Sanford Burnham Prebys Medical Discovery Institute

“Process used by management and/or governing body to review form 990: the 990 is prepared by the finance department. It is reviewed by the institute's tax advisors, selected members of management including the cfo and audit committee, and provided to members of the board prior to filing.”

“Description of process to monitor transactions for conflict of interest: sanford burnham prebys medical discovery institue has a conflict of interest policy that requires all trustees, principal officers or members of a committee with board delegated powers to annually confirm their receipt of the conflict of interest policy and disclose any new associations or interest that might potentially pose a conflict. This is a written confirmation that she or he read and understands the conflict of interest policy, will abide by the conflict of interest policy and certifies disclosure of all interests or relationships that may pose conflicts. New trustees receive training regarding the institute's conflict of interest policy, which includes how to identify a conflict of interest and how to handle possible conflicts of interest when they arise. The compliance department reviews each of the statements and assesses whether an actual or potential conflict of interest exists and refers the matter to the board to whether the individual should be prohibited from consideration of related items. Any trustee, principal officer or member of a committee with board delegated powers with a conflict in a matter requiring action by the board are prohibited from particpating in the board's deliberations and/or voting on the particular transaction or matter in which he or she has an interest; and otherwise refrain from exerting any influence to affect a decision. However, other measures may be required, depending on the nature of and the ability to reasonably manage a conflict.”

“Compensation for the ceo and president, chief financial officer, and other key employees is established according to institute policies that are designed to meet the irs standard for "rebuttable presumption of reasonableness". The compensation committee of the board of trustees, consisting of at least three independent trustees, reviews comparability data at least every two years provided by an independent external consultant/resource that incorporates and evaluates institute data and that of comparable organizations and markets from which the institute draws its executive talent. Utilizing this information, the compensation committee makes a determination whether the proposed compensation is reasonable. The compensation committee has been delegated authority by the board of trustees to review and approve compensation of all positions except for the ceo. The ceo's compensation package is reviewed and approved initially by the compensation committee and then goes to the executive committee for final approval. The compensation committee contemporaneously and adequately documents the basis for its determination and recommendation to the executive committee. If approved by the executive committee, the ceo compensation package is then implemented and such documentation is kept in the written and electronic records of the board of trustees. The process was last completed on june 27, 2023. The next review will be completed june 2025.”

“SEE ABOVE”

“Process for making documents available to the public: documents are available upon request and the institute's tax form 990 is available on charity navigator and guidestar.”

“ALL OTHER REVENUE - Total Revenue: 6000, Related or Exempt Function Revenue: 6000, Unrelated Business Revenue: , Revenue Excluded from Tax Under Sections 512, 513, or 514: ;”

“Sanford burnham prebys medical discovery institute's mission is to advance the biomedical sciences by cultivating the next generation of scientific leaders, providing meaningful opportunities for researchers of all backgrounds to learn, innovate, and make breakthrough discoveries that improve human health.”

“Form 990 - Part III, line 4 Program Service Accomplishments Sanford Burnham Prebys is an independent nonprofit medical research organization dedicated to uncovering the origins of disease and launching bold new strategies that lay the foundation for cures. The institute has deep expertise in fundamental biology highlighted by four disease-focused centers, two technology-enabling centers and four cross-cutting themes; stem cells and regenerative medicine; and the Sanford Children's Health Research Center. Cancer Selected published research How a protein component of nuclear pore complexes regulates development of blood cells and may contribute to myeloid disorders. Maximiliano D' Angelo, PhD, et al. Science Advances. June 5, 2024. How tumor stiffness alters immune cell behavior to escape destruction. Kevin Tharp, PhD, and Kelly Kersten, PhD, et al. Nature Cancer. June 3. 2024. Overlooked lipid connected to ancient cellular pathway with links to cancer. Brooke Emerling, PhD, et al. Science Signaling. May 28, 2024. AI tool predicts responses to cancer therapy using information from each cell of the tumor. Sanju Sinha, PhD, et al. Nature Cancer. Apr 18, 2024. What makes a pathogen antibiotic-resistant? Andrei L. Osterman, PhD, et al. npj Antimicrobials and Resistance. Mar 2, 2024. New genome mapping tool may uncover secrets for treating blood cancers. Kristiina Vuori, MD, PhD, et al. Cancers. Jan 18, 2024. The "Eph" system may pave the way for novel cancer therapies. Elena Pasquale, PhD, et al. Nature Reviews Cancer. Nov 27, 2023. "DNA loops" in pediatric brain tumors double relapse risk. Lukas Chavez, PhD, et al. Nature Genetics. Nov 14, 2023. Copycat nutrient leaves pancreatic tumors starving. Cosimo Commisso, PhD, et al. Nature Cancer. Oct 8, 2023. This sugar kills honeybees-it could also help fight cancer. Hudson Freeze, PhD, et al. eLife. July 17, 2023. Cardiovascular and Muscular Diseases Selected published research New genes implicated in deadly heart defect. Rolf Bodmer, PhD, and George Vogler, PhD, et al. eLife. July 17, 2023. Neurologic Diseases Selected published research Tiny brain bubbles carry complete codes. Jerold Chun, MD, PhD, et al. Cell Reports. Apr 23, 2024. Common HIV treatments may aid Alzheimer's disease patients. Jerold Chun, MD, PhD, et al. Pharmaceuticals. Mar 22, 2024. Similarity between vitamin B12 loss and multiple sclerosis revealed. Jerold Chun, MD, et al. Cell Reports. Dec 8, 2023. Inhibiting an enzyme associated with aging could help damaged nerves regrow and restore strength. Yu Xin Wang, PhD, et al. Science Translational Medicine. Oct 11, 2023. Metabolic and Liver Diseases Selected published research A new 3D bioprinted model offers a novel tool to study common liver disease, and perhaps find an effective treatment. David Brenner, MD, et al. American Journal of Pathology. Dec 27, 2023. How liver cells become scarring, and worse. David Brenner, MD, et al. Cellular and Molecular Gastroenterology and Hepatology. Sept 27, 2023. Cross-cutting Themes New roles for autophagy genes in cellular waste management and aging. Malene Hansen, PhD, et al. Nature Aging. Jan 4. 2024. A potential new weapon against a deadly, drug-resistant bacterial pathogen. Andrei Osterman, PhD, et al. Nature. Jan 3, 2024. Study reveals Zika's shape-shifting machinery-and a possible vulnerability. Alexey Terskikh, PhD, et al. PLOS Pathogens. Nov 27, 2023. Selected Awards and Grants Michael Jackson, PhD, and collaborators at Cedars-Sinai have received a four-year, $2.5 million grant from the National Cancer Institute to target the mutant promoter of TERT, which is associated with an increased risk of acute myeloid leukemia. Tim Huang, PhD, was awarded a five-year, $4.3 million grant from the National Institute on Aging to study the potential therapeutic value of SORLA against Alzheimer's disease and related tauopathies. The research is in collaboration with Kevin Yip, PhD. Sanjeev Ranade, PhD, received a three-year, $752,000 awar”

“Sanford Burnham Prebys Medical Discovery Institute does not maintain ongoing operations in foreign jurisdictions. However, the Institute's scientists do travel to various scientific conferences in other countries to share the Institute's scientific discoveries, as well as, to learn from other scientists across the world.”

“Specific Program Service Activity in all regions is employees attending and/or speaking at scientific conferences and collaborations.”

“The accrual method of accounting was used to determine the amounts in Part I, line 3, column F.”