American Diabetes Association Research Foundation Inc

“The main responsibilities and focus of the Foundations Board is to advance, support and promote charitable contributions by soliciting major gifts for the purpose of funding the American Diabetes Associations nationwide Research Program. The Board of Directors of the Foundation provides governance over the activities of the Foundation in accodance with the purposes, policies and procedures of the American Diabetes Association. The Board delegates to the Foundations Executive Committee responsibililty for management of the Foundation when the Board is not in session. The American Diabetes Association provides complete operational support to the Foundation including staff, facilities and administrative processes. The Foundations annual budget and audit process are governed by the American Diabetes Association Board of Directors and Audit Committee.”

“The Foundations affairs are managed by the Foundation Board of Directors. The Board of Directors of the Foundation supervises, directs and controls the activities of the Foundation in accordance with the mission, purposes, policies and procedures of the American Diabetes Association. The Board delegates to the Foundations Executive Committee responsibility for management of the Foundation when the Board is in session. The American Diabetes Association provides complete operational support to the Foundation including staff, facilities and administrative processes. The Foundations annual budget and audit process are governed by the American Diabetes Association Board of Directors and Audit Committee. If a vacancy occurs among the Foundations officers for any reason, the Board of Directors of the American Diabetes Association shall fill such position for the unexpired portion of the term.”

“IRS Form 990 Review Process by the Governing Body The American Diabetes Association Research Foundation the Foundation draft IRS 990 is reviewed by the American Diabetes Associations management and BDO. The final and signed IRS Form 990 was provided to the Associations Board of Directors and the Foundations Board of Directors prior to filing with the IRS.”

“Managing a Conflict of Interest To identify potential conflicts of interest with appropriate due dilligence, the Foundations Officers, Directors and Members of the Grant Review Panel must annually disclose any potential conflicts of interest. The American Diabetes Associations Audit Committee and senior staff in Legal Affairs manage the disclosure and monitoring processes of the Board. The senior staff of the Associations Scientific Medical Division manage the disclosure and monitoring processes of the Grant Review Panel. Through review of the annual disclosure and review of the agendas of relevant Board, Committee and other meetings, appropriate efforts are made in advance of the meetings to identify potential conflicts of interest. Each person also has the responsibility to report his/her own conflicts of interest actual or perceived as those conflicts may arise during a meeting.”

“Research Grants Review Committee Conflict of Interest COI within the Research Grants Review Committee is managed through a written COI policy and through COI declarations signed both before and after the review cycle. The COI for grant reviewers is self-reported. The primary considerations addressed in the COI policy and program guidelines are as follows - Institutional Individuals are required to recuse themselves from reviewing grants for scientists at the same institution, including any institutions with which they may be negotiating employment. - Financial Individuals are required to recuse themselves from reviewing grants from which they stand to gain financially if the grant is awarded co-PI, collaborator, subcontracts, etc.. - Personal Individuals are required to recuse themselves from reviewing grants for investigators with whom they either have a personal or professional relationship collaborators, colleagues or personal friends, or a long standing professional or scientific disagreement that prevents them from unbiased review.”

“The American Diabetes Association has a written whistleblower policy that applies to the American Diabetes Association Research Foundation.”

“Alabama AL97-256 Alaska N/A Arizona10145 Arkansas N/A California CT81471 Colorado 2002-3003670 Connecticut CHR.0005084 Delaware N/A District of Columbia 981855 Florida CH1618 GeorgiaCH-001422 Hawaii N/A Idaho N/A Illinois CO01-025537 Indiana103829 Iowa N/A Kansas 177-257-350 Kentucky ID 45 Louisiana 34629813X Maine CO-1247 Maryland 102 Massachusetts Attorney General 029317 Michigan MICS 10326 Minnesota N/A Mississippi 100000294 Missouri CO- 021-87 Montana N/A Nebraska N/A Nevada N/A New Hampshire 5006New Jersey CH-0581900 New Mexico 1936418 New York 01-30-65 North Carolina SL000618 North Dakota 7894 Ohio 01-0239 Oklahoma 29417396 Oregon16402 Pennsylvania 21 Rhode Island 9500233 South Carolina 641South Dakota N/A Tennessee CO1919 Texas N/A Utah 6536093-CHAR Vermont N/A Virginia N/A Washington 1100167 West Virginia N/A Wisconsin3020-800 WyomingN/A”

“The American Diabetes Association has a written Document Retention and Destruction policy that applies to the American Diabetes Research Foundation.”

“Document Disclosure The following Research Foundation documents are not available on the American Diabetes Association website http//www.diabetes.org but are available upon written request to the American Diabetes Association Legal Affairs Department Board of Directors, audited financial statements, IRS Form 990, whistleblower policy, current bylaws, articles of incorporation and conflict of interest policy.”

“The Chief Executive Officer is a non-voting member of the Research Foundation Board of Directors. The Chief Executive Officer, the Chief Financial Officer, the Chief Development Officer and the Chief Scientific Medical Officer are compensated by the American Diabetes Association based on a standard average of 37.5 hours per week.”

“Tracey D. Brown ended her tenure as Chief Executive Officer on October 6, 2021. On that day, the Chief Financial Officer, Chief Development Officer and Chief Scientific and Medical Officer were appointed to the Office of the CEO by the Associations Board of Directors.”

“Pearson C. Cummin, III, Secretary-Treasurer, and Linda Cummin, Board of Directors, have a family relationship.”

“The American Diabetes Association Research Foundation, Inc. the Foundation secures major gifts and grants to fund diabetes-related research.”

“Other changes in net assets or fund balances of 572,737 reflect prior year research grant award refunds and forfeitures. Net assets were adjusted by 8,403,794 for the merger of ADA Research Foundation, Inc. into the American Diabetes Association as of December 31, 2021.”

“Connected for Life”

“Today, more than 133 million Americans in the United States have diabetes or prediabetes an invasive, unrelenting, and debilitating disease that spans all ages, geographic areas, and educational levels. This chronic disease targets children, the elderly, and minority populations more than others and costs the United States 327 billion each year in lost productivity. It is a global epidemic that contributes to heart disease, stroke, nerve and kidney disease, and vision loss. The American Diabetes Association ADA is the only organization dedicated specifically to the research, education, and advocacy required to improve the lives of the 37.3 million adults and children in the U.S. with diabetes and the 96 million people with prediabetes. For 81 years, we have been working on the front lines to educate at-risk populations protect the rights of people with diabetes at work, school, and other aspects of daily life pioneer clinical and research breakthroughs and foster a pipeline of the best and brightest scientists.”

“The COVID-19 pandemic shined a very bright spotlight on diabetes as a public health crisis and on severe health inequities in our country. For people with diabetes, COVID-19 poses a much greater threat of severe complications, hospitalization, and even death. The ADA quickly adapted our resources, programs, and events in service to people living with diabetes and the health care professionals who treat them, and in 2021 we remained focused on ensuring people with diabetes could continue to get the care they needed to stay healthy and thrive.From research labs to the halls of the Capitol to the offices of health care practitioners to communities nationwide, the ADA is there. We are bending the curve to help people living with diabetes and their families thrive. Why Because we envision a life free of diabetes and all its burdens, which is fueled by our mission to prevent and cure diabetes and to improve the lives of all people affected by diabetes.”

“DIABETES RESEARCH”

“Diabetes is an extremely complex disease, caused by a combination of various genetic and environmental factors that progressively lead to an inability to produce or effectively use insulin. The complexity of causes conspiring to diminish the bodys production or response to insulin, leading to high blood glucose blood sugar and eventual development of diabetes, makes finding a single cure particularly difficult. While a cure has been elusive, critical research efforts in recent decades have led to significantly improved patient care, resulting in fewer complications and better health outcomes for individuals with diabetes.”

“As the only organization dedicated specifically to the research, education, and advocacy required to improve the lives of all people with diabetes, the ADA funds critical, innovative diabetes research and invests in promising scientists early in their careers. Our leadership in diabetes research extends back to the 1940s when Dr. Charles H. Best, one of four scientists credited with discovering insulin, provided the ADA with the framework and early leadership for a formalized diabetes research program.”

“Since the ADA started its Research Programs in 1952, we have invested nearly 900 million in more than 4,850 diabetes research projects. In 2021 alone, we supported over 250 research projects at 123 leading research institutions across the U.S., all dedicated to progressing the fight against diabetes. Of these projects, 96 were led by in-training or early-career investigators.”

“While we have learned much about diabetes, there is so much left to discover. The primary goals of the ADAs Research Program are to Support the highest-quality science across the broad spectrum of diabetes research. Support investigators early in their careers to encourage them to dedicate their efforts to diabetes research. Support innovative research with a high potential to have a significant impact for patients with diabetes.”

“Peer Review Process. One of the factors that sets ADA funded research apart and ensures that we are supporting the very best science is peer review. Peer review is a process whereby grant applications are reviewed and evaluated by individuals who are experts in the field or peers of the individual submitting the grant. ADA grant applications undergo peer review by three or more volunteer experts who are themselves experienced researchers. Reviewers provide both a score and detailed comments regarding the strengths and weaknesses of each grant they review. Scores from all reviewers for each grant are averaged to arrive at a composite merit score that is then used to determine which grants to support.”

“2021 Research Approach. The ADAs research strategy is targeted and laser focused, an approach that allows us to respond swiftly and decisively to the pressing needs of the diabetes community. For 2021 we prioritized action oriented research around health disparities, awarding funds to 11 projects including research on engaging grandmothers in care, using texting to improve diabetes management among people experiencing homelessness, and culinary education as a means for diabetes education. While we have a targeted approach to funding, we are also continuing to invest in our many career and training awards. Investing in early career diabetes professionals allows us to uplift, support, mentor, and secure the next generation of researchers as they prepare to care for the millions living with diabetes and prediabetes.”

“COVID-19 ResearchIn 2021 the ADA saw the first results of the 1 million we invested in 2020 to investigate the link between the coronavirus and diabetes. These 10 research projects began to paint a clearer picture of why people with obesity and diabetes are at higher risk for hospitalization, serious outcomes, and death from the virus.”

“Heres some of what weve learned about diabetes and COVID19”

“The coronavirus can infect and damage insulin-producing beta cells, causing them to produce significantly less insulin and more glucagon. This could account for higher rates of diabetes diagnoses among people infected with COVID19. Dr. Shuibing Chen, Weill Cornell Medicine”

“When delivered to the nose and throat of an animal model, the coronavirus could later be found in the beta cells of the pancreas. These beta cells appeared to show the hallmarks of stress seen in the pancreases of people with type 2 diabetes. Dr. Senta Georgia, Childrens Hospital Los Angeles”

“Individuals with metabolic syndrome of which diabetes is one factor were 3.4 times more likely to die from COVID19 and nearly 5 times more likely to be admitted to an ICU, need a ventilator, or develop acute respiratory distress syndrome. These findings suggest that the underlying inflammation seen with metabolic syndrome may be the driver that leads to more severe cases of COVID19. Dr. Joshua Denson, Tulane University”

“In a laboratory setting, the coronavirus can directly infect fat and associated immune cells, eliciting a dramatic inflammatory response. This work tells us that the more fat cells a person has, the more of a reservoir the virus has to multiply, which could explain why people with obesity are at higher risk of severe illness and death from COVID19. Dr. Tracey McLaughlin, Stanford University”

“While we have much more work ahead of us, these findings have opened important new avenues of research and helped identify potential therapeutic strategies which could ultimately reduce the burden of COVID19 in people with obesity and diabetes.”

“Scientific SessionsHeld annually, Scientific Sessions exemplifies the ADAs leadership role in the global diabetes community while providing a critical platform for driving diabetes awareness. Scientific Sessions is the worlds largest scientific and medical meeting focused on the latest basic and clinical science research related to diabetes and its complications.”

“For the second time in a row, the ADA conducted the five day conference completely online due to the COVID19 pandemic. Whether future meetings are in person, virtual, or hybrid, the Scientific Sessions remains a place for scientists to share their latest research findings, for physicians to learn how to best treat patients with diabetes, and for diabetes educators to exchange best practices for helping people manage the disease. The virtual 81th Scientific Sessions by the numbers 11,685 total attendees, 119 countries represented, 191 educational sessions, 850 presenters, 1,489 published abstracts, 1,098 eposter presentations”

“Were Connected for Life. The American Diabetes Association is the nations leading voluntary health organization fighting to bend the curve on the diabetes epidemic to help people live a better life and thrive until we ultimately find a cure. The moving force behind the work of the American Diabetes Association is a network of more than 565,000 volunteers, their families and caregivers, a professional society of nearly 16,000 health care professionals, as well as more than 250 staff members.”

“Diabetes has brought us all together, what we do next makes us Connected for Life. Learn more about the American Diabetes Association at diabetes.org.”

“On December 31, 2021, the American Diabetes Association Research Foundation, Inc. merged into the American Diabetes Association and has therefore ceased making research grants. The research grant program will be continued by the American Diabetes Association.”