCOVERY. BY APPLYING NEW MACHINE LEARNING TOOLS, THE IMAGING INSTITUTE RESEARCHERS AUTOMATICALLY ANNOTATED 13,000 TOMOGRAMS IN JUST THREE-AND-A-HALF DAYS. IN ADDITION, THE INSTITUTE LAUNCHED THE CRYOET DATA PORTAL, AN OPEN ACCESS DATA REPOSITORY THAT CONTAINS ABOUT 16,000 ANNOTATED CRYOET DATASETS IN STANDARDIZED FORMATS. BOTH ACHIEVEMENTS WILL BENEFIT BIOIMAGING SCIENTISTS WORLDWIDE BY ACCELERATING UNDERSTANDING OF THE PROTEINS THAT MAKE UP OUR CELLS.IN A SCIENTIFIC MILESTONE, THE SAN FRANCISCO BIOHUB RESEARCHERS RELEASED "ZEBRAHUB," AN ATLAS OF EARLY ZEBRAFISH DEVELOPMENT. PUBLISHED IN THE JOURNAL CELL IN NOVEMBER, ZEBRAHUB COMBINES STATE-OF-THE-ART 3D MICROSCOPY WITH COMPREHENSIVE GENE-EXPRESSION DATA FOR THE INDIVIDUAL CELLS THAT MAKE UP ZEBRAFISH EMBRYOS. THE MICROSCOPES, GENE-SEQUENCING TECHNIQUES, AND IMAGE ANALYSIS TOOLS USED TO CREATE ZEBRAHUB WERE DESIGNED AND BUILT AT THE BIOHUB. ABOUT 70% OF HUMAN GENES, INCLUDING THOSE INVOLVED IN DISEASES, HAVE COUNTERPARTS IN ZEBRAFISH, SO ZEBRAHUB WILL ACCELERATE DISEASE RESEARCH ACROSS CANCER, HEART DISEASE, AND NEUROLOGICAL DISORDERS PROVIDING FREELY ACCESSIBLE DATA THAT WILL HELP BIOMEDICAL RESEARCHERS WORLDWIDE IDENTIFY NEW TREATMENTS.OCTOBER SAW THE OFFICIAL LAUNCH OF THE NEW YORK BIOHUB, DEVOTED TO CHARACTERIZING AND ENGINEERING THE BEHAVIOR OF OUR IMMUNE CELLS. THESE ENGINEERED CELLS CAN BE ADAPTED TO DETECT SIGNALS THAT PREDICT SEVERAL DISEASES, FROM CANCERS TO ALZHEIMER'S AND PARKINSON'S, AT THEIR EARLIEST STAGES, WHEN THEY ARE EASIER TO TREAT OR PREVENT, AND LONG BEFORE THEY CAN BE DETECTED BY CONVENTIONAL DIAGNOSTIC METHODS. THE NEW YORK BIOHUB ALSO BEGAN CONSTRUCTION OF PERMANENT, STATE-OF-THE-ART LAB SPACE ON COLUMBIA UNIVERSITY'S MANHATTANVILLE CAMPUS, MADE NEW HIRES, AND FUNDED ITS FIRST COHORT OF INVESTIGATORS FROM ITS PARTNER INSTITUTIONS: COLUMBIA UNIVERSITY, THE ROCKEFELLER UNIVERSITY, AND YALE UNIVERSITY.THE TEAM AT CHICAGO BIOHUB TACKLED A LONGSTANDING PROBLEM IN BIOENGINEERING BY BUILDING A FIRST-OF-ITS-KIND IMPLANTABLE SENSOR THAT CAN MONITOR LEVELS OF THE PROTEINS INVOLVED IN INFLAMMATION IN REAL TIME. SENSORS THAT MONITOR GLUCOSE, A SMALL MOLECULE, HAVE REVOLUTIONIZED DIABETES CARE, BUT SCIENTISTS HAVE STRUGGLED TO OBTAIN THE RELIABLE, CONTINUOUS MEASUREMENTS OF PROTEINS ACHIEVED BY THE NEW SENSOR, AS REPORTED IN THE JOURNAL SCIENCE IN DECEMBER. IT HAS BEEN ESTIMATED THAT 50% OF ALL DEATHS ARE RELATED TO INFLAMMATORY CONDITIONS, AND THE NOVEL SENSOR PLACES AN IMPORTANT NEW TOOL IN THE HANDS OF RESEARCHERS TO BETTER UNDERSTAND AND POTENTIALLY PREVENT A RANGE OF DISEASES, FROM NEURODEGENERATION TO CANCER TO HEART DISEASE. |
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| IRS990/NoDonorRestrictionNetAssetsGrp/EOYAmt | 0 | 188428962 |
| IRS990/NondeductibleContributionsInd | 0 | 0 |
| IRS990/OccupancyGrp/ManagementAndGeneralAmt | 0 | 2063507 |
| IRS990/OccupancyGrp/ProgramServicesAmt | 0 | 17559414 |
| IRS990/OccupancyGrp/TotalAmt | 0 | 19622921 |
| IRS990/OfficeExpensesGrp/ManagementAndGeneralAmt | 0 | 592700 |
| IRS990/OfficeExpensesGrp/ProgramServicesAmt | 0 | 166499 |
| IRS990/OfficeExpensesGrp/TotalAmt | 0 | 759199 |
| IRS990/OfficerMailingAddressInd | 0 | 0 |
| IRS990/OperateHospitalInd | 0 | 0 |
| IRS990/Organization501c3Ind | 0 | X |
| IRS990/OrganizationFollowsFASB117Ind | 0 | X |
| IRS990/OtherAssetsTotalGrp/BOYAmt | 0 | 21779302 |
| IRS990/OtherAssetsTotalGrp/EOYAmt | 0 | 67225050 |
| IRS990/OtherChangesInNetAssetsAmt | 0 | 0 |
| IRS990/OtherEmployeeBenefitsGrp/ManagementAndGeneralAmt | 0 | 710025 |
| IRS990/OtherEmployeeBenefitsGrp/ProgramServicesAmt | 0 | 3424034 |
| IRS990/OtherEmployeeBenefitsGrp/TotalAmt | 0 | 4134059 |
| IRS990/OtherExpensesGrp/Desc | 0 | LAB SUPPLIES |
| IRS990/OtherExpensesGrp/Desc | 1 | MARKETING |
| IRS990/OtherExpensesGrp/Desc | 2 | SUBSCRIPTIONS/LICENSES |
| IRS990/OtherExpensesGrp/ManagementAndGeneralAmt | 0 | 24713 |
| IRS990/OtherExpensesGrp/ManagementAndGeneralAmt | 1 | 176547 |
| IRS990/OtherExpensesGrp/ProgramServicesAmt | 0 | 5042638 |
| IRS990/OtherExpensesGrp/ProgramServicesAmt | 1 | 549794 |
| IRS990/OtherExpensesGrp/ProgramServicesAmt | 2 | 110777 |
| IRS990/OtherExpensesGrp/TotalAmt | 0 | 5042638 |
| IRS990/OtherExpensesGrp/TotalAmt | 1 | 574507 |
| IRS990/OtherExpensesGrp/TotalAmt | 2 | 287324 |
| IRS990/OtherLiabilitiesGrp/BOYAmt | 0 | 23327818 |
| IRS990/OtherLiabilitiesGrp/EOYAmt | 0 | 66606769 |
| IRS990/OtherRevenueMiscGrp/BusinessCd | 0 | 900099 |
| IRS990/OtherRevenueMiscGrp/Desc | 0 | OTHER REVENUE |
| IRS990/OtherRevenueMiscGrp/ExclusionAmt | 0 | 107497 |
| IRS990/OtherRevenueMiscGrp/TotalRevenueColumnAmt | 0 | 107497 |
| IRS990/OtherRevenueTotalAmt | 0 | 107497 |
| IRS990/OtherSalariesAndWagesGrp/ManagementAndGeneralAmt | 0 | 8291901 |
| IRS990/OtherSalariesAndWagesGrp/ProgramServicesAmt | 0 | 29004359 |
| IRS990/OtherSalariesAndWagesGrp/TotalAmt | 0 | 37296260 |
| IRS990/PartialLiquidationInd | 0 | 0 |
| IRS990/PayPremiumsPrsnlBnftCntrctInd | 0 | 0 |
| IRS990/PayrollTaxesGrp/ManagementAndGeneralAmt | 0 | 428906 |
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