Civic Intelligence

The Ovarian Cancer Research Fund Inc

EIN 13-3806788 • 501(c)3 • New York, NY

Profile

The mission of the ovarian cancer research fund (ocrf) is to fund scientific research that leads to more effective identification, treatment, and ultimately a cure for ovarian cancer, as well as related educational and support initiatives.

45 Rockefeller Plaza 20th FloorNew York, NY 10111-3193

www.ocrfa.org

Siviq Scores

Precomputed percentiles relative to similar nonprofits. These scores are descriptive rather than judgmental.

Liabilities / Assets

96th percentile

0.39x

Higher debt load relative to assets than 96% of similar nonprofits.

NTEE T • $25M-$50M nonprofits • Source year 2024

Liabilities / Revenue

94th percentile

1.48x

Higher debt load relative to revenue than 94% of similar nonprofits.

NTEE T • $25M-$50M nonprofits • Source year 2024

Net Margin

16th percentile

-35%

Higher net margin than 16% of similar nonprofits.

NTEE T • $25M-$50M nonprofits • Source year 2024

Top Officer Pay

93rd percentile

$358,239

Higher top officer pay than 93% of similar nonprofits.

Top officer pay equals 3.6% of source-year revenue.

NTEE T • $25M-$50M nonprofits • Source year 2024

Asset Growth

17th percentile

-2.9%

Faster asset growth than 17% of similar nonprofits.

NTEE T • $25M-$50M nonprofits • Annualized from 2023 to 2024

Revenue Growth

17th percentile

-25%

Faster revenue growth than 17% of similar nonprofits.

NTEE T • $25M-$50M nonprofits • Annualized from 2023 to 2024

Assets

Down

$38,070,603

Down $1,132,754 (-2.9%) from 2023

Liabilities

Up

$14,914,782

Up $194,489 (+1.3%) from 2023

Net Assets

Down

$23,155,821

Down $1,327,243 (-5.4%) from 2023

Revenue

Down

$10,047,998

Down $3,394,517 (-25%) from 2023

Expenses

Down

$13,556,516

Down $196,244 (-1.4%) from 2023

Net Income

Down

-$3,508,518

Down $3,198,273 (-1031%) from 2023

Trend Graphs

Balance Sheet Trend

Grouped bars show assets, liabilities, and net assets across loaded filings.

$40M$30M$20M$10M$0Assets 2010: $25,010,502Liabilities 2010: $7,935,005Net Assets 2010: $17,075,4972010Assets 2011: $28,651,178Liabilities 2011: $9,657,971Net Assets 2011: $18,993,2072011Assets 2012: $31,416,587Liabilities 2012: $11,398,083Net Assets 2012: $20,018,5042012Assets 2013: $32,973,277Liabilities 2013: $11,935,973Net Assets 2013: $21,037,3042013Assets 2014: $33,254,984Liabilities 2014: $11,715,096Net Assets 2014: $21,539,8882014Assets 2015: $29,913,445Liabilities 2015: $10,776,634Net Assets 2015: $19,136,8112015Assets 2016: $31,267,081Liabilities 2016: $10,556,321Net Assets 2016: $20,710,7602016Assets 2017: $32,848,561Liabilities 2017: $10,337,614Net Assets 2017: $22,510,9472017Assets 2018: $28,825,539Liabilities 2018: $10,381,395Net Assets 2018: $18,444,1442018Assets 2019: $30,448,674Liabilities 2019: $11,448,782Net Assets 2019: $18,999,8922019Assets 2020: $29,388,979Liabilities 2020: $9,757,489Net Assets 2020: $19,631,4902020Assets 2021: $32,985,153Liabilities 2021: $11,821,697Net Assets 2021: $21,163,4562021Assets 2022: $37,659,088Liabilities 2022: $14,828,822Net Assets 2022: $22,830,2662022Assets 2023: $39,203,357Liabilities 2023: $14,720,293Net Assets 2023: $24,483,0642023Assets 2024: $38,070,603Liabilities 2024: $14,914,782Net Assets 2024: $23,155,8212024

Highlighted filing

2024

Assets$38,070,603
Liabilities$14,914,782
Net Assets$23,155,821

Operations Trend

Revenue, expenses, and net income by year, with the latest filing highlighted.

$20M$15M$10M$5.0M$0-$5.0MExpenses 2010: $8,916,2462010Expenses 2011: $7,436,8472011Expenses 2012: $7,585,0952012Revenue 2013: $9,330,930Expenses 2013: $8,633,550Net Income 2013: $697,3802013Revenue 2014: $8,836,443Expenses 2014: $8,368,155Net Income 2014: $468,2882014Revenue 2015: $7,138,289Expenses 2015: $8,345,217Net Income 2015: -$1,206,9282015Revenue 2016: $11,255,964Expenses 2016: $10,666,517Net Income 2016: $589,4472016Revenue 2017: $11,282,276Expenses 2017: $10,805,177Net Income 2017: $477,0992017Revenue 2018: $9,721,559Expenses 2018: $11,054,168Net Income 2018: -$1,332,6092018Revenue 2019: $8,409,768Expenses 2019: $10,684,965Net Income 2019: -$2,275,1972019Revenue 2020: $7,726,766Expenses 2020: $8,360,005Net Income 2020: -$633,2392020Revenue 2021: $13,088,201Expenses 2021: $11,092,931Net Income 2021: $1,995,2702021Revenue 2022: $16,425,940Expenses 2022: $11,462,650Net Income 2022: $4,963,2902022Revenue 2023: $13,442,515Expenses 2023: $13,752,760Net Income 2023: -$310,2452023Revenue 2024: $10,047,998Expenses 2024: $13,556,516Net Income 2024: -$3,508,5182024

Highlighted filing

2024

Revenue$10,047,998
Expenses$13,556,516
Net Income-$3,508,518

Filings

Balance SheetOperations
YearAssetsLiabilitiesNet AssetsRevenueExpensesNet Income
2024Facts available. Structured filing facts are available, but richer extracted sections are limited.$38.1$14.9$23.2$10.0$13.6$3.51
2023Facts available. Structured filing facts are available, but richer extracted sections are limited.$39.2$14.7$24.5$13.4$13.8$0.31
2022Facts available. Structured filing facts are available, but richer extracted sections are limited.$37.7$14.8$22.8$16.4$11.5$4.96
2021XML pending. An XML filing is linked for this year, but detailed extraction is still pending.$33.0$11.8$21.2$13.1$11.1$2.00
2020XML pending. An XML filing is linked for this year, but detailed extraction is still pending.$29.4$9.76$19.6$7.73$8.36$0.63
2019Facts available. Structured filing facts are available, but richer extracted sections are limited.$30.4$11.4$19.0$8.41$10.7$2.28
2018Detailed filing. Detailed filing data is available for this year.$28.8$10.4$18.4$9.72$11.1$1.33
2017XML pending. An XML filing is linked for this year, but detailed extraction is still pending.$32.8$10.3$22.5$11.3$10.8$0.48
2016XML pending. An XML filing is linked for this year, but detailed extraction is still pending.$31.3$10.6$20.7$11.3$10.7$0.59
2015Detailed filing. Detailed filing data is available for this year.$29.9$10.8$19.1$7.14$8.35$1.21
2014Detailed filing. Detailed filing data is available for this year.$33.3$11.7$21.5$8.84$8.37$0.47
2013Detailed filing. Detailed filing data is available for this year.$33.0$11.9$21.0$9.33$8.63$0.70
2012Facts available. Structured filing facts are available, but richer extracted sections are limited.$31.4$11.4$20.0$7.59
2011Facts available. Structured filing facts are available, but richer extracted sections are limited.$28.7$9.66$19.0$7.44
2010Facts available. Structured filing facts are available, but richer extracted sections are limited.$25.0$7.94$17.1$8.92
Latest Filing Detail
Jump To
Filing Snapshot
Filing Period
Jan 1, 2024 to Dec 31, 2024
Signed
Nov 5, 2025
Return Version
2024v5.2
Gross Receipts
$21,854,917
Mission and Program Overview

Mission

The mission of ovarian cancer research alliance (ocra) is to promote, advocate for and support scientific research as it relates to the causes, prevention, diagnosis, treatment, and cure for ovarian cancer; to provide education about ovarian cancer; to promote, advocate for and provide supportive services to persons affected by ovarian cancer; and to foster alliances to further those purposes.

Ovarian cancer research alliance is committed to preventing, developing better treatments for and ultimately curing ovarian and related gynecologic cancers through innovative research, raising awareness and ensuring the best care possible through advocacy and support for patients and families.

Balance Sheet Detail
LineBeginningEndChange
Assets
Investments in Publicly Traded Securities$34,459,485$33,033,627▼ $1,425,858
Cash and Non-Interest-Bearing Accounts$1,908,312$2,107,359▲ $199,047
Accounts Receivable$669,631$1,212,071▲ $542,440
Savings and Temporary Cash Investments$1,873,971$1,049,345▼ $824,626
Land, Buildings, and Equipment, Net$2,375$80,000▲ $77,625
Prepaid Expenses and Deferred Charges$112,347$69,269▼ $43,078
Total Assets$39,203,357$38,070,603▼ $1,132,754
Other Assets Total$177,236$518,932▲ $341,696
Liabilities
Grants Payable$14,388,180$14,132,020▼ $256,160
Other Liabilities$84,868$421,488▲ $336,620
Accounts Payable and Accrued Expenses$247,245$361,274▲ $114,029
Total Liabilities$14,720,293$14,914,782▲ $194,489
Net Assets / Fund Balance
Net Assets With Donor Restrictions$11,753,619$12,948,381▲ $1,194,762
Net Assets Without Donor Restrictions$12,729,445$10,207,440▼ $2,522,005
Total Net Assets Fund Balance$24,483,064$23,155,821▼ $1,327,243
Total Liabilities and Net Assets / Fund Balance$39,203,357$38,070,603▼ $1,132,754

Asset Categories

AssetBook ValueDepreciationBasis
Other Land Buildings$80,000$117,819$197,819
Equipment$0$115,471$115,471
Compensation and Service Providers

Employees

NameTitleFull / Part TimeBaseOtherTotal
Audra L MoranPresident & CEOFT$324,287$33,952$358,239
Jonathan ZeidmanChief Development OfficerFT$189,019$53,359$242,378
Sarah C DefeoChief Program OfficerFT$166,391$67,294$233,685
Tracy MooreVice President, Support & EducationFT$157,837$27,142$184,979
Nicole WargoVP - Philanthropic PartnerFT$126,274$36,184$162,458
Chad RamseyVice President, PolicyFT$123,276$25,678$148,954
Jessica Hughson AndradeSenior Director, Strategic AllianceFT$108,675$23,247$131,922
Brian PhairDirector, Donor RelationsFT$102,012$5,214$107,226

Highest Paid Contractors

ContractorServicesLocationCompensation
Adc Strategic CommunicationsCommunication Services14 KNOB HL, Putnam Valley, NY 10579-3314$213,604
Benjamin AustinMarketing Consulting Services32 MAGNOLIA DRIVE, Dobbs Ferry, NY 10522$190,589
AmplifiMailing Services600 RYERSON ROAD SUITE G, Lincoln Park, NJ 07035$170,647
Cosgrove AccountingAccounting Services11161 E STATE RD 70 STE 110-693, Lakewood Ranch, FL 34202$160,524
Color HealthHereditary Testing Kits831 MITTEN ROAD STE 100, Burlingame, CA 94010$110,464
Revenue and Support

Revenue Composition

Contributions and Grants
$8,538,194
Program Service Revenue
$301,023
Investment Income
$1,219,860
Other Revenue
$-11,079
All Other Contributions
$8,342,303
Change in Net Assets
$-3,508,518

Noncash Contribution Practices

Property subject to holding requirements
No
Reviewed unusual noncash gifts
Yes
Third parties used for noncash contributions
No

Noncash Contributions

Contribution TypeContribution CountReported AmountValuation Method
Securities Publicly Traded16$684,681Sales Price
Total Noncash Contributions16$684,681-

Audited Revenue Reconciliation

Revenue per Audited Statements
$9,953,833
Revenue Not Reported on Financial Statements
$94,165
Revenue Not Reported on Form 990
$2,514,919
Total Revenue per Audited Statements
$12,468,752
Total Revenue per Form 990
$10,047,998
Expenses and Functional Allocation

Major Expense Lines

Line ItemAmount
Grants and Similar Amounts Paid$6,428,064
Other Expenses$4,240,499
Salaries, Compensation, and Employee Benefits$2,887,953
Total Fundraising Expense$1,425,591
Professional Fundraising Fees$0

Functional Expense Allocation

Line ItemProgramManagementFundraisingTotal
Grants to Domestic Orgs$5,673,064--$5,673,064
Other Salaries and Wages$689,723$165,529$619,738$1,474,990
Fees for Services Other$802,454$257,486$10,823$1,070,763
Current Officers, Directors, Trustees, and Key Employees$648,759$137,600$47,943$834,302
Foreign Grants$755,000--$755,000
Office Expenses$306,672$61,593$359,576$727,841
Other Employee Benefits$179,809$45,332$126,746$351,887
Advertising$150,547$30,725$70,670$251,942
Fees for Services Accounting-$215,632-$215,632
Information Technology$99,368$49,662$52,456$201,486
Occupancy$99,489$22,851$52,519$174,859
Payroll Taxes$99,122$22,750$52,326$174,198
Fees for Services Legal$8,938$160,433-$169,371
Conferences and Meetings$129,842--$129,842
Fees for Service Investment Mgmnt Fees-$94,165-$94,165
Travel$43,613$10,292-$53,905
Pension Plan Contributions$25,891$5,947$20,738$52,576
Insurance$10,727$2,462$5,663$18,852
Depreciation Depletion$7,042$1,616$3,717$12,375
Other Expenses$1,579$360$831$2,770
All Other Expenses$1,525$348$802$2,675
Total Functional Expenses$9,918,693$2,212,232$1,425,591$13,556,516

Audited Expense Reconciliation

Line ItemAmount
Total Expenses per Audited Statements$13,795,995
Total Expenses per Form 990$13,556,516
Expenses per Audited Statements$13,283,335
Expenses Not Reported on Form 990$512,660
Expenses Not Reported on Financial Statements$273,181
Other Expense Adjustments$179,016
International Activity

Grant and Assistance Recipients

RecipientLocationCategoryPurposeAmount
The George Washington UniversityAshburn, VA501(c)(3)Research$900,000
University of MinnesotaBagley, MNState of MnResearch$900,000
CHILDREN'S HOSPITAL CORPORATION (DBA BOSTON CHILDREN'S HOSPITAL)Boston, MA501(c)(3)Research$899,439
Northwestern UniversityEvanston, IL501(c)(3)Research$550,000
Washington University in St LouisSaint Louis, MO501(c)(3)Research$549,837
Johns Hopkins UniversityBaltimore, MD501(c)(3)Research$450,000
H Lee Moffitt Cancer Center and Research Institute IncTampa, FL501(c)(3)Research$449,803
University of North Carolina at Chapel HillChapel Hill, NCState of NcResearch$200,000
The University of Texas Health Science Center at HoustonHouston, TXState of TXResearch$199,999
The University of New MexicoAlbuquerque, NMState of NmResearch$199,987
Stanford UniversityRedwood City, CA501(c)(3)Research$100,000
University of Illinois at ChicagoUrbana, ILState of IlResearch$99,999
The University of Texas Md Anderson Cancer CenterHouston, TXState of TXResearch$99,000
Society of Gynecologic OncologyChicago, IL501(c)(6)Research$75,000

International Summary

Offices
0
Employees
0
Spending
$755,000

International Compliance

Foreign grant records maintained
Yes
Activity in boycott countries
No
Foreign corporation ownership
No
Foreign partnership interest
No
Interest in foreign trust
No
Passive foreign investment company interest
No
Transfers to foreign corporations
No

International Activities

RegionActivityServicesOfficesEmployeesSpending
Europe (including Iceland & Greenland)Grantmaking-00$720,000
North AmericaGrantmaking-00$35,000
Fundraising, Events, and Gaming
Fundraising activities
Yes
Gaming activities
No
Professional fundraiser used
No

Fundraising and Gaming Totals

Line ItemAmount
Fundraising Direct Expenses$11,079
Fundraising Gross Income$0
Professional Fundraising Fees$0

Fundraising Events

EventGross ReceiptsGross RevenueDirect ExpensesNet Income
Ovarian Cycle & Fitness$195,891-$11,079-
Total Events$195,891-$11,079$-11,079
Political and Lobbying Activity
Political campaign activity
No
Lobbying activity
Yes
Subject to proxy tax
No
Debt and Bond Financing

Other Reported Liabilities

LiabilityAmount
Lease Liability$421,488
Governance and Compliance

Governance Checklist

Compiled or reviewed by an accountant
No
Annual disclosure for covered persons
Yes
Audit committee
Yes
Business relationship with 35% controlled entity
No
Business relationship with family members
No
Business relationship with organization members
No
Material changes to governing documents
No
Compensation from other sources disclosed
No
CEO compensation reviewed
Yes
Other officer compensation reviewed
Yes
Conflict-of-interest policy
Yes
Audited financial statements prepared
Yes
Key decisions subject to board approval
No
Management duties delegated
No

Governance Explanations

Form 990, Part VI, Section B, Line 11B

The form 990 is provided to the board of directors, audit committee, treasurer, and the ceo, and is reviewed with the external cpa prior to its filing with the irs.

Form 990, Part VI, Section B, Line 12C

Ocra's conflict of interest policy (the "policy") applies to directors, officers and other employees or other persons in a position to influence policy or expenditures ("key persons") who are annually provided a copy of the policy. The policy includes a reporting form for existing or potential conflicts, and each key person is required to complete annually the reporting form. In connection with any proposed transaction or arrangement between ocra and any such key person or related persons or entities that raises an actual or potential conflict of interest, the key person must disclose the existence and nature of his or her relationship and financial interest to the president or the chair or co-chair of the board of directors or the chair of any authorized committee. The policy provides for consideration of any such transaction or arrangement by board or committee members by following certain meeting, discussion, voting and documentation procedures. Other than to provide information or respond to questions, the key person is excluded from the discussion and the decision of whether a conflict of interest exists.

Form 990, Part VI, Section B, Line 15

Ocra has a compensation committee which meets annually to review the compensation of the ceo. The compensation committee determines the ceo's compensation by utilizing data from comparably-sized organizations (obtained form 990 filings). The compensation decision is documented in the records of the organization. Salary increases for key employees are recommended by the ceo to the compensation committee after an annual evaluation is completed. The compensation decision is documented in the records of the organization.

Form 990, Part VI, Section C, Line 19

Financial statements are available on ocra's website. All other documents are available upon request.

Filing and Contact Details

Filer

Filer Name
The Ovarian Cancer Research Fund Inc
EIN
13-3806788
Phone
2122681002
Address
45 ROCKEFELLER PLAZA 20TH FLOOR, NEW YORK, NY 10111-3193
Doing Business As
Ovarian Cancer Research Alliance

Signing Officer

Name
Audra L Moran
Title
President & CEO
Phone
2122681002
Signed
2025-11-05
Discuss with paid preparer
Yes

Organization Details

Principal Officer
Audra L Moran
Formed
1994
Legal Domicile
Ny
Voting Board Members
19
Independent Board Members
19
Employees
21
Volunteers
1,869

Preparer

Firm
PKF O'CONNOR DAVIES ADVISORY LLC
Address
500 MAMARONECK AVENUE SUITE 301, HARRISON, NY 10528-1633
Preparer
Melissa Modelson
Phone
9143818900
Supplemental Narrative

Additional Explanations

Form 990, Part I, Item C

Dba: ovarian cancer research alliance dba: the edmee firth fund for research on ovarian cancer dba: the edmee firth fund for research in ovarian cancer

FORM 990, PART XI, LINE 9:

GRANT REFUNDS 179,016.

Financial Statement Notes

PART X, LINE 2:

Ocra recognizes the effect of income tax positions only if those positions are more likely than not to be sustained. Management has determined that ocra had no uncertain tax positions that would require financial statement recognition or disclosure. Ocra is no longer subject to examinations by the applicable taxing jurisdictions for years prior to december 31, 2021.

PART XII, LINE 4B - OTHER ADJUSTMENTS:

GRANT REFUNDS 179,016.

Raw XML AppendixShowing 400 of 1,077 raw XML fields

This appendix keeps the raw XML leaves available for debugging and edge-case review. The human report above is the primary experience.

Path#Value
IRS990/AccountantCompileOrReviewInd00
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IRS990/AccountsReceivableGrp/EOYAmt01212071
IRS990/ActivitiesConductedPrtshpInd00
IRS990/ActivityOrMissionDesc0OVARIAN CANCER RESEARCH ALLIANCE IS COMMITTED TO PREVENTING, DEVELOPING BETTER TREATMENTS FOR AND ULTIMATELY CURING OVARIAN AND RELATED GYNECOLOGIC CANCERS THROUGH INNOVATIVE RESEARCH, RAISING AWARENESS AND ENSURING THE BEST CARE POSSIBLE THROUGH ADVOCACY AND SUPPORT FOR PATIENTS AND FAMILIES.
IRS990/AdvertisingGrp/FundraisingAmt070670
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IRS990/Desc0OVARIAN CANCER RESEARCH ALLIANCE WAS FOUNDED IN 1994 (AS THE OVARIAN CANCER RESEARCH FUND, INC.) AND IS A FULL-SPECTRUM ORGANIZATION FUNDING MEDICAL RESEARCH, ADVOCATING ON BEHALF OF PATIENTS AND PROVIDING SUPPORT AND RESOURCES TO PATIENTS AND THEIR FAMILIES.OVARIAN CANCER IS THE DEADLIEST OF ALL GYNECOLOGIC CANCERS AND RANKS FIFTH AS THE CAUSE OF CANCER DEATH IN WOMEN. IN 2024, THERE WERE 19,680 NEW CASES OF OVARIAN CANCER AND 12,740 DEATHS FROM THE DISEASE IN THE UNITED STATES. THE ACCOMPLISHMENTS OF OCRA'S PROGRAMS REFLECT OUR COMMITMENT TO THE OVARIAN AND GYNECOLOGIC CANCER COMMUNITIES. SINCE 1998, OCRA HAS AWARDED 435 GRANTS FOR OVARIAN AND RELATED CANCER RESEARCH TO PHYSICIANS AND SCIENTISTS AT 99 LEADING MEDICAL CENTERS, WHICH IS AN INVESTMENT TOTALING OVER $129 MILLION. THANKS TO THE GENEROSITY OF OUR DONORS, OUR INVESTIGATORS ARE WORKING ON MANY FRONTS TO DEFEAT OVARIAN CANCER. BY DEVELOPING INNOVATIVE STRATEGIES FOR EARLY DETECTION AND EXPLORING THE GENETICS THAT INCREASE RISK FOR OVARIAN CANCER, WE HOPE TO SAVE WOMEN'S LIVES BY FINDING THE CANCER EARLY OR STOPPING IT BEFORE IT EVEN STARTS. RESEARCHERS ARE GAINING INSIGHTS INTO THE MANY TYPES OF OVARIAN AND RELATED CANCERS TO DETERMINE THE ORIGINS, WHICH MAY LEAD TO MORE EFFECTIVE TESTING AND EFFECTIVE IMMUNOTHERAPY TREATMENT OPTIONS. FURTHERMORE, THEY ARE IDENTIFYING NEW AND BETTER TREATMENTS TO IMPROVE OVERALL SURVIVAL, PREVENT DRUG RESISTANCE, MINIMIZE SIDE EFFECTS, PREVENTING RECURRENCE AND METASTASIS, AND ENHANCE PATIENTS' QUALITY OF LIFE. OCRA CONTINUED THE HEALTH EQUITY RESEARCH GRANTS BEGUN IN 2023. THESE GRANTS FOCUS ON IMPROVING HEALTH EQUITY IN THE GYNECOLOGIC CANCER SPACE.ACCOMPLISHMENTS ACHIEVED AS A RESULT OF OCRA GRANTS INCLUDE:IDENTIFIED A MOLECULE THAT COULD BE KEY TO IMPROVING IMMUNE RESPONSE AGAINST OVARIAN CANCER; HIGHLIGHTED THE NEED FOR INDIVIDUAL ASSESSMENT OF COMPLEX VARIANTS TO CORRECTLY IDENTIFY INDIVIDUALS AT RISK; SOUGHT TO UNDERSTAND WHY CERTAIN OVARIAN CANCER CELLS RESIST OLAPARIB TREATMENT, AND DISCOVERED THAT INTRODUCING A SECOND DRUG (MIFEPRISTONE) WHILE TARGETING CERTAIN CELLS (POLYPLOID GIANT CANCER CELLS) MAY OFFER A SOLUTION; IDENTIFIED A PREVIOUSLY UNKNOWN CHEMORESISTANT PATHWAY IN HGSC WHICH LED TO WORKING ON A NEW THERAPY TO OVERCOME THIS; FOUND THAT MESOTHELIAL CELLS ARE IMPORTANT TO THE INITIAL STAGES OF OVARIAN CANCER GROWTH IN THE ABDOMINAL CAVITY; SHED NEW LIGHT ON HOW THE MOST COMMON SUBTYPE OF OVARIAN CANCER DEVELOPS AND METASTASIZES, BY IDENTIFYING A KEY MOLECULE THAT ALLOWS MALIGNANCIES IN THE FALLOPIAN TUBE TO MIGRATE TO THE OVARIES AND CONTINUE TO GROW; UNCOVERED SEVERAL MECHANISMS OF IMMUNE ESCAPE TO HELP EXPLAIN SOME OVARIAN CANCERS' RESISTANCE TO IMMUNOTHERAPY; SHOWN THAT RUCAPARIB EXTENDS PROGRESSION FREE SURVIVAL IN OVARIAN CANCER; DISCOVERED THAT 18% OF OVARIAN CANCER CASES INVOLVE INHERITED MUTATIONS; PINPOINTED TWO GENES THAT TRIGGER OVARIAN CANCER; IDENTIFIED A NEW THERAPEUTIC STRATEGY FOR CLEAR CELL OVARIAN CANCER; SHOWN HOW A PARP/IMMUNE THERAPY COMBO SHOWS PROMISE; DEMONSTRATED HOW GENE THERAPY MAY HELP PATIENTS WITH RECURRENT DISEASE; SHED LIGHT ON HOW OVARIAN CANCER GROWS; DISCOVERED THAT ANALYZING DATA FROM PAP SMEARS COULD HELP DETECT ENDOMETRIAL AND OVARIAN CANCER; ESTABLISHED THERE IS NO LINK BETWEEN OBESITY AND RISK FOR THE MOST COMMON TYPE OF OVARIAN CANCER; SHOWN THAT FGFR4 IS A PROGNOSTIC MARKER AND THERAPEUTIC TARGET FOR OVARIAN CANCER; DEFINED SIMILARITIES BETWEEN SOME ENDOMETRIAL, BREAST AND OVARIAN CANCERS; EXPLAINED HOW AN EXPERIMENTAL DRUG MAY BE HELPFUL IN FIGHTING PLATINUM-RESISTANT OVARIAN CANCER; IDENTIFIED AREAS OF THE HUMAN GENOME THAT ARE LINKED TO INCREASED RISK FOR OVARIAN CANCER; IDENTIFIED BIOMARKERS THAT CAN BE USED TO MONITOR THE DEVELOPMENT OF PLATINUM RESISTANCE THERAPIES; STUDIED MACROPHAGES TO IMPROVE TREATMENT; IDENTIFIED NOVEL BIOMARKERS OF HGSOC AND SPECIFIC DRUG TARGETS; TARGETED MDM2 DEGRADATION AS A NOVEL TREATMENT FOR OVARIAN CANCER; USED MACHINE LEARNING TO BRIDGE
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IRS990/InvestmentsPubTradedSecGrp/EOYAmt033033627

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