Testicular Cancer Commons

“Donor directed contribution from earl e and phyllis g nichols trust”

“Pdrior to the pandemic, testicular cancer commons (tcc) was able to accrue unspent rainy day funds through accumulation of incirect costs from two sources.”

“Dr nichols was elected as treasurer and a member of the executive committee for the american society of clinical oncology (asco)”

“As partial compensation for the time contributed to board and other activities, annual grants were given to tcc averaging $50,000 to $60,000 annually”

“Tcc accrued indirect costs and passed some through to dr. Nichols as monetary compensation for the significant time commitment away from tcc, his primary institution.”

“For some years, tcc was able to run positive balances through the asco donations and indirect cost accrual from other federal scientific grants.”

“This all changed markedly in early 2020 with the covid-19 pandemic which profoundly changed the business bodel and work flow of tcc.”

“At that time, dr. Nichols' asco term had been completed and asco grants discontinued.”

“His swog tenure ended and the business model changed from largely a face to face business to the telehealth model.”

“Concurrent with the pandemic and declining revenue, tcc was forced to pivot to an administrative only model of business to provide the infrastructure which fully transpired in 2022”

“As well, for reason of proximity to vanderbilt univeristy and uniformed services university (bethesda), tcc offices required relocation to knoxville, tn”

“Tcc invested in full telehealth capabilities to accomodate the current work model and primary grant relationships.”

“Productivity in terms of grants and publications and, most importantly, favorable patient impact in terms of reduction of need for chemotherapy and reduction in late treatment effects is approaching”

“A peak with the interim analysis of 956 patients on the north american clinical translational study-s1823/cctg gcc1 beginning in early 2024”

“In early 2023 and going forward, tcc will operate on a budget of around $20,000 with no direct compensation of any officers or dr. Nichols”

“The 2022 changes in fund balances and net assets reflect the winding down of direct compensation to dr. Nichols and the investment in new space and telehealth infrastructure”

“(adobe, office, zoom, quickbook subscriptions, business internet, computers, monitors, printers, network software and hardware and som travel to dc and british columbia”

“This investment largely came from unspent accrrued funds from prior years”

“Testicular cancer commons (tcc) is a 501(c)(3) established in 2012 with the mission of exchange of scientific and clinical information and knowledge for patients, families and medical professions experiencing or managing testicular germ cell cancer. Over the last decade, tcc has become a major content producer in the field and is a leader in not only generation of new knowledge, but a lead institution in knowledge implementation and dissemination. From an administrative and support standpoint, tcc has been fortunate in that we have not yet had to turn to public fund raising and has been supported by writing and receiving peer reviewed grants, generous support for administrative functions using donor directed funds from the earl e and phyllis g nichols trust through the lutheran church missouri synod foundation and through in-kind and direct financial support from founder and director dr. Craig nichols. Tcc is fortunate to have sage governance throught the engagement of our 5 physicians/scientists board. As of 2022, tcc no longer pays direct salaries and support is now directed toward administrative support only going forward”

“Tcc productivity 2021-2023. Publications in high impact journals:”

“1. Nappi l saxtena n mazurek s et al. Longitudinal evaluation of plasma mir371 to detec miminal residual disease and early relapse in germ cell maligancies (currently under second level peer review)”

“Nappi l, thi m, adra n, et al integrated expression of circulating mir375 and mir 371 to identify teratoma and active germ cell malignancy components in malignant germ cell tumors eur urol 2021 jan; 79(1): 16-19”

“Daneshmand s, cary c, msaterson t et al surgery in early metastatic seminoma (sems): a phase ii tria of retroperitoneal lymph node dissection for testicular seminoma with limited retroperitoneal lymphadenopathy. J clin oncol 2023 acceoted fir oybkucatuib”

“R01 (r37) - imaging, biomarkers and digital pathomics for the early detection of premetastatic aggressive cancer. National institue of health 05/03/2022 - 05/09/22025 nappi l pi funded with possible merit extension. Dod translational team science award (ttsa) building a personalized, population-leve; atient-oriented translational research and cancer care delivery platform for germ cell cancer within the active military health care system (scored but not funded). R-13 nih germ cell tumor wellsprong conference (start date 7-23) scored but not funded). Peer reviewed cancer research program dod impact award scheduled submission 7-23 currently under scientific review. Peer reviewed cancer research program dod patient well being and survivorship award submission 8-2023 under scientific review. R-37 merit extension (nappi) submission 10-2023 under scientific review.”