Civic Intelligence

International Foundation for Ethical Research Inc

EIN 22-2628153 • 501(c)3 • Chicago, IL

Profile

To advance the development and implementation of human-relevant, non-animal alternatives in research, testing and education.

444 North Wells Street 406Chicago, IL 60654-4594

ifer.org

Siviq Scores

Precomputed percentiles relative to similar nonprofits. These scores are descriptive rather than judgmental.

Liabilities / Assets

34th percentile

0.01x

Higher debt load relative to assets than 34% of similar nonprofits.

501(c)3 • $1M-$5M nonprofits • Source year 2024

Liabilities / Revenue

44th percentile

0.05x

Higher debt load relative to revenue than 44% of similar nonprofits.

501(c)3 • $1M-$5M nonprofits • Source year 2024

Net Margin

78th percentile

27%

Higher net margin than 78% of similar nonprofits.

501(c)3 • $1M-$5M nonprofits • Source year 2024

Top Officer Pay

86th percentile

$173,613

Higher top officer pay than 86% of similar nonprofits.

Top officer pay equals 56.0% of source-year revenue.

501(c)3 • $1M-$5M nonprofits • Source year 2024

Asset Growth

71st percentile

13%

Faster asset growth than 71% of similar nonprofits.

501(c)3 • $1M-$5M nonprofits • Annualized from 2023 to 2024

Revenue Growth

80th percentile

43%

Faster revenue growth than 80% of similar nonprofits.

501(c)3 • $1M-$5M nonprofits • Annualized from 2023 to 2024

Balance Sheet
Liabilities / Assets34th percentile

Assets

Up

$1,153,630

Up $134,858 (+13%) from 2023

Liabilities

Down

$15,000

Down $15,000 (-50%) from 2023

Net Assets

Up

$1,138,630

Up $149,858 (+15%) from 2023

Operations
Liabilities / Revenue44th percentileNet Margin78th percentile

Revenue

Up

$310,083

Up $92,649 (+43%) from 2023

Expenses

Up

$226,980

Up $37,799 (+20%) from 2023

Net Income

Up

$83,103

Up $54,850 (+194%) from 2023

Trend Graphs

Balance Sheet Trend

Asset Growth71st percentile

Grouped bars show assets, liabilities, and net assets across loaded filings.

$1.5M$1.0M$500K$0Assets 2011: $106,524Liabilities 2011: $02011Assets 2012: $121,112Liabilities 2012: $02012Assets 2013: $115,142Liabilities 2013: $02013Assets 2014: $92,241Liabilities 2014: $02014Assets 2015: $131,672Liabilities 2015: $02015Assets 2016: $97,746Liabilities 2016: $02016Assets 2017: $273,625Liabilities 2017: $0Net Assets 2017: $273,6252017Assets 2018: $251,379Liabilities 2018: $02018Assets 2019: $400,847Liabilities 2019: $02019Assets 2020: $605,029Liabilities 2020: $0Net Assets 2020: $605,0292020Assets 2021: $830,510Liabilities 2021: $0Net Assets 2021: $830,5102021Assets 2022: $870,064Liabilities 2022: $0Net Assets 2022: $870,0642022Assets 2023: $1,018,772Liabilities 2023: $30,000Net Assets 2023: $988,7722023Assets 2024: $1,153,630Liabilities 2024: $15,000Net Assets 2024: $1,138,6302024

Highlighted filing

2024

Assets$1,153,630
Liabilities$15,000
Net Assets$1,138,630
Open 2024 Filing

Operations Trend

Revenue Growth80th percentile

Revenue, expenses, and net income by year, with the latest filing highlighted.

$400K$300K$200K$100K$0-$100KRevenue 2011: $96,903Expenses 2011: $71,663Net Income 2011: $25,2402011Revenue 2012: $96,490Expenses 2012: $84,995Net Income 2012: $11,4952012Revenue 2013: $98,161Expenses 2013: $120,634Net Income 2013: -$22,4732013Revenue 2014: $96,969Expenses 2014: $121,961Net Income 2014: -$24,9922014Revenue 2015: $178,904Expenses 2015: $141,854Net Income 2015: $37,0502015Revenue 2016: $67,539Expenses 2016: $109,804Net Income 2016: -$42,2652016Revenue 2017: $352,764Expenses 2017: $122,523Net Income 2017: $230,2412017Revenue 2018: $140,091Expenses 2018: $87,513Net Income 2018: $52,5782018Revenue 2019: $146,449Expenses 2019: $76,286Net Income 2019: $70,1632019Revenue 2020: $257,967Expenses 2020: $113,791Net Income 2020: $144,1762020Revenue 2021: $312,624Expenses 2021: $101,391Net Income 2021: $211,2332021Revenue 2022: $287,613Expenses 2022: $124,028Net Income 2022: $163,5852022Revenue 2023: $217,434Expenses 2023: $189,181Net Income 2023: $28,2532023Revenue 2024: $310,083Expenses 2024: $226,980Net Income 2024: $83,1032024

Highlighted filing

2024

Revenue$310,083
Expenses$226,980
Net Income$83,103
Open 2024 Filing

Filings

Most recent year

2024 • Form 990Facts available. Structured filing facts are available, but richer extracted sections are limited.

Open filing
Assets
$1,153,630
Liabilities
$15,000
Net assets
$1,138,630
Revenue
$310,083
Expenses
$226,980
Net income
$83,103
Balance SheetOperations
YearAssetsLiabilitiesNet AssetsRevenueExpensesNet Income
2024Facts available. Structured filing facts are available, but richer extracted sections are limited.$1.15$0.02$1.14$0.31$0.23$0.08
2023Summary only. Only limited summary data is available for this year.$1.02$0.03$0.99$0.22$0.19$0.03
2022Facts available. Structured filing facts are available, but richer extracted sections are limited.$0.87$0.00$0.87$0.29$0.12$0.16
2021Facts available. Structured filing facts are available, but richer extracted sections are limited.$0.83$0.00$0.83$0.31$0.10$0.21
2020Facts available. Structured filing facts are available, but richer extracted sections are limited.$0.61$0.00$0.61$0.26$0.11$0.14
2019Summary only. Only limited summary data is available for this year.$0.40$0.00$0.15$0.08$0.07
2018Summary only. Only limited summary data is available for this year.$0.25$0.00$0.14$0.09$0.05
2017Summary only. Only limited summary data is available for this year.$0.27$0.00$0.27$0.35$0.12$0.23
2016Summary only. Only limited summary data is available for this year.$0.10$0.00$0.07$0.11$0.04
2015Summary only. Only limited summary data is available for this year.$0.13$0.00$0.18$0.14$0.04
2014Summary only. Only limited summary data is available for this year.$0.09$0.00$0.10$0.12$0.02
2013Summary only. Only limited summary data is available for this year.$0.12$0.00$0.10$0.12$0.02
2012Summary only. Only limited summary data is available for this year.$0.12$0.00$0.10$0.08$0.01
2011Summary only. Only limited summary data is available for this year.$0.11$0.00$0.10$0.07$0.03
Latest Filing Detail
Jump To
Filing Snapshot
Filing Period
Jan 1, 2024 to Dec 31, 2024
Signed
May 1, 2025
Return Version
2024v5.1
Gross Receipts
$483,562
Mission and Program Overview

Mission

To advance the development and implementation of human-relevant, non-animal alternatives in research, testing and education.

Balance Sheet Detail
LineBeginningEndChange
Assets
Investments in Publicly Traded Securities$756,230$837,268▲ $81,038
Savings and Temporary Cash Investments$216,340$314,272▲ $97,932
Cash and Non-Interest-Bearing Accounts$39,305$2,090▼ $37,215
Total Assets$1,018,772$1,153,630▲ $134,858
Other Assets Total$6,897$0▼ $6,897
Liabilities
Grants Payable$30,000$15,000▼ $15,000
Total Liabilities$30,000$15,000▼ $15,000
Net Assets / Fund Balance
Net Assets Without Donor Restrictions$988,772$1,138,630▲ $149,858
Total Net Assets Fund Balance$988,772$1,138,630▲ $149,858
Total Liabilities and Net Assets / Fund Balance$1,018,772$1,153,630▲ $134,858
Compensation and Service Providers
Top Officer Pay86th percentile

Board Members and Trustees

NameTitle
Kenneth KandarasPresident
Mary Margaret CunniffDirector
Pamela Osenkowski Ph DDirector
Sylvia O DeckerDirector
Thomas S MooreDirector
John H Scheid JrTreasurer/secretary
Revenue and Support

Revenue Composition

Contributions and Grants
$276,529
Program Service Revenue
$0
Investment Income
$33,554
Other Revenue
$0
All Other Contributions
$276,529
Change in Net Assets
$83,103
Expenses and Functional Allocation

Major Expense Lines

Line ItemAmount
Grants and Similar Amounts Paid$184,000
Other Expenses$42,980
Professional Fundraising Fees$0
Salaries, Compensation, and Employee Benefits$0
Total Fundraising Expense$0

Functional Expense Allocation

Line ItemProgramManagementFundraisingTotal
Grants to Domestic Orgs$150,000--$150,000
Foreign Grants$30,000--$30,000
Fees for Services Legal$18,000--$18,000
Fees for Services Accounting-$7,100-$7,100
Fees for Service Investment Mgmnt Fees-$6,847-$6,847
Grants to Domestic Individuals$4,000--$4,000
Office Expenses-$590-$590
Other Expenses$8,500$523-$523
Total Functional Expenses$210,500$16,480$0$226,980
International Activity

Grant and Assistance Recipients

RecipientLocationCategoryPurposeAmount
Cornell UniversityIthaca, NY-Research$15,000
Duke UniversityDurham, NC-Research$15,000
Harvard UniversityCambridge, MA-Research$15,000
Johns Hopkins UniversityBaltimore, MD-Research$15,000
New York UniversityNew York, NY-Research$15,000
UclaLos Angeles, CA-Research$15,000
University of DelawareNewark, DE-Research$15,000
University of Maryland - College ParkCollege Park, MD-Research$15,000
University of RochesterRochester, NY-Research$15,000
Wake ForestWinston Salem, NC-Research$15,000

International Summary

Offices
0
Employees
0
Spending
$30,000

International Compliance

Foreign grant records maintained
No
Activity in boycott countries
No
Foreign corporation ownership
No
Foreign partnership interest
No
Interest in foreign trust
No
Passive foreign investment company interest
No
Transfers to foreign corporations
No

International Activities

RegionActivityServicesOfficesEmployeesSpending
Europe (including Iceland & Greenland) - Albania, Andorra, Austria, BelgiumGrant MakingFunding Scientific Research00$15,000
East Asia and the PacificGrant MakingFunding Scientific Research00$15,000
Fundraising, Events, and Gaming
Fundraising activities
No
Gaming activities
No
Professional fundraiser used
No

Fundraising and Gaming Totals

Line ItemAmount
Professional Fundraising Fees$0
Political and Lobbying Activity
Political campaign activity
No
Lobbying activity
No
Subject to proxy tax
No
Insider Transactions and Loans

Interested-Person Transactions

Interested PartyRelationshipDescriptionShared RevenueAmount
Kenneth CunniffSpouse of Board MemberLegal Counsel and Program Coordinating for the OrganizationNo$18,000
Governance and Compliance

Governance Checklist

Compiled or reviewed by an accountant
Yes
Annual disclosure for covered persons
Yes
Audit committee
Yes
Business relationship with 35% controlled entity
No
Business relationship with family members
Yes
Business relationship with organization members
No
Material changes to governing documents
No
Compensation from other sources disclosed
No
CEO compensation reviewed
No
Other officer compensation reviewed
No
Conflict-of-interest policy
Yes
Audited financial statements prepared
No
Key decisions subject to board approval
No
Management duties delegated
No

Governance Explanations

Form 990, Part VI, Section B, Line 11B

“The president of the ifer presents the form 990 to the board of directors for their review prior to signing and filing the return.”

Form 990, Part VI, Section B, Line 12C

“The president and legal counsel maintain ongoing communication with board members to learn their activities and potential conflicts.”

Form 990, Part VI, Section C, Line 19

“The form 990, and all other governing documents are made available to the public upon their request. The form 990 for the current year and for prior years are available on the website irs.gov.”

Filing and Contact Details

Filer

Filer Name
International Foundation for Ethical
EIN
22-2628153
Phone
3124276025
Address
444 NORTH WELLS STREET 406, CHICAGO, IL 60654-4594

Signing Officer

Name
Kenneth Kandaras
Title
President
Phone
3124276025
Signed
2025-05-01
Discuss with paid preparer
Yes

Organization Details

Principal Officer
Kenneth Kandaras
Formed
1985
Legal Domicile
Il
Voting Board Members
6
Independent Board Members
6
Employees
0
Volunteers
10

Preparer

Firm
Reilly Penner & Benton Llp
Address
1233 NORTH MAYFAIR RD SUITE 302, MILWAUKEE, WI 53226-3255
Preparer
Katherine Hoffman
Phone
4142717800
Supplemental Narrative

Additional Explanations

FORM 990, PART XI, LINE 9:

“DISALLOWED WASH SALE 43.”

FORM 990, PART XII, LINE 2C:

“The process has not changed from prior years.”

Financial Statement Notes

PART X, LINE 2:

“Ifer has implemented accounting for uncertainty in income taxes in accordance with u.s. Gaap. This standard prescribes a recognition threshold and measurement attribute for financial statement recognition and measurement of a tax position taken or expected to be taken in a tax return and also provides guidance on various related matters such as derecognizing, interest, penalties and disclosures required. Management of ifer evaluates the uncertain tax positions taken, if any, and consults with outside counsel as deemed necessary. Ifer recognizes interest and penalties, if any, related to unrecognized tax liabilities in income tax expense. In management's opinion, ifer has not taken any uncertain tax positions, and accordingly, has not reported a corresponding liability in ifer' financial statements.”

Raw XML AppendixShowing 400 of 557 raw XML fields

This appendix keeps the raw XML leaves available for debugging and edge-case review. The human report above is the primary experience.

Path#Value
IRS990/AccountantCompileOrReviewInd01
IRS990/AcctCompileOrReviewBasisGrp/SeparateBasisFinclStmtInd0X
IRS990/ActivitiesConductedPrtshpInd00
IRS990/ActivityOrMissionDesc0TO ADVANCE THE DEVELOPMENT AND IMPLEMENTATION OF HUMAN-RELEVANT, NON-ANIMAL ALTERNATIVES IN RESEARCH, TESTING AND EDUCATION.
IRS990/AllOtherContributionsAmt0276529
IRS990/AnnualDisclosureCoveredPrsnInd01
IRS990/AuditCommitteeInd01
IRS990/BooksInCareOfDetail/BusinessName/BusinessNameLine1Txt0KENNETH KANDARAS
IRS990/BooksInCareOfDetail/PhoneNum03129404390
IRS990/BooksInCareOfDetail/USAddress/AddressLine1Txt0444 NORTH WELLS STREET 406
IRS990/BooksInCareOfDetail/USAddress/CityNm0CHICAGO
IRS990/BooksInCareOfDetail/USAddress/StateAbbreviationCd0IL
IRS990/BooksInCareOfDetail/USAddress/ZIPCd0606544594
IRS990/BusinessRlnWith35CtrlEntInd00
IRS990/BusinessRlnWithFamMemInd01
IRS990/BusinessRlnWithOrgMemInd00
IRS990/CashNonInterestBearingGrp/BOYAmt039305
IRS990/CashNonInterestBearingGrp/EOYAmt02090
IRS990/ChangeToOrgDocumentsInd00
IRS990/CntrctRcvdGreaterThan100KCnt00
IRS990/CollectionsOfArtInd00
IRS990/CompensationFromOtherSrcsInd00
IRS990/CompensationProcessCEOInd00
IRS990/CompensationProcessOtherInd00
IRS990/ConflictOfInterestPolicyInd01
IRS990/ConservationEasementsInd00
IRS990/ConsolidatedAuditFinclStmtInd00
IRS990/CreditCounselingInd00
IRS990/CYBenefitsPaidToMembersAmt00
IRS990/CYContributionsGrantsAmt0276529
IRS990/CYGrantsAndSimilarPaidAmt0184000
IRS990/CYInvestmentIncomeAmt033554
IRS990/CYOtherExpensesAmt042980
IRS990/CYOtherRevenueAmt00
IRS990/CYProgramServiceRevenueAmt00
IRS990/CYRevenuesLessExpensesAmt083103
IRS990/CYSalariesCompEmpBnftPaidAmt00
IRS990/CYTotalExpensesAmt0226980
IRS990/CYTotalFundraisingExpenseAmt00
IRS990/CYTotalProfFndrsngExpnsAmt00
IRS990/CYTotalRevenueAmt0310083
IRS990/DecisionsSubjectToApprovaInd00
IRS990/DeductibleArtContributionInd00
IRS990/DeductibleNonCashContriInd00
IRS990/DelegationOfMgmtDutiesInd00
IRS990/Desc0INTERNATIONAL FOUNDATION FOR ETHICAL RESEARCH, INC. HAS FUNDED 12 MEDICAL RESEACH PROJECTS THAT UTILIZE HUMAN-RELEVANT, NON-ANIMAL ALTERNATIVES AS THEIR TEST MODELS. THE PROJECTS MAY HELP COUNTLESS PATIENTS WITHOUT HARMING ANIMALS.
IRS990/DescribedInSection501c3Ind01
IRS990/DisregardedEntityInd00
IRS990/DocumentRetentionPolicyInd01
IRS990/DonorAdvisedFundInd00
IRS990/DonorRstrOrQuasiEndowmentsInd00
IRS990/ElectionOfBoardMembersInd00
IRS990/EmployeeCnt00
IRS990/EngagedInExcessBenefitTransInd00
IRS990/ExpenseAmt0210500
IRS990/FamilyOrBusinessRlnInd00
IRS990/FederalGrantAuditRequiredInd00
IRS990/FeesForServicesAccountingGrp/ManagementAndGeneralAmt07100
IRS990/FeesForServicesAccountingGrp/TotalAmt07100
IRS990/FeesForServicesLegalGrp/ProgramServicesAmt018000
IRS990/FeesForServicesLegalGrp/TotalAmt018000
IRS990/FeesForSrvcInvstMgmntFeesGrp/ManagementAndGeneralAmt06847
IRS990/FeesForSrvcInvstMgmntFeesGrp/TotalAmt06847
IRS990/ForeignActivitiesInd01
IRS990/ForeignFinancialAccountInd00
IRS990/ForeignGrantsGrp/ProgramServicesAmt030000
IRS990/ForeignGrantsGrp/TotalAmt030000
IRS990/ForeignOfficeInd00
IRS990/Form8282PropertyDisposedOfInd00
IRS990/Form990PartVIISectionAGrp/AverageHoursPerWeekRltdOrgRt040.00
IRS990/Form990PartVIISectionAGrp/AverageHoursPerWeekRt05.00
IRS990/Form990PartVIISectionAGrp/AverageHoursPerWeekRt10.50
IRS990/Form990PartVIISectionAGrp/AverageHoursPerWeekRt21.00
IRS990/Form990PartVIISectionAGrp/AverageHoursPerWeekRt30.50
IRS990/Form990PartVIISectionAGrp/AverageHoursPerWeekRt40.50
IRS990/Form990PartVIISectionAGrp/AverageHoursPerWeekRt55.00
IRS990/Form990PartVIISectionAGrp/IndividualTrusteeOrDirectorInd0X
IRS990/Form990PartVIISectionAGrp/IndividualTrusteeOrDirectorInd1X
IRS990/Form990PartVIISectionAGrp/IndividualTrusteeOrDirectorInd2X
IRS990/Form990PartVIISectionAGrp/IndividualTrusteeOrDirectorInd3X
IRS990/Form990PartVIISectionAGrp/IndividualTrusteeOrDirectorInd4X
IRS990/Form990PartVIISectionAGrp/IndividualTrusteeOrDirectorInd5X
IRS990/Form990PartVIISectionAGrp/OfficerInd0X
IRS990/Form990PartVIISectionAGrp/OfficerInd1X
IRS990/Form990PartVIISectionAGrp/OtherCompensationAmt00
IRS990/Form990PartVIISectionAGrp/OtherCompensationAmt10
IRS990/Form990PartVIISectionAGrp/OtherCompensationAmt20
IRS990/Form990PartVIISectionAGrp/OtherCompensationAmt30
IRS990/Form990PartVIISectionAGrp/OtherCompensationAmt40
IRS990/Form990PartVIISectionAGrp/OtherCompensationAmt50
IRS990/Form990PartVIISectionAGrp/PersonNm0KENNETH KANDARAS
IRS990/Form990PartVIISectionAGrp/PersonNm1JOHN H SCHEID JR
IRS990/Form990PartVIISectionAGrp/PersonNm2MARY MARGARET CUNNIFF
IRS990/Form990PartVIISectionAGrp/PersonNm3SYLVIA O DECKER
IRS990/Form990PartVIISectionAGrp/PersonNm4THOMAS S MOORE
IRS990/Form990PartVIISectionAGrp/PersonNm5PAMELA OSENKOWSKI PH D
IRS990/Form990PartVIISectionAGrp/ReportableCompFromOrgAmt00
IRS990/Form990PartVIISectionAGrp/ReportableCompFromOrgAmt10
IRS990/Form990PartVIISectionAGrp/ReportableCompFromOrgAmt20
IRS990/Form990PartVIISectionAGrp/ReportableCompFromOrgAmt30
IRS990/Form990PartVIISectionAGrp/ReportableCompFromOrgAmt40
IRS990/Form990PartVIISectionAGrp/ReportableCompFromOrgAmt50
IRS990/Form990PartVIISectionAGrp/ReportableCompFromRltdOrgAmt0173613
IRS990/Form990PartVIISectionAGrp/ReportableCompFromRltdOrgAmt10
IRS990/Form990PartVIISectionAGrp/ReportableCompFromRltdOrgAmt20
IRS990/Form990PartVIISectionAGrp/ReportableCompFromRltdOrgAmt30
IRS990/Form990PartVIISectionAGrp/ReportableCompFromRltdOrgAmt40
IRS990/Form990PartVIISectionAGrp/ReportableCompFromRltdOrgAmt50
IRS990/Form990PartVIISectionAGrp/TitleTxt0PRESIDENT
IRS990/Form990PartVIISectionAGrp/TitleTxt1TREASURER/SECRETARY
IRS990/Form990PartVIISectionAGrp/TitleTxt2DIRECTOR
IRS990/Form990PartVIISectionAGrp/TitleTxt3DIRECTOR
IRS990/Form990PartVIISectionAGrp/TitleTxt4DIRECTOR
IRS990/Form990PartVIISectionAGrp/TitleTxt5DIRECTOR
IRS990/Form990ProvidedToGvrnBodyInd01
IRS990/FormationYr01985
IRS990/FormerOfcrEmployeesListedInd00
IRS990/FSAuditedInd00
IRS990/FundraisingActivitiesInd00
IRS990/GainOrLossGrp/SecuritiesAmt02494
IRS990/GamingActivitiesInd00
IRS990/GoverningBodyVotingMembersCnt06
IRS990/GrantAmt0184000
IRS990/GrantsPayableGrp/BOYAmt030000
IRS990/GrantsPayableGrp/EOYAmt015000
IRS990/GrantsToDomesticIndividualsGrp/ProgramServicesAmt04000
IRS990/GrantsToDomesticIndividualsGrp/TotalAmt04000
IRS990/GrantsToDomesticOrgsGrp/ProgramServicesAmt0150000
IRS990/GrantsToDomesticOrgsGrp/TotalAmt0150000
IRS990/GrantsToIndividualsInd00
IRS990/GrantsToOrganizationsInd01
IRS990/GrantToRelatedPersonInd00
IRS990/GrossAmountSalesAssetsGrp/SecuritiesAmt0175973
IRS990/GrossReceiptsAmt0483562
IRS990/GroupReturnForAffiliatesInd00
IRS990/IncludeFIN48FootnoteInd01
IRS990/IndependentAuditFinclStmtInd00
IRS990/IndependentVotingMemberCnt06
IRS990/IndivRcvdGreaterThan100KCnt00
IRS990/IndoorTanningServicesInd00
IRS990/InfoInScheduleOPartVIInd0X
IRS990/InfoInScheduleOPartXIIInd0X
IRS990/InfoInScheduleOPartXIInd0X
IRS990/InvestmentIncomeGrp/ExclusionAmt031060
IRS990/InvestmentIncomeGrp/TotalRevenueColumnAmt031060
IRS990/InvestmentInJointVentureInd00
IRS990/InvestmentsPubTradedSecGrp/BOYAmt0756230
IRS990/InvestmentsPubTradedSecGrp/EOYAmt0837268
IRS990/IRPDocumentCnt01
IRS990/IRPDocumentW2GCnt00
IRS990/LegalDomicileStateCd0IL
IRS990/LessCostOthBasisSalesExpnssGrp/SecuritiesAmt0173479
IRS990/LoanOutstandingInd00
IRS990/LobbyingActivitiesInd00
IRS990/LocalChaptersInd00
IRS990/MaterialDiversionOrMisuseInd00
IRS990/MembersOrStockholdersInd00
IRS990/MethodOfAccountingAccrualInd0X
IRS990/MinutesOfCommitteesInd01
IRS990/MinutesOfGoverningBodyInd01
IRS990/MissionDesc0TO ADVANCE THE DEVELOPMENT AND IMPLEMENTATION OF HUMAN-RELEVANT, NON-ANIMAL ALTERNATIVES IN RESEARCH, TESTING AND EDUCATION.
IRS990/MoreThan5000KToIndividualsInd00
IRS990/MoreThan5000KToOrgInd01
IRS990/NetAssetsOrFundBalancesBOYAmt0988772
IRS990/NetAssetsOrFundBalancesEOYAmt01138630
IRS990/NetGainOrLossInvestmentsGrp/ExclusionAmt02494
IRS990/NetGainOrLossInvestmentsGrp/TotalRevenueColumnAmt02494
IRS990/NetUnrelatedBusTxblIncmAmt00
IRS990/NetUnrlzdGainsLossesInvstAmt066712
IRS990/NoDonorRestrictionNetAssetsGrp/BOYAmt0988772
IRS990/NoDonorRestrictionNetAssetsGrp/EOYAmt01138630
IRS990/NondeductibleContributionsInd00
IRS990/OfficeExpensesGrp/ManagementAndGeneralAmt0590
IRS990/OfficeExpensesGrp/TotalAmt0590
IRS990/OfficerMailingAddressInd00
IRS990/OperateHospitalInd00
IRS990/Organization501c3Ind0X
IRS990/OrganizationFollowsFASB117Ind0X
IRS990/OtherAssetsTotalGrp/BOYAmt06897
IRS990/OtherAssetsTotalGrp/EOYAmt00
IRS990/OtherChangesInNetAssetsAmt043
IRS990/OtherExpensesGrp/Desc0SPONSORSHIPS
IRS990/OtherExpensesGrp/Desc1STATE FILING FEES
IRS990/OtherExpensesGrp/Desc2FOREIGN TAXES
IRS990/OtherExpensesGrp/ManagementAndGeneralAmt01420
IRS990/OtherExpensesGrp/ManagementAndGeneralAmt1523
IRS990/OtherExpensesGrp/ProgramServicesAmt08500
IRS990/OtherExpensesGrp/TotalAmt08500
IRS990/OtherExpensesGrp/TotalAmt11420
IRS990/OtherExpensesGrp/TotalAmt2523
IRS990/OtherWebsiteInd0X
IRS990/PartialLiquidationInd00
IRS990/PayPremiumsPrsnlBnftCntrctInd00
IRS990/PoliticalCampaignActyInd00
IRS990/PrincipalOfficerNm0KENNETH KANDARAS
IRS990/ProfessionalFundraisingInd00
IRS990/ProhibitedTaxShelterTransInd00
IRS990/PYBenefitsPaidToMembersAmt00
IRS990/PYContributionsGrantsAmt0202520
IRS990/PYExcessBenefitTransInd00
IRS990/PYGrantsAndSimilarPaidAmt0142500
IRS990/PYInvestmentIncomeAmt014914
IRS990/PYOtherExpensesAmt046681
IRS990/PYOtherRevenueAmt00
IRS990/PYProgramServiceRevenueAmt00
IRS990/PYRevenuesLessExpensesAmt028253
IRS990/PYSalariesCompEmpBnftPaidAmt00
IRS990/PYTotalExpensesAmt0189181
IRS990/PYTotalProfFndrsngExpnsAmt00
IRS990/PYTotalRevenueAmt0217434
IRS990/QuidProQuoContributionsInd00
IRS990/RcvFndsToPayPrsnlBnftCntrctInd00
IRS990/ReconcilationRevenueExpnssAmt083103
IRS990/RegularMonitoringEnfrcInd01
IRS990/RelatedEntityInd01
IRS990/RelatedOrganizationCtrlEntInd00
IRS990/ReportInvestmentsOtherSecInd00
IRS990/ReportLandBuildingEquipmentInd00
IRS990/ReportOtherAssetsInd00
IRS990/ReportOtherLiabilitiesInd00
IRS990/ReportProgramRelatedInvstInd00
IRS990/SavingsAndTempCashInvstGrp/BOYAmt0216340
IRS990/SavingsAndTempCashInvstGrp/EOYAmt0314272
IRS990ScheduleA/GiftsGrantsContriRcvd170Grp/CurrentTaxYearAmt0276529
IRS990ScheduleA/GiftsGrantsContriRcvd170Grp/CurrentTaxYearMinus1YearAmt0202520
IRS990ScheduleA/GiftsGrantsContriRcvd170Grp/CurrentTaxYearMinus2YearsAmt0276170
IRS990ScheduleA/GiftsGrantsContriRcvd170Grp/CurrentTaxYearMinus3YearsAmt0291020
IRS990ScheduleA/GiftsGrantsContriRcvd170Grp/CurrentTaxYearMinus4YearsAmt0246200
IRS990ScheduleA/GiftsGrantsContriRcvd170Grp/TotalAmt01292439
IRS990ScheduleA/GrossInvestmentIncome170Grp/CurrentTaxYearAmt033554
IRS990ScheduleA/GrossInvestmentIncome170Grp/CurrentTaxYearMinus1YearAmt014914
IRS990ScheduleA/GrossInvestmentIncome170Grp/CurrentTaxYearMinus2YearsAmt011443
IRS990ScheduleA/GrossInvestmentIncome170Grp/CurrentTaxYearMinus3YearsAmt021604
IRS990ScheduleA/GrossInvestmentIncome170Grp/CurrentTaxYearMinus4YearsAmt07676
IRS990ScheduleA/GrossInvestmentIncome170Grp/TotalAmt089191
IRS990ScheduleA/OtherIncome170Grp/CurrentTaxYearMinus4YearsAmt04091
IRS990ScheduleA/OtherIncome170Grp/TotalAmt04091
IRS990ScheduleA/PublicOrganization170Ind0X
IRS990ScheduleA/PublicSupportCY170Pct00.93270
IRS990ScheduleA/PublicSupportPY170Pct00.94710
IRS990ScheduleA/PublicSupportTotal170Amt01292439
IRS990ScheduleA/ThirtyThrPctSuprtTestsCY170Ind0X
IRS990ScheduleA/TotalCalendarYear170Grp/CurrentTaxYearAmt0276529
IRS990ScheduleA/TotalCalendarYear170Grp/CurrentTaxYearMinus1YearAmt0202520
IRS990ScheduleA/TotalCalendarYear170Grp/CurrentTaxYearMinus2YearsAmt0276170
IRS990ScheduleA/TotalCalendarYear170Grp/CurrentTaxYearMinus3YearsAmt0291020
IRS990ScheduleA/TotalCalendarYear170Grp/CurrentTaxYearMinus4YearsAmt0246200
IRS990ScheduleA/TotalCalendarYear170Grp/TotalAmt01292439
IRS990ScheduleA/TotalSupportAmt01385721
IRS990ScheduleB/ContributorInformationGrp/ContributorBusinessName/BusinessNameLine10RESTRICTED
IRS990ScheduleB/ContributorInformationGrp/ContributorNum0RESTRICTED
IRS990ScheduleB/ContributorInformationGrp/ContributorUSAddress/AddressLine10RESTRICTED
IRS990ScheduleB/ContributorInformationGrp/ContributorUSAddress/AddressLine20RESTRICTED
IRS990ScheduleB/ContributorInformationGrp/ContributorUSAddress/City0RESTRICTED
IRS990ScheduleB/ContributorInformationGrp/ContributorUSAddress/State0RESTRICTED
IRS990ScheduleB/ContributorInformationGrp/ContributorUSAddress/ZIPCode0RESTRICTED
IRS990ScheduleB/ContributorInformationGrp/TotalContributionsAmt0RESTRICTED
IRS990/ScheduleBRequiredInd01
IRS990ScheduleD/FootnoteTextInd0X
IRS990ScheduleD/SupplementalInformationDetail/ExplanationTxt0IFER HAS IMPLEMENTED ACCOUNTING FOR UNCERTAINTY IN INCOME TAXES IN ACCORDANCE WITH U.S. GAAP. THIS STANDARD PRESCRIBES A RECOGNITION THRESHOLD AND MEASUREMENT ATTRIBUTE FOR FINANCIAL STATEMENT RECOGNITION AND MEASUREMENT OF A TAX POSITION TAKEN OR EXPECTED TO BE TAKEN IN A TAX RETURN AND ALSO PROVIDES GUIDANCE ON VARIOUS RELATED MATTERS SUCH AS DERECOGNIZING, INTEREST, PENALTIES AND DISCLOSURES REQUIRED. MANAGEMENT OF IFER EVALUATES THE UNCERTAIN TAX POSITIONS TAKEN, IF ANY, AND CONSULTS WITH OUTSIDE COUNSEL AS DEEMED NECESSARY. IFER RECOGNIZES INTEREST AND PENALTIES, IF ANY, RELATED TO UNRECOGNIZED TAX LIABILITIES IN INCOME TAX EXPENSE. IN MANAGEMENT'S OPINION, IFER HAS NOT TAKEN ANY UNCERTAIN TAX POSITIONS, AND ACCORDINGLY, HAS NOT REPORTED A CORRESPONDING LIABILITY IN IFER' FINANCIAL STATEMENTS.
IRS990ScheduleD/SupplementalInformationDetail/FormAndLineReferenceDesc0PART X, LINE 2:
IRS990ScheduleD/TotalBookValueLandBuildingsAmt00
IRS990ScheduleF/AccountActivitiesOutsideUSGrp/EmployeeCnt00
IRS990ScheduleF/AccountActivitiesOutsideUSGrp/EmployeeCnt10
IRS990ScheduleF/AccountActivitiesOutsideUSGrp/OfficesCnt00
IRS990ScheduleF/AccountActivitiesOutsideUSGrp/OfficesCnt10
IRS990ScheduleF/AccountActivitiesOutsideUSGrp/RegionTotalExpendituresAmt015000
IRS990ScheduleF/AccountActivitiesOutsideUSGrp/RegionTotalExpendituresAmt115000
IRS990ScheduleF/AccountActivitiesOutsideUSGrp/RegionTxt0EUROPE (INCLUDING ICELAND & GREENLAND) - ALBANIA, ANDORRA, AUSTRIA, BELGIUM
IRS990ScheduleF/AccountActivitiesOutsideUSGrp/RegionTxt1EAST ASIA AND THE PACIFIC
IRS990ScheduleF/AccountActivitiesOutsideUSGrp/SpecificServicesProvidedTxt0FUNDING SCIENTIFIC RESEARCH
IRS990ScheduleF/AccountActivitiesOutsideUSGrp/SpecificServicesProvidedTxt1FUNDING SCIENTIFIC RESEARCH
IRS990ScheduleF/AccountActivitiesOutsideUSGrp/TypeOfActivitiesConductedTxt0GRANT MAKING
IRS990ScheduleF/AccountActivitiesOutsideUSGrp/TypeOfActivitiesConductedTxt1GRANT MAKING
IRS990ScheduleF/BoycottCountriesInd00
IRS990ScheduleF/ContinuationSpentAmt00
IRS990ScheduleF/ContinuationTotalEmployeeCnt00
IRS990ScheduleF/ContinuationTotalOfficeCnt00
IRS990ScheduleF/ForeignCorpOwnershipInd00
IRS990ScheduleF/ForeignPartnershipInd00
IRS990ScheduleF/GrantRecordsMaintainedInd00
IRS990ScheduleF/GrantsToOrgOutsideUSGrp/CashGrantAmt015000
IRS990ScheduleF/GrantsToOrgOutsideUSGrp/CashGrantAmt115000
IRS990ScheduleF/GrantsToOrgOutsideUSGrp/NonCashAssistanceAmt00
IRS990ScheduleF/GrantsToOrgOutsideUSGrp/NonCashAssistanceAmt10
IRS990ScheduleF/GrantsToOrgOutsideUSGrp/PurposeOfGrantTxt0RESEARCH
IRS990ScheduleF/GrantsToOrgOutsideUSGrp/PurposeOfGrantTxt1RESEARCH
IRS990ScheduleF/GrantsToOrgOutsideUSGrp/RegionTxt0EUROPE (INCLUDING ICELAND & GREENLAND) - ALBANIA, ANDORRA, AUSTRIA, BELGIUM
IRS990ScheduleF/GrantsToOrgOutsideUSGrp/RegionTxt1EAST ASIA AND THE PACIFIC
IRS990ScheduleF/InterestInForeignTrustInd00
IRS990ScheduleF/PassiveForeignInvestmestCoInd00
IRS990ScheduleF/SubtotalEmployeesCnt00
IRS990ScheduleF/SubtotalOfficesCnt00
IRS990ScheduleF/SubtotalSpentAmt030000
IRS990ScheduleF/SupplementalInformationDetail/ExplanationTxt0KOREA ADVANCED INSTITUTE OF SCIENCE & TECHNOLOGY (KAIST): THE GRANT TO KAIST WILL SUPPORT EUNHO CHOI, WHO IS ENGINEERING A NEW TYPE OF PROBIOTIC THAT CAN SPECIFICALLY TARGET AND ELIMINATE GROUP B STREPTOCOCCUS (GBS), A DANGEROUS BACTERIUM THAT CAN CAUSE INFECTIONS IN NEWBORNS AND ADULTS. THIS ENGINEERED PROBIOTIC WILL BE TESTED USING A "COLON-ON-A-CHIP" MODEL, WHICH MIMICS THE HUMAN GUT AND ALLOWS SCIENTISTS TO STUDY HOW THE TREATMENT WORKS WITHOUT USING ANIMALS. THE GOAL IS TO CREATE A SAFE AND EFFECTIVE TREATMENT FOR GBS INFECTIONS WHILE PRESERVING THE BALANCE OF HEALTHY GUT BACTERIA. THIS PROJECT COULD ALSO REDUCE THE NEED FOR ANIMAL TESTING IN THE FUTURE AND IMPROVE OUR UNDERSTANDING OF HOW BACTERIA INTERACT IN THE HUMAN BODY. MASARYK UNIVERSITY: A GRANT WAS GIVEN TO MASARYK UNIVERSITY TO SUPPORT ELISKA REHURKOVA'S WORK TO CREATE A HUMAN-RELEVANT MODEL TO UNDERSTAND THE STAGES OF MALE SEX HORMONE PRODUCTION WITHIN THE TESTES, RECOGNIZING THE ROLE ENVIRONMENTAL POLLUTANTS AND DRUGS PLAY IN DISRUPTING THEIR LEVELS DURING DEVELOPMENT. ELISKA WILL DIFFERENTIATE HUMAN INDUCED PLURIPOTENT STEM CELLS INTO LEYDIG CELLS, CELLS OF THE TESTES THAT PRODUCE ANDROGENS, AND TRANSITION THE CELLS INTO 3D CELL CULTURE. SHE WILL CHARACTERIZE THE MODEL, VALIDATE IT WITH SELECT REFERENCE CHEMICALS, AND COMPARE HER FINDINGS TO THOSE OF OTHER EXISTING MODEL SYSTEMS. HER PROJECT REPRESENTS A CRUCIAL ADVANCEMENT IN MALE REPRODUCTIVE TOXICOLOGY, AS SHE IS DEVELOPING A SYSTEM THAT CAN ALLOW FOR THE TESTING OF ENVIRONMENTAL POLLUTANTS AND CHEMICALS ON TESTICULAR STEROIDOGENESIS IN A HUMAN-RELEVANT, ANIMAL-FREE CELL MODEL.
IRS990ScheduleF/SupplementalInformationDetail/FormAndLineReferenceDesc0SCHEDULE F PART II COLUMN D
IRS990ScheduleF/TotalEmployeeCnt00
IRS990ScheduleF/TotalOfficeCnt00
IRS990ScheduleF/TotalSpentAmt030000
IRS990ScheduleF/TransferToForeignCorpInd00
IRS990ScheduleI/GrantRecordsMaintainedInd01
IRS990ScheduleI/RecipientTable/CashGrantAmt015000
IRS990ScheduleI/RecipientTable/CashGrantAmt115000
IRS990ScheduleI/RecipientTable/CashGrantAmt215000
IRS990ScheduleI/RecipientTable/CashGrantAmt315000
IRS990ScheduleI/RecipientTable/CashGrantAmt415000
IRS990ScheduleI/RecipientTable/CashGrantAmt515000
IRS990ScheduleI/RecipientTable/CashGrantAmt615000
IRS990ScheduleI/RecipientTable/CashGrantAmt715000
IRS990ScheduleI/RecipientTable/CashGrantAmt815000
IRS990ScheduleI/RecipientTable/CashGrantAmt915000
IRS990ScheduleI/RecipientTable/NonCashAssistanceAmt00
IRS990ScheduleI/RecipientTable/NonCashAssistanceAmt10
IRS990ScheduleI/RecipientTable/NonCashAssistanceAmt20
IRS990ScheduleI/RecipientTable/NonCashAssistanceAmt30
IRS990ScheduleI/RecipientTable/NonCashAssistanceAmt40
IRS990ScheduleI/RecipientTable/NonCashAssistanceAmt50
IRS990ScheduleI/RecipientTable/NonCashAssistanceAmt60
IRS990ScheduleI/RecipientTable/NonCashAssistanceAmt70
IRS990ScheduleI/RecipientTable/NonCashAssistanceAmt80
IRS990ScheduleI/RecipientTable/NonCashAssistanceAmt90
IRS990ScheduleI/RecipientTable/PurposeOfGrantTxt0RESEARCH
IRS990ScheduleI/RecipientTable/PurposeOfGrantTxt1RESEARCH
IRS990ScheduleI/RecipientTable/PurposeOfGrantTxt2RESEARCH
IRS990ScheduleI/RecipientTable/PurposeOfGrantTxt3RESEARCH
IRS990ScheduleI/RecipientTable/PurposeOfGrantTxt4RESEARCH
IRS990ScheduleI/RecipientTable/PurposeOfGrantTxt5RESEARCH
IRS990ScheduleI/RecipientTable/PurposeOfGrantTxt6RESEARCH
IRS990ScheduleI/RecipientTable/PurposeOfGrantTxt7RESEARCH
IRS990ScheduleI/RecipientTable/PurposeOfGrantTxt8RESEARCH
IRS990ScheduleI/RecipientTable/PurposeOfGrantTxt9RESEARCH
IRS990ScheduleI/RecipientTable/RecipientBusinessName/BusinessNameLine1Txt0HARVARD UNIVERSITY
IRS990ScheduleI/RecipientTable/RecipientBusinessName/BusinessNameLine1Txt1CORNELL UNIVERSITY
IRS990ScheduleI/RecipientTable/RecipientBusinessName/BusinessNameLine1Txt2DUKE UNIVERSITY
IRS990ScheduleI/RecipientTable/RecipientBusinessName/BusinessNameLine1Txt3JOHNS HOPKINS UNIVERSITY
IRS990ScheduleI/RecipientTable/RecipientBusinessName/BusinessNameLine1Txt4UNIVERSITY OF MARYLAND - COLLEGE PARK
IRS990ScheduleI/RecipientTable/RecipientBusinessName/BusinessNameLine1Txt5UNIVERSITY OF ROCHESTER
IRS990ScheduleI/RecipientTable/RecipientBusinessName/BusinessNameLine1Txt6WAKE FOREST
IRS990ScheduleI/RecipientTable/RecipientBusinessName/BusinessNameLine1Txt7NEW YORK UNIVERSITY
IRS990ScheduleI/RecipientTable/RecipientBusinessName/BusinessNameLine1Txt8UCLA
IRS990ScheduleI/RecipientTable/RecipientBusinessName/BusinessNameLine1Txt9UNIVERSITY OF DELAWARE
IRS990ScheduleI/RecipientTable/RecipientEIN0042103580
IRS990ScheduleI/RecipientTable/RecipientEIN1150532082
IRS990ScheduleI/RecipientTable/RecipientEIN2562070036
IRS990ScheduleI/RecipientTable/RecipientEIN3520595110
IRS990ScheduleI/RecipientTable/RecipientEIN4152600203
IRS990ScheduleI/RecipientTable/RecipientEIN5160743209
IRS990ScheduleI/RecipientTable/RecipientEIN6510190238
IRS990ScheduleI/RecipientTable/RecipientEIN7135562308
IRS990ScheduleI/RecipientTable/RecipientEIN8956006143
IRS990ScheduleI/RecipientTable/RecipientEIN9911955015
IRS990ScheduleI/RecipientTable/USAddress/AddressLine1Txt01033 MASSACHUSETTS AVENUE 3RD FL
IRS990ScheduleI/RecipientTable/USAddress/AddressLine1Txt1616 THURSTON AVENUE
IRS990ScheduleI/RecipientTable/USAddress/AddressLine1Txt22138 COMPUS DRIVE
IRS990ScheduleI/RecipientTable/USAddress/AddressLine1Txt33910 KESWICK ROAD SUITE N2100
IRS990ScheduleI/RecipientTable/USAddress/AddressLine1Txt47901 REGENTS DRIVE
IRS990ScheduleI/RecipientTable/USAddress/AddressLine1Txt5601 ELMWOOD AVENUE
IRS990ScheduleI/RecipientTable/USAddress/AddressLine1Txt61834 WAKE FOREST ROAD BOX 7227
IRS990ScheduleI/RecipientTable/USAddress/AddressLine1Txt770 WASHINGTON SQUARE SOUTH NEW YORK
IRS990ScheduleI/RecipientTable/USAddress/AddressLine1Txt810889 WILSHIRE BOULEVARD SUITE 700
IRS990ScheduleI/RecipientTable/USAddress/AddressLine1Txt9413 ACADEMY ST STE 268
IRS990ScheduleI/RecipientTable/USAddress/CityNm0CAMBRIDGE
IRS990ScheduleI/RecipientTable/USAddress/CityNm1ITHACA
IRS990ScheduleI/RecipientTable/USAddress/CityNm2DURHAM
IRS990ScheduleI/RecipientTable/USAddress/CityNm3BALTIMORE
IRS990ScheduleI/RecipientTable/USAddress/CityNm4COLLEGE PARK
IRS990ScheduleI/RecipientTable/USAddress/CityNm5ROCHESTER
IRS990ScheduleI/RecipientTable/USAddress/CityNm6WINSTON SALEM
IRS990ScheduleI/RecipientTable/USAddress/CityNm7NEW YORK
IRS990ScheduleI/RecipientTable/USAddress/CityNm8LOS ANGELES
IRS990ScheduleI/RecipientTable/USAddress/CityNm9NEWARK
IRS990ScheduleI/RecipientTable/USAddress/StateAbbreviationCd0MA
IRS990ScheduleI/RecipientTable/USAddress/StateAbbreviationCd1NY
IRS990ScheduleI/RecipientTable/USAddress/StateAbbreviationCd2NC
IRS990ScheduleI/RecipientTable/USAddress/StateAbbreviationCd3MD
IRS990ScheduleI/RecipientTable/USAddress/StateAbbreviationCd4MD
IRS990ScheduleI/RecipientTable/USAddress/StateAbbreviationCd5NY
IRS990ScheduleI/RecipientTable/USAddress/StateAbbreviationCd6NC
IRS990ScheduleI/RecipientTable/USAddress/StateAbbreviationCd7NY
IRS990ScheduleI/RecipientTable/USAddress/StateAbbreviationCd8CA
IRS990ScheduleI/RecipientTable/USAddress/StateAbbreviationCd9DE
IRS990ScheduleI/RecipientTable/USAddress/ZIPCd002138
IRS990ScheduleI/RecipientTable/USAddress/ZIPCd114853
IRS990ScheduleI/RecipientTable/USAddress/ZIPCd227708
IRS990ScheduleI/RecipientTable/USAddress/ZIPCd321211
IRS990ScheduleI/RecipientTable/USAddress/ZIPCd4207425025
IRS990ScheduleI/RecipientTable/USAddress/ZIPCd514626
IRS990ScheduleI/RecipientTable/USAddress/ZIPCd627109
IRS990ScheduleI/RecipientTable/USAddress/ZIPCd710012
IRS990ScheduleI/RecipientTable/USAddress/ZIPCd890095
IRS990ScheduleI/RecipientTable/USAddress/ZIPCd919716
IRS990ScheduleI/SupplementalInformationDetail/ExplanationTxt0CORNELL UNIVERSITY (NEW YORK): THE GRANT WAS GIVEN TO CORNELL UNIVERSITY IN NEW YORK TO SUPPORT THE RESEARCH CONDUCTED BY YANSONG (HARRY) PENG. HARRY'S RESEARCH FOCUSES ON "A TISSUE-ENGINEERED PANCREATIC CANCER MODEL FOR DISSECTING THE ROLES OF LYMPHATIC VESSELS IN TUMOR IMMUNITY." DUKE UNIVERSITY (NORTH CAROLINA): THE GRANT WAS GIVEN TO DUKE UNIVERSITY TO SUPPORT THE RESEARCH CONDUCTED BY MINGZHI XU, "AN INTEGRATED MICROFLUIDIC SYSTEM WITH ENGINEERED BLOOD VESSEL MIMIC AND SKELETAL MUSCLE TO INVESTIGATE THE RELATION BETWEEN RHEUMATOID ARTHRITIS AND ATHEROSCLEROSIS." RHEUMATOID ARTHRITIS (RA) IS A CHRONIC INFLAMMATORY AUTOIMMUNE DISEASE THAT PRIMARILY TARGETS THE JOINTS, BUT ALSO SYSTEMICALLY PROMOTES INFLAMMATION. PATIENTS WITH RA EXPERIENCE MUSCLE WEAKNESS AND ELEVATED INFLAMMATORY CYTOKINES IN THEIR CIRCULATION HAVE INCREASED ATHEROSCLEROSIS, WHICH LEADS TO A HIGHER CARDIOVASCULAR DISEASE (CVD) RISK. SYSTEMIC INFLAMMATION PLAYS AN IMPORTANT ROLE IN ATHEROSCLEROSIS, AND AUTOIMMUNE DISEASES SUCH AS RA ACCELERATE ATHEROSCLEROSIS DUE TO ELEVATED SYSTEMIC INFLAMMATION. ANIMAL MODELS AVAILABLE FOR EITHER ATHEROSCLEROSIS OR RHEUMATOID ARTHRITIS HAVE LIMITATIONS, WITH PHENOTYPES THAT ARE COMPLICATED TO PRODUCE AND TAKE A LONG TIME TO DEVELOP. IN THIS PROPOSAL, MINGZHI WILL LINK TISSUE ENGINEERED BLOOD VESSELS (TEBV) AND ENGINEERED SKELETAL MUSCLE MYOBUNDLES MADE WITH HUMAN CELLS TO PRODUCE AN INTEGRATED SYSTEM. THIS SYSTEM WILL BE USED TO INVESTIGATE THE INTERACTION OF BLOOD VESSELS AND MUSCLE IN RA TO IDENTIFY THERAPEUTICS THAT LACK TOXICITY AND DEMONSTRATE EFFICACY IN HUMANS. JOHNS HOPKINS UNIVERSITY: A GRANT WAS GIVEN TO JOHNS HOPKINS TO SUPPORT THE RESEARCH CONDUCTED BY DOWLETTE-MARY ALAM EL DIN, "DEVELOPING COGNITION-IN-A-DISH TO INVESTIGATE THE IMPACT OF CHRONIC LOW DOSE DOMOIC ACID EXPOSURE ON NERUONAL DEVELOPMENT AND FUNCTION." DOMOIC ACID (DA) IS A NEUROTOXIN PRODUCED BY ALGAE BLOOMS THAT CAN CONTAMINATE SHELLFISH AND LEAD TO CELLULAR AND STRUCTURAL BRAIN DAMAGE IN EXPOSED HUMANS. ITS PRESENCE IN COASTAL AREAS HAS BECOME MORE FREQUENT DUE TO CLIMATE CHANGE CAUSING AN INCREASE IN THE NUMBER OF HARMFUL ALGAE BLOOMS. MOST STUDIES INVESTIGATING THE ROLE OF DA IN COGNITIVE IMPAIRMENT HAVE BEEN CONDUCTED IN ANIMAL MODELS, BUT DO NOT PROVIDE A BIOLOGICALLY RELEVANT MODEL FOR HUMAN COGNITIVE DEVELOPMENT. IN THIS PROPOSAL, DOWETTE PLANS TO DEVELOP A COGNITION-IN-A-DISH MODEL USING A HUMAN BRAIN ORGANOID TO INVESTIGATE THE EFFECTS OF CHRONIC LOW-DOSE DA EXPOSURE NEURODEVELOPMENTAL EVENTS, FUNCTIONAL NEURAL NETWORK FORMATION, AND COGNITIVE FUNCTIONS. IDENTIFICATION OF THE PATHWAYS THROUGH WHICH DA DISRUPTS COGNITIVE FUNCTION WILL IMPACT HUMAN HEALTH AND SAFETY BY INFORMING REGULATORY GUIDELINES FOR EXPOSURE. HARVARD UNIVERSITY: THE GRANT TO HARVARD IS IN SUPPORT OF ZEKE BENSHIRIM'S PROJECT, IN WHICH HE IS DEVELOPING A METHOD TO ENHANCE THE STRUCTURAL INTEGRITY OF BRAIN ORGANOIDS, WHICH CURRENTLY LOSE THEIR ORGANIZATION OVER TIME, LIMITING THEIR ABILITY TO ACCURATELY MIMIC HUMAN BRAIN DEVELOPMENT AND DISEASES LIKE EPILEPSY AND ALZHEIMER'S. TO ADDRESS THIS, ZEKE WILL REPLICATE THE NATURAL PROCESS OF NEURAL TUBE INFLATION BY CAREFULLY/PRECISELY INJECTING FLUID INTO THE CORE OF THE ORGANOID, MAINTAINING ITS STRUCTURE, AND PROMOTING PROPER GROWTH. THIS RESEARCH COULD LEAD TO MORE RELIABLE MODELS FOR STUDYING NEUROLOGICAL DISEASE AND TESTING TREATMENTS, OFFERING A POWERFUL ALTERNATIVE TO ANIMAL TESTING. NEW YORK UNIVERSITY: THE GRANT TO NEW YORK UNIVERSITY WILL SUPPORT LUNAN LIU'S PROJECT TO DEVELOP A HUMAN ORGAN-ON-ACHIP/ORGANOID SYSTEM TO INVESTIGATE PANCREATIC CANCER, A HIGHLY MALIGNANT CANCER THAT RESPONDS POORLY TO DRUGS AND IMMUNOTHERAPIES. TO MORE ACCURATELY REPRESENT COMPLEXITY SEEN IN VIVO, LUNAN WILL GENERATE CHIP MODELS THAT INCLUDE STROMAL, IMMUNE AND BLOOD VESSEL COMPONENTS, IN ADDITION TO ORGANOIDS DERIVED FROM THE CELLS OF DIFFERENT PANCREATIC CANCER PATIENTS TO BETTER UNDERSTAND HOW AND WHY THE CANCER IS DIFFICULT TO TREAT
IRS990ScheduleI/SupplementalInformationDetail/FormAndLineReferenceDesc0SCHEDULE I PART II COLUMN H
IRS990ScheduleJ/AnyNonFixedPaymentsInd00
IRS990ScheduleJ/CompBasedOnRevenueOfFlngOrgInd00
IRS990ScheduleJ/CompBsdNetEarnsFlngOrgInd00
IRS990ScheduleJ/CompBsdNetEarnsRltdOrgsInd00
IRS990ScheduleJ/CompBsdOnRevRelatedOrgsInd00
IRS990ScheduleJ/EquityBasedCompArrngmInd00
IRS990ScheduleJ/InitialContractExceptionInd00

Document Assets

No mirrored PDF or thumbnail assets are attached yet.

Peer Organizations

Similar nonprofits based on the same Siviq industry and scale cohort. 501(c)3 • $1M-$5M nonprofits