Civic Intelligence

Cancer Prevention Initiative Inc.

990 • Fiscal year 2021 • EIN 47-3425850

Jan 01, 2021 to Dec 31, 2021 • Filed on May 09, 2022

1722 Routh Street Suite 770Dallas, TX 75201

(844) 437-4891

Siviq Scores

Precomputed percentiles for this filing year versus similar nonprofits in the same peer cohort.

Liabilities / Assets

87th percentile

0.52x

Higher debt load relative to assets than 87% of similar nonprofits.

2021 filings • 501(c)3 • $500k-$1M nonprofits • Source year 2021

Liabilities / Revenue

100th percentile

3319.84x

Higher debt load relative to revenue than 100% of similar nonprofits.

2021 filings • 501(c)3 • $500k-$1M nonprofits • Source year 2021

Net Margin

1st percentile

-203901%

Higher net margin than 1% of similar nonprofits.

2021 filings • 501(c)3 • $500k-$1M nonprofits • Source year 2021

Top Officer Pay

68th percentile

$50,000

Higher top officer pay than 68% of similar nonprofits.

Top officer pay equals 33112.6% of source-year revenue.

2021 filings • 501(c)3 • $500k-$1M nonprofits • Source year 2021

Asset Growth

3rd percentile

-38%

Faster asset growth than 3% of similar nonprofits.

2021 filings • 501(c)3 • $500k-$1M nonprofits • Annualized from 2020 to 2021

Revenue Growth

1st percentile

-100%

Faster revenue growth than 1% of similar nonprofits.

2021 filings • 501(c)3 • $500k-$1M nonprofits • Annualized from 2020 to 2021

Assets

Down

$962,671

Down $584,023 (-38%) from 2020

Net Assets

Down

$461,375

Down $307,891 (-40%) from 2020

Liabilities

Down

$501,296

Down $276,132 (-36%) from 2020

Revenue

Down

$151

Down $481,639 (-100%) from 2020

Expenses

Down

$308,042

Down $264,841 (-46%) from 2020

Net Income

Down

-$307,891

Down $216,798 (-238%) from 2020

Historical Trend

Balance Sheet Trend

The highlighted filing sits inside the broader history for assets, liabilities, and net assets.

$4.0M$3.0M$2.0M$1.0M$0Assets 2015: $416,306Liabilities 2015: $72,509Net Assets 2015: $343,7972015Assets 2016: $3,210,955Liabilities 2016: $133,500Net Assets 2016: $3,077,4552016Assets 2017: $2,944,284Liabilities 2017: $1,959,664Net Assets 2017: $984,6202017Assets 2018: $2,632,592Liabilities 2018: $985,352Net Assets 2018: $1,647,2402018Assets 2019: $1,943,615Liabilities 2019: $1,083,256Net Assets 2019: $860,3592019Assets 2020: $1,546,694Liabilities 2020: $777,428Net Assets 2020: $769,2662020Assets 2021: $962,671Liabilities 2021: $501,296Net Assets 2021: $461,3752021Assets 2022: $1,056,196Liabilities 2022: $356,171Net Assets 2022: $700,0252022Assets 2023: $821,212Liabilities 2023: $145,996Net Assets 2023: $675,2162023Assets 2024: $2,225,249Liabilities 2024: $580,179Net Assets 2024: $1,645,0702024

Highlighted filing

2021

Assets$962,671
Liabilities$501,296
Net Assets$461,375

Operations Trend

Revenue, expenses, and net income across loaded years, with this filing highlighted.

$4.0M$2.0M$0-$2.0M-$4.0MRevenue 2015: $792,792Expenses 2015: $448,995Net Income 2015: $343,7972015Revenue 2016: $3,281,896Expenses 2016: $548,238Net Income 2016: $2,733,6582016Revenue 2017: $403,489Expenses 2017: $2,496,324Net Income 2017: -$2,092,8352017Revenue 2018: $1,224,228Expenses 2018: $561,608Net Income 2018: $662,6202018Revenue 2019: $297,410Expenses 2019: $1,084,291Net Income 2019: -$786,8812019Revenue 2020: $481,790Expenses 2020: $572,883Net Income 2020: -$91,0932020Revenue 2021: $151Expenses 2021: $308,042Net Income 2021: -$307,8912021Revenue 2022: $257,068Expenses 2022: $18,418Net Income 2022: $238,6502022Revenue 2023: $49,585Expenses 2023: $74,394Net Income 2023: -$24,8092023Revenue 2024: $1,673,681Expenses 2024: $703,827Net Income 2024: $969,8542024

Highlighted filing

2021

Revenue$151
Expenses$308,042
Net Income-$307,891
Jump To
Filing Snapshot
Filing Period
Jan 1, 2021 to Dec 31, 2021
Signed
May 9, 2022
Return Version
2021v4.0
Gross Receipts
$151
Mission and Program Overview

Mission

Cancer Prevention Initiative, Inc. (CPI) is a nonprofit corporation whose mission is to accelerate the discovery and development of new medicines that prevent cancer. CPI uses its research, medical and pharmaceutical expertise to invest in first-rate science that will discover new strategies for preventing cancer. Our strategy is to support research on prevention of inherited cancers as a path towards elimination of all cancers. CPI acts as a facilitator to ensure that good ideas can find sufficient funding to turn them into therapeutic solutions such as drugs or vaccines to prevent cancer. CPI provides financial support, guidance and expertise throughout the research and development process to help researchers use the resources (donations) for the highest possible impact.

Cancer Prevention Initiative, Inc. (CPI) is a nonprofit corporation whose mission is to accelerate the discovery and development of new medicines that prevent cancer.

Balance Sheet Detail
LineBeginningEndChange
Assets
Investments in Publicly Traded Securities$1,320,326$832,402▼ $487,924
Savings and Temporary Cash Investments$129,496$82,786▼ $46,710
Pledges and Grants Receivable$50,000$25,000▼ $25,000
Intangible Assets$15,765$12,175▼ $3,590
Prepaid Expenses and Deferred Charges$989$6,414▲ $5,425
Cash and Non-Interest-Bearing Accounts$30,061$3,894▼ $26,167
Total Assets$1,546,694$962,671▼ $584,023
Other Assets Total$57--
Liabilities
Grants Payable$776,760$500,358▼ $276,402
Accounts Payable and Accrued Expenses$668$938▲ $270
Other Liabilities$0$0→ $0
Total Liabilities$777,428$501,296▼ $276,132
Net Assets / Fund Balance
Net Assets With Donor Restrictions$350,000$289,764▼ $60,236
Net Assets Without Donor Restrictions$419,266$171,611▼ $247,655
Total Net Assets Fund Balance$769,266$461,375▼ $307,891
Total Liabilities and Net Assets / Fund Balance$1,546,694$962,671▼ $584,023
Compensation and Service Providers

Employees

NameTitleFull / Part TimeBaseTotal
Theodora RossPresident & Chief Scientific OfficerPT$50,000$50,000

Board Members and Trustees

NameTitle
Howard JanzenBoard Chair; Chief Financial Officer
Douglas HagerTrustee, Sr. Vice President, Project Management and Operations
Jan Livingston-MokhtariTrustee
Joi MorrisTrustee
Kirk PatrickSecretary
Revenue and Support

Revenue Composition

Contributions and Grants
$135
Program Service Revenue
$0
Investment Income
$16
Other Revenue
$0
All Other Contributions
$135
Change in Net Assets
$-307,891
Expenses and Functional Allocation

Major Expense Lines

Line ItemAmount
Grants and Similar Amounts Paid$215,236
Salaries, Compensation, and Employee Benefits$49,916
Other Expenses$42,890
Professional Fundraising Fees$0
Total Fundraising Expense$0

Functional Expense Allocation

Line ItemProgramManagementFundraisingTotal
Grants to Domestic Orgs$215,236--$215,236
Current Officers, Directors, Trustees, and Key Employees$50,000$0$0$50,000
Fees for Services Accounting$0$23,539$0$23,539
Information Technology$5,517$320$0$5,837
Office Expenses$0$4,234$0$4,234
Depreciation Depletion$0$3,590$0$3,590
Insurance$0$2,246$0$2,246
Fees for Service Investment Mgmnt Fees$0$1,703$0$1,703
Other Expenses$0$1,703$0$1,703
Payroll Taxes$0$-84$0$-84
Total Functional Expenses$270,753$37,289$0$308,042
International Activity

Grant and Assistance Recipients

RecipientLocationCategoryPurposeAmount
University of Texas Southwestern Medical CenterDallas, TX501(c)(3)Scientific and administrative oversight of all Cancer Prevention Initiative programs.$180,000
Cleveland Clinic FoundationCleveland, OH501(c)(3)The objective of this project is to identify proteins uniquely and highly expressed in breast cancer of BRCA1 mutation carriers. Identification of these proteins can be key to developing preventative vaccines.$150,000
Memorial Sloan Kettering Cancer CenterNew York, NY501(c)(3)The objective of this project is to generate a robust cellular assay that would allow for the screening of hundreds of compounds to identify determinants of Loss of Heterozygosity (LoH) of BRCA genes. LoH is a major driver in cancer initiation.$150,000
Fundraising, Events, and Gaming
Fundraising activities
No
Gaming activities
No
Professional fundraiser used
No

Fundraising and Gaming Totals

Line ItemAmount
Fundraising Direct Expenses$0
Fundraising Gross Income$0
Professional Fundraising Fees$0
Political and Lobbying Activity
Political campaign activity
No
Lobbying activity
No
Subject to proxy tax
No
Governance and Compliance

Governance Checklist

Compiled or reviewed by an accountant
No
Annual disclosure for covered persons
Yes
Backup withholding compliance
No
Business relationship with 35% controlled entity
No
Business relationship with family members
No
Business relationship with organization members
No
Material changes to governing documents
No
Compensation from other sources disclosed
No
CEO compensation reviewed
Yes
Other officer compensation reviewed
No
Conflict-of-interest policy
Yes
Audited financial statements prepared
No
Key decisions subject to board approval
No
Management duties delegated
No

Governance Explanations

Form 990, Part VI, Section A, Line 8B

Governing body has no committees with authority to act on behalf of the board.

Form 990, Part VI, Section B, Line 11B

Form 990, Park VI, Section B, Line 11b - All members of the governing body receive a copy of the 990 prior to filing with the opportunity for input and questions.

Form 990, Part VI, Section B, Line 12C

Form 990, Part VI, Section B, Line 12c - The Board of Trustees annually reviews the Conflict of Interest policy and each covered person is annually required to sign a statement that discloses all potential conflicts of interest and affirms that such person: 1. Has received a copy of the Conflict of Interest Policy; 2. Has read and understand the Conflict of Interest Policy; 3. Has agreed to comply with the Conflict of Interest Policy; 4. Understands that CPI is a charitable organization and that in order to maintain its federal tax exemption and the trust of the public it must diligently avoid conflicts of interest or the appearance of any conflict of interest and engage primarily in activities that accomplish one or more of its tax exempt purposes.

Form 990, Part VI, Section B, Line 15

Form 990, Part VI, Section B, Line 15 - The board conducted an independent review of the compensation for the Organization's President, who was compensated as an independent contractor. The deliberations and decision of the board are recorded in the board's minutes. All officers of the organization other than the President are volunteers and are not compensated. The organization does not have any employees. Accordingly, review and approval of compensation is not necessary other than for the President.

Form 990, Part VI, Section C, Line 19

Form 990 Part VI, Section C, Line 19 - The Organization complies with IRC Section 6104 in regards to public disclosure. As such, our annual information returns, conflict of interest policy, audited financial reports, and governing documents are available for public inspection upon request.

Filing and Contact Details

Filer

Filer Name
Cancer Prevention Initiative Inc
EIN
47-3425850
Phone
8444374891
Address
1722 Routh Street Suite 770, Dallas, TX 75201

Signing Officer

Name
Theodora Ross
Title
President
Phone
3103445641
Signed
2022-05-09

Organization Details

Principal Officer
Theodora Ross
Formed
2015
Legal Domicile
De
Voting Board Members
6
Independent Board Members
5
Employees
0
Volunteers
5
Supplemental Narrative

Additional Explanations

Form 990, Part IX, Line 1

New grants made in 2021 totaled $480,000 (see schedule I). This amount is offset by the return of $264,764 from a 2017 grant to Dana Farber Cancer Institute. The grantee was unable to complete their contracted project. Net grant expenses for 2021 were $480,000 - $264,764 = $215,236.

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IRS990/Desc0In 2021, the Cancer Prevention Initiative (CPI) programs have progressed and CPI continues to grow and develop. CPI's research grant recipients have continued to advance us towards understanding and preventing inherited cancers. A newly funded project with Cleveland Clinic seeks to identify proteins uniquely and highly expressed in breast cancer of BRCA1 mutation carriers. Identification of these unique proteins is an important link for developing preventative vaccines. Also newly funded is a project with Memorial Sloan Kettering Cancer Center to generate a robust cellular assay that would allow for the screening of hundreds of compounds to identify determinants of Loss of Heterozygosity (LoH) of BRCA genes. LoH is a major driver in cancer initiation, and discovery of compounds that cause LoH can be key for prevention discoveries. Ongoing projects include Harvard's Beth Israel Deaconess Medical Center where they are working to identify cancer risk predictors in the reproductive epithelium in BRCA mutation carriers. A project at City of Hope is progressing to repurpose a safe, FDA approved anti-parasitic drug that has great promise for reducing breast cancer growth. Repurposing drugs is a safe way to bring therapies to patients quickly. Related to this is a need for ways to evaluate known drugs for new purposes. A team at the University of Toronto is developing a test to screen for drugs that can restore normal BRCA1 function to BRCA1 deficient cells. An international collaboration has co-developed a candidate vaccine for the prevention of triple negative breast cancers in patients who have inherited a BRCA1 mutation. New grants were made in 2021 totaled $480,000. This amount is offset by the return of $264,764 from a 2017 grant where the grantee was not able to complete their contracted project. The grant expenses for 2021 are $480,000 - 264,764 = $215,236.
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IRS990/Form990PartVIISectionAGrp/PersonNm0Theodora Ross
IRS990/Form990PartVIISectionAGrp/PersonNm1Howard Janzen
IRS990/Form990PartVIISectionAGrp/PersonNm2Kirk Patrick
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IRS990/Form990PartVIISectionAGrp/TitleTxt0President & Chief Scientific Officer
IRS990/Form990PartVIISectionAGrp/TitleTxt1Board Chair; Chief Financial Officer
IRS990/Form990PartVIISectionAGrp/TitleTxt2Secretary
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IRS990/MissionDesc0Cancer Prevention Initiative, Inc. (CPI) is a nonprofit corporation whose mission is to accelerate the discovery and development of new medicines that prevent cancer. CPI uses its research, medical and pharmaceutical expertise to invest in first-rate science that will discover new strategies for preventing cancer. Our strategy is to support research on prevention of inherited cancers as a path towards elimination of all cancers. CPI acts as a facilitator to ensure that good ideas can find sufficient funding to turn them into therapeutic solutions such as drugs or vaccines to prevent cancer. CPI provides financial support, guidance and expertise throughout the research and development process to help researchers use the resources (donations) for the highest possible impact.
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IRS990/ProgSrvcAccomActy2Grp/Desc0Education and community engagement programs: As we move closer to our goal of eradicating all cancers through preventative medicines, we believe that educating the public and raising awareness about inherited cancer syndromes will inspire more individuals to take proactive, life-saving preventive measures. One of the goals is to enhance the scientific reach of the organization and raise awareness on cancer prevention to a broader audience of patients, advocates and donors. Thus, regular updates on scientific and medical research advances, recent clinical trials, and interviews with experts in cancer prevention are published on web-based platforms.
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