Civic Intelligence

New York Structural Biology Center Inc

EIN 13-4043587 • 501(c)3 • New York, NY

Profile

The nysbc mission is to provide advanced research resources to the faculty of its participating member institutions and researchers from the national community in three key areas of structural biology: nuclear magnetic resonance spectroscopy; cryoelectron microscopy; and x-ray crystallography.

89 Convent Ave 133rd StNew York, NY 10027

www.nysbc.org

Siviq Scores

Precomputed percentiles relative to similar nonprofits. These scores are descriptive rather than judgmental.

Liabilities / Assets

26th percentile

0.08x

Higher debt load relative to assets than 26% of similar nonprofits.

501(c)3 • $100M-$250M nonprofits • Source year 2024

Liabilities / Revenue

59th percentile

0.56x

Higher debt load relative to revenue than 59% of similar nonprofits.

501(c)3 • $100M-$250M nonprofits • Source year 2024

Net Margin

5th percentile

-43%

Higher net margin than 5% of similar nonprofits.

501(c)3 • $100M-$250M nonprofits • Source year 2024

Top Officer Pay

67th percentile

$685,846

Higher top officer pay than 67% of similar nonprofits.

Top officer pay equals 3.4% of source-year revenue.

501(c)3 • $100M-$250M nonprofits • Source year 2024

Asset Growth

54th percentile

6.7%

Faster asset growth than 54% of similar nonprofits.

501(c)3 • $100M-$250M nonprofits • Annualized from 2023 to 2024

Revenue Growth

3rd percentile

-47%

Faster revenue growth than 3% of similar nonprofits.

501(c)3 • $100M-$250M nonprofits • Annualized from 2023 to 2024

Assets

Up

$133,938,928

Up $8,384,947 (+6.7%) from 2023

Liabilities

Up

$11,192,289

Up $6,890,321 (+160%) from 2023

Net Assets

Up

$122,746,639

Up $1,494,626 (+1.2%) from 2023

Revenue

Down

$19,952,697

Down $17,773,770 (-47%) from 2023

Expenses

Up

$28,453,802

Up $3,597,093 (+14%) from 2023

Net Income

Down

-$8,501,105

Down $21,370,863 (-166%) from 2023

Trend Graphs

Balance Sheet Trend

Grouped bars show assets, liabilities, and net assets across loaded filings.

$150M$100M$50M$0Assets 2010: $50,850,495Liabilities 2010: $6,193,191Net Assets 2010: $44,657,3042010Assets 2011: $50,598,257Liabilities 2011: $5,478,929Net Assets 2011: $45,119,3282011Assets 2012: $47,592,766Liabilities 2012: $4,564,502Net Assets 2012: $43,028,2642012Assets 2013: $46,758,846Liabilities 2013: $4,718,456Net Assets 2013: $42,040,3902013Assets 2014: $68,047,914Liabilities 2014: $7,110,531Net Assets 2014: $60,937,3832014Assets 2015: $72,730,856Liabilities 2015: $5,267,265Net Assets 2015: $67,463,5912015Assets 2016: $82,793,879Liabilities 2016: $7,623,490Net Assets 2016: $75,170,3892016Assets 2017: $79,284,903Liabilities 2017: $5,069,560Net Assets 2017: $74,215,3432017Assets 2018: $80,809,299Liabilities 2018: $5,587,079Net Assets 2018: $75,222,2202018Assets 2019: $90,105,650Liabilities 2019: $5,205,762Net Assets 2019: $84,899,8882019Assets 2020: $108,730,364Liabilities 2020: $4,097,997Net Assets 2020: $104,632,3672020Assets 2021: $108,370,731Liabilities 2021: $4,315,025Net Assets 2021: $104,055,7062021Assets 2022: $110,945,662Liabilities 2022: $3,612,976Net Assets 2022: $107,332,6862022Assets 2023: $125,553,981Liabilities 2023: $4,301,968Net Assets 2023: $121,252,0132023Assets 2024: $133,938,928Liabilities 2024: $11,192,289Net Assets 2024: $122,746,6392024

Highlighted filing

2024

Assets$133,938,928
Liabilities$11,192,289
Net Assets$122,746,639

Operations Trend

Revenue, expenses, and net income by year, with the latest filing highlighted.

$40M$20M$0-$20MExpenses 2010: $10,229,6202010Expenses 2011: $14,169,8562011Revenue 2012: $10,878,204Expenses 2012: $13,107,759Net Income 2012: -$2,229,5552012Revenue 2013: $12,423,050Expenses 2013: $13,610,266Net Income 2013: -$1,187,2162013Revenue 2014: $31,533,905Expenses 2014: $12,636,800Net Income 2014: $18,897,1052014Revenue 2015: $19,709,765Expenses 2015: $12,859,970Net Income 2015: $6,849,7952015Revenue 2016: $21,799,272Expenses 2016: $12,773,593Net Income 2016: $9,025,6792016Revenue 2017: $18,149,228Expenses 2017: $19,548,077Net Income 2017: -$1,398,8492017Revenue 2018: $17,359,253Expenses 2018: $15,583,009Net Income 2018: $1,776,2442018Revenue 2019: $26,205,562Expenses 2019: $16,565,914Net Income 2019: $9,639,6482019Revenue 2020: $38,246,753Expenses 2020: $18,801,616Net Income 2020: $19,445,1372020Revenue 2021: $20,379,459Expenses 2021: $21,817,471Net Income 2021: -$1,438,0122021Revenue 2022: $28,684,129Expenses 2022: $23,931,083Net Income 2022: $4,753,0462022Revenue 2023: $37,726,467Expenses 2023: $24,856,709Net Income 2023: $12,869,7582023Revenue 2024: $19,952,697Expenses 2024: $28,453,802Net Income 2024: -$8,501,1052024

Highlighted filing

2024

Revenue$19,952,697
Expenses$28,453,802
Net Income-$8,501,105

Filings

Balance SheetOperations
YearAssetsLiabilitiesNet AssetsRevenueExpensesNet Income
2024Facts available. Structured filing facts are available, but richer extracted sections are limited.$134$11.2$123$20.0$28.5$8.50
2023Detailed filing. Detailed filing data is available for this year.$126$4.30$121$37.7$24.9$12.9
2022Detailed filing. Detailed filing data is available for this year.$111$3.61$107$28.7$23.9$4.75
2021Detailed filing. Detailed filing data is available for this year.$108$4.32$104$20.4$21.8$1.44
2020Detailed filing. Detailed filing data is available for this year.$109$4.10$105$38.2$18.8$19.4
2019Detailed filing. Detailed filing data is available for this year.$90.1$5.21$84.9$26.2$16.6$9.64
2018Detailed filing. Detailed filing data is available for this year.$80.8$5.59$75.2$17.4$15.6$1.78
2017Detailed filing. Detailed filing data is available for this year.$79.3$5.07$74.2$18.1$19.5$1.40
2016Detailed filing. Detailed filing data is available for this year.$82.8$7.62$75.2$21.8$12.8$9.03
2015Detailed filing. Detailed filing data is available for this year.$72.7$5.27$67.5$19.7$12.9$6.85
2014Detailed filing. Detailed filing data is available for this year.$68.0$7.11$60.9$31.5$12.6$18.9
2013Detailed filing. Detailed filing data is available for this year.$46.8$4.72$42.0$12.4$13.6$1.19
2012Summary only. Only limited summary data is available for this year.$47.6$4.56$43.0$10.9$13.1$2.23
2011Facts available. Structured filing facts are available, but richer extracted sections are limited.$50.6$5.48$45.1$14.2
2010Facts available. Structured filing facts are available, but richer extracted sections are limited.$50.9$6.19$44.7$10.2
Latest Filing Detail
Jump To
Filing Snapshot
Filing Period
Jan 1, 2024 to Dec 31, 2024
Signed
Oct 30, 2025
Return Version
2024v5.2
Gross Receipts
$19,961,030
Mission and Program Overview

Mission

The nysbc mission is to provide advanced research resources to the faculty of nysbc's 9 member institutions in three key areas of structural biology: nuclear magnetic resonance spectroscopy; cryoelectron microscopy; and x-ray crystallography. These resources serve more than 100 principal investigators. In addition, the nysbc serves its member institutions by offering accredited academic courses and informal seminars; and by developing multi-institutional research collaborations.

See schedule o.to operate a state-of-the-art facility for advanced research in structural biology and provide advanced resources to the faculty of its participating member institutions and researchers from the national community.

Balance Sheet Detail
LineBeginningEndChange
Assets
Land, Buildings, and Equipment, Net$82,983,465$92,245,620▲ $9,262,155
Pledges and Grants Receivable$21,581,508$16,295,915▼ $5,285,593
Investments in Publicly Traded Securities$13,751,866$15,241,225▲ $1,489,359
Savings and Temporary Cash Investments$6,707,715$1,441,062▼ $5,266,653
Prepaid Expenses and Deferred Charges$179,440$319,627▲ $140,187
Cash and Non-Interest-Bearing Accounts$176,836$144,245▼ $32,591
Accounts Receivable$173,151$56,047▼ $117,104
Total Assets$125,553,981$133,938,928▲ $8,384,947
Other Assets Total$0$8,195,187▲ $8,195,187
Liabilities
Other Liabilities$2,097,298$8,892,300▲ $6,795,002
Deferred Revenue$1,335,358$1,262,777▼ $72,581
Accounts Payable and Accrued Expenses$869,312$1,037,212▲ $167,900
Total Liabilities$4,301,968$11,192,289▲ $6,890,321
Net Assets / Fund Balance
Net Assets Without Donor Restrictions$95,383,473$106,207,663▲ $10,824,190
Net Assets With Donor Restrictions$25,868,540$16,538,976▼ $9,329,564
Total Net Assets Fund Balance$121,252,013$122,746,639▲ $1,494,626
Total Liabilities and Net Assets / Fund Balance$125,553,981$133,938,928▲ $8,384,947

Asset Categories

AssetBook ValueDepreciationBasis
Equipment$58,299,809$50,333,990$108,633,799
Leasehold Improvements$20,683,624$23,247,294$43,930,918
Other Land Buildings$11,383,690-$11,383,690
Buildings$1,878,497$2,374,723$4,253,220
Other Assets Org$8,195,187--
Compensation and Service Providers

Employees

NameTitleFull / Part TimeBaseOtherTotal
Dr Jeffrey KieftExecutive DirectorFT$581,635$104,211$685,846
Dr Alex De MarcoSemc DirectorFT$372,535$104,211$476,746
Mr Arjun KoshalManaging DirectorFT$320,368$85,604$405,972
Ms Debbie TrifilioDirector of Finance and OperationsFT$259,823$64,200$324,023
Dr Kevin BattaileNys Beamline Director/lead ScientistFT$260,599$41,771$302,370
Dr Michael GogerSenior Scientist & Nmr ManagerFT$218,979$22,742$241,721

Board Members and Trustees

NameTitle
Dr Kevin GardnerChairman
Dr Aneel AggarwalBoard Member
Dr Ann McdermottBoard Member
Dr Christopher LimaBoard Member
Dr Crina NimigeanBoard Member
Dr David CowburnBoard Member
Dr David HirshBoard Member
Dr Ming-ming ZhouBoard Member
Dr Nina GrayBoard Member
Dr Pilar CossioBoard Member
Dr Rajendra K AgrawalBoard Member
Dr Seth DarstBoard Member
Dr Stephen LongBoard Member
Dr Steven C AlmoBoard Member
Dr Tony M LissBoard Member
Dr Frederick MaxfieldSecretary
DR TIMOTHY P O'CONNORTreasurer

Highest Paid Contractors

ContractorServicesLocationCompensation
Fei CompanyScientific Equipment Servicer5350 NE DIVISION CREEK DRIVE, Hillsboro, OR 97124$1,433,517
Allan Briteway Electrical ContractorElectrical Services300-1 ROUTE 17 SOUTH SUITE 3, Lodi, NJ 07644$483,409
Bruker Biospin CorporationScientific Equipment Servicer15 FORTUNE DRIVE, Billerica, MA 01821$295,989
Doyle Security Systems INCSecurity Staffing17 MERRICK ROAD SUITE 301, Rockville Centre, NY 11570$243,383
Fresh Meadow Chiller Associates LLCConstruction Services6501 FRESH MEADOW LANE, Fresh Meadows, NY 11365$221,619
Revenue and Support

Revenue Composition

Contributions and Grants
$18,634,211
Program Service Revenue
$0
Investment Income
$687,795
Other Revenue
$630,691
All Other Contributions
$4,860,358
Change in Net Assets
$-8,501,105

Audited Revenue Reconciliation

Revenue per Audited Statements
$19,961,030
Revenue Not Reported on Financial Statements
$-8,333
Revenue Not Reported on Form 990
$985,731
Other Revenue Adjustments
$-8,333
Total Revenue per Audited Statements
$20,946,761
Total Revenue per Form 990
$19,952,697
Expenses and Functional Allocation

Major Expense Lines

Line ItemAmount
Other Expenses$15,479,556
Salaries, Compensation, and Employee Benefits$12,804,246
Grants and Similar Amounts Paid$170,000
Professional Fundraising Fees$0
Total Fundraising Expense$0

Functional Expense Allocation

Line ItemProgramManagementFundraisingTotal
Other Salaries and Wages$7,575,001$1,689,989-$9,264,990
Depreciation Depletion$7,692,472$724,168-$8,416,640
Other Employee Benefits$1,063,673$289,789-$1,353,462
Occupancy$799,350$67,798-$867,148
Pension Plan Contributions$653,879$158,644-$812,523
Payroll Taxes$520,082$167,343-$687,425
Current Officers, Directors, Trustees, and Key Employees-$685,846-$685,846
Office Expenses$515,763$55,333-$571,096
Fees for Services Other$365,093$23,424-$388,517
Insurance$48,781$285,404-$334,185
Other Expenses$259,916$17,214-$259,916
Conferences and Meetings$194,021$38,999-$233,020
Grants to Domestic Orgs$170,000--$170,000
Fees for Services Legal$168,357--$168,357
Information Technology$117,276$30,941-$148,217
All Other Expenses$101,769$12,749-$114,518
Fees for Services Accounting-$68,500-$68,500
Travel$53,926$4,054-$57,980
Interest-$1,130-$1,130
Total Functional Expenses$23,796,275$4,657,527$0$28,453,802

Audited Expense Reconciliation

Line ItemAmount
Expenses per Audited Statements$28,453,802
Total Expenses per Audited Statements$28,453,802
Total Expenses per Form 990$28,453,802
Expenses Not Reported on Financial Statements$0
Expenses Not Reported on Form 990$0
International Activity

Grant and Assistance Recipients

RecipientLocationCategoryPurposeAmount
Trustees of Columbia University in the City of New YorkNew York, NY501(c)(3)Research$170,000
Fundraising, Events, and Gaming
Fundraising activities
No
Gaming activities
No
Professional fundraiser used
No

Fundraising and Gaming Totals

Line ItemAmount
Professional Fundraising Fees$0
Political and Lobbying Activity
Political campaign activity
No
Lobbying activity
No
Subject to proxy tax
No
Debt and Bond Financing

Other Reported Liabilities

LiabilityAmount
Operating Lease Liability$8,195,187
Construction Costs and Retainage Payable$697,113
Governance and Compliance

Governance Checklist

Compiled or reviewed by an accountant
No
Annual disclosure for covered persons
Yes
Audit committee
Yes
Backup withholding compliance
Yes
Business relationship with 35% controlled entity
No
Business relationship with family members
No
Business relationship with organization members
No
Material changes to governing documents
No
Compensation from other sources disclosed
No
CEO compensation reviewed
Yes
Other officer compensation reviewed
No
Conflict-of-interest policy
Yes
Audited financial statements prepared
No
Key decisions subject to board approval
Yes
Management duties delegated
No

Governance Explanations

Form 990, Part VI, Section A, Line 6

On june 30, 1999, the corporation entered into a members contribution agreement (the agreement) with its member parties. The agreement included, among other things, a legal requirement that the then nine member institutions (all tax-exempt under the internal revenue code) make a stipulated capital contribution in order to fund the corporation's construction of a research facility and acquisition of high-field nuclear magnetic resonance instruments. At present eight (8) current members also make annual operating contributions. (cuny is exempt from this requirement by virtue of its capital in-kind contribution of land and a building). Annual operating contributions entitle each member institution to a pro-rata share of time on the instruments owned and operated by the corporation.

Form 990, Part VI, Section A, Line 7A

As provided for in the by-laws, the sustaining, contributing and associate member representatives vote by class for board directors using principles of cumulative voting. In each case, members of a class divide their votes evenly among the individuals nominated by the members. This election occurs at every annual meeting.

Form 990, Part VI, Section A, Line 7B

Members have the power to elect board directors of the corporation and are entitled to vote on all other business of the corporation on which members of a not-for-profit corporation are entitled to vote pursuant to not-for-profit corporation laws of the state of new york or pursuant to the by-laws of the corporation.

Form 990, Part VI, Section B, Line 11B

The executive director has been designated to review and approve the form 990 on behalf of its board of directors prior to filing with the irs. The administration staff and the executive director complete a 990 questionnaire provided to nysbc by its independent audit firm. A draft form 990 is then prepared by the independent audit firm. It is reviewed and approved by the executive director of the corporation before the final form 990 is submitted to the irs. The form 990 is then made available to the members of the board of directors upon request.

Form 990, Part VI, Section B, Line 12C

The board of directors approved the creation of a conflicts resolution committee composed of members of the board of directors. Nysbc's conflict of interest policy is reviewed and revised periodically by the organization's officers and counsel. All employees are provided with a copy of the policy and are required to complete a conflict of interest disclosure form annually. Disclosure forms are reviewed by the executive director and conflicts are submitted to the conflicts resolution committee for appropriate action, if necessary. The conflict of interest policy is posted on nysbc's intranet.

Form 990, Part VI, Section B, Line 15A

The executive committee of the board of directors determines compensation for the organization's executive director. The process includes a comparison of compensation for a similar position at similar institutions. The executive committee meets to discuss executive compensation. Comparison administrator data was reviewed from ivy league schools and a cohort of not-for-profit research institutes. In january 2024 the executive committee held a meeting regarding dr. Jeffrey kieft's compensation for fiscal year 2024.

Form 990, Part VI, Section C, Line 19

The corporation's governing documents, conflict of interest policy and financial statements are available to the public upon request.

Filing and Contact Details

Filer

Filer Name
New York Structural Biology Center Inc
EIN
13-4043587
Phone
2129390660
Address
89 CONVENT AVE 133RD ST, NEW YORK, NY 10027

Signing Officer

Name
Dr Jeffrey Kieft
Title
Executive Director
Phone
2129390660
Signed
2025-10-30
Discuss with paid preparer
Yes

Organization Details

Principal Officer
Dr Jeffrey Kieft
Formed
1999
Legal Domicile
Ny
Voting Board Members
17
Independent Board Members
17
Employees
85
Volunteers
17

Preparer

Firm
Bonadio & Co Llp
Address
171 SULLYS TRAIL, PITTSFORD, NY 14534
Preparer
Richard Leicht
Phone
5853811000
Supplemental Narrative

Additional Explanations

FORM 990, PART XI, LINE 9:

Transfer of titan krios and glacios cryo-electron microscopes and related equipment 9,010,000.

Form 990, Part XII, Line 2C

The process has not changed from the prior year.

Financial Statement Notes

PART XI, LINE 2D - OTHER ADJUSTMENTS:

Investment expenses -44,136.

PART XI, LINE 4B - OTHER ADJUSTMENTS:

Loss on disposal of fixed assets -8,333.

Raw XML AppendixShowing 400 of 747 raw XML fields

This appendix keeps the raw XML leaves available for debugging and edge-case review. The human report above is the primary experience.

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IRS990/Desc0RESEARCH CONDUCTED AT THE SIMONS ELECTRON MICROSCOPY CENTER (SEMC) IS AIMED AT DETERMINING THE STRUCTURE OF MACROMOLECULES TO HELP UNDERSTAND THEIR FUNCTION. AS OF DECEMBER 31, 2024, THE FACILITY HAD 15 TRANSMISSION ELECTRON MICROSCOPES, 3 DUAL-BEAM FOCUSED ION BEAM SCANNING ELECTRON MICROSCOPES, AS WELL AS ANCILLARY EQUIPMENT FOR CRYOEM SAMPLE PREPARATION. SEMC SERVES USERS FROM NYSBC'S NINE MEMBER INSTITUTIONS AS WELL AS USERS FROM THE NATIONAL COMMUNITY THROUGH NIH-FUNDED CENTERS (NATIONAL CENTER FOR CRYOEM ACCESS AND TRAINING AND NATIONAL CENTER FOR IN-SITU TOMOGRAPHIC ULTRAMICROSCOPY). SEMC DEVELOPS OPEN-SOURCE TECHNOLOGIES TO ACCELERATE CRYOEM WORKFLOWS FROM SAMPLE PREPARATION TO STRUCTURE DETERMINATION THROUGH ITS SIMONS FOUNDATION INITIATIVES (SIMONS RESOURCE FOR AUTOMATED MOLECULAR MICROSCOPY AND SIMONS MACHINE LEARNING CENTER). SEMC ALSO PROVIDES EXTENSIVE TRAINING TO MEMBERS OF THE COMMUNITY THROUGH WORKSHOPS, COURSES, AND OTHER TRAINING SESSIONS. IN SEVERAL PROJECTS, SEMC STAFF HAS BEEN INVOLVED EXTENSIVELY AS COLLABORATORS DEVELOPING NEW MACHINE LEARNING ALGORITHMS AND SOFTWARE FOR AUTOMATING CRYOEM, AND CONTRIBUTING TO SOLVING THE STRUCTURES OF: CRISPR-CAS COMPLEXES, ION CHANNELS, GPCRS, AND MANY DRUG TARGETS, E.G., AGAINST DISEASES LIKE COVID-19. OVER 200 SCIENTIFIC ARTICLES ACKNOWLEDGED SEMC SUPPORT IN 2024.
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