The Ruth K Broad Biomedical

“5 individuals are family members of the late ruth k. Broad. Those individuals are: her daughter, ann b. Bussel; her son, morris n. Broad; and her grandchildren, karen b. Berman, daniel j. Bussel and deborah l. Bussel.”

“The trustees of duke university have the authority to approve or disapprove nominations for directors of the ruth k. Broad biomedical research foundation, inc. Further, the trustees of duke university also have the authority to remove a director of the ruth k. Broad biomedical research foundation.”

“The trustees of duke university have the authority to approve or disapprove any decisions made by the governing body.”

“The ruth k. Broad biomedical research foundation, provides the members of the governing body with a draft of form 990 for individual review prior to filing.”

“The ruth k. Broad biomedical research foundation monitors and enforces compliance related to conflict of interest via the ruth k. Broad biomedical research foundation form 990 conflict of interest questionnaire. This questionnaire is sent out annually.”

“The ruth k. Broad biomedical research foundation form 990 is available to the public on www.guidestar.org. Guidestar independently posts tax-exempt organization's form 990's on their website, obtained from the internal revenue service.”

“The governing documents are available on the north carolina secretary of state website. The ruth k. Broad biomedical research foundation is included in the consolidated, independently audited financial statements of duke university which are available at https://finance.duke.edu/resources/docs/financial_reports.pdf”

“Investment fund duke university (and therefore the ruth k. Broad biomedical research foundation) manages its investment funds in accordance with the uniform prudent management of institutional funds act of north carolina. As permitted by the act, the university (and therefore the ruth k. Broad biomedical research foundation) utilizes two investment pools to invest its funds and these funds operate on a total return concept. It is, therefore, not possible to separate earnings as set forth on lines 3, 4, and 7c; earnings are combined and reported on line 7c.”

“Program service accomplishments the foundation continues to be committed to funding collaborative research in neurosciences at the duke university school of medicine as well as at other academic medical centers. Funded are principal investigators, postdoctoral fellows, and graduate and medical students. The research is concerned with futhering the knowledge available as to causes and potentital treatments for alzheimer's disease (ad) and related neurological disorders. An extramural principal investigator awardee who recently completed her research project on amyloid-beta receptor driving synapse loss in alzheimer's disease reported results that keep her on track to identify and begin to characterize novel blockers of the ab-pirb interaction. These efforts could result in promising and novel therapeutic leads to combat ad, potentially even in its earliest stages. A postdoctoral awardee who recently completed his project funded by the ruth k. Broad foundation reports discovering that retinal ganglion cells (rgcs) guide colonization of the retina by astrocytes in mice, supporting a model in which astrocytes coordinate the vascularization of the neural retina. This work was recently presented at the association for research in vision and ophthalmology (arvo) 2016 annual meeting. The medical student awardee was able to pursue research on a rare genetic mutation found to be associated with tourette's syndrome and work to develop a mouse model for a movement disorder called dystonia. The foundation also funds the ruth k. Broad seminar series in neurobiology and disease, bringing noted scientists to duke's campus throughout the academic year to share research findings, to promote networking among the scientific community, and to mentor budding scientists. Results of grants awarded by the foundation are shared through this program as well. In 2015-2016 the seminar series featured lectures from david julius, professor of physiology, ucsf; silvia arber, professor of neurobiology, university of basel; carla shatz, director of stanford bio-x; joshua sanes, professor of molecular and cellular biology, harvard university; and daniel wolpert, professor of engineering, university of cambridge.”

“The organization did not have unrelated business gross income of $1,000 or more during the fiscal year ended june 30, 2016. As a result, form 990-t is not required for the fiscal year ended june 30, 2016.”