Civic Intelligence

Torrey Pines Institute for Molecular Studies Inc

EIN 33-0319501 • 501(c)3

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Profile

Torrey pines institute for molecular studies is a nonprofit public benefit corporation and is not organized for the private gain of any person. The specific purpose of this corporation is to conduct scientific research in the public interest.

11350 SW Village Parkway34987-2352

www.tpims.org

Siviq Scores

Precomputed percentiles relative to similar nonprofits. These scores are descriptive rather than judgmental.

Liabilities / Assets

43rd percentile

0.15x

Higher debt load relative to assets than 43% of similar nonprofits.

501(c)3 • $25M-$50M nonprofits • Source year 2014

Liabilities / Revenue

25th percentile

0.10x

Higher debt load relative to revenue than 25% of similar nonprofits.

501(c)3 • $25M-$50M nonprofits • Source year 2014

Net Margin

87th percentile

42%

Higher net margin than 87% of similar nonprofits.

501(c)3 • $25M-$50M nonprofits • Source year 2014

Top Officer Pay

79th percentile

$445,027

Higher top officer pay than 79% of similar nonprofits.

Top officer pay equals 1.5% of source-year revenue.

501(c)3 • $25M-$50M nonprofits • Source year 2014

Asset Growth

99th percentile

227%

Faster asset growth than 99% of similar nonprofits.

501(c)3 • $25M-$50M nonprofits • Annualized from 2013 to 2014

Revenue Growth

Score unavailable

No value available

No earlier valid filing was available within the previous three public years.

Source year 2014

Balance Sheet
Liabilities / Assets43rd percentile

Assets

Up

$19,225,819

Up $13,340,720 (+227%) from 2013

Liabilities

Up

$2,979,439

Up $544,358 (+22%) from 2013

Net Assets

Up

$16,246,380

Up $12,796,362 (+371%) from 2013

Operations
Liabilities / Revenue25th percentileNet Margin87th percentile

Revenue

$30,210,535

No earlier filing loaded for comparison.

Expenses

Down

$17,408,836

Down $1,668,041 (-8.7%) from 2013

Net Income

$12,801,699

No earlier filing loaded for comparison.

Trend Graphs

Balance Sheet Trend

Asset Growth99th percentile

Grouped bars show assets, liabilities, and net assets across loaded filings.

$20M$15M$10M$5.0M$0Assets 2011: $14,255,701Liabilities 2011: $9,404,562Net Assets 2011: $4,851,1392011Assets 2012: $11,000,830Liabilities 2012: $5,793,187Net Assets 2012: $5,207,6432012Assets 2013: $5,885,099Liabilities 2013: $2,435,081Net Assets 2013: $3,450,0182013Assets 2014: $19,225,819Liabilities 2014: $2,979,439Net Assets 2014: $16,246,3802014

Highlighted filing

2014

Assets$19,225,819
Liabilities$2,979,439
Net Assets$16,246,380
Open 2014 Filing

Operations Trend

Revenue GrowthScore unavailable

Revenue, expenses, and net income by year, with the latest filing highlighted.

$40M$30M$20M$10M$0Expenses 2011: $17,933,1842011Expenses 2012: $18,627,0822012Expenses 2013: $19,076,8772013Revenue 2014: $30,210,535Expenses 2014: $17,408,836Net Income 2014: $12,801,6992014

Highlighted filing

2014

Revenue$30,210,535
Expenses$17,408,836
Net Income$12,801,699
Open 2014 Filing

Filings

Most recent year

2014 • Form 990Detailed filing. Detailed filing data is available for this year.

Open filing
Assets
$19,225,819
Liabilities
$2,979,439
Net assets
$16,246,380
Revenue
$30,210,535
Expenses
$17,408,836
Net income
$12,801,699
Balance SheetOperations
YearAssetsLiabilitiesNet AssetsRevenueExpensesNet Income
2014Detailed filing. Detailed filing data is available for this year.$19.2$2.98$16.2$30.2$17.4$12.8
2013Facts available. Structured filing facts are available, but richer extracted sections are limited.$5.89$2.44$3.45$19.1
2012Facts available. Structured filing facts are available, but richer extracted sections are limited.$11.0$5.79$5.21$18.6
2011Facts available. Structured filing facts are available, but richer extracted sections are limited.$14.3$9.40$4.85$17.9
Latest Filing Detail
Jump To
Filing Snapshot
Filing Period
Jul 1, 2013 to Jun 30, 2014
Signed
May 14, 2015
Return Version
2013v4.0
Gross Receipts
$30,251,685
Mission and Program Overview

Mission

Torrey pines institute for molecular studies is a nonprofit public benefit corporation and is not organized for the private gain of any person. The specific purpose of this corporation is to conduct scientific research in the public interest.

Torrey pines institute for molecular studies pursues innovative research that leads to the understanding and treatment of major medical conditions, including multiple sclerosis, aids, alzheimer's disease, pain, arthritis, heart disease, many types of cancer, and more. Our philosophy is that discovery and excellence in science are fostered by providing a stimulating and collaborative research environment.

Balance Sheet Detail
LineBeginningEndChange
Assets
Land, Buildings, and Equipment, Net$1,996,740$15,675,268▲ $13,678,528
Pledges and Grants Receivable$1,279,502$1,947,055▲ $667,553
Savings and Temporary Cash Investments$1,756,485$1,085,513▼ $670,972
Intangible Assets$325,963$244,613▼ $81,350
Prepaid Expenses and Deferred Charges$174,215$51,100▼ $123,115
Accounts Receivable$160,298$19,373▼ $140,925
Cash and Non-Interest-Bearing Accounts$1,250$1,250→ $0
Total Assets$5,885,099$19,225,819▲ $13,340,720
Other Assets Total$190,646$201,647▲ $11,001
Liabilities
Other Liabilities$192,297$1,238,852▲ $1,046,555
Deferred Revenue$486,792$730,890▲ $244,098
Unsecured Notes Loans Payable$464,842$669,180▲ $204,338
Accounts Payable and Accrued Expenses$1,241,150$287,487▼ $953,663
Mortgage Notes Payable Secured by Investment Property$50,000$53,030▲ $3,030
Total Liabilities$2,435,081$2,979,439▲ $544,358
Net Assets / Fund Balance
Unrestricted Net Assets$2,012,246$14,376,720▲ $12,364,474
Temporarily Rstr Net Assets$1,437,772$1,869,660▲ $431,888
Total Net Assets Fund Balance$3,450,018$16,246,380▲ $12,796,362
Total Liabilities and Net Assets / Fund Balance$5,885,099$19,225,819▲ $13,340,720

Asset Categories

AssetBook ValueDepreciationBasis
Buildings$12,333,333$166,667$12,500,000
Equipment$1,491,935$6,273,946$7,765,881
Land$1,850,000-$1,850,000
Leasehold Improvements$0$1,780,655$1,780,655
Other Land Buildings$0$6,734$6,734
Compensation and Service Providers
Top Officer Pay79th percentile

Employees

NameTitleFull / Part TimeBaseOtherTotal
Richard HoughtenPresident & CEOFT$401,297$43,730$445,027
Gregg FieldsVP of Scientific AffairsFT$252,000$36,937$288,937
Karen DouthittVice President of AdministrationFT$263,516$21,501$285,017
Larry TollMemberFT$199,700$39,618$239,318
James BinleyMemberFT$172,350$36,883$209,233
Marc GiulianottiDirector of Chemistry OperFT$157,258$36,873$194,131
Greg WelmakerScientific Assistant/director of Fl Drug DiscoveryFT$154,500$23,041$177,541
Greg WelmakerScientific Assistant/director of Fl-$154,500$23,041$177,541
Kim NovenaAssistant Corporate SecretFT$118,045$18,128$136,173
Donald B CooperCFO (march 2012 - PresFT$134,095-$134,095
Pam HoughtenVP of Administration & OutFT$79,500$22,275$101,775

Board Members and Trustees

NameTitle
Andrea ResnickTrustee
Daniel RicheyTrustee
Ken PruittTrustee
Mark RobitailleTrustee
Patricia WuTrustee
Robert HodgesTrustee
Robin OffordTrustee
Weaver GainesTrustee

Highest Paid Contractors

ContractorServicesLocationCompensation
Dean MeadLegal-$114,715
Revenue and Support

Revenue Composition

Contributions and Grants
$28,584,201
Program Service Revenue
$632,218
Investment Income
$-35,653
Other Revenue
$1,029,769
All Other Contributions
$15,775,250
Change in Net Assets
$12,801,699

Noncash Contribution Practices

Property subject to holding requirements
No
Reviewed unusual noncash gifts
Yes
Third parties used for noncash contributions
No

Noncash Contributions

Contribution TypeContribution CountReported AmountValuation Method
Real Estate Commercial2$14,350,000Fair Market Value (FMV)
Total Noncash Contributions2$14,350,000-

Audited Revenue Reconciliation

Revenue per Audited Statements
$30,210,535
Revenue Not Reported on Financial Statements
$0
Revenue Not Reported on Form 990
$-638,090
Total Revenue per Audited Statements
$29,572,445
Total Revenue per Form 990
$30,210,535
Expenses and Functional Allocation

Major Expense Lines

Line ItemAmount
Salaries, Compensation, and Employee Benefits$8,882,056
Other Expenses$7,750,374
Grants and Similar Amounts Paid$776,406
Total Fundraising Expense$54,485
Professional Fundraising Fees$0

Functional Expense Allocation

Line ItemProgramManagementFundraisingTotal
Other Salaries and Wages$4,572,813$457,534$20,902$5,051,249
Occupancy$3,023,894$104,935-$3,128,829
Current Officers, Directors, Trustees, and Key Employees$2,001,806$200,291$9,150$2,211,247
Depreciation Depletion$1,060,650--$1,060,650
Grants to Domestic Orgs$776,406--$776,406
Pension Plan Contributions$533,496$53,379$2,439$589,314
Other Employee Benefits$509,650$50,993$2,330$562,973
Payroll Taxes$423,014$42,325$1,934$467,273
Office Expenses$361,633$36,713$3,435$401,781
Fees for Services Other$336,340$23,971$14,238$374,549
Other Expenses$206,970$7,551-$214,521
Fees for Services Legal$530$136,460-$136,990
Information Technology$91,962$9,354-$101,316
Travel$67,811$31,832$57$99,700
Insurance$3,684$85,127-$88,811
Fees for Services Accounting-$63,198-$63,198
All Other Expenses$52,263$308-$52,571
Conferences and Meetings$32,866$4,944-$37,810
Interest$7,234$1,440-$8,674
Total Functional Expenses$15,056,850$2,297,501$54,485$17,408,836

Audited Expense Reconciliation

Line ItemAmount
Expenses per Audited Statements$17,408,836
Total Expenses per Form 990$17,408,836
Total Expenses per Audited Statements$16,741,592
Expenses Not Reported on Financial Statements$0
Expenses Not Reported on Form 990$-667,244
International Activity

Grant and Assistance Recipients

RecipientLocationCategoryPurposeAmount
33-0435954-501(c)(3)Medical Research$462,982
04-2697981-501(c)(3)Medical Research$126,009
43-6003859-501(c)(3)Medical Research$47,560
94-1160950-501(c)(3)Medical Research$33,091

International Summary

Offices
0
Employees
0
Spending
$84,529

International Compliance

Activity in boycott countries
No
Foreign corporation ownership
No
Foreign partnership interest
No
Interest in foreign trust
No
Passive foreign investment company interest
No
Transfers to foreign corporations
No

International Activities

RegionActivityServicesOfficesEmployeesSpending
Europe (including Iceland & Greenland)Program ServicesCost Reimbursable Subcontract00$84,529
Fundraising, Events, and Gaming
Fundraising activities
No
Gaming activities
No
Professional fundraiser used
No

Fundraising and Gaming Totals

Line ItemAmount
Professional Fundraising Fees$0
Political and Lobbying Activity
Political campaign activity
No
Lobbying activity
Yes
Subject to proxy tax
No
Insider Transactions and Loans

Interested-Person Transactions

Interested PartyRelationshipDescriptionShared RevenueAmount
Pamela HoughtenVp of Administration & Outreach, FlBase CompensationNo$79,500
Debt and Bond Financing

Other Reported Liabilities

LiabilityAmount
Due to Affiliates$1,147,479
Other Liabilities$79,546
Research Grants Payable to Tpims$6,175
Refundable Sublease Deposits$5,652
Governance and Compliance

Governance Checklist

Compiled or reviewed by an accountant
No
Annual disclosure for covered persons
Yes
Audit committee
Yes
Backup withholding compliance
Yes
Business relationship with family members
Yes
Business relationship with organization members
No
Material changes to governing documents
No
Compensation from other sources disclosed
No
CEO compensation reviewed
Yes
Other officer compensation reviewed
Yes
Conflict-of-interest policy
Yes
Audited financial statements prepared
Yes
Key decisions subject to board approval
No
Management duties delegated
No

Governance Explanations

Form 990, Part VI, Section B, Line 11

“The president & ceo, chief business and financial officer and controller review the form 990 in detail and a copy is provided to the board of trustees prior to being filed with the irs.”

Form 990, Part VI, Section B, Line 12C

“Monitoring of conflict of interest policy: each trustee, principal officer and member of a committee shall sign a statement annually which affirms such person: a) has received a copy of the conflict of interest policy, b) has read and understands the policy, c) has agreed to comply with the policy, and d) understands the corporation is charitable and in order to maintain its federal tax exemption, it must engage primarily in activities which accomplish one or more of its tax-exempt purposes.”

Form 990, Part VI, Section B, Line 15

“The compensation and benefits of officers, trustees and key employees are reviewed and approved in advance by the board of trustees (or a committee of the board of trustees), provided that persons with conflicts of interest with respect to the compensation arrangement at issue are not involved in the review and approval. The compensation is reviewed and approved using data as to comparable compensation for similarly qualified persons in functionally comparable positions at similarly situated organizations. There is contemporaneous documentation and recordkeeping with respect to the deliberations and decisions regarding the compensation arrangement. Generally, this is done through minutes of the meeting of the reviewing body prepared within 60 days of its action.”

Form 990, Part VI, Section C, Line 18

“The organization's form 990 is available for public inspection on selected websites and upon request”

Form 990, Part VI, Section C, Line 19

“The organization makes its governing documents, conflict of interest policy, and financial statements available to the public upon request.”

Filing and Contact Details

Filer

EIN
33-0319501
Phone
7723454800

Signing Officer

Name
Donald B Cooper
Title
Chief Business/financial Officer
Phone
7723454800
Signed
2015-05-14
Discuss with paid preparer
Yes

Organization Details

Principal Officer
Donald B Cooper
Formed
1988
Legal Domicile
CA
Voting Board Members
10
Independent Board Members
9
Employees
162
Volunteers
8

Preparer

Preparer
Rebekuh a Eley
Phone
4122812501
Supplemental Narrative

Financial Statement Notes

PART X, LINE 2:

“Accounting principles generally accepted in the united states of america require the institute's management to evaluate tax positions taken by the institute and recognize a tax liability (or asset) if the institute has taken a position that is uncertain. An uncertain position is defined as one in which there is a 50% or greater likelihood that the position will not be sustained upon examination by a taxing authority. Management has analyzed the tax positions taken by the institute and has concluded that, as of june 30, 2014, there are no uncertain tax positions taken or expected to be taken. The institute has recognized no interest or penalties related to uncertain tax positions. The institute is subject to routine audits by taxing jurisdictions; however, there are currently no audits for any tax periods in progress. Management believes all tax years since june 30, 2010 remain open for income tax examinations.”

PART XI, LINE 2D - OTHER ADJUSTMENTS:

“Related organizations -679,240. Investment loss 41,150.”

PART XII, LINE 2D - OTHER ADJUSTMENTS:

“Related organizations -708,394. Investment loss 41,150.”

Raw XML AppendixShowing 400 of 970 raw XML fields

This appendix keeps the raw XML leaves available for debugging and edge-case review. The human report above is the primary experience.

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IRS990/ActivityOrMissionDesc0TORREY PINES INSTITUTE FOR MOLECULAR STUDIES PURSUES INNOVATIVE RESEARCH THAT LEADS TO THE UNDERSTANDING AND TREATMENT OF MAJOR MEDICAL CONDITIONS, INCLUDING MULTIPLE SCLEROSIS, AIDS, ALZHEIMER'S DISEASE, PAIN, ARTHRITIS, HEART DISEASE, MANY TYPES OF CANCER, AND MORE. OUR PHILOSOPHY IS THAT DISCOVERY AND EXCELLENCE IN SCIENCE ARE FOSTERED BY PROVIDING A STIMULATING AND COLLABORATIVE RESEARCH ENVIRONMENT.
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IRS990/Desc0CANCER AND AGING:CANCER IS NOT ONE DISEASE, BUT A GROUP OF MORE THAN 100 DIFFERENT DISEASES. RESEARCHERS AND DOCTORS ARE FINDING NEW WAYS TO PREVENT AND TREAT CANCER, BUT IT IS STILL COMMON AND OFTEN DEADLY. THE AMERICAN CANCER SOCIETY ESTIMATES THAT CANCER IS RESPONSIBLE FOR ABOUT 10% OF DEATHS THROUGHOUT THE WORLD, AND IN THE U.S. ALONE, HALF OF ALL MEN AND A THIRD OF ALL WOMEN WILL EXPERIENCE CANCER DURING THEIR LIFETIME. SOME OF THE MOST COMMON CANCERS ARE BREAST CANCER, PROSTATE CANCER, AND LUNG CANCER. TORREY PINES INSTITUTE SCIENTISTS ARE CONDUCTING INTENSIVE RESEARCH INTO EACH OF THESE CANCERS.TORREY PINES INSTITUTE SCIENTISTS ARE AT THE FOREFRONT OF THE SEARCH FOR NEW WAYS TO PREVENT AND TREAT MANY TYPES OF CANCER INCLUDING BREAST CANCER, LUNG CANCER AND PROSTATE CANCER. WE HAVE PROGRAMS THAT ARE SEARCHING FOR NEW DRUGS THAT CRIPPLE ESSENTIAL PATHWAYS INSIDE CANCER CELLS. WE ARE HARNESSING THE POWER OF THE IMMUNE SYSTEM TO SEEK OUT AND DESTROY DIFFERENT TYPES OF CANCER. OUR SCIENTISTS ARE ALSO LEADING RESEARCH TO UNDERSTAND THE BASIC INNER WORKINGS OF CANCER CELLS, SO THAT WE MAY FIND THE TRIGGERS THAT START UNCONTROLLED GROWTH. ALL OF OUR RESEARCHERS COLLABORATE EXTENSIVELY, BECAUSE A BREAKTHROUGH IN UNDERSTANDING ONE CANCER OFTEN INCREASES OUR UNDERSTANDING OF OTHER CANCERS.PRINCIPAL INVESTIGATORS ARE WORKING ON SEVERAL CHALLENGES IN THE AREA OF CANCER. SCIENTISTS ARE DISCOVERING WAYS TO BOOST OUR NATURAL IMMUNITY, USING VACCINES THAT TRAIN OUR IMMUNE CELLS TO KILL CANCER CELLS, OR TO DAMAGE THE BLOOD VESSELS THAT SUSTAIN GROWTH OF TUMORS, UNDERSTANDING HOW CANCER CELLS MOVE AROUND THE BODY TO FORM METASTASES, AND HOW THIS CAN BE TARGETED WITH NEW THERAPIES, DISCOVERING NEW DRUGS THAT KILL CANCER CELLS BY INTERFERING WITH CRITICAL PATHWAYS INSIDE THE CELLS AND MAKING THEM SENSITIVE TO THERAPY, UNDERSTANDING THE RELATIONSHIP BETWEEN OBESITY AND CANCER, AND DISCOVERING HOW FATS IN THE BLOODSTREAM CAN PROTECT CANCER CELLS FROM OUR IMMUNE SYSTEM. SCIENTISTS ARE ALSO DISCOVERING HOW CANCER CAN DEVELOP FROM 'STEM CELLS' THAT CAN KEEP DIVIDING WHEN MOST OTHER CANCER CELLS HAVE BEEN DESTROYED AND DEVELOPING STRATEGIES TO DELIVER THERAPEUTIC GENES TO TUMORS. THE RESEARCH IS FUNDED BY GRANTS RECEIVED FROM THE NATIONAL INSTITUTES OF HEALTH, DEPARTMENT OF DEFENSE, AND ALZHEIMER'S AND AGING RESEARCH CENTER, FLORIDA DEPARTMENT OF HEALTH AND GENEROUS DONATIONS FROM THE PUBLIC.ALZHEIMER'S DISEASE IS A COMPLEX AND AN IRREVERSIBLE NEURODEGENERATIVE DISORDER OF THE ELDERLY CHARACTERIZED BY PROGRESSIVE COGNITIVE DECLINE AND LOSS OF MEMORY. ALZHEIMER'S DISEASE IS CONSIDERED AS THE SECOND MOST FEARED DISEASE AFTER CANCER. THIS IS BECAUSE MEMORY LOSS OCCURS TO SUCH AN EXTENT THAT THE AFFECTED PATIENTS CAN'T RECOGNIZE THEIR OWN FAMILY MEMBERS AND FRIENDS AND THEY MAY COMPLETELY DEPEND ON NURSING CARE AS THE DISEASE ADVANCES. IT IS ESTIMATED THAT NEARLY 5.3 MILLION PATIENTS IN THE UNITED STATES ALONE OR 35.6 MILLION PATIENTS WORLDWIDE SUFFER FROM ALZHEIMER'S DISEASE. BECAUSE THERE IS NO EFFECTIVE TREATMENT AVAILABLE NOW TO AT LEAST SLOWDOWN ALZHEIMER'S DISEASE, AND ALSO BECAUSE OF GRADUAL INCREASE IN LIFE SPAN OF HUMAN BEINGS DUE TO IMPROVED HEALTH CARE, BY 2050, 115.6 MILLION PEOPLE WORLDWIDE ARE PREDICTED TO SUFFER FROM ALZHEIMER'S DISEASE. THE CURRENT FDA APPROVED DRUGS ARE USEFUL ONLY FOR TEMPORARY SYMPTOMATIC RELIEF, BUT THEY CANNOT REVERSE OR AT LEAST SLOW DOWN THE DISEASE FROM FURTHER DETERIORATION SINCE THEY WERE NOT DESIGNED TO TREAT THE UNDERLYING CAUSE OF THE DISEASE.ALZHEIMER'S DISEASE IS PATHOLOGICALLY CHARACTERIZED BY THE PRESENCE OF NEUROFIBRILLARY TANGLES INSIDE THE NEURON, THE FUNDAMENTAL UNITS OF THE BRAIN. TANGLES ARE FORMED AS A RESULT OF ALTERATION IN A PROTEIN CALLED TAU WHICH AFFECTS TRANSPORTATION OF ESSENTIAL MATERIALS WITHIN THE NEURON. THE DISEASE IS ALSO CHARACTERIZED BY THE ACCUMULATION OF TOXIC PROTEIN CALLED AMYLOID BETA OUTSIDE THE NEURON. THE AGGREGATION OF THESE TOXIC PROTEINS IS BELIEVED TO BE RESPONSIBLE
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IRS990/Form990PartVIISectionAGrp/TitleTxt0PRESIDENT & CEO
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IRS990/Form990PartVIISectionAGrp/TitleTxt9CFO (MARCH 2012 - PRES
IRS990/Form990PartVIISectionAGrp/TitleTxt10VP OF SCIENTIFIC AFFAIRS
IRS990/Form990PartVIISectionAGrp/TitleTxt11ASSISTANT CORPORATE SECRET
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IRS990/Form990PartVIISectionAGrp/TitleTxt16DIRECTOR OF CHEMISTRY OPER
IRS990/Form990PartVIISectionAGrp/TitleTxt17SCIENTIFIC ASSISTANT/DIRECTOR OF FL DRUG DISCOVERY
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IRS990/MissionDesc0TORREY PINES INSTITUTE FOR MOLECULAR STUDIES IS A NONPROFIT PUBLIC BENEFIT CORPORATION AND IS NOT ORGANIZED FOR THE PRIVATE GAIN OF ANY PERSON. THE SPECIFIC PURPOSE OF THIS CORPORATION IS TO CONDUCT SCIENTIFIC RESEARCH IN THE PUBLIC INTEREST.
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IRS990/ProgSrvcAccomActy2Grp/Desc0CHEMISTRY:WHEN TORREY PINES INSTITUTE FOR MOLECULAR STUDIES FIRST OPENED ITS LABORATORIES TWENTY-TWO YEARS AGO, THE MAIN RESEARCH FOCUS WAS IN THE AREA OF CHEMISTRY. THE RESEARCH RESULTED IN A NEW METHOD OF DRUG DISCOVERY CALLED, "COMBINATORIAL CHEMISTRY", WHICH IS NOW BEING USED BY RESEARCHERS WORLDWIDE TO HELP FIND NEW DRUGS AND DIAGNOSTICS FOR DISEASES. THIS GROUP ALSO SUPPORTS ALL OF THE OTHER RESEARCH BEING CONDUCTED AT THE INSTITUTE BY PROVIDING THE "CHEMICAL LIBRARIES" NEEDED FOR GROUPS IN THEIR SEARCH FOR VACCINES, THERAPEUTICS, AND DIAGNOSTIC COMPOUNDS. AS A RESULT OF THE METHODS INVESTED AND DEVELOPED IN TPIMS CHEMISTRY LABORATORIES, WE HAVE BEEN ABLE TO MAKE SIGNIFICANT PROGRESS IN ALL RESEARCH GROUPS. TPIMS NOW PARTNERS WITH OTHER RESEARCH CENTERS TO MAKE COMPOUNDS TO BE USED BY RESEARCHERS ALL OVER THE WORLD IN AREAS SUCH AS CANCER RESEARCH. RESEARCH RESULTS HAVE BEEN PRESENTED TO THE PUBLIC IN HUNDREDS OF SCIENTIFIC JOURNAL ARTICLES AND IN SCIENTIFIC PRESENTATIONS WORLDWIDE. TPIMS HAS TRAINED MANY SCIENTISTS IN THESE METHODS NOT ONLY IN SAN DIEGO AND FLORIDA, BUT ALSO ACROSS THE UNITED STATES AND AROUND THE WORLD. THIS GROUP IS SUPPORTED BY THE NATIONAL INSTITUTES OF HEALTH, THE STATE OF FLORIDA, VARIOUS CORPORATE RESEARCH CONTRACTS AND GENEROUS DONATIONS FROM THE PUBLIC.
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IRS990/ProgSrvcAccomActy3Grp/Desc0PAIN MANAGEMENT:THE COST OF CHRONIC PAIN IN THE U.S. EXCEEDS $70 BILLION ANNUALLY, WITH DIRECT COSTS FOR PAIN ASSOCIATED WITH DIABETES ALONE EXCEEDING $10 BILLION. UNFORTUNATELY, LONG TERM TREATMENTS WITH OPIATES FOR CHRONIC PAIN HAVE HIGH DROPOUT RATES AND STUDIES SUGGEST THAT PAIN RELIEF BY OPIATES BECOME MASKED BY DEVELOPMENT OF ADVERSE SIGNALS BETWEEN CELLS THAT ARE RESPONSIBLE FOR TOLERANCE, DEPENDENCE, ADDICTION, AND CHRONIC PAIN.THE INSTITUTE IS INTERESTED IN FINDING COMPOUNDS THAT ALLEVIATE PAIN THROUGH SIGNAL PREVENTION OR BY RESETTING THE BODY TO RESTORE THE NATURAL CAPACITY TO ALLEVIATE PAIN. PAIN FACILITATION, OPIATE TOLERANCE, AND ADDICTION CAN BE LINKED TO INTER-COMMUNICATION BETWEEN NEURONS AND IMMUNE CELLS IN THE BRAIN.A COMPOUND DISCOVERED BY SCIENTISTS AT TORREY PINES HAS RECENTLY COMPLETED PHASE II CLINICAL TRIALS FOR THE TREATMENT OF PAIN.PRINCIPAL INVESTIGATORS ARE WORKING ON SEVERAL CHALLENGES IN THE AREA OF PAIN MANAGEMENT. SCIENTISTS ARE DISCOVERING COMPOUNDS THAT ALLEVIATE PAIN THROUGH SIGNAL PREVENTION OR BY RESETTING THE BODY TO RESTORE THE NATURAL CAPACITY TO ALLEVIATE PAIN, REFINING THE BIOLOGICAL PROPERTIES OF SYNTHESIZED CONE SNAIL VENOM TO DEVELOP MORE EFFECTIVE PAIN DRUGS WITH FEWER SIDE EFFECTS THAN PRESENT OPTIONS LIKE OPIATES, AND DEVELOPING NEW THERAPIES FOR MOOD DISORDERS, LEARNING AND MEMORY DISORDERS, AND DRUG ABUSE BY IDENTIFYING AND CHARACTERIZING THE NEUROTRANSMITTER SYSTEMS THAT UNDERLIE THE BEHAVIORS OF HORMONES AND HOW THEY ARE RELEASED IN RESPONSE TO STRESS.
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IRS990/ProgSrvcAccomActyOtherGrp/Desc0OTHER PROGRAM SERVICES INCLUDE THE FOLLOWING:MULTIPLE SCLEROSIS:MULTIPLE SCLEROSIS NATIONAL RESEARCH INSTITUTE (THE "MS INSTITUTE") IS A DIVISION OF TPIMS DEVOTED TO STUDYING THE CAUSES, DIAGNOSIS, AND POSSIBLE TREATMENTS FOR MS, WITH THE ULTIMATE GOAL OF FINDING A CURE. OUR WORLD-RENOWNED SCIENTISTS CONDUCT THE RESEARCH NEEDED TO UNDERSTAND AND TREAT THIS DISEASE SO THAT MS PATIENTS MAY RETURN TO LIVING HEALTHY AND DISEASE-FREE LIVES. ONGOING RESEARCH INCLUDES STUDIES TO UNDERSTAND THE CAUSES OF MS, THE DEVELOPMENT OF TREATMENTS FOR MS, AND THE DESIGN OF NOVEL STRATEGIES FOR THE DEVELOPMENT OF VACCINES AGAINST MS WHICH MAY HOLD THE PROMISE OF A CURE. FUNDING FOR THE MS INSTITUTE IS PROVIDED PRIMARILY THROUGH GENEROUS DONATIONS FROM THE PUBLIC.AIDS & OTHER INFECTIOUS DISEASES:INFECTIOUS DISEASES ARE CAUSED BY BACTERIA, VIRUSES, PARASITES, AND FUNGI THAT CAN BE SPREAD FROM PERSON TO PERSON. THESE DISEASES ARE THE WORLD'S MOST IMPORTANT HEALTH PROBLEM, AS THEY KILL MORE PEOPLE WORLDWIDE THAN ANY OTHER SINGLE CAUSE. IN THE U.S. ALONE, THE COST OF TREATING INFECTIOUS DISEASES IS $120 BILLION EACH YEAR. DISEASES THAT WERE ONCE THOUGHT UNDER CONTROL ARE RE-EMERGING BECAUSE OF GLOBAL TRAVEL AND MIGRATION PATTERNS, AND NEW DISEASE-CAUSING AGENTS, OR PATHOGENS, ARE EMERGING ALL THE TIME. IN THE LAST 35 YEARS, THERE HAVE BEEN AT LEAST 30 NEW PATHOGENS DESCRIBED, INCLUDING HIV.OUR SCIENTISTS ARE DISCOVERING A NEW WAY TO MAKE AN HIV VACCINE THAT TEACHES THE IMMUNE SYSTEM TO IGNORE THE DECOYS LAID DOWN BY HIV. THEY ARE ALSO UNDERSTANDING HOW VIRUSES CAN REMAIN DORMANT FOR DECADES AND DO NO HARM TO OUR BODIES, UNTIL THEY ARE SUDDENLY TRIGGERED TO RAMP UP AN ATTACK. IN ADDITION, SCIENTISTS ARE UNDERSTANDING THE IMMUNE RESPONSE TO SMALLPOX VACCINES, TO AID IN THE DESIGN OF BETTER VACCINES, UNDERSTANDING HOW VIRAL AND SECONDARY BACTERIAL INFECTIONS INTERACT TO ESCALATE FROM MANAGEABLE INFECTIONS TO LIFE-THREATENING ILLNESSES, AND UNDERSTANDING HOW TO GENERATE A PROTECTIVE IMMUNE RESPONSE TO THE LEISHMANIA PARASITE, TO AID IN DEVELOPING NEW VACCINES. FUNDING FOR INFECTIOUS DISEASE RESEARCH IS PROVIDED BY THE NATIONAL INSTITUTES OF HEALTH, BILL & MELINDA GATES FOUNDATION, VARIOUS CORPORATE RESEARCH CONTRACTS, AND GENEROUS DONATIONS FROM THE PUBLIC.OUTREACH AND EDUCATION:THE GOAL OF TPIMS' OUTREACH AND EDUCATION PROGRAM IS TO EDUCATE THE PUBLIC, TEACHERS AND STUDENTS REGARDING THE IMPORTANCE OF SCIENTIFIC RESEARCH AND ALL THAT IT HAS TO OFFER. TPIMS ASPIRES TO INSPIRE FUTURE SCIENTISTS, TEACHERS AND THE PUBLIC THROUGHOUT THE FLORIDA RESEARCH COAST AND IN SAN DIEGO, CALIFORNIA. THE MAIN COMPONENTS OF THE PROGRAM ARE:- EXPLORATION DAY AT TORREY PINES INSTITUTE- INTERNSHIPS FOR STUDENTS AND TEACHERS- ENHANCING SCIENCE CURRICULUM IN THE AREA THROUGH TEACHER WORKSHOPS, CAREER DAY AND SCIENCE FAIRS- COLLABORATIONS WITH THE PRIVATE SECTOR ON SPONSORED RESEARCH AND OTHER PROJECTSIN ADDITION, TPIMS WORKS CLOSELY WITH THE COMMUNITY IN PORT ST. LUCIE AND THROUGHOUT FLORIDA AS PART OF ITS OUTREACH EFFORTS. THIS INCLUDES COLLABORATIONS WITH MANY COLLEGES, UNIVERSITIES AND OTHER RESEARCH INSTITUTES THROUGHOUT THE AREA.DIABETES:DIABETES IS A LIFE-LONG DISEASE THAT AFFECTS MORE THAN 23 MILLION AMERICANS, AND OCCURS BECAUSE THE BODY IS UNABLE TO PRODUCE ENOUGH INSULIN, OR BECAUSE OUR BODIES CANNOT USE INSULIN EFFICIENTLY. INSULIN IS NECESSARY FOR CELLS TO TAKE UP GLUCOSE TO USE FOR ENERGY, AND WHEN THEY CANNOT DO SO GLUCOSE BUILDS UP IN THE BLOODSTREAM. THIS IS DANGEROUS AS HIGH BLOOD GLUCOSE CAN CAUSE SERIOUS AND SOMETIMES LIFE-THREATENING COMPLICATIONS. THE TWO MAIN FORMS OF DIABETES ARE TYPE I AND TYPE II WHICH HAVE DIFFERENT CAUSES.THERE IS NO CURE FOR DIABETES, AND RESEARCH MUST FOCUS ON REPLACING THE INSULIN-PRODUCING CELLS, STOPPING THE IMMUNE SYSTEM FROM ATTACKING THE NEW INSULIN-PRODUCING CELLS, OR FINDING WAYS TO HELP CELLS USE INSULIN MORE EFFICIENTLY. OUR SCIENTISTS ARE UNDERSTANDING HOW GENETIC FACTORS CONTROL THE ONSET OF TYPE I DIABETES, DISCOVERIN
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IRS990/PYRevenuesLessExpensesAmt0-1748456
IRS990/PYSalariesCompEmpBnftPaidAmt011262291
IRS990/PYTotalExpensesAmt019076877
IRS990/PYTotalProfFndrsngExpnsAmt00
IRS990/PYTotalRevenueAmt017328421
IRS990/QuidProQuoContributionsInd00
IRS990/RcvFndsToPayPrsnlBnftCntrctInd00
IRS990/ReconcilationRevenueExpnssAmt012801699
IRS990/RegularMonitoringEnfrcInd01
IRS990/RelatedEntityInd01
IRS990/RelatedOrganizationCtrlEntInd01
IRS990/RelatedOrganizationsAmt0237416
IRS990/RentalIncomeOrLossGrp/RealAmt042637

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