Civic Intelligence

Massachusetts Eye & Ear Infirmary

990 • Fiscal year 2017 • EIN 04-2103591

Oct 01, 2016 to Sep 30, 2017 • Filed on Jul 17, 2018

243 Charles StreetBoston, MA 02114

(617) 573-3942

Siviq Scores

Precomputed percentiles for this filing year versus similar nonprofits in the same peer cohort.

Liabilities / Assets

92nd percentile

0.98x

Higher debt load relative to assets than 92% of similar nonprofits.

2017 filings • 501(c)3 • $250M-$1B nonprofits • Source year 2017

Liabilities / Revenue

83rd percentile

1.47x

Higher debt load relative to revenue than 83% of similar nonprofits.

2017 filings • 501(c)3 • $250M-$1B nonprofits • Source year 2017

Net Margin

33rd percentile

1.0%

Higher net margin than 33% of similar nonprofits.

2017 filings • 501(c)3 • $250M-$1B nonprofits • Source year 2017

Top Officer Pay

66th percentile

$1,260,057

Higher top officer pay than 66% of similar nonprofits.

Top officer pay equals 0.5% of source-year revenue.

2017 filings • 501(c)3 • $250M-$1B nonprofits • Source year 2017

Asset Growth

92nd percentile

26%

Faster asset growth than 92% of similar nonprofits.

2017 filings • 501(c)3 • $250M-$1B nonprofits • Annualized from 2016 to 2017

Revenue Growth

58th percentile

7.2%

Faster revenue growth than 58% of similar nonprofits.

2017 filings • 501(c)3 • $250M-$1B nonprofits • Annualized from 2016 to 2017

Assets

Up

$417,880,268

Up $87,068,978 (+26%) from 2016

Net Assets

Up

$7,357,059

Up $10,588,734 (+328%) from 2016

Liabilities

Up

$410,523,209

Up $76,480,244 (+23%) from 2016

Revenue

Up

$278,938,745

Up $18,821,316 (+7.2%) from 2016

Expenses

Up

$276,098,408

Up $15,444,632 (+5.9%) from 2016

Net Income

Up

$2,840,337

Up $3,376,684 (+630%) from 2016

Historical Trend

Balance Sheet Trend

The highlighted filing sits inside the broader history for assets, liabilities, and net assets.

$600M$400M$200M$0-$200MAssets 2010: $254,755,693Liabilities 2010: $212,217,115Net Assets 2010: $42,538,5782010Assets 2011: $248,076,965Liabilities 2011: $214,774,227Net Assets 2011: $33,302,7382011Assets 2012: $236,179,653Liabilities 2012: $210,336,333Net Assets 2012: $25,843,3202012Assets 2013: $224,049,415Liabilities 2013: $187,529,630Net Assets 2013: $36,519,7852013Assets 2014: $209,199,752Liabilities 2014: $180,665,195Net Assets 2014: $28,534,5572014Assets 2015: $212,622,120Liabilities 2015: $215,069,116Net Assets 2015: -$2,446,9962015Assets 2016: $330,811,290Liabilities 2016: $334,042,965Net Assets 2016: -$3,231,6752016Assets 2017: $417,880,268Liabilities 2017: $410,523,209Net Assets 2017: $7,357,0592017Assets 2018: $523,876,840Liabilities 2018: $493,098,652Net Assets 2018: $30,778,1882018

Highlighted filing

2017

Assets$417,880,268
Liabilities$410,523,209
Net Assets$7,357,059

Operations Trend

Revenue, expenses, and net income across loaded years, with this filing highlighted.

$300M$200M$100M$0-$100MExpenses 2010: $202,059,0082010Expenses 2011: $212,288,5512011Expenses 2012: $200,480,6222012Revenue 2013: $221,665,628Expenses 2013: $222,744,370Net Income 2013: -$1,078,7422013Revenue 2014: $228,069,599Expenses 2014: $228,061,270Net Income 2014: $8,3292014Revenue 2015: $235,731,595Expenses 2015: $252,784,400Net Income 2015: -$17,052,8052015Revenue 2016: $260,117,429Expenses 2016: $260,653,776Net Income 2016: -$536,3472016Revenue 2017: $278,938,745Expenses 2017: $276,098,408Net Income 2017: $2,840,3372017Revenue 2018: $299,721,576Expenses 2018: $292,087,720Net Income 2018: $7,633,8562018

Highlighted filing

2017

Revenue$278,938,745
Expenses$276,098,408
Net Income$2,840,337
Jump To
Filing Snapshot
Filing Period
Oct 1, 2016 to Sep 30, 2017
Signed
Jul 17, 2018
Return Version
2016v3.1
Gross Receipts
$278,938,745
Mission and Program Overview

Mission

SEE SCHEDULE O.

Balance Sheet Detail
LineBeginningEndChange
Assets
Land, Buildings, and Equipment, Net$152,903,737$153,916,970▲ $1,013,233
Accounts Receivable$34,429,492$30,816,896▼ $3,612,596
Prepaid Expenses and Deferred Charges$5,002,989$5,161,230▲ $158,241
Inventories for Sale or Use$4,047,488$4,835,627▲ $788,139
Cash and Non-Interest-Bearing Accounts$1,194,722$1,507,830▲ $313,108
Savings and Temporary Cash Investments$0$0→ $0
Other Notes and Loans Receivable, Net$0$0→ $0
Pledges and Grants Receivable$0$0→ $0
Receivable From Disqualified Prsn$0$0→ $0
Receivables From Officers Etc$0$0→ $0
Investments Other Securities$0$0→ $0
Investments Program Related$0$0→ $0
Investments in Publicly Traded Securities$0$0→ $0
Intangible Assets$0$0→ $0
Loans From Officers Directors$0$0→ $0
Total Assets$330,811,290$417,880,268▲ $87,068,978
Other Assets Total$133,232,862$221,641,715▲ $88,408,853
Liabilities
Other Liabilities$92,942,827$179,505,238▲ $86,562,411
Tax Exempt Bond Liabilities$118,496,159$124,421,361▲ $5,925,202
Accounts Payable and Accrued Expenses$111,343,756$95,705,517▼ $15,638,239
Deferred Revenue$11,260,223$10,891,093▼ $369,130
Grants Payable$0$0→ $0
Mortgage Notes Payable Secured by Investment Property$0$0→ $0
Unsecured Notes Loans Payable$0$0→ $0
Escrow Account Liability$0$0→ $0
Total Liabilities$334,042,965$410,523,209▲ $76,480,244
Net Assets / Fund Balance
Unrestricted Net Assets$-3,231,675$7,357,059▲ $10,588,734
Permanently Rstr Net Assets$0$0→ $0
Temporarily Rstr Net Assets$0$0→ $0
Total Net Assets Fund Balance$-3,231,675$7,357,059▲ $10,588,734
Total Liabilities and Net Assets / Fund Balance$330,811,290$417,880,268▲ $87,068,978

Asset Categories

AssetBook ValueDepreciationBasis
Buildings$64,367,262$134,119,782$198,487,044
Equipment$63,596,304$115,852,805$179,449,109
Leasehold Improvements$14,048,680$5,209,720$19,258,400
Other Land Buildings$11,369,400$10,623$11,380,023
Land$535,324-$535,324
Other Assets Org$384--

Endowment Activity

PeriodBeginningContrib.Gain/LossOther UsesEnd
2016$72,460,656$10,372,206▲ $4,293,494$12,552,747$73,437,271
2015$72,613,174$1,960,347▲ $2,728,854$3,796,280$72,460,656
2014$78,511,651$1,229,040▼ $274,466$5,028,553$72,613,174
2013$87,204,661$746,394▲ $5,114,694$12,790,645$78,511,651
2012$89,724,541$2,692,680▲ $3,521,682$7,238,559$87,204,661
Compensation and Service Providers

Employees

NameTitleFull / Part TimeBaseOtherTotal
John R FernandezPresidentFT$758,265$501,792$1,260,057
Carolann WilliamsCFO & VP Finance and AdminFT$419,684$66,327$486,011
Jennifer StreetVP Communications & PlanningFT$327,481$70,805$398,286
Martha Pyle FarrellAsst SecretaryFT$292,606$92,379$384,985
Jeffrey J PikeChief Operating OfficerFT$327,345$52,974$380,319
Melissa M PaulChief Development OfficerFT$251,196$83,534$334,730
Eileen O LowellCNO & VP Pat Care SvsFT$268,352$61,726$330,078
Kenneth HolmesCFO MeeaPT$233,333$85,351$318,684
Rachel WasserstromVP OtolaryngologyPT$247,083$59,562$306,645
Debra RogersVP OphthalmologyPT$234,185$70,879$305,064
Alan K LongVP Research AdministrationPT$155,230$145,977$301,207
Michael RicciChief Information OfficerFT$221,077$59,545$280,622
Glenn W BuntingVoice & Speech Clinical DirectorFT$195,063$50,064$245,127
Barbara J ScullyDirector Prof Rev CyclePT$181,007$45,792$226,799
Maureen KelleyAsst SecretaryFT$190,384$33,147$223,531
Ralph T PelosiDirector Facilities PlanningFT$180,910$17,825$198,735
Deborah L Cronin-waeldeExec Director Ambulatory OperationsFT$180,969$16,293$197,262
Leo J HillDeputy CIOFT$173,935$18,668$192,603

Board Members and Trustees

NameTitle
Wycliffe GrousbeckChair
Annette NovaDirector
Charles De GunzbergDirector
D Bradley WellingDirector
Dewalt Pete AnkenyDirector
Diane E KanebDirector
Eugene HillDirector
Harvey FreishtatDirector
James CarlisleDirector
Joan W Miller MdDirector
Jonathan KutchinsDirector
Robert AtchinsonDirector
Robert KnappDirector
Thomas LauerDirector
William RomanDirector
Samuel FlemingDirector (until December 2016)
Sunil Eappen MdChief Medical Officer
Lyle HowlandSecretary
Jonathan UhrigTreasurer

Highest Paid Contractors

ContractorServicesLocationCompensation
Kpmg LLPConsultingDEPT 0579 PO BOX 120579, Dallas, TX 75312-0579$1,813,528
Seaman Dicarlo General ContractorsContractor9 WHITNEY STREET, Holliston, MA 01746$836,746
Suffolk Construction Co INCConstruction65 ALLERTON STREET, Boston, MA 02119$700,000
Fish And Richardson PCLegalPO BOX 3295, Boston, MA 02241$697,576
Alku Technologies LLCConsulting200 BRICKSTONE SQUARE SUITE 503, Andover, MA 01810$613,027
Revenue and Support

Revenue Composition

Contributions and Grants
$47,291,002
Program Service Revenue
$226,533,383
Investment Income
$410,621
Other Revenue
$4,703,739
All Other Contributions
$9,373,279
Change in Net Assets
$2,840,337
Expenses and Functional Allocation

Major Expense Lines

Line ItemAmount
Other Expenses$139,687,369
Salaries, Compensation, and Employee Benefits$117,853,083
Grants and Similar Amounts Paid$18,435,862
Total Fundraising Expense$2,414,612
Professional Fundraising Fees$122,094

Functional Expense Allocation

Line ItemProgramManagementFundraisingTotal
Other Salaries and Wages$67,221,065$18,311,050$1,441,890$86,974,005
Depreciation Depletion$14,461,387$7,499,416-$21,960,803
Grants to Domestic Orgs$18,309,002--$18,309,002
Other Employee Benefits$12,733,075$3,224,981$271,601$16,229,657
All Other Expenses$10,615,964$4,416,398$98,017$15,130,379
Occupancy$1,085,282$10,769,824$21$11,855,127
Payroll Taxes$6,157,662$1,824,909$129,797$8,112,368
Current Officers, Directors, Trustees, and Key Employees$1,758,321$3,016,255-$4,774,576
Information Technology$2,699,132$1,671,561$898$4,371,591
Interest$2,486,369$1,289,387-$3,775,756
Fees for Services Other$2,473,859$572,822-$3,046,681
Fees for Services Legal$99,766$2,318,515-$2,418,281
Insurance$90,873$1,733,726-$1,824,599
Office Expenses$703,641$914,067$203,115$1,820,823
Pension Plan Contributions$1,345,228$367,097$28,810$1,741,135
Other Expenses$1,328,612$319,797$4,017$1,652,426
Advertising$20,055$983,167-$1,003,222
Travel$615,792$264,873$62,709$943,374
Fees for Services Accounting-$370,979-$370,979
Conferences and Meetings$212,188$118,228$6,158$336,574
Foreign Grants$126,860--$126,860
Fees for Services Lobbying-$123,000-$123,000
Fees for Services Professional Fundraising--$122,094$122,094
Comp Disqual Persons--$21,342$21,342
Total Functional Expenses$210,237,797$63,445,999$2,414,612$276,098,408
International Activity

Grant and Assistance Recipients

RecipientLocationCategoryPurposeAmount
Massachusetts Eye and Ear Associates IncBoston, MA501(c)(3)Institutional Support$14,251,289
Massachusetts General HospitalBoston, MA501(c)(3)Research$803,900
Bionic Eye Technologies IncFishkill, NY501(c)(3)Research$769,160
President & Fellows of HarvardCambridge, MA501(c)(3)Research$526,306
BRIGHAM AND WOMEN'S HOSPITALBoston, MA501(c)(3)Research$363,401
Case Western Reserve University School of MedicineCleveland, OH501(c)(3)Research$211,222
Schepens Eye Research InstituteBoston, MA501(c)(3)Research$170,886
Rhode Island HospitalProvidence, RI501(c)(3)Research$163,380
BOSTON CHILDREN'S HOSPITALBoston, MA501(c)(3)Research$138,016
University of WisconsinMadison, WI501(c)(3)Research$104,175
University of MiamiMiami, FL501(c)(3)Research$103,172
Portland Va Research Foundation IncPortland, OR501(c)(3)Research$80,315
University of IowaIowa City, IA501(c)(3)Research$59,253
Emory UniversityAtlanta, GA501(c)(3)Research$58,598
Wills Eye HospitalPhiladelphia, PA501(c)(3)Research$47,528
Weill Cornell Medical CollegeNew York, NY501(c)(3)Research$46,589
Duke UniversityDurham, NC501(c)(3)Research$46,238
Worcester Polytechnic InstituteWorcester, MA501(c)(3)Research$36,223
University of MaineOrono, ME501(c)(3)Research$35,263
NATIONWIDE CHILDREN'S HOSPITALColumbus, OH501(c)(3)Research$28,582
Research Foundation for SunyAlbany, NY501(c)(3)Research$28,296
University of MichiganAnn Arbor, MI501(c)(3)Research$27,787
Johns Hopkins Univ School of MedicineBaltimore, MD501(c)(3)Research$14,423
Mayo Medical LabratoriesRochester, MN501(c)(3)Research$11,790
Stanford UniversityPalo Alto, CA501(c)(3)Research$9,668

International Summary

Spending
$251,002

International Compliance

Foreign grant records maintained
Yes
Activity in boycott countries
No
Foreign corporation ownership
Yes
Foreign partnership interest
No
Interest in foreign trust
No
Passive foreign investment company interest
No
Transfers to foreign corporations
No

International Activities

RegionActivityServicesOfficesEmployeesSpending
Europe (Including Iceland and Greenland)GrantmakingConference--$71,264
North AmericaGrantmakingConference--$55,596
East Asia and the PacificProgram ServicesConference--$45,338
Europe (Including Iceland and Greenland)Program ServicesConference--$34,478
Sub-Saharan AfricaProgram Services---$23,112
South AmericaProgram ServicesConference--$9,376
North AmericaProgram ServicesConference--$8,516
South AsiaProgram Services---$2,143
Middle East and North AfricaProgram ServicesConference--$1,179
Fundraising, Events, and Gaming
Fundraising activities
No
Gaming activities
No
Professional fundraiser used
Yes

Fundraising and Gaming Totals

Line ItemAmount
Professional Fundraising Fees$122,094
Fundraising Direct Expenses$0
Fundraising Gross Income$0
Gaming Direct Expenses$0
Gaming Gross Income$0
Political and Lobbying Activity
Political campaign activity
No
Lobbying activity
Yes
Subject to proxy tax
No
Insider Transactions and Loans

Interested-Person Transactions

Interested PartyRelationshipDescriptionShared RevenueAmount
Joan Miller MdDrctr Is Licensor to OrgPatent License ProceedsNo$202,762
Sally ReileyDaughter of DirectorAnnual SalaryNo$21,342

Loans and Receivables

Line ItemBeginningEndChange
Loans from Officers, Directors, Trustees, and Key Employees$0$0→ $0
Receivables from Disqualified Persons$0$0→ $0
Receivables from Officers, Directors, Trustees, and Key Employees$0$0→ $0
Debt and Bond Financing

Other Reported Liabilities

LiabilityAmount
Due to Affiliates$168,068,669
Estimate 3rd Party Settlement$4,682,861
Professional Liability Reserve$3,105,530
Tax Deferred Liability$2,310,072
Mdfa Revenue Bonds Intr Rate S$1,338,106

Bond Issues

BondIssuerIssuedIssue PricePurpose
BMassachusetts Development Finance Agency2015-12-30$70,394,000Refndng(2010)&facility improvemnts
AMassachusetts Health and Education Facilities2010-09-29$63,156,092FACILITY IMPROVEMENTS

Bond Proceeds

BondTotal ProceedsSpentRetiredIssuance Costs
B$70,394,000$15,079,333$779,547$441,892
A$63,156,092$0$6,980,000$1,243,623

Bond Financing Compliance

No rebate due
Yes
Rebate not yet due
Yes
Form 8038-T filed
No
Gross proceeds invested
No
Gross proceeds invested in GIC
No
Corrective action procedures
Yes
Governance and Compliance

Governance Checklist

Compiled or reviewed by an accountant
No
Annual disclosure for covered persons
Yes
Audit committee
Yes
Backup withholding compliance
Yes
Business relationship with family members
Yes
Business relationship with organization members
Yes
Material changes to governing documents
No
Compensation from other sources disclosed
No
CEO compensation reviewed
Yes
Other officer compensation reviewed
Yes
Conflict-of-interest policy
Yes
Audited financial statements prepared
Yes
Key decisions subject to board approval
Yes
Management duties delegated
No

Governance Explanations

Form 990, Part VI, Line 1A

The infirmary's bylaws state the following: there shall be an executive committee consisting of those individuals who are serving as members of the executive committee of the member. The executive committee shall have the power to transact all emergency business of the corporation during the period between the meetings of the board of directors. The executive committee shall also transact such business, perform such duties, and exercise such powers as may be directed or delegated by the board of directors from tme to time. The executive committee shall keep a record of its proceedings. All actions of the executive committee shall be reported to the board of directors at its next regular meeting.

Form 990, Part VI, Line 7A

The governor of the commonwealth has the authority to appoint two directors. The bylaws of the infirmary state that the remaining directors are those individuals serving as directors of its sole member, the foundation of the massachusetts eye and ear infirmary, inc. ("the foundation"). Form 990, part vi, line 7b the foundation is the sole member of the infirmary and retains the authority to make decisions regarding the infirmary. Form 990, part vi, line 11b the infirmary's form 990 is prepared by pricewaterhousecoopers, llp using information prepared by management. After the form 990 is completed, it is reviewed by the manager of investments and foundation accounting. The form 990 is then presented to the finance committee for review and approval as authorized by the board of directors. The board of directors are also given the form 990 for review with time to submit comments and questions before final filing. Form 990, part vi, line 12c members of the staff are required to disclose conflicts of interest to their chief of service or department and director of laboratory/unit. Members of the board of directors are required to disclose annually, in writing, any interests that could give rise to conflicts. The office of the internal legal counsel obtains and reviews the annual conflicts of interest statements submitted by members of the board of directors, and reports on the same to the audit and compliance committee of the board. With respect to interests disclosed by board members that could give rise to conflicts of interest, the internal legal counsel reviews all transactions between such interests and affiliates of the infirmary, to determine whether these transactions were conducted at arm's length. Form 990, part vi, line 15 the chairman of the compensation committee of the board of the infirmary presents a recommendation to the compensation committee who have final approval of the ceo's base salary and bonus amount. The ceo recommends the salaries of the chiefs and vice presidents to the compensation committee of the board who has final authorization to approve it. Compensation of those at the director level, including the director of professional revenue cycle, director of facilities planning, and chief information officer is reviewed and approved by the vice president of operations. The compensation committee meeting was held on november 16, 2016. Total compensation for the ceo, chiefs and vice presidents, including bonus payments, including comparability data, is analyzed by independent compensation consultants and is determined to be reasonable.

Form 990, Part VI, Line 19

Summarized financial statements are available on the infirmary's website: www.masseyeandear.org. Audited financial statements are available upon request. The infirmary's governing documents and form 990 are available upon request. The conflict of interest policy is also available upon request.

Filing and Contact Details

Filer

Filer Name
Massachusetts Eye & Ear Infirmary
EIN
04-2103591
In Care Of
% JACK MALLEY
Phone
6175733942
Address
243 CHARLES STREET, BOSTON, MA 02114

Signing Officer

Name
Carolann Williams
Title
CFO & VP Fin & Admin
Phone
6175733012
Signed
2018-07-17
Discuss with paid preparer
Yes

Organization Details

Principal Officer
Carolann Williams
Formed
1827
Legal Domicile
Ma
Voting Board Members
18
Independent Board Members
14
Employees
2,134
Volunteers
213

Preparer

Firm
PricewaterhouseCoopers LLP
Address
101 SEAPORT BLVD SUITE 500, BOSTON, MA 02210
Preparer
Erin Couture
Phone
6175305000
Supplemental Narrative

Additional Explanations

Form 990 Part I, Line 1 & Part III, Line 1

The massachusetts eye and ear infirmary ("the infirmary") is a not-for-profit teaching hospital conducting patient care and research. The infirmary is a teaching hospital of harvard medical school and an international center for research. It has the most competitive program in the country for eye, ear, nose, and throat residency training and the world's largest ophthalmic fellowship program. It is part of a system of related entities that provide specialized medical care collectively known as "massachusetts eye and ear infirmary" ("meei"). Form 990, part iii, line 4a: massachusetts eye and ear is a specialty hospital dedicated to excellence in the care of disorders that affect the eye, ear, nose, throat and adjacent regions of the head and neck. In the 2017-2018 best hospitals survey, u.s. News & world report ranked mass. Eye and ear #2 in the nation for ear, nose and throat care and #4 for eye care. The commitment to provide compassionate and accessible patient care continued in 2017 with the expansion to nineteen clinical care locations. A major focus of the organization over the past year was the process to become a member of partners healthcare. The goal is for mass. Eye and ear to become a tier 1 entity within the top healthcare organization in the northeast. Mass. Eye and ear and partners have a long history of collaboration and the hope is that this will allow for a more seamless sharing of some of the centralized services partners extends to its entities, including peoplesoft (enterprise resource planning) and epic (unified patient care system). The process, nearing a final vote (as of this writing) will enable mass. Eye and ear to maintain its own hospital license, board of directors and independent departments, with the support of partners healthcare. Clinical highlights department of ophthalmology faculty hires mary e. Aronow, md emma davies, md thaddeus dryja, md (part-time) rosario fernandez-godino, phd, msc gabriel fickett, od zhigang he, phd john kempen, md, mph, mhs, phd francois lebreton, phd michael price, md shrinivas pundlik, phd jane schweitzer, md ayellet segr, msc, phd david sol - del valle, md tomasz stryjewski, md jo-ann haney tilton, md jia yin, md faculty appointments ophthalmology alex bowers, phd: associate professor of ophthalmology sunil chauhan, phd: associate professor of ophthalmology joseph ciolino, md: associate professor of ophthalmology jack greiner, do, od, phd: assistant professor of ophthalmology (part-time) xiaoqing guo, md: instructor in ophthalmology nahyoung grace lee, md: assistant professor of ophthalmology heitian lei, phd: assistant professor of ophthalmology yang liu, md: instructor in ophthalmology richard masland, phd: distinguished david glendenning cogan professor of ophthalmology joan w. Miller, md: david glendenning cogan professor of ophthalmology eric pierce, md, phd: solman and libe friedman professor of ophthalmology shivakumar vasanth, phd: instructor in ophthalmology department of otolaryngology new recruits full-time medical staff kevin h. Franck, phd, mba, ccc-a kenneth m. Grundfast, md, facs yuna c. Larrabee, md community-based medical staff christina v. Scirica, md sean t. Doherty, md, facs jordan glicksman, md, mph jong chul park, md (part-time mass. Eye and ear) otolaryngology faculty appointments professor gregory w. Randolph, md, facs, face associate professor benjamin s. Bleier, md eric h. Holbrook, md hideko heidi nakajima, md, phd jeremy d. Richmon, md assistant professor nate jowett, md, frcsc david h. Jung, md, phd felipe santos, md other promotions/new leadership benjamin s. Bleier, md, was named the director of endoscopic skull base surgery. Stacey t. Gray, md, was appointed president of the otolaryngology medical staff. Richard f. Lewis, md, was appointed director of the jenks vestibular physiology laboratory. Daniel b. Polley, phd, was appointed the director of the lauer tinnitus research center. Meaghan reed, aud, was promoted to associate director

Research

Department of ophthalmology amd center of excellence researchers identify potential biomarkers of age-related macular degeneration a study by authors including joan w. Miller, md, ines lains, md, deeba husain, md, john b. Miller, md, demetrios g. Vavvas, md, phd, and ivana k. Kim, md, found that patients with any stage of age-related macular degeneration (amd) carry signs of the disease in their blood that may be found through special laboratory tests. The study describes a new technique known as metabolomics, which can identify blood profiles associated with amd - the leading cause of adult blindness in developed countries - and its level of severity. These potential lipid biomarkers in human blood plasma may lead to earlier diagnosis, better prognostic information, and more precise treatment of patients with amd, as well as potential new targets for amd treatment. Researchers identify key compounds to resolve abnormal vascular growth in age-related macular degeneration a study led by kip connor, phd, showed that a compound of specific bioactive products from a major family of enzymes reduced the severity of age-related macular degeneration (amd) in a preclinical model. The report suggests that it may be possible to prevent the vision loss resulting from disease-causing angiogenesis and inflammation observed in wet amd by increasing the expression of specific bioactive lipid metabolites in the retina. The research demonstrates that these bioactive lipids have the ability to regulate inflammatory immune cells in the retina, key regulators of the angiogenic process in this disease. Given this, these molecules show promising therapeutic potential not only for amd, but also for other major conditions that involve angiogenesis and inflammation, such as cardiovascular disease and cancer. Choroidal changes associated with subretinal drusenoid deposits in age-related macular degeneration using swept-source oct john b. Miller, md, ines lains, md, and colleagues identified a reduction in choroidal thickness and vessel volume in subjects with intermediate age-related macular generation (amd) when subretinal drusenoid deposits were present - an important clinical feature of amd. Understanding choroidal abnormalities may shed light upon the development of subretinal drusenoid deposits and provide insight into the pathogenesis of amd. Cornea center of excellence new technique may prevent graft rejection in high-risk corneal transplant patients reza dana, md, msc, mph, and researchers developed a novel strategy to promote the tolerance of corneal transplants in patients at high risk for rejection. They targeted antigen-presenting cells in donor tissues with a combination of two cytokines, tgf-? And il-10, that work together to promote tolerance of the graft by the transplant recipient's immune system. Restoration of corneal transparency by mesenchymal stem cells a study led by sunil chauhan, phd, identified hepatocyte growth factor (hgf), secreted by mesenchymal stem cells, as the key factor responsible for restoring corneal transparency and promoting wound healing in preclinical models of corneal injury. The findings suggest that hgf-based treatments may be effective in restoring vision in patients with severely scarred corneas. Translational research on lubricin demonstrates significant improvement of multiple signs and symptoms of dry eye disease david a. Sullivan, phd, in collaboration with colleagues from several institutions worldwide, evaluated the use of recombinant human lubricin as a treatment for patients with dry eye disease. A clinical trial based on this research showed significant improvement in signs and symptoms of dry eye disease compared to sodium hyaluronate without adverse events during the investigation. Researchers find stem cells in normal and fuchs corneal endothelium ula jurkunas, md, was the principal investigator of a study that, for the first time, identified stem cells not only in normal corneal endothelium but

Ocular Genomics Institute

Copy-number variation is an important contributor to the genetic causality of inherited retinal degenerations gene therapy shows promise for treating some forms of inherited retinal degeneration (ird), but for about 40% of patients with ird-related vision loss, the genetic cause is unknown. A team led by eric a. Pierce, md, phd, and kinga bujakowska, phd, reported that copy number variations are to blame, in part, with most deletions occurring through non-allelic homologous recombination (nahr). The team mapped nahr-prone regions with overlapping ird genes and suggested that extending the search to these regions and other structural variations may reveal more genetic causality and speed diagnosis for patients. Other research genome editing with crispr-cas9 prevents angiogenesis of the retina a research team led by hetian lei, phd, successfully prevented mice from developing angiogenesis of the retina-the sensory tissue at the back of the eye-using gene-editing techniques with crispr-cas9. Angiogenesis causes vision loss and blindness and is a feature of several degenerative eye conditions, including proliferative diabetic retinopathy (pdr), wet age-related macular degeneration (amd), and retinopathy of prematurity (rop). The researchers presented a novel gene-editing technique to prevent retinal angiogenesis, which could lead to the development of new therapies for eye conditions marked by pathological intraocular angiogenesis. Systemic therapy outperforms intraocular implant for treating uveitis john kempen, md, mph, mhs, phd, and colleagues worked on a seven-year, multi-center clinical trial funded by the national eye institute, in which they found that systemic therapy consisting of corticosteroids and immunosuppressants preserved vision of uveitis patients better - and had fewer adverse outcomes - than a long-lasting corticosteroid intraocular implant. After seven years, visual acuity on average remained stable among participants on systemic therapy but declined by an average of six letters (about one line on an eye chart) among participants who had the implant. Researchers identify mechanism of retina damage following chemical eye burns eleftherios paschalis, phd, led a research team that has identified an inflammatory factor, tumor necrosis factor alpha (tnf-alpha), as the mechanism responsible for causing retinal damage from alkali eye burns. This finding may lead to the development of therapies that prevent damage to the retina. Chemical eye burns caused by alkali agents not only injure the front of the eye - the cornea, where the contact takes place - but also cause widespread damage to the light-sensitive tissue at the back of the eye (the retina) as well, often leading to optic nerve damage and glaucoma. Researchers identify factors responsible for chronic nature of autoimmune disease researchers led by reza dana, md, msc, mph, have uncovered two factors responsible for the chronic, lifelong nature of autoimmune disorders, which tend to flare up intermittently in affected patients. These two factors are cell-signaling proteins called cytokines-specifically interleukin-7 and -15 (il-7 and il-15)-that are secreted by cells of the immune system and help modulate memory th17 cells, a subset of t cells which are known to contribute to autoimmune disorders. Until now, it was unclear how th17 cells maintained memory; the study results show that il-7 and il-15 signal the th17 cells to chronically reside in the body. These findings may lead to the development of new therapies to address a variety of chronic autoimmune disorders. Department of otolaryngology research faculty artur a. Indzhykulian, md, phd kristina simonyan, md, phd, dr. Med. Anne e. Takesian, phd basic science gene therapy restores hearing in deaf mice down to a whisper efforts to develop gene therapies for hearing loss have been hampered by the lack of safe, efficient, and clinically relevant delivery modalities. In a study led by lukas landegger, md, phd, a

Attenuating the Ear Canal Feedback Pressure of A Laser-driven

Hearing aid microphone placement behind the pinna, which minimizes feedback but also reduces perception of the high-frequency pinna cues needed for sound localization, is one reason why hearing-aid users often complain about the poor sound quality and difficulty understanding speech in noisy situations. Mass. Eye and ear/harvard medical school researcher sunil puria, phd, in collaboration with earlens corporation, investigated strategies for minimizing the feedback pressure and developed finite element models of the human middle ear using stapes velocity, cochlear pressure, ear canal impedance, and middle ear power reflectance from living and cadaver temporal bones. These models have applications in the design of improved hearing aids that mechanically drive the umbo (the central, most inverted portion of the ear drum). Such design applications could reduce feedback pressure using acoustic dampers in the canal tip. This new design paves the path towards placing the microphones of future devices that mechanically simulate the middle ear in the ear canal. Khaleghia m, puria s. Attenuating the ear canal feedback pressure of a laser-driven hearing aid. J acoust soc of am. 2017;141:3,16831693. Connectome-wide phenotypical and genotypical associations in focal dystonia laryngeal dystonia (ld), or spasmodic dysphonia, is a movement disorder that selectively affects the production of speech due to impaired voluntary control of vocal fold movements. Early studies have pointed to segregated changes in brain activity and connectivity and only recently, the notion that dystonia pathophysiology may lie in abnormalities of large-scale brain networks has appeared in the literature. In support of this emerging view, a team of researchers including kristina simonyan, md, phd, conducted detailed investigation of the architecture of large-scale functional brain networks in a uniquely large population of 90 ld patients and 32 healthy subjects. Their findings provide the first comprehensive atlas of functional topology across different phenotypes and genotypes of focal dystonia. As such, this study constitutes an important paradigm-shifting step towards defining dystonia as a large-scale network disorder for understanding of its causative pathophysiology and the identification of disorder-specific markers. Fuertinger s, simonyan k. Connectome-wide phenotypical and genotypical associations in focal dystonia. J neurosci. 2017 aug 2;37(31):74387449. Histopathology histopathology of the human inner ear in cogans syndrome with cochlear implantation cogan syndrome is a rare disorder characterized by non-syphilitic interstitial keratitis and audiovestibular symptoms with profound sensorineural hearing loss reported in approximately 50 percent of patients with this disorder, often resulting in candidacy for cochlear implantation. A team of researchers including joesph b. Nadol, jr., md, recently completed a study that became the first histopathologic report of a patient with cogans syndrome who, during life, had undergone bilateral cochlear implantation. Although severe bilateral degeneration of the spiral ganglion neurons was seen, the postoperative word discrimination score was between 50 and 60 percent bilaterally. The histopathology seen within the inner ear was the result of labyrinthitis secondary to cogans syndrome in addition to the immune-mediated response to the implantation process. Kamakura t, lee dj, herrmann bs, nadol jb jr. Histopathology of the human inner ear in the cogan syndrome with cochlear implantation. Audiol neurootol. 2017;22(2):116123. Clinical practice patients with severe chronic rhinosinusitis show improvement with verapamil treatment a clinical trial studying the use of verapamil, a drug currently in use for cardiovascular disease and cluster headache, in alleviating chronic rhinosinusitis (crs) with nasal polyps revealed significant improvement in the symptoms of this subset of patients. Led by benjamin s. Bleier, md, it is

Duration of Analgesic Use and Risk of Hearing Loss in Women

Aspirin, non-steroidal anti-inflammatory drugs (nsaids), and acetaminophen are the most commonly used medications in the us. Frequent use of analgesics has been associated with higher risk of hearing loss. However, the association between duration of analgesic use and risk of hearing loss is unclear. Therefore, a team of researchers including brian m. Lin, md, prospectively investigated the relation between duration of analgesic use and self-reported hearing loss among 55,850 women in the nurses health study. They found that longer duration of nsaid use was associated with a ten percent increase in risk of hearing and longer duration of acetaminophen use was associated with a nine percent increase in risk of hearing loss. Duration of aspirin use was not associated with hearing loss. Considering the high prevalence of analgesic use and the high probability of frequent and/or prolonged exposure in women of more advanced ages, our findings suggest nsaid use and acetaminophen use may be modifiable risk factors for hearing loss. Lin bm, curhan sg, wang m, eavey r, stankovic km, curhan gc. Duration of analgesic use and risk of hearing loss in women. Am j epidemiol. 2017 jan 1. 185(1):4047. Patients with depression symptoms due to chronic sinus disease may be less productive depressed patients with chronic rhinosinusitis (crs) are more likely to miss days of work or school than those without depression symptoms, according to the results of a study led by ahmad r. Sedaghat, md, phd. The findings, published in annals of allergy, asthma and immunology, identify depression symptoms as the primary driver of lost days of productivity in patients with crs. In search of an association with lost productivity, the researchers assessed the main symptoms of crs-disturbances of sleep, nasal obstruction, ear and facial pain, and emotional function-in 107 patients using a standardized survey. On average, study participants reported three missed days of work or school in a three-month period, or 12 missed days in a year. When the researchers took a closer look at the surveys, they identified emotional symptoms, in which depression symptoms are the strongest feature, as the primary driver of missed days of work or school. Campbell ap, phillips km, hoehle lp, feng al, bergmark rw, caradonna ds, gray st, sedaghat ar. Depression symptoms and lost productivity in chronic rhinosinusitis. Ann allergy asthma immunol. 2017 mar;118(3):286289. Global surgery effect of removing the barrier of transportation costs on surgical utilisation eighty-one million people face impoverishment from surgical costs every year. The majority of this impoverishment is attributable to the non-medical costs of care such as transportation, food, and lodging. Of these, transportation is the largest, but because it is not viewed as an actual medical cost, it is frequently unaddressed. In a study led by mark g. Shrime, md, mph, phd, facs, researchers examined the barrier that transportation costs raise to accessing surgery in low-income countries. The researchers used data over four years from mercy ships, an organization that delivers free specialized surgical care in sub-saharan africa. Over these four years, the ship was docked in three countries (guinea, republic of congo, and madagascar) and saw 4,340 surgical patients, 2,629 of whom lived further than five hours away. They found that when controlling for all possible confounders, the no-show rate dropped by nearly half when transportation was paid for. This highlights that decreasing demand-side barriers to surgical care cannot be limited only to the removal of user fees. Shrime mg, hamer m, mukhopadhyay s, kunz lm, claus nh, randall k, jean-baptiste jh, maevatombo ph, toh mps, biddell jr, bos r, white m. Effect of removing the barrier of transportation costs on surgical utilisation in guinea, madagascar, and the republic of congo. Bmj glob health 2017;2:e000434. Doi:10.1136/ bmjgh-2017-000434. Radiology dr. Amy juliano continu

Form 990, Part III, Line 4B

Education ent education highlights this year we celebrated the graduation of the class of 2017 at a june 23rd ceremony held in the meltzer auditorium at mass. Eye and ear. Our graduates included francis pete x. Creighton, jr., md, rebecca j. Hammon, md, taha a. Jan, md, matthew r. Naunheim, md, mba, and george a. Scangas, md. We also celebrated the graduation of five clinical fellows: regan w. Bergmark, md, rhinology adam p. Campbell, md, rhinology callum faris, md, facial plastic and reconstructive surgery ruwan kiringoda, md, neurotology heather a. Osborn, md, frcsc, head and neck surgical oncology/microvascular surgery following graduation, we welcomed several new trainees in otolaryngology to mass. Eye and ear, including five new otolaryngology interns and eight clinical fellows. Our otolaryngology interns include eric r. Barbarite, md, adeeb derakhshan, md, krupa r. Patel, md, tiffany v. Wang, md, and phoebe kuo yu, md. Our clinical fellows include joseph r. Dusseldorp, md (facial plastic and reconstructive surgery), jacqueline j. Greene, md (facial plastic and reconstructive surgery), joseph zenga, md (head and neck oncology/ microvascular surgery), nicholas a. Dewyer, md (neurtology), sarah bouhabel, md (pediatric otolaryngology), edward t. El rassi, md (rhinology), george a. Scangas, md (rhinology), and mohamed shama, md (thyroid and parathyroid surgery). In other education news, we continue to enjoy our state-of-the-art otolaryngology surgical training laboratory and have held several major courses there over the past year, from resident dissection courses to cme courses with international attendees. This year, two new lectureships were established, including the donald g. Keamy, sr., lectureship and the c.t. Lee endowed lectureship in spirituality, compassion, and healing. Awards and honors ophthalmology teresa chen, md: a. Clifford barger excellence in mentoring award, harvard medical school kip connor, phd: young mentor award, harvard medical school patricia d'amore, phd, mba: president-elect, association of university professors of ophthalmology research directors council reza dana, md, msc, mph: 2018 friedenwald award, association for research in vision and ophthalmology; 2017 senior achievement award, american academy of ophthalmology dean eliott, md: lifetime mentorship award, vit-buckle society evangelos gragoudas, md: 2017 simmons lessell excellence in education award, department of ophthalmology, mass. Eye and ear, harvard medical school kathryn hatch, md: named an outstanding female leader in ophthalmology by millenialeye jae-hyun jung, phd: 2017 alice j. Adler fellowship of schepens eye research institute of mass. Eye and ear, eleanor and miles shore 50th anniversary fellowship, harvard medical school frederick jakobiec, md, dsc: merrill reeh prize from the american society of ophthalmic plastic and reconstructive surgery ula jurkunas, md: 2017 pfizer ophthalmics carl camras translational research award carolyn kloek, md: 2017 educator award, women in ophthalmology gang luo, phd: innovations in technology low vision research award, research to prevent blindness/reader's digest partners for sight foundation/consumer technology association foundation joan w. Miller, md: inducted into the dowling society, association for research in vision and ophthalmology; appointed to the board of trustees, association for university professors in ophthalmology louis pasquale, md: 2017 gold fellow, association for research in vision and ophthalmology eli peli, msc, od: charles f. Prentice medal award, american academy of optometry roberto pineda ii, md: accepted into the international intraocular implant club brian song, md, mph: joanne angle investigator award, prevent blindness david sullivan, ms, phd: dr. Donald r. Korb award, american optometric association contact lens and cornea section luk vandenberghe, phd: nelson trust award, research to prevent blindness; 2017 ed gollob board of directors' award, foundation fight

Community Engagement

Michael s. Cohen, md, sent earmuff-style hearing protection to the new england patriots players for their kids to wear during super bowl li. He also hosted his annual hearing center family carnival, which brings dozens of patient families to mass. Eye and ear for a day of fun. Aaron k. Remenschneider, md, mph, alicia m. Quesnel, md, and research fellow iman a. Ghanad are working with the massachusetts commission for the deaf and hard of hearing on continued support for the boston marathon bombing victims. They have established a formal collaboration with them to serve and support survivors, and collect clinical outcomes data on patients who are local. The voice and speech laboratory (vsl) went to concord-carlisle regional high school in for a full-day program geared toward juniors and seniors, many of whom are interested in pursuing careers in health science. Staff from mass. Eye and ear, stoneham held a holiday toy drive for the children of malden. A new collaboration between mass. Eye and ear and symphony new hampshire was established. The goal of this partnership is to bring medically based music therapy programs to mass. Eye and ear patients. Otolaryngology faculty and residents met with harvard medical school students at the mass. Eye and ear, longwood campus to review basic head and neck exam skills. Ophthalmology facility/programmatic established the simmons lessell fellowship in neuro-ophthalmology established the thomas j. Madden fellowship in retina established the iraty award for research in retinal diseases established the monte j. Wallace ophthalmology chair in retina new ophthalmology patient care location opened in malden, ma - offers comprehensive ophthalmology, including cataract surgery and contact lenses, as well as eye plastics services - optometry, glaucoma and cornea services in the future. First medical center in new england to offer state-of-the-art retinal surgery using the ngenuity 3d visualization system offering new fda-approved corneal cross-linking procedure to halt progression of keratoconus mass. Eye and ear is participating in a new harvard medical school faculty mentoring leadership certificate program that runs from november 8, 2017 through june 13, 2018. This program is a multi-session, peer-learning experience for mid-career and senior faculty physician and scientist mentors. The goal for participants of this program is to become leaders in mentoring who will go on to facilitate the program in future years, or develop similar programs at their own institutions. Launched the retinal disease institute (rdi) cabinet-an advisory council of leaders in retinal research philanthropy who will work with mass. Eye and ear/harvard ophthalmology retina leaders to accelerate cures for retinal diseases. Cabinet members include: joan miller, wyc grousbeck, charles de gunzburg, pete ankeny, chris snook, george yancopoulos, tony adamis, and gene hill. As the first of its kind, the rdi is designed to foster partnerships between mass. Eye and ear/harvard ophthalmology faculty working in fields related to retinal disease and the worlds leading scientists (basic biomedical researchers, clinician scientists, engineers, and clinicians) working outside vision research.

Form 990, Part XI, Line 9

Other changes in net assets or fund balances: adjustment for pension and postretirement related changes other than net periodic pension cost: $4,668,500

Financial Statement Notes

SCHEDULE D, PART III, LINE 4:

The rare books collection consists mainly of several hundred books in the meei specialties of ophthalmology and otolaryngology as well as a few on the medical history of boston and massachusetts. The majority were donated originally by moses lurie, md and mrs. Lucien howe (wife of lucien howe, md). A few were donated by other physicians through the years. Endowment funds set up between mrs. Howe and dr. Lurie were designated for the occasional purchase of rare books to supplement the original donations. The rare books are available to the scientific, medical and academic community for purposes of research and education.

SCHEDULE D, PART V, LINE 4:

The endowment functions to support the mission of the massachusetts eye and ear infirmary to provide superior patient care and research. The income from the endowment funds is subject to donor-imposed stipulations usually for research, education and patient care.

SCHEDULE D, PART X, LINE 2:

The massachusetts eye and ear infirmary ("infirmary") was included in consolidated financial statements with its affiliated organizations. The income tax footnote is as follows: the foundation and its affiliates qualify as tax-exempt organizations under the internal revenue code. The foundation, infirmary, associates, schepens and embankment are tax-exempt under section 501(c)(3) of the internal revenue code and circle is tax-exempt under 501(c)(25) of the internal revenue code. Accordingly, no provision for income taxes has been made in the accompanying financial statements. Management has evaluated accounting for uncertainty in income taxes and there was no impact to the foundation's financial statements for the year ended september 30, 2017.

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